HER kinase inhibition in patients with HER2- and HER3-mutant cancers von Hyman, David M., Piha-Paul, Sarina A., Won, Helen, Rodon, Jordi, Saura, Cristina, Shapiro, Geoffrey I., Juric, Dejan, Quinn, David I., Moreno, Victor, Doger, Bernard, Mayer, Ingrid A., Boni, Valentina, Calvo, Emiliano, Loi, Sherene, Lockhart, Albert C., Erinjeri, Joseph P., Scaltriti, Maurizio, Ulaner, Gary A., Patel, Juber, Tang, Jiabin, Beer, Hannah, Selcuklu, S. Duygu, Hanrahan, Aphrothiti J., Bouvier, Nancy, Melcer, Myra, Murali, Rajmohan, Schram, Alison M., Smyth, Lillian M., Jhaveri, Komal, Li, Bob T., Drilon, Alexander, Harding, James J., Iyer, Gopa, Taylor, Barry S., Berger, Michael F., Cutler Jr, Richard E., Xu, Feng, Butturini, Anna, Eli, Lisa D., Mann, Grace, Farrell, Cynthia, Lalani, Alshad S., Bryce, Richard P., Arteaga, Carlos L., Meric-Bernstam, Funda, Baselga, José, Solit, David B.

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Evaluating Cancer of the Central Nervous System Through Next-Generation Sequencing of Cerebrospinal Fluid von Pentsova, Elena I, Shah, Ronak H, Tang, Jiabin, Boire, Adrienne, You, Daoqi, Briggs, Samuel, Omuro, Antonio, Lin, Xuling, Fleisher, Martin, Grommes, Christian, Panageas, Katherine S, Meng, Fanli, Selcuklu, S Duygu, Ogilvie, Shahiba, Distefano, Natalie, Shagabayeva, Larisa, Rosenblum, Marc, DeAngelis, Lisa M, Viale, Agnes, Mellinghoff, Ingo K, Berger, Michael F

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Genomic and transcriptomic determinants of response to neoadjuvant therapy in rectal cancer von Chatila, Walid K., Kim, Jin K., Walch, Henry, Marco, Michael R., Chen, Chin-Tung, Wu, Fan, Omer, Dana M., Khalil, Danny N., Ganesh, Karuna, Qu, Xuan, Luthra, Anisha, Choi, Seo-Hyun, Ho, Yu-Jui, Kundra, Ritika, Groves, Katharine I., Chow, Oliver S., Cercek, Andrea, Weiser, Martin R., Widmar, Maria, Wei, Iris H., Pappou, Emmanouil P., Nash, Garrett M., Paty, Philip B., Shi, Qian, Vakiani, Efsevia, Duygu Selcuklu, S., Donoghue, Mark T. A., Solit, David B., Berger, Michael F., Shia, Jinru, Pelossof, Raphael, Romesser, Paul B., Yaeger, Rona, Smith, J. Joshua, Schultz, Nikolaus, Sanchez-Vega, Francisco, Garcia-Aguilar, Julio

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Antitumour activity of neratinib in patients with HER2-mutant advanced biliary tract cancers von Harding, James J., Piha-Paul, Sarina A., Shah, Ronak H., Murphy, Jessica J., Cleary, James M., Shapiro, Geoffrey I., Quinn, David I., Braña, Irene, Moreno, Victor, Borad, Mitesh, Loi, Sherene, Spanggaard, Iben, Park, Haeseong, Ford, James M., Arnedos, Mónica, Stemmer, Salomon M., de la Fouchardiere, Christelle, Fountzilas, Christos, Zhang, Jie, DiPrimeo, Daniel, Savin, Casey, Duygu Selcuklu, S., Berger, Michael F., Eli, Lisa D., Meric-Bernstam, Funda, Jhaveri, Komal, Solit, David B., Abou-Alfa, Ghassan K.

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Overcoming Barriers to Tumor Genomic Profiling through Direct-to-Patient Outreach von Doe-Tetteh, Seyram A, Camp, Sabrina Y, Reales, Dalicia, Crowdis, Jett, Noronha, Anne Marie, Wolff, Bernadette, Alano, Tina, Galle, Jesse, Selcuklu, S Duygu, Viale, Agnes, Socci, Nicholas D, Liu, Ying L, Tew, William P, Aghajanian, Carol, Ladanyi, Marc, He, Meng Xiao, AlDubayan, Saud H, Mazor, Roei David, Shpilberg, Ofer, Hershkovitz-Rokah, Oshrat, Riancho, Jose A, Hernandez, Jose L, Gonzalez-Vela, M Carmen, Buthorn, Justin J, Wilson, Manda, Webber, Amy E, Yabe, Mariko, Petrova-Drus, Kseniya, Rosenblum, Marc, Durham, Benjamin H, Abdel-Wahab, Omar, Berger, Michael F, Donoghue, Mark T A, Kung, Andrew L, Glade Bender, Julia, Shukla, Neerav N, Funt, Samuel A, Dogan, Ahmet, Soslow, Robert A, Al-Ahmadie, Hikmat, Feldman, Darren R, Van Allen, Eliezer M, Diamond, Eli L, Solit, David B

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Tracking tumour evolution in glioma through liquid biopsies of cerebrospinal fluid von Miller, Alexandra M., Shah, Ronak H., Pentsova, Elena I., Pourmaleki, Maryam, Briggs, Samuel, Distefano, Natalie, Zheng, Youyun, Skakodub, Anna, Mehta, Smrutiben A., Campos, Carl, Hsieh, Wan-Ying, Selcuklu, S. Duygu, Ling, Lilan, Meng, Fanli, Jing, Xiaohong, Samoila, Aliaksandra, Bale, Tejus A., Tsui, Dana W. Y., Grommes, Christian, Viale, Agnes, Souweidane, Mark M., Tabar, Viviane, Brennan, Cameron W., Reiner, Anne S., Rosenblum, Marc, Panageas, Katherine S., DeAngelis, Lisa M., Young, Robert J., Berger, Michael F., Mellinghoff, Ingo K.

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Tumour lineage shapes BRCA-mediated phenotypes von Jonsson, Philip, Bandlamudi, Chaitanya, Cheng, Michael L., Srinivasan, Preethi, Chavan, Shweta S., Friedman, Noah D., Rosen, Ezra Y., Richards, Allison L., Bouvier, Nancy, Selcuklu, S. Duygu, Bielski, Craig M., Abida, Wassim, Mandelker, Diana, Birsoy, Ozge, Zhang, Liying, Zehir, Ahmet, Donoghue, Mark T. A., Baselga, José, Offit, Kenneth, Scher, Howard I., O’Reilly, Eileen M., Stadler, Zsofia K., Schultz, Nikolaus, Socci, Nicholas D., Viale, Agnes, Ladanyi, Marc, Robson, Mark E., Hyman, David M., Berger, Michael F., Solit, David B., Taylor, Barry S.

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Targeting Aurora B kinase prevents and overcomes resistance to EGFR inhibitors in lung cancer by enhancing BIM- and PUMA-mediated apoptosis von Tanaka, Kosuke, Yu, Helena A., Yang, Shaoyuan, Han, Song, Selcuklu, S. Duygu, Kim, Kwanghee, Ramani, Shriram, Ganesan, Yogesh Tengarai, Moyer, Allison, Sinha, Sonali, Xie, Yuchen, Ishizawa, Kota, Osmanbeyoglu, Hatice U., Lyu, Yang, Roper, Nitin, Guha, Udayan, Rudin, Charles M., Kris, Mark G., Hsieh, James J., Cheng, Emily H.

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Resistance to TRK inhibition mediated by convergent MAPK pathway activation von Cocco, Emiliano, Schram, Alison M., Kulick, Amanda, Misale, Sandra, Won, Helen H., Yaeger, Rona, Razavi, Pedram, Ptashkin, Ryan, Hechtman, Jaclyn F., Toska, Eneda, Cownie, James, Somwar, Romel, Shifman, Sophie, Mattar, Marissa, Selçuklu, S. Duygu, Samoila, Aliaksandra, Guzman, Sean, Tuch, Brian B., Ebata, Kevin, de Stanchina, Elisa, Nagy, Rebecca J., Lanman, Richard B., Houck-Loomis, Brian, Patel, Juber A., Berger, Michael F., Ladanyi, Marc, Hyman, David M., Drilon, Alexander, Scaltriti, Maurizio

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AKT Inhibition in Solid Tumors With AKT1 Mutations von Hyman, David M, Smyth, Lillian M, Donoghue, Mark T A, Westin, Shannon N, Bedard, Philippe L, Dean, Emma J, Bando, Hideaki, El-Khoueiry, Anthony B, Pérez-Fidalgo, José A, Mita, Alain, Schellens, Jan H M, Chang, Matthew T, Reichel, Jonathan B, Bouvier, Nancy, Selcuklu, S Duygu, Soumerai, Tara E, Torrisi, Jean, Erinjeri, Joseph P, Ambrose, Helen, Barrett, J Carl, Dougherty, Brian, Foxley, Andrew, Lindemann, Justin P O, McEwen, Robert, Pass, Martin, Schiavon, Gaia, Berger, Michael F, Chandarlapaty, Sarat, Solit, David B, Banerji, Udai, Baselga, José, Taylor, Barry S

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Genomic Biomarkers of a Randomized Trial Comparing First-line Everolimus and Sunitinib in Patients with Metastatic Renal Cell Carcinoma von Hsieh, James J, Chen, David, Wang, Patricia I, Marker, Mahtab, Redzematovic, Almedina, Chen, Ying-Bei, Selcuklu, S. Duygu, Weinhold, Nils, Bouvier, Nancy, Huberman, Kety H, Bhanot, Umesh, Chevinsky, Michael S, Patel, Parul, Pinciroli, Patrizia, Won, Helen H, You, Daoqi, Viale, Agnes, Lee, William, Hakimi, A. Ari, Berger, Michael F, Socci, Nicholas D, Cheng, Emily H, Knox, Jennifer, Voss, Martin H, Voi, Maurizio, Motzer, Robert J

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Phase 2 study of LY3023414 in patients with advanced endometrial cancer harboring activating mutations in the PI3K pathway von Rubinstein, Maria M., Hyman, David M., Caird, Imogen, Won, Helen, Soldan, Krysten, Seier, Kenneth, Iasonos, Alexia, Tew, William P., O’Cearbhaill, Roisin E., Grisham, Rachel N., Hensley, Martee L., Troso‐Sandoval, Tiffany, Sabbatini, Paul, Guillen, Joyce, Selcuklu, S. Duygu, Zimel, Catherine, Torrisi, Jean, Aghajanian, Carol, Makker, Vicky

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Isoform Switching as a Mechanism of Acquired Resistance to Mutant Isocitrate Dehydrogenase Inhibition von Harding, James J, Lowery, Maeve A, Shih, Alan H, Schvartzman, Juan M, Hou, Shengqi, Famulare, Christopher, Patel, Minal, Roshal, Mikhail, Do, Richard K, Zehir, Ahmet, You, Daoqi, Selcuklu, S Duygu, Viale, Agnes, Tallman, Martin S, Hyman, David M, Reznik, Ed, Finley, Lydia W S, Papaemmanuil, Elli, Tosolini, Alessandra, Frattini, Mark G, MacBeth, Kyle J, Liu, Guowen, Fan, Bin, Choe, Sung, Wu, Bin, Janjigian, Yelena Y, Mellinghoff, Ingo K, Diaz, Luis A, Levine, Ross L, Abou-Alfa, Ghassan K, Stein, Eytan M, Intlekofer, Andrew M

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MicroRNA-9 Inhibition of Cell Proliferation and Identification of Novel miR-9 Targets by Transcriptome Profiling in Breast Cancer Cells von Selcuklu, S.Duygu, Donoghue, Mark T.A., Rehmet, Kristina, de Souza Gomes, Matheus, Fort, Antoine, Kovvuru, Prasad, Muniyappa, Mohan K., Kerin, Michael J., Enright, Anton J., Spillane, Charles

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Efficacy and Determinants of Response to HER Kinase Inhibition in HER2 -Mutant Metastatic Breast Cancer von Smyth, Lillian M, Piha-Paul, Sarina A, Won, Helen H, Schram, Alison M, Saura, Cristina, Loi, Sherene, Lu, Janice, Shapiro, Geoffrey I, Juric, Dejan, Mayer, Ingrid A, Arteaga, Carlos L, de la Fuente, Macarena I, Brufksy, Adam M, Spanggaard, Iben, Mau-Sørensen, Morten, Arnedos, Monica, Moreno, Victor, Boni, Valentina, Sohn, Joohyuk, Schwartzberg, Lee S, Gonzàlez-Farré, Xavier, Cervantes, Andrés, Bidard, François-Clement, Gorelick, Alexander N, Lanman, Richard B, Nagy, Rebecca J, Ulaner, Gary A, Chandarlapaty, Sarat, Jhaveri, Komal, Gavrila, Elena I, Zimel, Catherine, Selcuklu, S Duygu, Melcer, Myra, Samoila, Aliaksandra, Cai, Yanyan, Scaltriti, Maurizio, Mann, Grace, Xu, Feng, Eli, Lisa D, Dujka, Melanie, Lalani, Alshad S, Bryce, Richard, Baselga, José, Taylor, Barry S, Solit, David B, Meric-Bernstam, Funda, Hyman, David M

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An NTD-Associated Polymorphism in the 3′ UTR of MTHFD1L can Affect Disease Risk by Altering miRNA Binding von Minguzzi, Stefano, Selcuklu, S. Duygu, Spillane, Charles, Parle-McDermott, Anne

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Phase II Trial and Correlative Genomic Analysis of Everolimus Plus Bevacizumab in Advanced Non-Clear Cell Renal Cell Carcinoma von Voss, Martin H, Molina, Ana M, Chen, Ying-Bei, Woo, Kaitlin M, Chaim, Joshua L, Coskey, Devyn T, Redzematovic, Almedina, Wang, Patricia, Lee, William, Selcuklu, S Duygu, Lee, Chung-Han, Berger, Michael F, Tickoo, Satish K, Reuter, Victor E, Patil, Sujata, Hsieh, James J, Motzer, Robert J, Feldman, Darren R

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Tumor fraction-guided cell-free DNA profiling in metastatic solid tumor patients von Tsui, Dana W Y, Cheng, Michael L, Shady, Maha, Yang, Julie L, Stephens, Dennis, Won, Helen, Srinivasan, Preethi, Huberman, Kety, Meng, Fanli, Jing, Xiaohong, Patel, Juber, Hasan, Maysun, Johnson, Ian, Gedvilaite, Erika, Houck-Loomis, Brian, Socci, Nicholas D, Selcuklu, S Duygu, Seshan, Venkatraman E, Zhang, Hongxin, Chakravarty, Debyani, Zehir, Ahmet, Benayed, Ryma, Arcila, Maria, Ladanyi, Marc, Funt, Samuel A, Feldman, Darren R, Li, Bob T, Razavi, Pedram, Rosenberg, Jonathan, Bajorin, Dean, Iyer, Gopa, Abida, Wassim, Scher, Howard I, Rathkopf, Dana, Viale, Agnes, Berger, Michael F, Solit, David B

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Allele-specific splicing effects on DKKL1 and ZNF419 transcripts in HeLa cells von Martin, Grace, Selcuklu, S. Duygu, Schouest, Katherine, Nembaware, Victoria, McKeown, Peter C., Seoighe, Cathal, Spillane, Charles

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Regulatory interplay between miR-21, JAG1 and 17beta-estradiol (E2) in breast cancer cells von Selcuklu, S. Duygu, Donoghue, Mark T.A., Kerin, Michael J., Spillane, Charles

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