Ex-527 inhibits Sirtuins by exploiting their unique NAD⁺-dependent deacetylation mechanism von Gertz, Melanie, Fischer, Frank, Nguyen, Giang Thi Tuyet, Lakshminarasimhan, Mahadevan, Schutkowski, Mike, Weyand, Michael, Steegborn, Clemens

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Crystal structure analysis of human Sirt2 and its ADP-ribose complex von Moniot, Sébastien, Schutkowski, Mike, Steegborn, Clemens

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Crystal structures of the mitochondrial deacylase Sirtuin 4 reveal isoform-specific acyl recognition and regulation features von Pannek, Martin, Simic, Zeljko, Fuszard, Matthew, Meleshin, Marat, Rotili, Dante, Mai, Antonello, Schutkowski, Mike, Steegborn, Clemens

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Comparative Structure-Based Virtual Screening Utilizing Optimized AlphaFold Model Identifies Selective HDAC11 Inhibitor von Baselious, Fady, Hilscher, Sebastian, Robaa, Dina, Barinka, Cyril, Schutkowski, Mike, Sippl, Wolfgang

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Characterization of the class IIa histone deacetylases substrate specificity von Kutil, Zsofia, Meleshin, Marat, Baranova, Petra, Havlinova, Barbora, Schutkowski, Mike, Barinka, Cyril

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SIRT5 regulation of ammonia-induced autophagy and mitophagy von Polletta, Lucia, Vernucci, Enza, Carnevale, Ilaria, Arcangeli, Tania, Rotili, Dante, Palmerio, Silvia, Steegborn, Clemens, Nowak, Theresa, Schutkowski, Mike, Pellegrini, Laura, Sansone, Luigi, Villanova, Lidia, Runci, Alessandra, Pucci, Bruna, Morgante, Emanuela, Fini, Massimo, Mai, Antonello, Russo, Matteo A, Tafani, Marco

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Selective Sirt2 inhibition by ligand-induced rearrangement of the active site von Rumpf, Tobias, Schiedel, Matthias, Karaman, Berin, Roessler, Claudia, North, Brian J., Lehotzky, Attila, Oláh, Judit, Ladwein, Kathrin I., Schmidtkunz, Karin, Gajer, Markus, Pannek, Martin, Steegborn, Clemens, Sinclair, David A., Gerhardt, Stefan, Ovádi, Judit, Schutkowski, Mike, Sippl, Wolfgang, Einsle, Oliver, Jung, Manfred

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Sirt5 deacylation activities show differential sensitivities to nicotinamide inhibition von Fischer, Frank, Gertz, Melanie, Suenkel, Benjamin, Lakshminarasimhan, Mahadevan, Schutkowski, Mike, Steegborn, Clemens

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Continuous Fluorescent Sirtuin Activity Assay Based on Fatty Acylated Lysines von Zessin, Matthes, Meleshin, Marat, Hilscher, Sebastian, Schiene-Fischer, Cordelia, Barinka, Cyril, Jung, Manfred, Schutkowski, Mike

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The unraveling of substrate specificity of histone deacetylase 6 domains using acetylome peptide microarrays and peptide libraries von Kutil, Zsofia, Skultetyova, Lubica, Rauh, David, Meleshin, Marat, Snajdr, Ivan, Novakova, Zora, Mikesova, Jana, Pavlicek, Jiri, Hadzima, Martin, Baranova, Petra, Havlinova, Barbora, Majer, Pavel, Schutkowski, Mike, Barinka, Cyril

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Molecular Mechanism of Sirtuin 1 Modulation by the AROS Protein von Weiss, Sandra, Adolph, Ramona S., Schweimer, Kristian, DiFonzo, Andrea, Meleshin, Marat, Schutkowski, Mike, Steegborn, Clemens

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Epigenetic-based differentiation therapy for Acute Myeloid Leukemia von San José-Enériz, Edurne, Gimenez-Camino, Naroa, Rabal, Obdulia, Garate, Leire, Miranda, Estibaliz, Gómez-Echarte, Nahia, García, Fernando, Charalampopoulou, Stella, Sáez, Elena, Vilas-Zornoza, Amaia, San Martín-Uriz, Patxi, Valcárcel, Luis V., Barrena, Naroa, Alignani, Diego, Tamariz-Amador, Luis Esteban, Pérez-Ruiz, Ana, Hilscher, Sebastian, Schutkowski, Mike, Alfonso-Pierola, Ana, Martinez-Calle, Nicolás, Larrayoz, María José, Paiva, Bruno, Calasanz, María José, Muñoz, Javier, Isasa, Marta, Martin-Subero, José Ignacio, Pineda-Lucena, Antonio, Oyarzabal, Julen, Agirre, Xabier, Prósper, Felipe

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Synthesis, Molecular Docking and Biological Characterization of Pyrazine Linked 2-Aminobenzamides as New Class I Selective Histone Deacetylase (HDAC) Inhibitors with Anti-Leukemic... von Ibrahim, Hany S, Abdelsalam, Mohamed, Zeyn, Yanira, Zessin, Matthes, Mustafa, Al-Hassan M, Fischer, Marten A, Zeyen, Patrik, Sun, Ping, Bülbül, Emre F, Vecchio, Anita, Erdmann, Frank, Schmidt, Matthias, Robaa, Dina, Barinka, Cyril, Romier, Christophe, Schutkowski, Mike, Krämer, Oliver H, Sippl, Wolfgang

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A 1-phytase type III effector interferes with plant hormone signaling von Blüher, Doreen, Laha, Debabrata, Thieme, Sabine, Hofer, Alexandre, Eschen-Lippold, Lennart, Masch, Antonia, Balcke, Gerd, Pavlovic, Igor, Nagel, Oliver, Schonsky, Antje, Hinkelmann, Rahel, Wörner, Jakob, Parvin, Nargis, Greiner, Ralf, Weber, Stefan, Tissier, Alain, Schutkowski, Mike, Lee, Justin, Jessen, Henning, Schaaf, Gabriel, Bonas, Ulla

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Application of Ligand- and Structure-Based Prediction Models for the Design of Alkylhydrazide-Based HDAC3 Inhibitors as Novel Anti-Cancer Compounds von Bülbül, Emre F, Robaa, Dina, Sun, Ping, Mahmoudi, Fereshteh, Melesina, Jelena, Zessin, Matthes, Schutkowski, Mike, Sippl, Wolfgang

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Docking, Binding Free Energy Calculations and In Vitro Characterization of Pyrazine Linked 2-Aminobenzamides as Novel Class I Histone Deacetylase (HDAC) Inhibitors von Bülbül, Emre F, Melesina, Jelena, Ibrahim, Hany S, Abdelsalam, Mohamed, Vecchio, Anita, Robaa, Dina, Zessin, Matthes, Schutkowski, Mike, Sippl, Wolfgang

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N4-(2-Amino-4-fluorophenyl)-N1-(3-{2-[2-(3-{[2-(2,6-dioxo-3-piperidyl)-1,3-dioxoisoindolin-4-yl]amino}propoxy)ethoxy]ethoxy}propyl)terephthalamide von Abdelsalam, Mohamed, Zessin, Matthes, Schmidt, Matthias, Schutkowski, Mike, Sippl, Wolfgang

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1,3-Diphenylureido hydroxamate as a promising scaffold for generation of potent antimalarial histone deacetylase inhibitors von Tavares, Maurício T., Krüger, Arne, Yan, Sun L. Rei, Waitman, Karoline B., Gomes, Vinícius M., de Oliveira, Daffiny Sumam, Paz, Franciarli, Hilscher, Sebastian, Schutkowski, Mike, Sippl, Wolfgang, Ruiz, Claudia, Toledo, Mônica F. Z. J., Hassimotto, Neuza M. A., Machado-Neto, João A., Poso, Antti, Cameron, Michael D., Bannister, Thomas D., Palmisano, Giuseppe, Wrenger, Carsten, Kronenberger, Thales, Parise-Filho, Roberto

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A continuous sirtuin activity assay without any coupling to enzymatic or chemical reactions von Schuster, Sabine, Roessler, Claudia, Meleshin, Marat, Zimmermann, Philipp, Simic, Zeljko, Kambach, Christian, Schiene-Fischer, Cordelia, Steegborn, Clemens, Hottiger, Michael O., Schutkowski, Mike

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The SH2 Domain Interaction Landscape von Tinti, Michele, Kiemer, Lars, Costa, Stefano, Miller, Martin L., Sacco, Francesca, Olsen, Jesper V., Carducci, Martina, Paoluzi, Serena, Langone, Francesca, Workman, Christopher T., Blom, Nikolaj, Machida, Kazuya, Thompson, Christopher M., Schutkowski, Mike, Brunak, Søren, Mann, Matthias, Mayer, Bruce J., Castagnoli, Luisa, Cesareni, Gianni

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