The clinical mutatome of core binding factor leukemia von Opatz, Sabrina, Bamopoulos, Stefanos A., Metzeler, Klaus H., Herold, Tobias, Ksienzyk, Bianka, Bräundl, Kathrin, Tschuri, Sebastian, Vosberg, Sebastian, Konstandin, Nikola P., Wang, Christine, Hartmann, Luise, Graf, Alexander, Krebs, Stefan, Blum, Helmut, Schneider, Stephanie, Thiede, Christian, Middeke, Jan Moritz, Stölzel, Friedrich, Röllig, Christoph, Schetelig, Johannes, Ehninger, Gerhard, Krämer, Alwin, Braess, Jan, Görlich, Dennis, Sauerland, Maria Cristina, Berdel, Wolfgang E., Wörmann, Bernhard J., Hiddemann, Wolfgang, Spiekermann, Karsten, Bohlander, Stefan K., Greif, Philipp A.

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PAX5 biallelic genomic alterations define a novel subgroup of B-cell precursor acute lymphoblastic leukemia von Bastian, Lorenz, Schroeder, Michael P., Eckert, Cornelia, Schlee, Cornelia, Tanchez, Jutta Ortiz, Kämpf, Sebastian, Wagner, Dimitrios L., Schulze, Veronika, Isaakidis, Konstandina, Lázaro-Navarro, Juan, Hänzelmann, Sonja, James, Alva Rani, Ekici, Arif, Burmeister, Thomas, Schwartz, Stefan, Schrappe, Martin, Horstmann, Martin, Vosberg, Sebastian, Krebs, Stefan, Blum, Helmut, Hecht, Jochen, Greif, Philipp A., Rieger, Michael A., Brüggemann, Monika, Gökbuget, Nicola, Neumann, Martin, Baldus, Claudia D.

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Loss of KDM6A confers drug resistance in acute myeloid leukemia von Stief, Sophie M., Hanneforth, Anna-Li, Weser, Sabrina, Mattes, Raphael, Carlet, Michela, Liu, Wen-Hsin, Bartoschek, Michael D., Domínguez Moreno, Helena, Oettle, Matthias, Kempf, Julia, Vick, Binje, Ksienzyk, Bianka, Tizazu, Belay, Rothenberg-Thurley, Maja, Quentmeier, Hilmar, Hiddemann, Wolfgang, Vosberg, Sebastian, Greif, Philipp A., Metzeler, Klaus H., Schotta, Gunnar, Bultmann, Sebastian, Jeremias, Irmela, Leonhardt, Heinrich, Spiekermann, Karsten

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Whole-exome sequencing in adult ETP-ALL reveals a high rate of DNMT3A mutations von Neumann, Martin, Heesch, Sandra, Schlee, Cornelia, Schwartz, Stefan, Gökbuget, Nicola, Hoelzer, Dieter, Konstandin, Nikola P., Ksienzyk, Bianka, Vosberg, Sebastian, Graf, Alexander, Krebs, Stefan, Blum, Helmut, Raff, Thorsten, Brüggemann, Monika, Hofmann, Wolf-Karsten, Hecht, Jochen, Bohlander, Stefan K., Greif, Philipp A., Baldus, Claudia D.

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Fusion gene detection by RNA-sequencing complements diagnostics of acute myeloid leukemia and identifies recurring NRIP1-MIR99AHG rearrangements von Kerbs, Paul, Vosberg, Sebastian, Krebs, Stefan, Graf, Alexander, Blum, Helmut, Swoboda, Anja, Batcha, Aarif M N, Mansmann, Ulrich, Metzler, Dirk, Heckman, Caroline A, Herold, Tobias, Greif, Philipp A

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Evolution of Cytogenetically Normal Acute Myeloid Leukemia During Therapy and Relapse: An Exome Sequencing Study of 50 Patients von Greif, Philipp A, Hartmann, Luise, Vosberg, Sebastian, Stief, Sophie M, Mattes, Raphael, Hellmann, Ines, Metzeler, Klaus H, Herold, Tobias, Bamopoulos, Stefanos A, Kerbs, Paul, Jurinovic, Vindi, Schumacher, Daniela, Pastore, Friederike, Bräundl, Kathrin, Zellmeier, Evelyn, Ksienzyk, Bianka, Konstandin, Nikola P, Schneider, Stephanie, Graf, Alexander, Krebs, Stefan, Blum, Helmut, Neumann, Martin, Baldus, Claudia D, Bohlander, Stefan K, Wolf, Stephan, Görlich, Dennis, Berdel, Wolfgang E, Wörmann, Bernhard J, Hiddemann, Wolfgang, Spiekermann, Karsten

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DNA methylation epitypes highlight underlying developmental and disease pathways in acute myeloid leukemia von Giacopelli, Brian, Wang, Min, Cleary, Ada, Wu, Yue-Zhong, Schultz, Anna Reister, Schmutz, Maximilian, Blachly, James S, Eisfeld, Ann-Kathrin, Mundy-Bosse, Bethany, Vosberg, Sebastian, Greif, Philipp A, Claus, Rainer, Bullinger, Lars, Garzon, Ramiro, Coombes, Kevin R, Bloomfield, Clara D, Druker, Brian J, Tyner, Jeffrey W, Byrd, John C, Oakes, Christopher C

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Relapse of acute myeloid leukemia after allogeneic stem cell transplantation is associated with gain of WT1 alterations and high mutation load von Vosberg, Sebastian, Hartmann, Luise, Metzeler, Klaus H, Konstandin, Nikola P, Schneider, Stephanie, Varadharajan, Ashok, Hauser, Andreas, Krebs, Stefan, Blum, Helmut, Bohlander, Stefan K, Hiddemann, Wolfgang, Tischer, Johanna, Spiekermann, Karsten, Greif, Philipp A

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Exome sequencing identifies recurring FLT3 N676K mutations in core-binding factor leukemia von Opatz, Sabrina, Polzer, Harald, Herold, Tobias, Konstandin, Nikola P., Ksienzyk, Bianka, Zellmeier, Evelyn, Vosberg, Sebastian, Graf, Alexander, Krebs, Stefan, Blum, Helmut, Hopfner, Karl-Peter, Kakadia, Purvi M., Schneider, Stephanie, Dufour, Annika, Braess, Jan, Sauerland, Maria Cristina, Berdel, Wolfgang E., Büchner, Thomas, Woermann, Bernhard J., Hiddemann, Wolfgang, Spiekermann, Karsten, Bohlander, Stefan K., Greif, Philipp A.

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Clonal evolution of acute myeloid leukemia from diagnosis to relapse von Vosberg, Sebastian, Greif, Philipp A.

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Young woman with mild bone marrow dysplasia, GATA2 and ASXL1 mutation treated with allogeneic hematopoietic stem cell transplantation von Lübking, Anna, Vosberg, Sebastian, Konstandin, Nikola P, Dufour, Annika, Graf, Alexander, Krebs, Stefan, Blum, Helmut, Weber, Axel, Lenhoff, Stig, Ehinger, Mats, Spiekermann, Karsten, Greif, Philipp A, Cammenga, Jörg

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Acute Myeloid Leukemia with Isolated Trisomy 4 Is Characterized By Frequent Mutations of TET2 and a Distinct DNA Methylation Signature von Dutta, Sayantanee, Kerbs, Paul, Rothenberg-Thurley, Maja, Ksienzyk, Bianka, Krebs, Stefan, Blum, Helmut, Spiekermann, Karsten, Metzeler, Klaus H., Herold, Tobias, Vosberg, Sebastian, Greif, Philipp A.

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Gene Fusion Detection By RNA-Seq in Acute Myeloid Leukemia (AML) von Kerbs, Paul, Nazeer Batcha, Aarif Mohamed, Vosberg, Sebastian, Metzler, Dirk, Herold, Tobias, Greif, Philipp A.

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In-depth mutational analyses of colorectal neuroendocrine carcinomas with adenoma or adenocarcinoma components von Woischke, Christine, Schaaf, Christian W, Yang, Hui-Min, Vieth, Michael, Veits, Lothar, Geddert, Helene, Märkl, Bruno, Stömmer, Peter, Schaeffer, David F, Frölich, Matthias, Blum, Helmut, Vosberg, Sebastian, Greif, Philipp A, Jung, Andreas, Kirchner, Thomas, Horst, David

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Engineering an inducible leukemia-associated fusion protein enables large-scale ex vivo production of functional human phagocytes von Windisch, Roland, Soliman, Sarah, Hoffmann, Adrian, Chen-Wichmann, Linping, Danese, Anna, Vosberg, Sebastian, Bravo, Jimena, Lutz, Sebastian, Kellner, Christian, Fischer, Alexander, Gebhard, Claudia, Redondo Monte, Enric, Hartmann, Luise, Schneider, Stephanie, Beier, Fabian, Strobl, Carolin Dorothea, Weigert, Oliver, Peipp, Matthias, Schündeln, Michael, Stricker, Stefan H, Rehli, Michael, Bernhagen, Jürgen, Humpe, Andreas, Klump, Hannes, Brendel, Christian, Krause, Daniela S, Greif, Philipp A, Wichmann, Christian

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In vivo PDX CRISPR/Cas9 screens reveal mutual therapeutic targets to overcome heterogeneous acquired chemo-resistance von Wirth, Anna-Katharina, Wange, Lucas, Vosberg, Sebastian, Henrich, Kai-Oliver, Rausch, Christian, Özdemir, Erbey, Zeller, Christina M., Richter, Daniel, Feuchtinger, Tobias, Kaller, Markus, Hermeking, Heiko, Greif, Philipp A., Senft, Daniela, Jurinovic, Vindi, Bahrami, Ehsan, Jayavelu, Ashok Kumar, Westermann, Frank, Mann, Matthias, Enard, Wolfgang, Herold, Tobias, Jeremias, Irmela

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D DX41-Low Expression Mimics Germline DDX41-Phenotype in Acute Myeloid Leukemia von Shahbaz, Wajma, Jurinovic, Vindi, Batcha, Aarif M. N., Rausch, Christian, Rothenberg-Thurley, Maja, Dufour, Annika Maria, Ksienzyk, Bianka, Schneider, Stephanie, Neusser, Michaela, Sauerland, Maria Cristina, Görlich, Dennis, Berdel, Wolfgang E., Woermann, Bernhard J., Krug, Utz, Braess, Jan, Hiddemann, Wolfgang, Mansmann, Ulrich, Vosberg, Sebastian, Greif, Philipp A., Spiekermann, Karsten, Metzeler, Klaus H, Herold, Tobias

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Characterization of the immune microenvironment in matched primary and metastatic breast cancer lesions from the AURORA study: BIG 14-01 von Hilbers, Florentine, Venet, David, Agostinetto, Elisa, Benelli, Matteo, Guerrero, Angel, Martins-Branco, Diogo, Raimbault, Alice, Fimereli, Danai, Ferrando, Lorenzo, Sommariva, Sara, Biagioni, Chiara, Paoli, Marta, Llinas-Bertran, Arnau, Dadiani, Maya, Zoppoli, Gabriele, Balic, Marija, Albanell, Joan, Vosberg, Sebastian, Irrthum, Alexandre, Salgado, Roberto

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Molecular subgroups of T-cell acute lymphoblastic leukemia in adults treated according to pediatric-based GMALL protocols von Neumann, Martin, Beder, Thomas, Bastian, Lorenz, Hänzelmann, Sonja, Bultmann, Miriam, Wolgast, Nadine, Hartmann, Alina, Trautmann, Heiko, Ortiz-Tanchez, Jutta, Schlee, Cornelia, Schroeder, Michael, Fransecky, Lars, Vosberg, Sebastian, Fiedler, Walter, Alakel, Nael, Heberling, Lisa, Kondakci, Mustafa, Starck, Michael, Schwartz, Stefan, Raffel, Simon, Müller-Tidow, Carsten, Schneller, Folker, Reichle, Albrecht, Burmeister, Thomas, Greif, Philipp A., Brüggemann, Monika, Gökbuget, Nicola, Baldus, Claudia D.

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Prevalence, Clinical and Molecular Features, and Prognostic Value of Tetraploidy/Near-Tetraploidy in Patients with Acute Myeloid Leukemia von Ruhnke, Leo, Frimmel, Julia, Röllig, Christoph, Mohr, Brigitte, Altmann, Heidi, Poitz, David, Zukunft, Sven, Schranz, Katrin, Vosberg, Sebastian, Spiekermann, Karsten, von Bergwelt, Michael, Jost, Edgar, Dressler, Sabine, Schäfer-Eckart, Kerstin, Chavakis, Triantafyllos, Aust, Daniela, Jöhrens, Korinna, Baretton, Gustavo, Bornhäuser, Martin, Greif, Philipp A., Stölzel, Friedrich, Herold, Sylvia, Wagenführ, Lisa

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