MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates von Dondelinger, Yves, Declercq, Wim, Montessuit, Sylvie, Roelandt, Ria, Goncalves, Amanda, Bruggeman, Inge, Hulpiau, Paco, Weber, Kathrin, Sehon, Clark A., Marquis, Robert W., Bertin, John, Gough, Peter J., Savvides, Savvas, Martinou, Jean-Claude, Bertrand, Mathieu J.M., Vandenabeele, Peter

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RIP3 Induces Apoptosis Independent of Pronecrotic Kinase Activity von Mandal, Pratyusha, Berger, Scott B., Pillay, Sirika, Moriwaki, Kenta, Huang, Chunzi, Guo, Hongyan, Lich, John D., Finger, Joshua, Kasparcova, Viera, Votta, Bart, Ouellette, Michael, King, Bryan W., Wisnoski, David, Lakdawala, Ami S., DeMartino, Michael P., Casillas, Linda N., Haile, Pamela A., Sehon, Clark A., Marquis, Robert W., Upton, Jason, Daley-Bauer, Lisa P., Roback, Linda, Ramia, Nancy, Dovey, Cole M., Carette, Jan E., Chan, Francis Ka-Ming, Bertin, John, Gough, Peter J., Mocarski, Edward S., Kaiser, William J.

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Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases von Harris, Philip A, Berger, Scott B, Jeong, Jae U, Nagilla, Rakesh, Bandyopadhyay, Deepak, Campobasso, Nino, Capriotti, Carol A, Cox, Julie A, Dare, Lauren, Dong, Xiaoyang, Eidam, Patrick M, Finger, Joshua N, Hoffman, Sandra J, Kang, James, Kasparcova, Viera, King, Bryan W, Lehr, Ruth, Lan, Yunfeng, Leister, Lara K, Lich, John D, MacDonald, Thomas T, Miller, Nathan A, Ouellette, Michael T, Pao, Christina S, Rahman, Attiq, Reilly, Michael A, Rendina, Alan R, Rivera, Elizabeth J, Schaeffer, Michelle C, Sehon, Clark A, Singhaus, Robert R, Sun, Helen H, Swift, Barbara A, Totoritis, Rachel D, Vossenkämper, Anna, Ward, Paris, Wisnoski, David D, Zhang, Daohua, Marquis, Robert W, Gough, Peter J, Bertin, John

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Identification of benzimidazole diamides as selective inhibitors of the nucleotide-binding oligomerization domain 2 (NOD2) signaling pathway von Rickard, David J, Sehon, Clark A, Kasparcova, Viera, Kallal, Lorena A, Zeng, Xin, Montoute, Monica N, Chordia, Tushar, Poore, Derek D, Li, Hu, Wu, Zining, Eidam, Patrick M, Haile, Pamela A, Yu, Jong, Emery, John G, Marquis, Robert W, Gough, Peter J, Bertin, John

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A key role for the endothelium in NOD1 mediated vascular inflammation: comparison to TLR4 responses von Gatheral, Timothy, Reed, Daniel M, Moreno, Laura, Gough, Peter J, Votta, Bart J, Sehon, Clark A, Rickard, David J, Bertin, John, Lim, Eric, Nicholson, Andrew G, Mitchell, Jane A

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Total Syntheses of Ningalin A, Lamellarin O, Lukianol A, and Permethyl Storniamide A Utilizing Heterocyclic Azadiene Diels−Alder Reactions von Boger, Dale L, Boyce, Christopher W, Labroli, Marc A, Sehon, Clark A, Jin, Qing

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Identification of selective small molecule inhibitors of the nucleotide-binding oligomerization domain 1 (NOD1) signaling pathway von Rickard, David J, Sehon, Clark A, Kasparcova, Viera, Kallal, Lorena A, Haile, Pamela A, Zeng, Xin, Montoute, Monica N, Poore, Derek D, Li, Hu, Wu, Zining, Eidam, Patrick M, Emery, John G, Marquis, Robert W, Gough, Peter J, Bertin, John

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Potent, Selective and Orally Bioavailable Dihydropyrimidine Inhibitors of Rho Kinase (ROCK1) as Potential Therapeutic Agents for Cardiovascular Diseases von Sehon, Clark A, Wang, Gren Z, Viet, Andrew Q, Goodman, Krista B, Dowdell, Sarah E, Elkins, Patricia A, Semus, Simon F, Evans, Christopher, Jolivette, Larry J, Kirkpatrick, Robert B, Dul, Edward, Khandekar, Sanjay S, Yi, Tracey, Wright, Lois L, Smith, Gary K, Behm, David J, Bentley, Ross, Doe, Christopher P, Hu, Erding, Lee, Dennis

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Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase von Harris, Philip A, Faucher, Nicolas, George, Nicolas, Eidam, Patrick M, King, Bryan W, White, Gemma V, Anderson, Niall A, Bandyopadhyay, Deepak, Beal, Allison M, Beneton, Veronique, Berger, Scott B, Campobasso, Nino, Campos, Sebastien, Capriotti, Carol A, Cox, Julie A, Daugan, Alain, Donche, Frederic, Fouchet, Marie-Hélène, Finger, Joshua N, Geddes, Brad, Gough, Peter J, Grondin, Pascal, Hoffman, Bonnie L, Hoffman, Sandra J, Hutchinson, Susan E, Jeong, Jae U, Jigorel, Emilie, Lamoureux, Pauline, Leister, Lara K, Lich, John D, Mahajan, Mukesh K, Meslamani, Jamel, Mosley, Julie E, Nagilla, Rakesh, Nassau, Pamela M, Ng, Sze-Ling, Ouellette, Michael T, Pasikanti, Kishore K, Potvain, Florent, Reilly, Michael A, Rivera, Elizabeth J, Sautet, Stéphane, Schaeffer, Michelle C, Sehon, Clark A, Sun, Helen, Thorpe, James H, Totoritis, Rachel D, Ward, Paris, Wellaway, Natalie, Wisnoski, David D, Woolven, James M, Bertin, John, Marquis, Robert W

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Synthesis of Furans and 2,5-Dihydrofurans by Ag(I)-Catalyzed Isomerization of Allenones, Alkynyl Allylic Alcohols, and Allenylcarbinols von Marshall, James A, Sehon, Clark A

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Development of Dihydropyridone Indazole Amides as Selective Rho-Kinase Inhibitors von Goodman, Krista B, Cui, Haifeng, Dowdell, Sarah E, Gaitanopoulos, Dimitri E, Ivy, Robert L, Sehon, Clark A, Stavenger, Robert A, Wang, Gren Z, Viet, Andrew Q, Xu, Weiwei, Ye, Guosen, Semus, Simon F, Evans, Christopher, Fries, Harvey E, Jolivette, Larry J, Kirkpatrick, Robert B, Dul, Edward, Khandekar, Sanjay S, Yi, Tracey, Jung, David K, Wright, Lois L, Smith, Gary K, Behm, David J, Bentley, Ross, Doe, Christopher P, Hu, Erding, Lee, Dennis

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Pharmacological Inhibition of C-C Chemokine Receptor 2 Decreases Macrophage Infiltration in the Aortic Root of the Human C-C Chemokine Receptor 2/Apolipoprotein E−/− Mouse: Magneti... von Olzinski, Alan R, Turner, Gregory H, Bernard, Roberta E, Karr, Heather, Cornejo, Carla A, Aravindhan, Karpagam, Hoang, Bao, Ringenberg, Michael A, Qin, Pu, Goodman, Krista B, Willette, Robert N, Macphee, Colin H, Jucker, Beat M, Sehon, Clark A, Gough, Peter J

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CCR2 receptor antagonists: Optimization of biaryl sulfonamides to increase activity in whole blood von Wang, Gren Z., Haile, Pamela A., Daniel, Tom, Belot, Benjamin, Viet, Andrew Q., Goodman, Krista B., Sha, Deyou, Dowdell, Sarah E., Varga, Norbert, Hong, Xuan, Chakravorty, Subhas, Webb, Christine, Cornejo, Carla, Olzinski, Alan, Bernard, Roberta, Evans, Christopher, Emmons, Amanda, Briand, Jacques, Chung, Chun-Wa, Quek, Ruben, Lee, Dennis, Gough, Peter J., Sehon, Clark A.

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Practical and Scalable Synthesis of a Selective CCK1 Receptor Antagonist von Mapes, Christopher M, Mani, Neelakandha S, Deng, Xiaohu, Pandit, Chennagiri R, McClure, Kelly J, Pippel, Marna C. W, Sehon, Clark A, Gomez, Laurent, Shinde, Shirin, Breitenbucher, J. Guy, Jones, Todd K

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Discovery and SAR studies of a novel series of noncovalent cathepsin S inhibitors von Gustin, Darin J., Sehon, Clark A., Wei, Jianmei, Cai, Hui, Meduna, Steven P., Khatuya, Haripada, Sun, Siquan, Gu, Yin, Jiang, Wen, Thurmond, Robin L., Karlsson, Lars, Edwards, James P.

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Aminomethylpiperazines as selective urotensin antagonists von Hilfiker, Mark A., Zhang, Daohua, Dowdell, Sarah E., Goodman, Krista B., McAtee, John J., Dodson, Jason W., Viet, Andrew Q., Wang, Gren Z., Sehon, Clark A., Behm, David J., Wu, Zining, Carballo, Luz H., Douglas, Stephen A., Neeb, Michael J.

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Total Synthesis of the Enantiomer of the Furanocembrane Rubifolide von Marshall, James A, Sehon, Clark A

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Development of potent and selective small-molecule human Urotensin-II antagonists von McAtee, John J., Dodson, Jason W., Dowdell, Sarah E., Girard, Gerald R., Goodman, Krista B., Hilfiker, Mark A., Sehon, Clark A., Sha, Deyou, Wang, Gren Z., Wang, Ning, Viet, Andrew Q., Zhang, Daohua, Aiyar, Nambi V., Behm, David J., Carballo, Luz H., Evans, Christopher A., Fries, Harvey E., Nagilla, Rakesh, Roethke, Theresa J., Xu, Xiaoping, Yuan, Catherine C.K., Douglas, Stephen A., Neeb, Michael J.

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The SAR of 4-substituted (6,6-bicyclic) piperidine cathepsin S inhibitors von Grice, Cheryl A., Tays, Kevin, Khatuya, Haripada, Gustin, Darin J., Butler, Christopher R., Wei, Jianmei, Sehon, Clark A., Sun, Siquan, Gu, Yin, Jiang, Wen, Thurmond, Robin L., Karlsson, Lars, Edwards, James P.

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Potent and selective small-molecule human urotensin-II antagonists with improved pharmacokinetic profiles von McAtee, John J., Dodson, Jason W., Dowdell, Sarah E., Erhard, Karl, Girard, Gerald R., Goodman, Krista B., Hilfiker, Mark A., Jin, Jian, Sehon, Clark A., Sha, Deyou, Shi, Dongchuan, Wang, Feng, Wang, Gren Z., Wang, Ning, Wang, Yonghui, Viet, Andrew Q., Yuan, Catherine C.K., Zhang, Daohua, Aiyar, Nambi V., Behm, David J., Carballo, Luz H., Evans, Christopher A., Fries, Harvey E., Nagilla, Rakesh, Roethke, Theresa J., Xu, Xiaoping, Douglas, Stephen A., Neeb, Michael J.

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