In vivo activity and low toxicity of the second-generation antimicrobial peptide DGL13K von Gorr, Sven-Ulrik, Flory, Craig M, Schumacher, Robert J

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Phosphonooxymethyl Prodrug of Triptolide: Synthesis, Physicochemical Characterization, and Efficacy in Human Colon Adenocarcinoma and Ovarian Cancer Xenografts von Patil, Satish, Lis, Lev G, Schumacher, Robert J, Norris, Beverly J, Morgan, Monique L, Cuellar, Rebecca A. D, Blazar, Bruce R, Suryanarayanan, Raj, Gurvich, Vadim J, Georg, Gunda I

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Clinical and microbiologic investigation of an expedited peri-implantitis dog model: an animal study von Seong, Wook Jin, Kotsakis, Georgios, Huh, Jong-Ki, Jeong, Soo Cheol, Nam, Ki Young, Kim, Jong Ryul, Heo, Young Cheul, Kim, Hyeon-Cheol, Zhang, Lei, Evans, Michael D, Conrad, Heather, Schumacher, Robert J

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A Preclinical Safety Study of Thyroid Hormone Instilled into the Lungs of Healthy Rats-an Investigational Therapy for ARDS von Flory, Craig M., Norris, Beverly J., Larson, Nicole A., Coicou, Lia G., Koniar, Brenda L., Mysz, Margaret A., Rich, Timothy P., Ingbar, David H., Schumacher, Robert J.

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Implantable and Degradable Thermoplastic Elastomer von Siehr, Allison, Flory, Craig, Callaway, Trenton, Schumacher, Robert J, Siegel, Ronald A, Shen, Wei

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Chaperonin-Mediated Folding in the Eukaryotic Cytosol Proceeds through Rounds of Release of Native and Nonnative Forms von Farr, George W, Scharl, Elizabeth C, Schumacher, Robert J, Sondek, Stacey, Horwich, Arthur L

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Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria von Guo, Zhijun, Sevrioukova, Irina F., Denisov, Ilia G., Zhang, Xia, Chiu, Ting-Lan, Thomas, Dafydd G., Hanse, Eric A., Cuellar, Rebecca A.D., Grinkova, Yelena V., Langenfeld, Vanessa Wankhede, Swedien, Daniel S., Stamschror, Justin D., Alvarez, Juan, Luna, Fernando, Galván, Adela, Bae, Young Kyung, Wulfkuhle, Julia D., Gallagher, Rosa I., Petricoin, Emanuel F., Norris, Beverly, Flory, Craig M., Schumacher, Robert J., O'Sullivan, M. Gerard, Cao, Qing, Chu, Haitao, Lipscomb, John D., Atkins, William M., Gupta, Kalpna, Kelekar, Ameeta, Blair, Ian A., Capdevila, Jorge H., Falck, John R., Sligar, Stephen G., Poulos, Thomas L., Georg, Gunda I., Ambrose, Elizabeth, Potter, David A.

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Cooperative Action of Hsp70, Hsp90, and DnaJ Proteins in Protein Renaturation von Schumacher, Robert J, Hansen, William J, Freeman, Brian C, Alnemri, Emad, Litwack, Gerald, Toft, David O

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Novel N-1 substituted fluoroquinolones inhibit human topoisomerase I activity and exhibit anti-proliferative activity von Oppegard, Lisa M., Delgado, Justine L., Kulkarni, Chaitanya A., Towle, Tyrell R., Hart, Delaney E., Williams, Bridget P., Lentz, Sarah R. C., Norris, Beverly J., Flory, Craig M., Schumacher, Robert J., Murry, Daryl J., Kerns, Robert J., Hiasa, Hiroshi

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Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria von Guo, Zhijun, Sevrioukova, Irina F., Denisov, Ilia G., Zhang, Xia, Chiu, Ting-Lan, Thomas, Dafydd G., Hanse, Eric A., Cuellar, Rebecca A.D., Grinkova, Yelena V., Langenfeld, Vanessa Wankhede, Swedien, Daniel S., Stamschror, Justin D., Alvarez, Juan, Luna, Fernando, Galván, Adela, Bae, Young Kyung, Wulfkuhle, Julia D., Gallagher, Rosa I., Petricoin, Emanuel F., Norris, Beverly, Flory, Craig M., Schumacher, Robert J., O’Sullivan, M. Gerard, Cao, Qing, Chu, Haitao, Lipscomb, John D., Atkins, William M., Gupta, Kalpna, Kelekar, Ameeta, Blair, Ian A., Capdevila, Jorge H., Falck, John R., Sligar, Stephen G., Poulos, Thomas L., Georg, Gunda I., Ambrose, Elizabeth, Potter, David A.

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Hop Modulates hsp70/hsp90 Interactions in Protein Folding von Johnson, B D, Schumacher, R J, Ross, E D, Toft, D O

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Maturation of Human Cyclin E Requires the Function of Eukaryotic Chaperonin CCT von Won, Kwang-Ai, Schumacher, Robert J., Farr, George W., Horwich, Arthur L., Reed, Steven I.

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Steady-State Pharmacokinetics Following Application of a Novel Transdermal Estradiol Spray in Healthy Postmenopausal Women von Morton, Terri L., Gattermeir, David J., Petersen, Craig A., Day, Wesley W., Schumacher, Robert J.

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The Effects of Intravaginal Clindamycin and Metronidazole Therapy on Vaginal Mobiluncus Morphotypes in Patients With Bacterial Vaginosis von NYIRJESY, PAUL, MCINTOSH, MATTHEW J., STEINMETZ, JANA I., SCHUMACHER, ROBERT J., JOFFRION, JAMES L.

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The effects of intravaginal clindamycin and metronidazole therapy on vaginal lactobacilli in patients with bacterial vaginosis von Nyirjesy, Paul, McIntosh, Matthew J., Gattermeir, David J., Schumacher, Robert J., Steinmetz, Jana I., Joffrion, James L.

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Abstract LB078: Hexyl-(cuban-1-yl-methyl)-biguanide (HCB) inhibits hormone therapy resistant breast cancer cells, in part by Inhibiting CYP3A4 arachidonic acid epoxygenase activity von Guo, Zhijun, Lei, Jianxun, Hong, Kwon Ho, Norris, Beverly, Flory, Craig M., Jayaraman, Swaathi, McDermott, Connor, Ambrose, Elizabeth, Sevrioukova, Irina, Poulos, Tom, Denisov, Ilia, Sliga, Stephen, Schumacher, Robert J., Georg, Gunda I., Hawse, John R., Goetz, Matthew P., Potter, David A.

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An open-label, two-period, crossover study of the systemic bioavailability in healthy women of clindamycin phosphate from two vaginal cream formulations von Saul Levinson, R., Mitan, Steven J., Steinmetz, Jana I., Gattermeir, David J., Schumacher, Robert J., Joffrion, James L.

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Abstract 5925: A novel oncolytic adenovirus for radioiodine therapy and imaging von Koodie, Lisa, Kawakami, Eriko Iguchi, Jacobsen, Kari, Cayci, Zuzan, Taylor, Andrew, Greeno, Edward W., Schumacher, Robert J., Morris, John C., Fernandez-Zapico, Martin E., Davydova, Julia

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Abstract LB102: Hexyl-(cuban-1-yl-methyl)-biguanide (HCB) suppresses N-glycosylation of immune checkpoint proteins B7-H3 and B7-H4, reverses tumor hypoxia, decreases intratumoral r... von Guo, Zhijun, Lei, Jianxun, Venkatesh, Hrishi, Owen, David, Bass, Adam, Cannon, Christine, McCarra, Joshua, Koniar, Brenda, Flory, Craig, Norris, Beverly, Schumacher, Robert J., Jayaraman, Swaathi, Hawse, John, Antonarakis, Emmanuel S., Petricoin, Emanuel F., Wulfkuhle, Julia, Cardiff, Robert D., Ambrose, Elizabeth A., Georg, Gunda I., Schwertfeger, Kaylee L., Farrar, Michael A., Croix, Brad St, Goetz, Matthew P., Potter, David A.

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Abstract 3568: CYP3A4 epoxygenase activity mediates ER+ mammary tumor growth and angiogenesis, in part, through EET biosynthesis and is inhibited by biguanides von Guo, Zhijun, Sevrioukova, Irina F., Hanse, Eric, Denisov, Ilia, Zhang, Xia, Chiu, Ting-Lan, Swedien, Daniel, Stamschror, Justin, Alvarez, Juan, Ortiz, William Marerro, Morgan, Monique, Maher, Michael, Chavez, Kathryn J., Thomas, Dafydd, Bae, Young Kyung, Henriksen, Jonathan, Norris, Beverly, Schumacher, Robert J., Wang, Henry, Bliss, Robin, Chu, Haitao, Cuellar, Rebecca, Poulos, Thomas L., Sligar, Stephen G., Atkins, William, Schmechel, Stephen, Capdevila, Jorge, Falck, John, Blair, Ian, Jones, Jeffrey P., Georg, Gunda, Gupta, Kalpna, Kelekar, Ameeta, Amin, Elizabeth, Potter, David A.

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