Assessment of an Anti-Alpha-Toxin Monoclonal Antibody for Prevention and Treatment of Staphylococcus aureus-Induced Pneumonia von Hua, L, Hilliard, J J, Shi, Y, Tkaczyk, C, Cheng, L I, Yu, X, Datta, V, Ren, S, Feng, H, Zinsou, R, Keller, A, O'Day, T, Du, Q, Cheng, L, Damschroder, M, Robbie, G, Suzich, J, Stover, C K, Sellman, B R

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Microbial burden and viral exacerbations in a longitudinal multicenter COPD cohort von Bouquet, Jerome, Tabor, David E, Silver, Jonathan S, Nair, Varsha, Tovchigrechko, Andrey, Griffin, M Pamela, Esser, Mark T, Sellman, Bret R, Jin, Hong

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Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source von Boland, Michelle L, Oró, Denise, Tølbøl, Kirstine S, Thrane, Sebastian T, Nielsen, Jens Christian, Cohen, Taylor S, Tabor, David E, Fernandes, Fiona, Tovchigrechko, Andrey, Veidal, Sanne S, Warrener, Paul, Sellman, Bret R, Jelsing, Jacob, Feigh, Michael, Vrang, Niels, Trevaskis, James L, Hansen, Henrik H

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Differential expression and roles of Staphylococcus aureus virulence determinants during colonization and disease von Jenkins, Amy, Diep, Binh An, Mai, Thuy T, Vo, Nhung H, Warrener, Paul, Suzich, Joann, Stover, C Kendall, Sellman, Bret R

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Moving toward endotypes in atopic dermatitis: Identification of patient clusters based on serum biomarker analysis von Thijs, Judith L., MD, Strickland, Ian, PhD, Bruijnzeel-Koomen, Carla A.F.M., MD, PhD, Nierkens, Stefan, PhD, Giovannone, Barbara, PhD, Csomor, Eszter, PhD, Sellman, Bret R., PhD, Mustelin, Tomas, MD, PhD, Sleeman, Matthew A., PhD, de Bruin-Weller, Marjolein S., MD, PhD, Herath, Athula, PhD, Drylewicz, Julia, PhD, May, Richard D., PhD, Hijnen, DirkJan, MD, PhD

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Bispecific antibody targets multiple Pseudomonas aeruginosa evasion mechanisms in the lung vasculature von Thanabalasuriar, Ajitha, Surewaard, Bas Gj, Willson, Michelle E, Neupane, Arpan S, Stover, Charles K, Warrener, Paul, Wilson, George, Keller, Ashley E, Sellman, Bret R, DiGiandomenico, Antonio, Kubes, Paul

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A fungal metabolic regulator underlies infectious synergism during Candida albicans-Staphylococcus aureus intra-abdominal co-infection von Paul, Saikat, Todd, Olivia A, Eichelberger, Kara R, Tkaczyk, Christine, Sellman, Bret R, Noverr, Mairi C, Cassat, James E, Fidel, Jr, Paul L, Peters, Brian M

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S. aureus Evades Macrophage Killing through NLRP3-Dependent Effects on Mitochondrial Trafficking von Cohen, Taylor S., Boland, Michelle L., Boland, Brandon B., Takahashi, Virginia, Tovchigrechko, Andrey, Lee, Young, Wilde, Aimee D., Mazaitis, Mark J., Jones-Nelson, Omari, Tkaczyk, Christine, Raja, Rajiv, Stover, C. Kendall, Sellman, Bret R.

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Neutralizing Alpha-Toxin Accelerates Healing of Staphylococcus aureus-Infected Wounds in Nondiabetic and Diabetic Mice von Ortines, Roger V, Liu, Haiyun, Cheng, Lily I, Cohen, Taylor S, Lawlor, Heather, Gami, Abhishek, Wang, Yu, Dillen, Carly A, Archer, Nathan K, Miller, Robert J, Ashbaugh, Alyssa G, Pinsker, Bret L, Marchitto, Mark C, Tkaczyk, Christine, Stover, C Kendall, Sellman, Bret R, Miller, Lloyd S

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Treatment Efficacy of MEDI3902 in Pseudomonas aeruginosa Bloodstream Infection and Acute Pneumonia Rabbit Models von Le, Hoan N, Tran, Vuvi G, Vu, Trang T T, Gras, Emmanuelle, Le, Vien T M, Pinheiro, Marcos Gabriel, Aguiar-Alves, Fábio, Schneider-Smith, Erika, Carter, Henry Clay, Sellman, Bret R, Stover, C Kendall, DiGiandomenico, Antonio, Diep, Binh An

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The complex biology and contribution of Staphylococcus aureus in atopic dermatitis, current and future therapies von Hepburn, L., Hijnen, D.J., Sellman, B.R., Mustelin, T., Sleeman, M.A., May, R.D., Strickland, I.

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MEDI4893 Promotes Survival and Extends the Antibiotic Treatment Window in a Staphylococcus aureus Immunocompromised Pneumonia Model von Hua, L, Cohen, T S, Shi, Y, Datta, V, Hilliard, J J, Tkaczyk, C, Suzich, J, Stover, C K, Sellman, B R

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Monoclonal antibodies neutralizing alpha-hemolysin, bicomponent leukocidins, and clumping factor A protected against Staphylococcus aureus -induced acute circulatory failure in a m... von Nguyen, Nhu T Q, Doan, Thien N M, Sato, Kei, Tkaczyk, Christine, Sellman, Bret R, Diep, Binh An

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Staphylococcus aureus alpha toxin suppresses effective innate and adaptive immune responses in a murine dermonecrosis model von Tkaczyk, Christine, Hamilton, Melissa M, Datta, Vivekananda, Yang, Xiang Ping, Hilliard, Jamese J, Stephens, Geoffrey L, Sadowska, Agnieszka, Hua, Lei, O'Day, Terrence, Suzich, JoAnn, Stover, Charles Kendall, Sellman, Bret R

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Dominant: Negative Mutants of a Toxin Subunit: An Approach to Therapy of Anthrax von Sellman, Bret R., Mourez, Michael, Collier, R. John

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Alpha-Toxin Contributes to Biofilm Formation among Staphylococcus aureus Wound Isolates von Anderson, Michele J, Schaaf, Emily, Breshears, Laura M, Wallis, Heidi W, Johnson, James R, Tkaczyk, Christine, Sellman, Bret R, Sun, Jisun, Peterson, Marnie L

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Identification of Anti-Alpha Toxin Monoclonal Antibodies That Reduce the Severity of Staphylococcus aureus Dermonecrosis and Exhibit a Correlation between Affinity and Potency von Tkaczyk, C, Hua, L, Varkey, R, Shi, Y, Dettinger, L, Woods, R, Barnes, A, MacGill, R S, Wilson, S, Chowdhury, P, Stover, C K, Sellman, B R

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Alanine Scanning Mutagenesis of the MEDI4893 (Suvratoxumab) Epitope Reduces Alpha Toxin Lytic Activity In Vitro and Staphylococcus aureus Fitness in Infection Models von Tkaczyk, C, Semenova, E, Shi, Y Y, Rosenthal, K, Oganesyan, V, Warrener, P, Stover, C K, Sellman, B R

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Antibacterial monoclonal antibodies: the next generation? von DiGiandomenico, Antonio, Sellman, Bret R

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Multimechanistic Monoclonal Antibodies (MAbs) Targeting Staphylococcus aureus Alpha-Toxin and Clumping Factor A: Activity and Efficacy Comparisons of a MAb Combination and an Engin... von Tkaczyk, C, Kasturirangan, S, Minola, A, Jones-Nelson, O, Gunter, V, Shi, Y Y, Rosenthal, K, Aleti, V, Semenova, E, Warrener, P, Tabor, D, Stover, C K, Corti, D, Rainey, G, Sellman, B R

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