Hexanucleotide Repeats in ALS/FTD Form Length-Dependent RNA Foci, Sequester RNA Binding Proteins, and Are Neurotoxic von Lee, Youn-Bok, Chen, Han-Jou, Peres, João N., Gomez-Deza, Jorge, Attig, Jan, Štalekar, Maja, Troakes, Claire, Nishimura, Agnes L., Scotter, Emma L., Vance, Caroline, Adachi, Yoshitsugu, Sardone, Valentina, Miller, Jack W., Smith, Bradley N., Gallo, Jean-Marc, Ule, Jernej, Hirth, Frank, Rogelj, Boris, Houart, Corinne, Shaw, Christopher E.

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TDP-43 pathology: From noxious assembly to therapeutic removal von Keating, Sean S., San Gil, Rebecca, Swanson, Molly E.V., Scotter, Emma L., Walker, Adam K.

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Differential roles of the ubiquitin proteasome system and autophagy in the clearance of soluble and aggregated TDP-43 species von Scotter, Emma L, Vance, Caroline, Nishimura, Agnes L, Lee, Youn-Bok, Chen, Han-Jou, Urwin, Hazel, Sardone, Valentina, Mitchell, Jacqueline C, Rogelj, Boris, Rubinsztein, David C, Shaw, Christopher E

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The heat shock response plays an important role in TDP-43 clearance: evidence for dysfunction in amyotrophic lateral sclerosis von Chen, Han-Jou, Mitchell, Jacqueline C, Novoselov, Sergey, Miller, Jack, Nishimura, Agnes L, Scotter, Emma L, Vance, Caroline A, Cheetham, Michael E, Shaw, Christopher E

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ALS mutant FUS disrupts nuclear localization and sequesters wild-type FUS within cytoplasmic stress granules von Vance, Caroline, Scotter, Emma L, Nishimura, Agnes L, Troakes, Claire, Mitchell, Jacqueline C, Kathe, Claudia, Urwin, Hazel, Manser, Catherine, Miller, Christopher C, Hortobágyi, Tibor, Dragunow, Mike, Rogelj, Boris, Shaw, Christopher E

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Transcriptional targets of amyotrophic lateral sclerosis/frontotemporal dementia protein TDP-43 – meta-analysis and interactive graphical database von Cao, Maize C., Scotter, Emma L.

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The endocannabinoid system as a target for the treatment of neurodegenerative disease von Scotter, Emma L, Abood, Mary E, Glass, Michelle

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TGF-beta1 regulates human brain pericyte inflammatory processes involved in neurovasculature function von Rustenhoven, Justin, Aalderink, Miranda, Scotter, Emma L, Oldfield, Robyn L, Bergin, Peter S, Mee, Edward W, Graham, E Scott, Faull, Richard L M, Curtis, Maurice A, Park, Thomas I-H, Dragunow, Mike

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Altered microglia and neurovasculature in the Alzheimer's disease cerebellum von Singh-Bains, Malvindar K., Linke, Vanessa, Austria, Micah D.R., Tan, Adelie Y.S., Scotter, Emma L., Mehrabi, Nasim F., Faull, Richard L.M., Dragunow, Mike

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ALS/FTD mutations in UBQLN2 impede autophagy by reducing autophagosome acidification through loss of function von Wu, Josephine J., Cai, Ashley, Greenslade, Jessie E., Higgins, Nicole R., Fan, Cong, Le, Nhat T. T., Tatman, Micaela, Whiteley, Alexandra M., Prado, Miguel A., Dieriks, Birger V., Curtis, Maurice A., Shaw, Christopher E., Siddique, Teepu, Faull, Richard L. M., Scotter, Emma L., Finley, Daniel, Monteiro, Mervyn J.

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Cytoplasmic TDP-43 is involved in cell fate during stress recovery von Lee, Youn-Bok, Scotter, Emma L, Lee, Do-Young, Troakes, Claire, Mitchell, Jacqueline, Rogelj, Boris, Gallo, Jean-Marc, Shaw, Christopher E

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A panel of TDP-43-regulated splicing events verifies loss of TDP-43 function in amyotrophic lateral sclerosis brain tissue von Cao, Maize C., Ryan, Brigid, Wu, Jane, Curtis, Maurice A., Faull, Richard L.M., Dragunow, Mike, Scotter, Emma L.

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Serum biomarkers of neuroinflammation and blood-brain barrier leakage in amyotrophic lateral sclerosis von Cao, Maize C, Cawston, Erin E, Chen, Grace, Brooks, Collin, Douwes, Jeroen, McLean, Dave, Graham, E Scott, Dragunow, Mike, Scotter, Emma L

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Novel mutations support a role for Profilin 1 in the pathogenesis of ALS von Smith, Bradley N, Vance, Caroline, Scotter, Emma L, Troakes, Claire, Wong, Chun Hao, Topp, Simon, Maekawa, Satomi, King, Andrew, Mitchell, Jacqueline C, Lund, Karan, Al-Chalabi, Ammar, Ticozzi, Nicola, Silani, Vincenzo, Sapp, Peter, Brown, Robert H, Landers, John E, Al-Sarraj, Safa, Shaw, Christopher E

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Microglial CD68 and L-ferritin upregulation in response to phosphorylated-TDP-43 pathology in the amyotrophic lateral sclerosis brain von Swanson, Molly E V, Mrkela, Miran, Murray, Helen C, Cao, Maize C, Turner, Clinton, Curtis, Maurice A, Faull, Richard L M, Walker, Adam K, Scotter, Emma L

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Inconsistencies in histone acetylation patterns among different HD model systems and HD post-mortem brains von Narayan, Pritika, Reid, Suzanne, Scotter, Emma L., McGregor, Ailsa L., Mehrabi, Nasim F., Singh-Bains, Malvindar K., Glass, Michelle, Faull, Richard L.M., Snell, Russell G., Dragunow, Mike

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Identification of a dysfunctional microglial population in human Alzheimer's disease cortex using novel single-cell histology image analysis von Swanson, Molly E. V., Scotter, Emma L., Smyth, Leon C. D., Murray, Helen C., Ryan, Brigid, Turner, Clinton, Faull, Richard L. M., Dragunow, Mike, Curtis, Maurice A.

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Allele-specific knockdown of ALS-associated mutant TDP-43 in neural stem cells derived from induced pluripotent stem cells von Nishimura, Agnes L, Shum, Carole, Scotter, Emma L, Abdelgany, Amr, Sardone, Valentina, Wright, Jamie, Lee, Youn-Bok, Chen, Han-Jou, Bilican, Bilada, Carrasco, Monica, Maniatis, Tom, Chandran, Siddharthan, Rogelj, Boris, Gallo, Jean-Marc, Shaw, Christopher E

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TDP-43 Proteinopathy and ALS: Insights into Disease Mechanisms and Therapeutic Targets von Scotter, Emma L., Chen, Han-Jou, Shaw, Christopher E.

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Shared Regulatory Pathways Reveal Novel Genetic Correlations Between Grip Strength and Neuromuscular Disorders von Gokuladhas, Sreemol, Schierding, William, Cameron-Smith, David, Wake, Melissa, Scotter, Emma L., O'Sullivan, Justin

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