Inhibition of RNA Polymerase I as a Therapeutic Strategy to Promote Cancer-Specific Activation of p53 von Bywater, Megan J., Poortinga, Gretchen, Sanij, Elaine, Hein, Nadine, Peck, Abigail, Cullinane, Carleen, Wall, Meaghan, Cluse, Leonie, Drygin, Denis, Anderes, Kenna, Huser, Nanni, Proffitt, Chris, Bliesath, Joshua, Haddach, Mustapha, Schwaebe, Michael K., Ryckman, David M., Rice, William G., Schmitt, Clemens, Lowe, Scott W., Johnstone, Ricky W., Pearson, Richard B., McArthur, Grant A., Hannan, Ross D.

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CX-4945, an orally bioavailable selective inhibitor of protein kinase CK2, inhibits prosurvival and angiogenic signaling and exhibits antitumor efficacy von Siddiqui-Jain, Adam, Drygin, Denis, Streiner, Nicole, Chua, Peter, Pierre, Fabrice, O'Brien, Sean E, Bliesath, Josh, Omori, Mayuko, Huser, Nanni, Ho, Caroline, Proffitt, Chris, Schwaebe, Michael K, Ryckman, David M, Rice, William G, Anderes, Kenna

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Discovery and SAR of 5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-8-carboxylic Acid (CX-4945), the First Clinical Stage Inhibitor of Protein Kinase CK2 for the Treatment of Ca... von Pierre, Fabrice, Chua, Peter C, O’Brien, Sean E, Siddiqui-Jain, Adam, Bourbon, Pauline, Haddach, Mustapha, Michaux, Jerome, Nagasawa, Johnny, Schwaebe, Michael K, Stefan, Eric, Vialettes, Anne, Whitten, Jeffrey P, Chen, Ta Kung, Darjania, Levan, Stansfield, Ryan, Anderes, Kenna, Bliesath, Josh, Drygin, Denis, Ho, Caroline, Omori, May, Proffitt, Chris, Streiner, Nicole, Trent, Katy, Rice, William G, Ryckman, David M

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Targeting RNA Polymerase I with an Oral Small Molecule CX-5461 Inhibits Ribosomal RNA Synthesis and Solid Tumor Growth von DRYGIN, Denis, LIN, Amy, STREINER, Nicole, QUIN, Jaclyn E, SANIJ, Elaine, BYWATE, Megan J, HANNAN, Ross D, RYCKMAN, David, ANDERES, Kenna, RICE, William G, BLIESATH, Josh, HO, Caroline B, O'BRIEN, Sean E, PROFFITT, Chris, OMORI, Mayuko, HADDACH, Mustapha, SCHWAEBE, Michael K, SIDDIQUI-JAIN, Adam

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Anticancer Activity of CX-3543: A Direct Inhibitor of rRNA Biogenesis von DRYGIN, Denis, SIDDIQUI-JAIN, Adam, LIM, John K. C, VON HOFF, Daniel, ANDERES, Kenna, RICE, William G, O'BRIEN, Sean, SCHWAEBE, Michael, LIN, Amy, BLIESATH, Josh, HO, Caroline B, PROFFITT, Chris, TRENT, Katy, WHITTEN, Jeffrey P

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Pre-clinical characterization of CX-4945, a potent and selective small molecule inhibitor of CK2 for the treatment of cancer von Pierre, Fabrice, Chua, Peter C., O’Brien, Sean E., Siddiqui-Jain, Adam, Bourbon, Pauline, Haddach, Mustapha, Michaux, Jerome, Nagasawa, Johnny, Schwaebe, Michael K., Stefan, Eric, Vialettes, Anne, Whitten, Jeffrey P., Chen, Ta Kung, Darjania, Levan, Stansfield, Ryan, Bliesath, Joshua, Drygin, Denis, Ho, Caroline, Omori, May, Proffitt, Chris, Streiner, Nicole, Rice, William G., Ryckman, David M., Anderes, Kenna

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Discovery of CX-5461, the First Direct and Selective Inhibitor of RNA Polymerase I, for Cancer Therapeutics von Haddach, Mustapha, Schwaebe, Michael K, Michaux, Jerome, Nagasawa, Johnny, O'Brien, Sean E, Whitten, Jeffrey P, Pierre, Fabrice, Kerdoncuff, Pauline, Darjania, Levan, Stansfield, Ryan, Drygin, Denis, Anderes, Kenna, Proffitt, Chris, Bliesath, Josh, Siddiqui-Jain, Adam, Omori, May, Huser, Nanni, Rice, William G, Ryckman, David M

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Discovery of CX-6258. A Potent, Selective, and Orally Efficacious pan-Pim Kinases Inhibitor von Haddach, Mustapha, Michaux, Jerome, Schwaebe, Michael K, Pierre, Fabrice, O’Brien, Sean E, Borsan, Cosmin, Tran, Joe, Raffaele, Nicholas, Ravula, Suchitra, Drygin, Denis, Siddiqui-Jain, Adam, Darjania, Levan, Stansfield, Ryan, Proffitt, Chris, Macalino, Diwata, Streiner, Nicole, Bliesath, Joshua, Omori, May, Whitten, Jeffrey P, Anderes, Kenna, Rice, William G, Ryckman, David M

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Novel potent pyrimido[4,5- c]quinoline inhibitors of protein kinase CK2: SAR and preliminary assessment of their analgesic and anti-viral properties von Pierre, Fabrice, O’Brien, Sean E., Haddach, Mustapha, Bourbon, Pauline, Schwaebe, Michael K., Stefan, Eric, Darjania, Levan, Stansfield, Ryan, Ho, Caroline, Siddiqui-Jain, Adam, Streiner, Nicole, Rice, William G., Anderes, Kenna, Ryckman, David M.

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Synthesis and SAR of inhibitors of protein kinase CK2: Novel tricyclic quinoline analogs von Haddach, Mustapha, Pierre, Fabrice, Regan, Collin F., Borsan, Cosmin, Michaux, Jerome, Stefan, Eric, Kerdoncuff, Pauline, Schwaebe, Michael K., Chua, Peter C., Siddiqui-Jain, Adam, Macalino, Diwata, Drygin, Denis, O’Brien, Sean E., Rice, William G., Ryckman, David M.

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Facile and efficient generation of quinolone amides from esters using aluminum chloride von Schwaebe, Michael K., Ryckman, David M., Nagasawa, Johnny Y., Pierre, Fabrice, Vialettes, Anne, Haddach, Mustapha

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Potent, Orally Active Corticotropin-Releasing Factor Receptor-1 Antagonists Containing a Tricyclic Pyrrolopyridine or Pyrazolopyridine Core von Dyck, Brian, Grigoriadis, Dimitri E, Gross, Raymond S, Guo, Zhiqiang, Haddach, Mustapha, Marinkovic, Dragan, McCarthy, James R, Moorjani, Manisha, Regan, Collin F, Saunders, John, Schwaebe, Michael K, Szabo, Tomas, Williams, John P, Zhang, Xiaohu, Bozigian, Haig, Chen, Ta Kung

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Determination of the importance of the stereochemistry of psorospermin in topoisomerase II–induced alkylation of DNA and in vitro and in vivo biological activity von Fellows, Ingrid M, Schwaebe, Michael, Dexheimer, Thomas S, Vankayalapati, Hariprasad, Gleason-Guzman, Mary, Whitten, Jeffrey P, Hurley, Laurence H

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Nickel(0)-catalyzed coupling of vinylzirconiums to α-bromo-α,α-difluoro esters. Convenient generation of a functionalized allyldifluoro moiety von Schwaebe, Michael K, McCarthy, James R, Whitten, Jeffrey P

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Atom Transfer Reactions of TMM Diyls Directed toward the Synthesis of Rudmollin von Carroll, Georgia Law, Allan, Amy Kim, Schwaebe, Michael K, Little, R. Daniel

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Asymmetric Reductive Cyclization. Total Synthesis of (−)-C10-Desmethyl Arteannuin B von Schwaebe, Michael, Little, R. Daniel

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Total synthesis of psorospermin von Schwaebe, Michael K., Moran, Terence J., Whitten, Jeffrey P.

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A novel and efficient synthesis of 3-carboxy-4-oxo-1,8-naphthyridines using magnesium chloride von Chua, Peter C., Nagasawa, Johnny Y., Pierre, Fabrice, Schwaebe, Michael K., Vialettes, Anne, Whitten, Jeffrey P.

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A modified electrochemical approach to diazenes von Schwaebe, Michael K., Little, R.Daniel

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Abstract PR15: Inhibition of RNA Polymerase I as a therapeutic strategy for cancer-specific activation of p53 von Bywater, Megan J., Anderes, Kenna, Huser, Nanni, Proffitt, Chris, Bleisath, Joshua, Haddach, Mustapha, Schwaebe, Michael, Ryckman, David, Rice, William G., Lowe, Scott W., Johnstone, Ricky W., Poortinga, Gretchen, Pearson, Richard B., McArthur, Grant A., Hannan, Ross D., Sanij, Elaine, Hein, Nadine, Peck, Abigail, Cullinane, Carleen, Wall, Meaghan, Cluse, Leonie, Drygin, Denis

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