Oncogenic fusion protein EWS-FLI1 is a network hub that regulates alternative splicing von Selvanathan, Saravana P., Graham, Garrett T., Erkizan, Hayriye V., Dirksen, Uta, Natarajan, Thanemozhi G., Dakic, Aleksandra, Yu, Songtao, Liu, Xuefeng, Paulsen, Michelle T., Ljungman, Mats E., Wu, Cathy H., Lawlor, Elizabeth R., Üren, Aykut, Toretsky, Jeffrey A.

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Inhibition of the oncogenic fusion protein EWS-FLI1 causes G2-M cell cycle arrest and enhanced vincristine sensitivity in Ewing’s sarcoma von Zöllner, Stefan K, Selvanathan, Saravana P, Graham, Garrett T, Commins Ryan M T, Hong, Sung Hyeok, Moseley, Eric, Parks, Sydney, Haladyna, Jessica N, Erkizan, Hayriye V, Dirksen Uta, Hogarty, Michael D, Üren Aykut, Toretsky, Jeffrey A

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Ezrin Binds to DEAD-Box RNA Helicase DDX3 and Regulates Its Function and Protein Level von Çelik, Haydar, Sajwan, Kamal P., Selvanathan, Saravana P., Marsh, Benjamin J., Pai, Amrita V., Kont, Yasemin Saygideger, Han, Jenny, Minas, Tsion Z., Rahim, Said, Erkizan, Hayriye Verda, Toretsky, Jeffrey A., Üren, Aykut

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Single enantiomer of YK-4-279 demonstrates specificity in targeting the oncogene EWS-FLI1 von Barber-Rotenberg, Julie S, Selvanathan, Saravana P, Kong, Yali, Erkizan, Hayriye V, Snyder, Tara M, Hong, S Peter, Kobs, Christina L, South, Natalie L, Summer, Steven, Monroe, Philip J, Chruszcz, Maksymilian, Dobrev, Veselin, Tosso, Perrer N, Scher, Lauren J, Minor, Wladek, Brown, Milton L, Metallo, Steven J, Üren, Aykut, Toretsky, Jeffrey A

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Widespread hypertranscription in aggressive human cancers von Zatzman, Matthew, Fuligni, Fabio, Ripsman, Ryan, Suwal, Tannu, Comitani, Federico, Edward, Lisa-Monique, Denroche, Rob, Jang, Gun Ho, Notta, Faiyaz, Gallinger, Steven, Selvanathan, Saravana P, Toretsky, Jeffrey A, Hellmann, Matthew D, Tabori, Uri, Huang, Annie, Shlien, Adam

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Inhibition of the oncogenic fusion protein EWS-FLI1 causes G 2 -M cell cycle arrest and enhanced vincristine sensitivity in Ewing's sarcoma von Zöllner, Stefan K, Selvanathan, Saravana P, Graham, Garrett T, Commins, Ryan M T, Hong, Sung Hyeok, Moseley, Eric, Parks, Sydney, Haladyna, Jessica N, Erkizan, Hayriye V, Dirksen, Uta, Hogarty, Michael D, Üren, Aykut, Toretsky, Jeffrey A

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Schizosaccharomyces pombe Dss1p Is a DNA Damage Checkpoint Protein That Recruits Rad24p, Cdc25p, and Rae1p to DNA Double-strand Breaks von Selvanathan, Saravana P., Thakurta, Anjan G., Dhakshnamoorthy, Jothy, Zhou, Ming, Veenstra, Timothy D., Dhar, Ravi

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The Nuclear Export Signal of Splicing Factor Uap56p Interacts with Nuclear Pore-associated Protein Rae1p for mRNA Export in Schizosaccharomyces pombe von Thakurta, Anjan G., Selvanathan, Saravana P., Patterson, Andrew D., Gopal, Ganesh, Dhar, Ravi

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Therapeutic effect of tamoxifen and energy-modulating vitamins on carbohydrate-metabolizing enzymes in breast cancer von SELVANATHAN SARAVANA PERUMAL, SHANTHI, Palanivelu, SACHDANANDAM, Panchanadham

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Abstract 694: TK-216: a novel, first-in-class, small molecule inhibitor of EWS-FLI1 in early clinical development, for the treatment of Ewing Sarcoma von Selvanathan, Saravana P., Moseley, Eric, Graham, Garrett T., Jessen, Katti, Lannutti, Brian, Üren, Aykut, Toretsky, Jeffrey A.

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Augmented efficacy of tamoxifen in rat breast tumorigenesis when gavaged along with riboflavin, niacin, and CoQ10: effects on lipid peroxidation and antioxidants in mitochondria von Perumal, Selvanathan Saravana, Shanthi, Palanivelu, Sachdanandam, Panchanadham

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Abstract A39: Alternative splicing in Ewing sarcoma may be driven by phase separation of spliceosome proteins von Toretsky, Jeffrey, Graham, Garrett, Dirksen, Uta, Erkizan, Hayriye Verda, Lawlor, Elizabeth, Uren, Aykut, Selvanathan, Saravana

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Development of an Ewing sarcoma cell line with resistance to EWS-FLI1 inhibitor YK-4-279 von Conn, Erin, Hour, Sarah, Allegakoen, David, Graham, Garrett, Petro, Jeff, Kouassi-Brou, Marilyn, Hong, Sung Hyeok, Selvanathan, Saravana, Celik, Haydar, Toretsky, Jeffrey, Uren, Aykut

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