Maintenance of the HIV Reservoir Is Antagonized by Selective BCL2 Inhibition von Cummins, Nathan W, Sainski-Nguyen, Amy M, Natesampillai, Sekar, Aboulnasr, Fatma, Kaufmann, Scott, Badley, Andrew D

Volltext

Optimizing single cell proteomics using trapped ion mobility spectrometry for label-free experiments von Mun, Dong-Gi, Bhat, Firdous A, Ding, Husheng, Madden, Benjamin J, Natesampillai, Sekar, Badley, Andrew D, Johnson, Kenneth L, Kelly, Ryan T, Pandey, Akhilesh

Volltext

Reactivating latent HIV with PKC agonists induces resistance to apoptosis and is associated with phosphorylation and activation of BCL2 von French, Andrea J, Natesampillai, Sekar, Krogman, Ashton, Correia, Cristina, Peterson, Kevin L, Alto, Alecia, Chandrasekar, Aswath P, Misra, Anisha, Li, Ying, Kaufmann, Scott H, Badley, Andrew D, Cummins, Nathan W

Volltext

Extensive virologic and immunologic characterization in an HIV-infected individual following allogeneic stem cell transplant and analytic cessation of antiretroviral therapy: A cas... von Cummins, Nathan W, Rizza, Stacey, Litzow, Mark R, Hua, Stephane, Lee, Guinevere Q, Einkauf, Kevin, Chun, Tae-Wook, Rhame, Frank, Baker, Jason V, Busch, Michael P, Chomont, Nicolas, Dean, Patrick G, Fromentin, Rémi, Haase, Ashley T, Hampton, Dylan, Keating, Sheila M, Lada, Steven M, Lee, Tzong-Hae, Natesampillai, Sekar, Richman, Douglas D, Schacker, Timothy W, Wietgrefe, Stephen, Yu, Xu G, Yao, Joseph D, Zeuli, John, Lichterfeld, Mathias, Badley, Andrew D

Volltext

Both HIV-Infected and Uninfected Cells Express TRAILshort, Which Confers TRAIL Resistance upon Bystander Cells within the Microenvironment von Nie, Zilin, Aboulnasr, Fatma, Natesampillai, Sekar, Burke, Stephen P, Krogman, Ashton, Bren, Gary D, Chung, Thomas D Y, Anderson, Jeff R, Smart, Michele K, Katzmann, David J, Rajagopalan, Govindarajan, Cummins, Nathan W, Badley, Andrew D

Volltext

Increasing procaspase 8 expression using repurposed drugs to induce HIV infected cell death in ex vivo patient cells von Sampath, Rahul, Cummins, Nathan W, Natesampillai, Sekar, Bren, Gary D, Chung, Thomas D, Baker, Jason, Henry, Keith, Pagliuzza, Amélie, Badley, Andrew D

Volltext

The HIV-1-Specific Protein Casp8p41 Induces Death of Infected Cells through Bax/Bak von SAINSKI, Amy M, NATESAMPILLAI, Sekar, CUMMINS, Nathan W, BREN, Gary D, TAYLOR, Julie, SAENZ, Dyana T, POESCHLA, Eric M, BADLEY, Andrew D

Volltext

Single center, open label dose escalating trial evaluating once weekly oral ixazomib in ART-suppressed, HIV positive adults and effects on HIV reservoir size in vivo von Cummins, Nathan W, Baker, Jason, Chakraborty, Rana, Dean, Patrick G, Garcia-Rivera, Enrique, Krogman, Ashton, Kumar, Shaji, Kuzmichev, Yury V, Laird, Gregory M, Landay, Alan, Lichterfeld, Mathias, Mahmood, Maryam, Martinson, Jeffrey, Maynes, Mark, Natesampillai, Sekar, Rajkumar, Vincent, Rassadkina, Yelizaveta, Ritter, Kristen D., Rivera, Christina G, Rizza, Stacey A, Subramanian, Krupa, Tande, Aaron J, Wonderlich, Elizabeth R, Whitaker, Jennifer A, Zeuli, John, Badley, Andrew D

Volltext

Patients with discordant responses to antiretroviral therapy have impaired killing of HIV-infected T cells von Natesampillai, Sekar, Nie, Zilin, Cummins, Nathan W, Jochmans, Dirk, Bren, Gary D, Angel, Jonathan B, Badley, Andrew D

Volltext

TRAIL dependent fratricidal killing of gp120 primed hepatocytes by HCV core expressing hepatocytes von Rizza, Stacey A, Challagundla, Kishore B, Natesampillai, Sekar, Bren, Gary D, Sykora, Jaromir, Walczak, Henning, Badley, Andrew D

Volltext

A Novel Functional Interaction between the Sp1-like Protein KLF13 and SREBP-Sp1 Activation Complex Underlies Regulation of Low Density Lipoprotein Receptor Promoter Function von Natesampillai, Sekar, Fernandez-Zapico, Martin E., Urrutia, Raul, Veldhuis, Johannes D.

Volltext

The BCL-2 Inhibitor Venetoclax Augments Immune Effector Function Mediated by Fas Ligand, TRAIL, and Perforin/Granzyme B, Resulting in Reduced Plasma Viremia and Decreased HIV Reser... von Chandrasekar, Aswath P, Cummins, Nathan W, Natesampillai, Sekar, Misra, Anisha, Alto, Alecia, Laird, Greg, Badley, Andrew D

Volltext

Targeting a Dominant Negative Splice Variant of TRAIL to Enhance CART Cell Functions von Can, Ismail, Natesampillai, Sekar, Sakemura, Reona Leo, Siegler, Elizabeth L., Manriquez-Roman, Claudia, Jalali, Shahrzad, Huynh, Truc, Krogman, Ashton, Maynes, Mark, Badley, Andrew D., Kenderian, Saad S., Hefazi, Mehrdad

Volltext

Prime, Shock, and Kill: Priming CD4 T Cells from HIV Patients with a BCL-2 Antagonist before HIV Reactivation Reduces HIV Reservoir Size von Cummins, Nathan W, Sainski, Amy M, Dai, Haiming, Natesampillai, Sekar, Pang, Yuan-Ping, Bren, Gary D, de Araujo Correia, Maria Cristina Miranda, Sampath, Rahul, Rizza, Stacey A, O'Brien, Daniel, Yao, Joseph D, Kaufmann, Scott H, Badley, Andrew D

Volltext

The combination of venetoclax and ixazomib selectively and efficiently kills HIV infected cell lines, but has unacceptable toxicity in primary cell models von Alto, Alecia, Natesampillai, Sekar, Chandrasekar, Aswath P, Krogman, Ashton, Misra, Anisha, Shweta, F N U, VanLith, Caitlin, Yao, Joseph D, Cummins, Nathan W, Badley, Andrew D

Volltext

An advanced BLT-humanized mouse model for extended HIV-1 cure studies von Lavender, Kerry J, Pace, Craig, Sutter, Kathrin, Messer, Ronald J, Pouncey, Dakota L, Cummins, Nathan W, Natesampillai, Sekar, Zheng, Jim, Goldsmith, Joshua, Widera, Marek, Van Dis, Erik S, Phillips, Katie, Race, Brent, Dittmer, Ulf, Kukolj, George, Hasenkrug, Kim J

Volltext

HIV Protease-Generated Casp8p41, When Bound and Inactivated by Bcl2, Is Degraded by the Proteasome von Natesampillai, Sekar, Cummins, Nathan W, Nie, Zilin, Sampath, Rahul, Baker, Jason V, Henry, Keith, Pinzone, Marilia, O'Doherty, Una, Polley, Eric C, Bren, Gary D, Katzmann, David J, Badley, Andrew D

Volltext

HIV elite control is associated with reduced TRAILshort expression von Paim, Ana C, Cummins, Nathan W, Natesampillai, Sekar, Garcia-Rivera, Enrique, Kogan, Nicole, Neogi, Ujjwal, Sönnerborg, Anders, Sperk, Maike, Bren, Gary D, Deeks, Steve, Polley, Eric, Badley, Andrew D

Volltext

Human Cancers Express TRAILshort, a Dominant Negative TRAIL Splice Variant, Which Impairs Immune Effector Cell Killing of Tumor Cells von Aboulnasr, Fatma, Krogman, Ashton, Graham, Rondell P, Cummins, Nathan W, Misra, Anisha, Garcia-Rivera, Enrique, Anderson, Jeff R, Natesampillai, Sekar, Kogan, Nicole, Aravamudan, Murali, Nie, Zilin, Chung, Thomas D Y, Buick, Richard, Feldman, Andrew L, King, Rebecca L, Novak, Anne J, Ansell, Stephen M, Kenderian, Saad, Badley, Andrew D

Volltext

TRAILshort Protects against CD4 T Cell Death during Acute HIV Infection von Natesampillai, Sekar, Paim, Ana C, Cummins, Nathan W, Chandrasekar, Aswath P, Bren, Gary D, Lewin, Sharon R, Kiem, Hans-Peter, Badley, Andrew D

Volltext