Assessment of robustness and significance of climate change signals for an ensemble of distribution-based scaled climate projections von Seaby, L.P., Refsgaard, J.C., Sonnenborg, T.O., Stisen, S., Christensen, J.H., Jensen, K.H.

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Climate change impact on groundwater levels: ensemble modelling of extreme values von Kidmose, J, Refsgaard, J. C, Troldborg, L, Seaby, L. P, Escrivà, M. M

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Climate change effects on irrigation demands and minimum stream discharge: impact of bias-correction method von Rasmussen, J, Sonnenborg, T. O, Stisen, S, Seaby, L. P, Christensen, B. S. B, Hinsby, K

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Climate change impacts on groundwater hydrology - where are the main uncertainties and can they be reduced? von Refsgaard, J.C., Sonnenborg, T.O., Butts, M.B., Christensen, J.H., Christensen, S., Drews, M., Jensen, K.H., Jørgensen, F., Jørgensen, L.F., Larsen, M.A.D., Rasmussen, S.H., Seaby, L.P., Seifert, D., Vilhelmsen, T.N.

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Spatial uncertainty in bias corrected climate change projections and hydrogeological impacts von Seaby, L. P., Refsgaard, J. C., Sonnenborg, T. O., Højberg, A. L.

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Assessing and managing multiple risks in a changing worldThe Roskilde recommendations von Selck, Henriette, Adamsen, Peter B., Backhaus, Thomas, Banta, Gary T., Bruce, Peter K. H., Burton, G. Allen, Butts, Michael B., Boegh, Eva, Clague, John J., Dinh, Khuong V., Doorn, Neelke, Gunnarsson, Jonas S., Hauggaard-Nielsen, Henrik, Hazlerigg, Charles, Hunka, Agnieszka D., Jensen, John, Lin, Yan, Loureiro, Susana, Miraglia, Simona, Munns, Wayne R., Nadim, Farrokh, Palmqvist, Annemette, Rämö, Robert A., Seaby, Lauren P., Syberg, Kristian, Tangaa, Stine R., Thit, Amalie, Windfeld, Ronja, Zalewski, Maciej, Chapman, Peter M.

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Assessing and managing multiple risks in a changing world—The Roskilde recommendations von Selck, Henriette, Adamsen, Peter B., Backhaus, Thomas, Banta, Gary T., Bruce, Peter K.H., Burton, G. Allen, Butts, Michael B., Boegh, Eva, Clague, John J., Dinh, Khuong V., Doorn, Neelke, Gunnarsson, Jonas S., Hauggaard‐Nielsen, Henrik, Hazlerigg, Charles, Hunka, Agnieszka D., Jensen, John, Lin, Yan, Loureiro, Susana, Miraglia, Simona, Munns, Wayne R., Nadim, Farrokh, Palmqvist, Annemette, Rämö, Robert A., Seaby, Lauren P., Syberg, Kristian, Tangaa, Stine R., Thit, Amalie, Windfeld, Ronja, Zalewski, Maciej, Chapman, Peter M.

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Effect of a high-end CO₂-emission scenario on hydrology von Karlsson, Ida B., Sonnenborg, Torben O., Seaby, Lauren P., Jensen, Karsten H., Refsgaard, Jens Christian

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Uncertainty of simulated groundwater recharge at different global warming levels: a global-scale multi-model ensemble study von Reinecke, Robert, Müller Schmied, Hannes, Trautmann, Tim, Andersen, Lauren Seaby, Burek, Peter, Flörke, Martina, Gosling, Simon N, Grillakis, Manolis, Hanasaki, Naota, Koutroulis, Aristeidis, Pokhrel, Yadu, Thiery, Wim, Wada, Yoshihide, Yusuke, Satoh, Döll, Petra

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The mutational constraint spectrum quantified from variation in 141,456 humans von Karczewski, Konrad J., Francioli, Laurent C., Tiao, Grace, Cummings, Beryl B., Alföldi, Jessica, Wang, Qingbo, Collins, Ryan L., Laricchia, Kristen M., Ganna, Andrea, Birnbaum, Daniel P., Gauthier, Laura D., Brand, Harrison, Solomonson, Matthew, Watts, Nicholas A., Rhodes, Daniel, Singer-Berk, Moriel, England, Eleina M., Seaby, Eleanor G., Kosmicki, Jack A., Walters, Raymond K., Tashman, Katherine, Farjoun, Yossi, Banks, Eric, Poterba, Timothy, Wang, Arcturus, Seed, Cotton, Whiffin, Nicola, Chong, Jessica X., Samocha, Kaitlin E., Pierce-Hoffman, Emma, Zappala, Zachary, O’Donnell-Luria, Anne H., Minikel, Eric Vallabh, Weisburd, Ben, Lek, Monkol, Ware, James S., Vittal, Christopher, Armean, Irina M., Bergelson, Louis, Cibulskis, Kristian, Connolly, Kristen M., Covarrubias, Miguel, Donnelly, Stacey, Ferriera, Steven, Gabriel, Stacey, Gentry, Jeff, Gupta, Namrata, Jeandet, Thibault, Kaplan, Diane, Llanwarne, Christopher, Munshi, Ruchi, Novod, Sam, Petrillo, Nikelle, Roazen, David, Ruano-Rubio, Valentin, Saltzman, Andrea, Schleicher, Molly, Soto, Jose, Tibbetts, Kathleen, Tolonen, Charlotte, Wade, Gordon, Talkowski, Michael E., Neale, Benjamin M., Daly, Mark J., MacArthur, Daniel G.

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Treatment of Multisystem Inflammatory Syndrome in Children: Understanding Differences in Results of Comparative Effectiveness Studies von Melgar, Michael, Seaby, Eleanor G., McArdle, Andrew J., Young, Cameron C., Campbell, Angela P., Murray, Nancy L., Patel, Manish M., Levin, Michael, Randolph, Adrienne G., Son, Mary Beth F.

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Understanding each other's models: an introduction and a standard representation of 16 global water models to support intercomparison, improvement, and communication von Telteu, Camelia-Eliza, Müller Schmied, Hannes, Thiery, Wim, Leng, Guoyong, Burek, Peter, Liu, Xingcai, Boulange, Julien Eric Stanislas, Andersen, Lauren Seaby, Grillakis, Manolis, Gosling, Simon Newland, Satoh, Yusuke, Rakovec, Oldrich, Stacke, Tobias, Chang, Jinfeng, Wanders, Niko, Shah, Harsh Lovekumar, Trautmann, Tim, Mao, Ganquan, Hanasaki, Naota, Koutroulis, Aristeidis, Pokhrel, Yadu, Samaniego, Luis, Wada, Yoshihide, Mishra, Vimal, Liu, Junguo, Döll, Petra, Zhao, Fang, Gädeke, Anne, Rabin, Sam S, Herz, Florian

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Transcript expression-aware annotation improves rare variant interpretation von Cummings, Beryl B., Karczewski, Konrad J., Kosmicki, Jack A., Seaby, Eleanor G., Watts, Nicholas A., Singer-Berk, Moriel, Mudge, Jonathan M., Karjalainen, Juha, Satterstrom, F. Kyle, O’Donnell-Luria, Anne H., Poterba, Timothy, Seed, Cotton, Solomonson, Matthew, Alföldi, Jessica, Daly, Mark J., MacArthur, Daniel G.

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Author Correction: Transcript expression-aware annotation improves rare variant interpretation von Cummings, Beryl B., Karczewski, Konrad J., Kosmicki, Jack A., Seaby, Eleanor G., Watts, Nicholas A., Singer-Berk, Moriel, Mudge, Jonathan M., Karjalainen, Juha, Satterstrom, F. Kyle, O’Donnell-Luria, Anne H., Poterba, Timothy, Seed, Cotton, Solomonson, Matthew, Alföldi, Jessica, Daly, Mark J., MacArthur, Daniel G.

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Targeting de novo loss-of-function variants in constrained disease genes improves diagnostic rates in the 100,000 Genomes Project von Seaby, Eleanor G., Thomas, N. Simon, Webb, Amy, Brittain, Helen, Taylor Tavares, Ana Lisa, Baralle, Diana, Rehm, Heidi L., O’Donnell-Luria, Anne, Ennis, Sarah

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A gene pathogenicity tool “GenePy” identifies missed biallelic diagnoses in the 100,000 Genomes Project von Seaby, Eleanor G., Leggatt, Gary, Cheng, Guo, Thomas, N. Simon, Ashton, James J., Stafford, Imogen, Baralle, Diana, Rehm, Heidi L., O’Donnell-Luria, Anne, Ennis, Sarah, Ambrose, J.C., Arumugam, P., Bevers, R., Bleda, M., Boardman-Pretty, F., Boustred, C.R., Brittain, H., Brown, M.A., Caulfield, M.J., Chan, G.C., Giess, A., Griffin, J.N., Hamblin, A., Henderson, S., Hubbard, T.J.P., Jackson, R., Jones, L.J., Kasperaviciute, D., Kayikci, M., Kousathanas, A., Lahnstein, L., Lakey, A., Leigh, S.E.A., Leong, I.U.S., Lopez, F.J., Maleady-Crowe, F., McEntagart, M., Minneci, F., Mitchell, J., Moutsianas, L., Mueller, M., Murugaesu, N., Need, A.C., O‘Donovan, P., Odhams, C.A., Patch, C., Perez-Gil, D., Pereira, M.B., Pullinger, J., Rahim, T., Rendon, A., Rogers, T., Savage, K., Sawant, K., Scott, R.H., Siddiq, A., Sieghart, A., Smith, S.C., Sosinsky, A., Stuckey, A., Tanguy, M., Taylor Tavares, A.L., Thomas, E.R.A., Thompson, S.R., Tucci, A., Welland, M.J., Williams, E., Witkowska, K., Wood, S.M., Zarowiecki, M.

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Addendum: The mutational constraint spectrum quantified from variation in 141,456 humans von Gudmundsson, Sanna, Karczewski, Konrad J., Francioli, Laurent C., Tiao, Grace, Cummings, Beryl B., Alföldi, Jessica, Wang, Qingbo, Collins, Ryan L., Laricchia, Kristen M., Ganna, Andrea, Birnbaum, Daniel P., Gauthier, Laura D., Brand, Harrison, Solomonson, Matthew, Watts, Nicholas A., Rhodes, Daniel, Singer-Berk, Moriel, England, Eleina M., Seaby, Eleanor G., Kosmicki, Jack A., Walters, Raymond K., Tashman, Katherine, Farjoun, Yossi, Banks, Eric, Poterba, Timothy, Wang, Arcturus, Seed, Cotton, Whiffin, Nicola, Chong, Jessica X., Samocha, Kaitlin E., Pierce-Hoffman, Emma, Zappala, Zachary, O’Donnell-Luria, Anne H., Minikel, Eric Vallabh, Weisburd, Ben, Lek, Monkol, Ware, James S., Vittal, Christopher, Armean, Irina M., Bergelson, Louis, Cibulskis, Kristian, Connolly, Kristen M., Covarrubias, Miguel, Donnelly, Stacey, Ferriera, Steven, Gabriel, Stacey, Gentry, Jeff, Gupta, Namrata, Jeandet, Thibault, Kaplan, Diane, Llanwarne, Christopher, Munshi, Ruchi, Novod, Sam, Petrillo, Nikelle, Roazen, David, Ruano-Rubio, Valentin, Saltzman, Andrea, Schleicher, Molly, Soto, Jose, Tibbetts, Kathleen, Tolonen, Charlotte, Wade, Gordon, Talkowski, Michael E., Neale, Benjamin M., Daly, Mark J., MacArthur, Daniel G.

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Author Correction: The mutational constraint spectrum quantified from variation in 141,456 humans von Karczewski, KJ, Francioli, LC, Tiao, G, Cummings, BB, Alfoldi, J, Wang, Q, Collins, RL, Laricchia, KM, Ganna, A, Birnbaum, DP, Gauthier, LD, Brand, H, Solomonson, M, Watts, NA, Rhodes, D, Singer-Berk, M, England, EM, Seaby, EG, Kosmicki, JA, Walters, RK, Tashman, K, Farjoun, Y, Banks, E, Poterba, T, Wang, A, Seed, C, Whiffin, N, Chong, JX, Samocha, KE, Pierce-Hoffman, E, Zappala, Z, O'Donnell-Luria, AH, Minikel, EV, Weisburd, B, Lek, M, Ware, JS, Vittal, C, Armean, IM, Bergelson, L, Cibulskis, K, Connolly, KM, Covarrubias, M, Donnelly, S, Ferriera, S, Gabriel, S, Gentry, J, Gupta, N, Jeandet, T, Kaplan, D, Llanwarne, C, Munshi, R, Novod, S, Petrillo, N, Roazen, D, Ruano-Rubio, V, Saltzman, A, Schleicher, M, Soto, J, Tibbetts, K, Tolonen, C, Wade, G, Talkowski, ME, Aggregation, G, Neale, BM, Daly, MJ, MacArthur, DG

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The mutational constraint spectrum quantified from variation in 141,456 humans (vol 581, pg 434, 2020) von Gudmundsson, S, Karczewski, KJ, Francioli, LC, Tiao, G, Cummings, BB, Alfoldi, J, Wang, Q, Collins, RL, Laricchia, KM, Ganna, A, Birnbaum, DP, Gauthier, LD, Brand, H, Solomonson, M, Watts, NA, Rhodes, D, Singer-Berk, M, England, EM, Seaby, EG, Kosmicki, JA, Walters, RK, Tashman, K, Farjoun, Y, Banks, E, Poterba, T, Wang, A, Seed, C, Whiffin, N, Chong, JX, Samocha, KE, Pierce-Hoffman, E, Zappala, Z, O'Donnell-Luria, AH, Minikel, EV, Weisburd, B, Lek, M, Ware, JS, Vittal, C, Armean, IM, Bergelson, L, Cibulskis, K, Connolly, KM, Covarrubias, M, Donnelly, S, Ferriera, S, Gabriel, S, Gentry, J, Gupta, N, Jeandet, T, Kaplan, D, Llanwarne, C, Munshi, R, Novod, S, Petrillo, N, Roazen, D, Ruano-Rubio, V, Saltzman, A, Schleicher, M, Soto, J, Tibbetts, K, Tolonen, C, Wade, G, Talkowski, ME, Neale, BM, Daly, MJ, MacArthur, DG

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The mutational constraint spectrum quantified from variation in 141,456 humans von Karczewski, KJ, Francioli, LC, Tiao, G, Cummings, BB, Alföldi, J, Wang, Q, Collins, RL, Laricchia, KM, Ganna, A, Birnbaum, DP, Gauthier, LD, Brand, H, Solomonson, M, Watts, NA, Rhodes, D, Singer-Berk, M, England, EM, Seaby, EG, Kosmicki, JA, Walters, RK, Tashman, K, Farjoun, Y, Banks, E, Poterba, T, Wang, A, Seed, C, Whiffin, N, Chong, JX, Samocha, KE, Pierce-Hoffman, E, Zappala, Z, O’Donnell-Luria, AH, Vallabh Minikel, E, Weisburd, B, Lek, M, Ware, JS, Vittal, C, Armean, IM, Bergelson, L, Cibulskis, K, Connolly, JM, Covarrubias, M, Donnelly, S, Ferriera, S, Gabriel, S, Gentry, J, Gupta, N, Jeandet, T, Kaplan, D, Llanwarne, C, Munshi, J, Novod, S, Petrillo, N, Roazen, D, Ruano-Rubio, V, Saltzman, A, Schleicher, M, Soto, J, Tibbetts, K, Tolonen, C, Wade, G, Talkowski, ME, Genome Aggregation Database (gnomAD) Consortium, Neale, BM, Daly, MJ, MacArthur, DG

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