Combined MYC and P53 Defects Emerge at Medulloblastoma Relapse and Define Rapidly Progressive, Therapeutically Targetable Disease von Hill, Rebecca M., Kuijper, Sanne, Lindsey, Janet C., Petrie, Kevin, Schwalbe, Ed C., Barker, Karen, Boult, Jessica K.R., Williamson, Daniel, Ahmad, Zai, Hallsworth, Albert, Ryan, Sarra L., Poon, Evon, Robinson, Simon P., Ruddle, Ruth, Raynaud, Florence I., Howell, Louise, Kwok, Colin, Joshi, Abhijit, Nicholson, Sarah Leigh, Crosier, Stephen, Ellison, David W., Wharton, Stephen B., Robson, Keith, Michalski, Antony, Hargrave, Darren, Jacques, Thomas S., Pizer, Barry, Bailey, Simon, Swartling, Fredrik J., Weiss, William A., Chesler, Louis, Clifford, Steven C.

Volltext

TERT promoter mutation and aberrant hypermethylation are associated with elevated expression in medulloblastoma and characterise the majority of non-infant SHH subgroup tumours von Lindsey, Janet C., Schwalbe, Ed. C., Potluri, Sandeep, Bailey, Simon, Williamson, Daniel, Clifford, Steven C.

Volltext

MYC family amplification and clinical risk-factors interact to predict an extremely poor prognosis in childhood medulloblastoma von Ryan, Sarra L., Schwalbe, Ed C., Cole, Michael, Lu, Yuan, Lusher, Meryl E., Megahed, Hisham, O’Toole, Kieran, Nicholson, Sarah Leigh, Bognar, Laszlo, Garami, Miklos, Hauser, Peter, Korshunov, Andrey, Pfister, Stefan M., Williamson, Daniel, Taylor, Roger E., Ellison, David W., Bailey, Simon, Clifford, Steven C.

Volltext

Histologically defined central nervous system primitive neuro-ectodermal tumours (CNS-PNETs) display heterogeneous DNA methylation profiles and show relationships to other paediatr... von Schwalbe, Ed. C., Hayden, James T., Rogers, Hazel A., Miller, Suzanne, Lindsey, Janet C., Hill, Rebecca M., Nicholson, Sarah-Leigh, Kilday, John-Paul, Adamowicz-Brice, Martyna, Storer, Lisa, Jacques, Thomas S., Robson, Keith, Lowe, Jim, Williamson, Daniel, Grundy, Richard G., Bailey, Simon, Clifford, Steven C.

Volltext

Rapid Diagnosis of Medulloblastoma Molecular Subgroups von SCHWALBE, Ed C, LINDSEY, Janet C, ELLISON, David W, BAILEY, Simon, CLIFFORD, Steven C, STRAUGHTON, Debbie, HOGG, Twala L, COLE, Michael, MEGAHED, Hisham, RYAN, Sarra L, LUSHER, Meryl E, TAYLOR, Michael D, GILBERTSON, Richard J

Volltext

TP53 mutations in favorable-risk Wnt/Wingless-subtype medulloblastomas von Lindsey, Janet C, Hill, Rebecca M, Megahed, Hisham, Lusher, Meryl E, Schwalbe, Ed C, Cole, Michael, Hogg, Twala L, Gilbertson, Richard J, Ellison, David W, Bailey, Simon, Clifford, Steven C

Volltext

Subgroup-Specific Prognostic Implications of TP53 Mutation in Medulloblastoma von ZHUKOVA, Nataliya, RAMASWAMY, Vijay, VON BUEREN, André O, JONES, David T. W, NORTHCOTT, Paul A, KOOL, Marcel, STURM, Dominik, PUGH, Trevor J, POMEROY, Scott L, CHO, Yoon-Jae, PIETSCH, Torsten, GESSI, Marco, REMKE, Marc, RUTKOWSKI, Stefan, BOGNAR, Laszlo, KLEKNER, Almos, CHO, Byung-Kyu, KIM, Seung-Ki, WANG, Kyu-Chang, EBERHART, Charles G, FEVRE-MONTANGE, Michelle, FOULADI, Maryam, FRENCH, Pim J, PFAFF, Elke, KROS, Max, GRAJKOWSKA, Wieslawa A, GUPTA, Nalin, WEISS, William A, HAUSER, Peter, JABADO, Nada, JOUVET, Anne, SHIN JUNG, KUMABE, Toshihiro, LACH, Boleslaw, SHIH, David J. H, LEONARD, Jeffrey R, RUBIN, Joshua B, LIAU, Linda M, MASSIMI, Luca, POLLACK, Ian F, YOUNG SHIN RA, VAN MEIR, Erwin G, ZITTERBART, Karel, SCHÜLLER, Ulrich, HILL, Rebecca M, MARTIN, Dianna C, LINDSEY, Janet C, SCHWALBE, Ed C, BAILEY, Simon, ELLISON, David W, HAWKINS, Cynthia, MALKIN, David, CLIFFORD, Steven C, KORSHUNOV, Andrey, PFISTER, Stefan, TAYLOR, Michael D, CASTELO-BRANCO, Pedro, BASKIN, Berivan, RAY, Peter N, BOUFFET, Eric

Volltext

Biomarker-driven stratification of disease-risk in non-metastatic medulloblastoma: Results from the multi-center HIT-SIOP-PNET4 clinical trial von Clifford, Steven C, Lannering, Birgitta, Schwalbe, Ed C, Hicks, Debbie, O'Toole, Kieran, Nicholson, Sarah Leigh, Goschzik, Tobias, Zur Mühlen, Anja, Figarella-Branger, Dominique, Doz, François, Rutkowski, Stefan, Gustafsson, Göran, Pietsch, Torsten

Volltext

Supratentorial and spinal pediatric ependymomas display a hypermethylated phenotype which includes the loss of tumor suppressor genes involved in the control of cell growth and dea... von Rogers, Hazel A., Kilday, John-Paul, Mayne, Cerys, Ward, Jennifer, Adamowicz-Brice, Martyna, Schwalbe, Ed C., Clifford, Steven C., Coyle, Beth, Grundy, Richard G.

Volltext

Genome-Wide Analysis of Alternative Splicing in Medulloblastoma Identifies Splicing Patterns Characteristic of Normal Cerebellar Development von MENGHI, Francesca, JACQUES, Thomas S, BARENCO, Martino, SCHWALBE, Ed C, CLIFFORD, Steven C, HUBANK, Mike, HAM, Jonathan

Volltext

Abstract LB-324: A whole chromosome aberration phenotype in non-WNT/non-SHH tumors predicts outcome within standard-risk medulloblastomas from the HIT-SIOP-PNET4 clinical trial von Goschzik, Tobias, Schwalbe, Ed C., Hicks, Debbie, Figarella-Branger, Dominique, Doz, Francois, Rutkowski, Stefan, Gustafsson, Goran, Lannering, Birgitta, Pietsch, Torsten, Clifford, Steve C.

Volltext

Cross-species epigenetics identifies a critical role for VAV1 in SHH subgroup medulloblastoma maintenance von Lindsey, J C, Kawauchi, D, Schwalbe, E C, Solecki, D J, Selby, M P, McKinnon, P J, Olson, J M, Hayden, J T, Grundy, R G, Ellison, D W, Williamson, D, Bailey, S, Roussel, M F, Clifford, S C

Volltext

MBRS-29. IN-VIVO METABOLITE PROFILES FOR THE NON-INVASIVE AND RAPID IDENTIFICATION OF MOLECULAR SUBGROUP IN MEDULLOBLASTOMA von Kohe, Sarah E, Babourina-Brooks, Ben, Scerif, Fatma, Hicks, Debbie, Schwalbe, Ed C, Crosier, Stephen, Lindsey, Janet, Adiamah, Magretta, Storer, Lisa C D, Lourdusamy, Anbarasu, Gill, Simrandip K, Bennett, Christopher D, Wilson, Martin, Avula, Shivaram, Mitra, Dipayan, Dineen, Rob, Bailey, Simon, Williamson, Daniel, Grundy, Richard G, Clifford, Steven C, Peet, Andrew C

Volltext

MB-84IDENTIFICATION OF MEDULLOBLASTOMA MOLECULAR SUBGROUPS USING METABOLITE PROFILES von Kohe, Sarah, Gill, Simrandip K., Hicks, Debbie, Schwalbe, Ed C., Crosier, Stephen, Storer, Lisa, Lourdusamy, Anbarasu, Bennett, Christopher D., Wilson, Martin, Bailey, Simon, Williamson, Daniel, Grundy, Richard G., Clifford, Steven C., Peet, Andrew C.

Volltext

Abstract LB-201: MYC and TP53 defects interact at medulloblastoma relapse to define rapidly progressive disease and can be targeted therapeutically von Hill, Rebecca M., Kuijper, Sanne, Lindsey, Janet, Schwalbe, Ed C., Barker, Karen, Boult, Jessica, Williamson, Daniel, Ahmad, Zai, Hallsworth, Albert, Ryan, Sarra, Poon, Evon, Robinson, Simon, Ruddle, Ruth, Raynaud, Florence, Howell, Louise, Kwok, Colin, Joshi, Abhijit, Nicholson, Sarah, Crosier, Stephen, Wharton, Stephen, Jacques, Tom, Robson, Keith, Michalski, Antony, Hargrave, Darren, Pizer, Barry, Bailey, Simon, Swartling, Fredrik J., Petrie, Kevin, Weiss, William A., Chesler, Louis, Clifford, Steve

Volltext

MYC and TP53 defects interact at medulloblastoma relapse to define rapidly progressive disease and can be targeted therapeutically von Hill, Rebecca M., Kuijper, Sanne, Lindsey, Janet, Schwalbe, Ed C., Barker, Karen, Boult, Jessica, Williamson, Daniel, Ahmad, Zai, Hallsworth, Albert, Ryan, Sarra, Poon, Evon, Robinson, Simon, Ruddle, Ruth, Raynaud, Florence, Howell, Louise, Kwok, Colin, Joshi, Abhijit, Nicholson, Sarah, Crosier, Stephen, Wharton, Stephen, Jacques, Tom, Robson, Keith, Michalski, Antony, Hargrave, Darren, Pizer, Barry, Bailey, Simon, Swartling, Fredrik J., Petrie, Kevin, Weiss, William A., Chesler, Louis, Clifford, Steve

Volltext

Abstract 3442: TP53 mutations in favorable risk WNT subtype medulloblastomas von Hill, Rebecca M., Lindsey, Janet C., Megahed, Hisham, Schwalbe, Ed C., Cole, Michael, Hogg, Twala L., Gilbertson, Richard J., Ellison, David W., Bailey, Simon, Clifford, Steven C.

Volltext

Abstract 3449: Epigenomics identifies conserved DNA methylation events associated with medulloblastoma development in humans and mice von Lindsey, Janet C., Schwalbe, Ed C., Kawauchi, Daisuke, Olson, Jim M., McKinnon, Peter J., Gilbertson, Richard J., Roussel, Martine F., Ellison, David W., Bailey, Simon, Clifford, Steven C.

Volltext

Combined MYC and P53 Defects Emerge at Medulloblastoma Relapse and Define Rapidly Progressive, Therapeutically Targetable Disease von Hill, Rebecca M, Kuijper, Sanne, Lindsey, Janet C, Petrie, Kevin, Schwalbe, Ed C, Barker, Karen, Boult, Jessica K. R, Williamson, Daniel, Ahmad, Zai, Hallsworth, Albert, Ryan, Sarra L, Poon, Evon, Robinson, Simon P, Ruddle, Ruth, Raynaud, Florence I, Howell, Louise, Kwok, Colin, Joshi, Abhijit, Nicholson, Sarah Leigh, Crosier, Stephen, Ellison, David W, Wharton, Stephen B, Robson, Keith, Michalski, Antony, Hargrave, Darren, Jacques, Thomas S, Pizer, Barry, Bailey, Simon, Swartling, Fredrik J, Weiss, William A, Chesler, Louis, Clifford, Steven C

Volltext bestellen

Treating childhood acute lymphoblastic leukemia in Malawi von Chagaluka, George, Carey, Peter, Banda, Kondwani, Schwab, Claire, Chilton, Lucy, Schwalbe, Ed, Skinner, Roderick, Israels, Trijn, Moorman, Anthony, Molyneux, Elizabeth, Bailey, Simon

Volltext