From micrograms to grams: scale-up synthesis of eribulin mesylate von Yu, Melvin J, Zheng, Wanjun, Seletsky, Boris M

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Eribulin Induces Irreversible Mitotic Blockade: Implications of Cell-Based Pharmacodynamics for In vivo Efficacy under Intermittent Dosing Conditions von TOWLE, Murray J, SALVATO, Kathleen A, LITTLEFIELD, Bruce A, WELS, Bruce F, AALFS, Kimberley K, WANJUN ZHENG, SELETSKY, Boris M, XIAOJIE ZHU, LEWIS, Bryan M, KISHI, Yoshito, YU, Melvin J

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Discovery of CC-99677, a selective targeted covalent MAPKAPK2 (MK2) inhibitor for autoimmune disorders von Malona, JOHN, CHUAQUI, CLAUDIO, SELETSKY, BORIS M., BEEBE, LISA, CANTIN, SUSAN, KALKEN, DANIEL VAN, FAHNOE, KELLY, WANG, ZHIGANG, BROWNING, BETH, SZABO, HILARY, KOOPMAN, LOUISE A., ORAVECZ, TAMAS, MCDONALD, JOSEPH J., RAMIREZ-VALLE, FRANCISCO, GAUR, RAJULA, MENSAH, KOFI A., THOMAS, MICHAEL, CONNARN, JAMIE N., HU, HAIQING, ALEXANDER, MATTHEW D., CORIN, ALAN F.

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Tubulin-based antimitotic mechanism of E7974, a novel analogue of the marine sponge natural product hemiasterlin von Kuznetsov, Galina, TenDyke, Karen, Towle, Murray J, Cheng, Hongsheng, Liu, Junke, Marsh, Joanne P, Schiller, Shawn E R, Spyvee, Mark R, Yang, Hu, Seletsky, Boris M, Shaffer, Christina J, Marceau, Veronique, Yao, Ye, Suh, Edward M, Campagna, Silvio, Fang, Francis G, Kowalczyk, James J, Littlefield, Bruce A

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In vitro and in vivo anticancer activities of synthetic macrocyclic ketone analogues of halichondrin B von TOWLE, Murray J, SALVATO, Kathleen A, HABGOOD, Gregory J, SINGER, Lori A, DIPIETRO, Lucian V, YUAN WANG, CHEN, Jack J, QUINCY, David A, DAVIS, Ashley, YOSHIMATSU, Kentaro, KISHI, Yoshito, YU, Melvin J, BUDROW, Jacqueline, LITTLEFIELD, Bruce A, WELS, Bruce F, KUZNETSOV, Galina, AALFS, Kimberley K, WELSH, Susan, WANJUN ZHENG, SELETSKY, Boris M, PALME, Monica H

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Novel second generation analogs of eribulin. Part III: Blood–brain barrier permeability and in vivo activity in a brain tumor model von Narayan, Sridhar, Carlson, Eric M., Cheng, Hongsheng, Condon, Krista, Du, Hong, Eckley, Sean, Hu, Yongbo, Jiang, Yimin, Kumar, Vipul, Lewis, Bryan M., Saxton, Philip, Schuck, Edgar, Seletsky, Boris M., Tendyke, Karen, Zhang, Huiming, Zheng, Wanjun, Littlefield, Bruce A., Towle, Murray J., Yu, Melvin J.

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Macrocyclic ketone analogues of halichondrin B von Zheng, Wanjun, Seletsky, Boris M., Palme, Monica H., Lydon, Paul J., Singer, Lori A., Chase, Charles E., Lemelin, Charles A., Shen, Yongchun, Davis, Heather, Tremblay, Lynda, Towle, Murray J., Salvato, Kathleen A., Wels, Bruce F., Aalfs, Kimberley K., Kishi, Yoshito, Littlefield, Bruce A., Yu, Melvin J.

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Novel second generation analogs of eribulin. Part I: Compounds containing a lipophilic C32 side chain overcome P-glycoprotein susceptibility von Narayan, Sridhar, Carlson, Eric M., Cheng, Hongsheng, Du, Hong, Hu, Yongbo, Jiang, Yimin, Lewis, Bryan M., Seletsky, Boris M., Tendyke, Karen, Zhang, Huiming, Zheng, Wanjun, Littlefield, Bruce A., Towle, Murray J., Yu, Melvin J.

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Novel second generation analogs of eribulin. Part II: Orally available and active against resistant tumors in vivo von Narayan, Sridhar, Carlson, Eric M., Cheng, Hongsheng, Condon, Krista, Du, Hong, Eckley, Sean, Hu, Yongbo, Jiang, Yimin, Kumar, Vipul, Lewis, Bryan M., Saxton, Philip, Schuck, Edgar, Seletsky, Boris M., Tendyke, Karen, Zhang, Huiming, Zheng, Wanjun, Littlefield, Bruce A., Towle, Murray J., Yu, Melvin J.

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Structurally simplified macrolactone analogues of halichondrin B von Seletsky, Boris M., Wang, Yuan, Hawkins, Lynn D., Palme, Monica H., Habgood, Gregory J., DiPietro, Lucian V., Towle, Murray J., Salvato, Kathleen A., Wels, Bruce F., Aalfs, Kimberley K., Kishi, Yoshito, Littlefield, Bruce A., Yu, Melvin J.

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Abstract 4493: Eribulin recognizes the nucleotide states of soluble tubulin and binds with high-affinity on a site distinct from known tubulin inhibitors von Agarwala, Kishan Lal, Kubara, Kenji, Sagane, Koji, Seletsky, Boris M., Littlefield, Bruce A.

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Synthesis of Protected Carbohydrate Derivatives Through Homologation of Threose and Erythrose Derivatives with Chiral .gamma.-Alkoxy Allylic Stannanes von Marshall, James A, Seletsky, Boris M, Luke, George P

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Highly syn-Selective Additions of Allylic Stannanes to Protected .alpha.-Amino Aldehydes von Marshall, James A, Seletsky, Boris M, Coan, Paul S

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ChemInform Abstract: From Micrograms to Grams. Scale-up Synthesis of Eribulin Mesylate von Yu, Melvin J., Zheng, Wanjun, Seletsky, Boris M.

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Addition of Enantioenriched γ-Oxygenated Allylic Stannanes to N-Acyl Iminium Intermediates: A New Synthesis of syn-Amino Alcohol Derivatives von Marshall, James A., Gill, Kevin, Seletsky, Boris M.

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HETEROCYCLIC PAD4 INHIBITORS von SELETSKY, Boris M, ROSS, Audrey Graham, GORMISKY, Paul E, MIAO, Guobin, ZHU, Xiao, ANTROPOW, Alyssa H

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MK2 INHIBITORS AND USES THEREOF von Miao, Guobin, Cao, Min, Hu, Xirui, Seletsky, Boris, Qiao, Lixin, Patton, Matthew, McDonald, Ivar, Dzierba, Carolyn, van der Mei, Farid

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HETEROCYCLIC PAD4 INHIBITORS von ANTROPOW, Alyssa, NIU, Deqiang, ROSS, Audrey, GORMISKY, Paul, MIAO, Guobin, CUERVO, Julio, ZHU, Xiao, ZHU, Zhengdong, SELETSKY, Boris

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MK2 INHIBITORS AND USES THEREOF von CAO, Min, MCDONALD, Ivar, DZIERBA, Carolyn, MIAO, Guobin, HU, Xirui, VAN DER MEI, Farid, PATTON, Matthew, QIAO, Lixin, SELETSKY, Boris

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MK2 INHIBITORS AND USES THEREOF von CAO, Min, MCDONALD, Ivar, DZIERBA, Carolyn, MIAO, Guobin, HU, Xirui, VAN DER MEI, Farid, PATTON, Matthew, QIAO, Lixin, SELETSKY, Boris

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