Genetic association between human chitinases and lung function in COPD von Aminuddin, F., Akhabir, L., Stefanowicz, D., Paré, P. D., Connett, J. E., Anthonisen, N. R., Fahy, J. V., Seibold, M. A., Burchard, E. G., Eng, C., Gulsvik, A., Bakke, P., Cho, M. H., Litonjua, A., Lomas, D. A., Anderson, W. H., Beaty, T. H., Crapo, J. D., Silverman, E. K., Sandford, A. J.

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CRISPR–Cas9-mediated gene knockout in primary human airway epithelial cells reveals a proinflammatory role for MUC18 von Chu, H W, Rios, C, Huang, C, Wesolowska-Andersen, A, Burchard, E G, O’Connor, B P, Fingerlin, T E, Nichols, D, Reynolds, S D, Seibold, M A

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Differential enzymatic activity of common haplotypic versions of the human acidic Mammalian chitinase protein von Seibold, M.A., Reese, T.A., Choudhry, S., Salam, M.T., Beckman, K., Eng, C., Atakilit, A., Meade, K., Lenoir, M., Watson, H.G., Thyne, S., Kumar, R., Weiss, K.B., Grammer, L.C., Avila, P., Schleimer, R.P., Fahy, J.V., Rodriguez-Santana, J., Rodriguez-Cintron, W., Boot, R.G., Sheppard, D., Gilliland, F.D., Locksley, R.M., Burchard, E.G.

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P115 A retrospective analysis of the ECFSPR to characterise the pulmonary phenotype and use of intravenous antibiotics in people with cystic fibrosis harbouring bi-allelic CFTR cla... von Orenti, A., Mountford, W.K., Davies, J.C., Polineni, D., Adamoli, A., Bakkeheim, E., Isabelle, I., Mall, M.A., Alves, C.P., Seibold, W., Sigmund, R., Carr, S.B.

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P045 Lenticlair™ 1: A phase 1/2 trial evaluating the safety, tolerability and efficacy of an inhaled F/HN-pseudotyped lentiviral vector for CF gene therapy in people with CF inelig... von Davies, J.C., Mall, M.A., Polineni, D., Donaldson, S.H., Fajac, I., Jain, R., Rubin, B.K., Boyd, A.C., Gill, D.R., Griesenbach, U., Hyde, S.C., McLachlan, G., Avis, M., Diefenbach, C., Sigmund, R., Seibold, W., Gupta, A., Alton, E.

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Gene-based association identifies SPATA13-AS1 as a pharmacogenomic predictor of inhaled short-acting beta-agonist response in multiple population groups von Padhukasahasram, B, Yang, J J, Levin, A M, Yang, M, Burchard, E G, Kumar, R, Kwok, P-Y, Seibold, M A, Lanfear, D E, Williams, L K

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P222 An update on BALANCE-CF™ 1: a Phase II trial of the inhaled ENaC inhibitor BI 1265162 in adults and adolescents with cystic fibrosis von Fajac, I., Mall, M.A., Jain, R., Seibold, W., Picard, A.-C., Hsu, M.-C., Gupta, A., Goss, C.H.

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Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with prognosis of estrogen receptor-negative breast cancer after chemotherapy von Lei, Jieping, Rudolph, Anja, Moysich, Kirsten B, Rafiq, Sajjad, Behrens, Sabine, Goode, Ellen L, Pharoah, Paul P.D, Seibold, Petra, Fasching, Peter A, Andrulis, Irene L, Kristensen, Vessela N, Couch, Fergus J, Hamann, Ute, Hooning, Maartje J, Nevanlinna, Heli, Eilber, Ursula, Bolla, Manjeet K, Dennis, Joe, Wang, Qin, Lindblom, Annika, Mannermaa, Arto, Lambrechts, Diether, García-Closas, Montserrat, Hall, Per, Chenevix-Trench, Georgia, Shah, Mitul, Luben, Robert, Haeberle, Lothar, Ekici, Arif B, Beckmann, Matthias W, Knight, Julia A, Glendon, Gord, Tchatchou, Sandrine, Alnæs, Grethe I. Grenaker, Borresen-Dale, Anne-Lise, Nord, Silje, Olson, Janet E, Hallberg, Emily, Vachon, Celine, Torres, Diana, Ulmer, Hans-Ulrich, Rüdiger, Thomas, Jager, Agnes, van Deurzen, Carolien H.M, Tilanus-Linthorst, Madeleine M.A, Muranen, Taru A, Aittomäki, Kristiina, Blomqvist, Carl, Margolin, Sara, Kosma, Veli-Matti, Hartikainen, Jaana M, Kataja, Vesa, Hatse, Sigrid, Wildiers, Hans, Smeets, Ann, Figueroa, Jonine, Chanock, Stephen J, Lissowska, Jolanta, Li, Jingmei, Humphreys, Keith, Phillips, Kelly-Anne, kConFab Investigators, Linn, Sabine, Cornelissen, Sten, van den Broek, Sandra Alexandra J, Kang, Daehee, Choi, Ji-Yeob, Park, Sue K, Yoo, Keun-Young, Hsiung, Chia-Ni, Wu, Pei-Ei, Hou, Ming-Feng, Shen, Chen-Yang, Teo, Soo Hwang, Taib, Nur Aishah Mohd, Yip, Cheng Har, Ho, Gwo Fuang, Matsuo, Keitaro, Ito, Hidemi, Iwata, Hiroji, Tajima, Kazuo, Dunning, Alison M, Benitez, Javier, Czene, Kamila, Sucheston, Lara E, Maishman, Tom, Tapper, William J, Eccles, Diana, Easton, Douglas F, Schmidt, Marjanka K, Chang-Claude, Jenny

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Optimal Prediction in Molecular Dynamics von Seibold, B.

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Genetic and microbial factors modulating the ubiquitin proteasome system in inflammatory bowel disease von Cleynen, I., Vazeille, E., Artieda, M., Verspaget, H.W., Szczypiorska, M., Bringer, M.A., Lakatos, P.L., Seibold, F., Parnell, K., Weersma, R.K., John, J.M.M., Morgan-Walsh, R., Staelens, D., Arijs, I., Hertogh, G. de, Muller, S., Tordai, A., Hommes, D.W., Ahmad, T., Wijmenga, C., Pender, S., Rutgeerts, P., Steen, K. van, Lottaz, D., Vermeire, S., Darfeuille-Michaud, A.

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Solar physics at the Observatorio Nacional de F sica C smica, San Miguel, Argentina von Greco, M.A., Gallegos, H.Grossi, Seibold, J.R.

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