AGC protein kinases: From structural mechanism of regulation to allosteric drug development for the treatment of human diseases von Arencibia, José M., Pastor-Flores, Daniel, Bauer, Angelika F., Schulze, Jörg O., Biondi, Ricardo M.

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Bidirectional Allosteric Communication between the ATP-Binding Site and the Regulatory PIF Pocket in PDK1 Protein Kinase von Schulze, Jörg O., Saladino, Giorgio, Busschots, Katrien, Neimanis, Sonja, Süß, Evelyn, Odadzic, Dalibor, Zeuzem, Stefan, Hindie, Valerie, Herbrand, Amanda K., Lisa, María-Natalia, Alzari, Pedro M., Gervasio, Francesco L., Biondi, Ricardo M.

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Crystal Structure of a Non-discriminating Glutamyl-tRNA Synthetase von Schulze, Jörg O., Masoumi, Ava, Nickel, Daniel, Jahn, Martina, Jahn, Dieter, Schubert, Wolf-Dieter, Heinz, Dirk W.

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2‑(3-Oxo-1,3-diphenylpropyl)malonic Acids as Potent Allosteric Ligands of the PIF Pocket of Phosphoinositide-Dependent Kinase-1: Development and Prodrug Concept von Wilhelm, Adriana, Lopez-Garcia, Laura A, Busschots, Katrien, Fröhner, Wolfgang, Maurer, Frauke, Boettcher, Stefan, Zhang, Hua, Schulze, Jörg O, Biondi, Ricardo M, Engel, Matthias

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AGC kinases, mechanisms of regulation ‎and innovative drug development von Leroux, Alejandro E, Schulze, Jörg, Biondi, Ricardo M

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Crystal structure of 5-aminolevulinate synthase, the first enzyme of heme biosynthesis, and its link to XLSA in humans von Astner, Isabel, Schulze, Jörg O, van den Heuvel, Joop, Jahn, Dieter, Schubert, Wolf-Dieter, Heinz, Dirk W

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An Allosteric Inhibitor Scaffold Targeting the PIF-Pocket of Atypical Protein Kinase C Isoforms von Arencibia, Jose M, Fröhner, Wolfgang, Krupa, Magdalena, Pastor-Flores, Daniel, Merker, Piotr, Oellerich, Thomas, Neimanis, Sonja, Schmithals, Christian, Köberle, Verena, Süß, Evelyn, Zeuzem, Stefan, Stark, Holger, Piiper, Albrecht, Odadzic, Dalibor, Schulze, Jörg O, Biondi, Ricardo M

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Molecular insights into the regulatory landscape of PKC-related kinase-2 (PRK2/PKN2) using targeted small compounds von Gross, Lissy Z.F., Winkel, Angelika F., Galceran, Facundo, Schulze, Jörg O., Fröhner, Wolfgang, Cämmerer, Simon, Zeuzem, Stefan, Engel, Matthias, Leroux, Alejandro E., Biondi, Ricardo M.

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Substrate-Selective Inhibition of Protein Kinase PDK1 by Small Compounds that Bind to the PIF-Pocket Allosteric Docking Site von Busschots, Katrien, Lopez-Garcia, Laura A., Lammi, Carmen, Stroba, Adriana, Zeuzem, Stefan, Piiper, Albrecht, Alzari, Pedro M., Neimanis, Sonja, Arencibia, Jose M., Engel, Matthias, Schulze, Jörg O., Biondi, Ricardo M.

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Camptothecin and its analog SN-38, the active metabolite of irinotecan, inhibit binding of the transcriptional regulator and oncoprotein FUBP1 to its DNA target sequence FUSE von Khageh Hosseini, Sabrina, Kolterer, Stefanie, Steiner, Marlene, von Manstein, Viktoria, Gerlach, Katharina, Trojan, Jörg, Waidmann, Oliver, Zeuzem, Stefan, Schulze, Jörg O., Hahn, Steffen, Steinhilber, Dieter, Gatterdam, Volker, Tampé, Robert, Biondi, Ricardo M., Proschak, Ewgenij, Zörnig, Martin

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Modulation of the substrate specificity of the kinase PDK1 by distinct conformations of the full-length protein von Sacerdoti, Mariana, Gross, Lissy Z F, Riley, Andrew M, Zehnder, Karin, Ghode, Abhijeet, Klinke, Sebastián, Anand, Ganesh Srinivasan, Paris, Kristina, Winkel, Angelika, Herbrand, Amanda K, Godage, H Yasmin, Cozier, Gyles E, Süß, Evelyn, Schulze, Jörg O, Pastor-Flores, Daniel, Bollini, Mariela, Cappellari, María Victoria, Svergun, Dmitri, Gräwert, Melissa A, Aramendia, Pedro F, Leroux, Alejandro E, Potter, Barry V L, Camacho, Carlos J, Biondi, Ricardo M

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Discovery of a Potent Allosteric Kinase Modulator by Combining Computational and Synthetic Methods von Kroon, Edwin, Schulze, Jörg O., Süß, Evelyn, Camacho, Carlos J., Biondi, Ricardo M., Dömling, Alexander

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Structural and functional characterization of human Iba proteins von Schulze, Jörg O, Quedenau, Claudia, Roske, Yvette, Adam, Thomas, Schüler, Herwig, Behlke, Joachim, Turnbull, Andrew P, Sievert, Volker, Scheich, Christoph, Mueller, Uwe, Heinemann, Udo, Büssow, Konrad

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Discovery of a Potent Allosteric Kinase Modulator by Combining Computational and Synthetic Methods von Kroon, Edwin, Schulze, Jörg O., Süß, Evelyn, Camacho, Carlos J., Biondi, Ricardo M., Dömling, Alexander

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Lipid regulators of Pkh2 in Candida albicans, the protein kinase ortholog of mammalian PDK1 von Pastor-Flores, Daniel, Schulze, Jörg O., Bahí, Anna, Süß, Evelyn, Casamayor, Antonio, Biondi, Ricardo M.

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PIF-Pocket as a Target for C. albicans Pkh Selective Inhibitors von Pastor-Flores, Daniel, Schulze, Jörg O, Bahí, Anna, Giacometti, Romina, Ferrer-Dalmau, Jofre, Passeron, Susana, Engel, Matthias, Süß, Evelyn, Casamayor, Antonio, Biondi, Ricardo M

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Modulation of the substrate specificity of the kinase PDK1 by distinct conformations of the full-length protein von Sacerdoti, Mariana, Gross, Lissy, Riley, Andrew M., Zehnder, Karin, Ghode, Abhijeet, Klinke, Sebastian, Srinivasan Anand, Ganesh, Paris, Kristina, Winkel, Angelika, Herbrand, Amanda K., Godage, H. Yasmin, Cozier, Gyles, Sub, Evelyn, Schulze, Jorg O., Pastor-Flores, Daniel, Bollini, Mariela, Cappellari, Maria Victoria, Svergun, Dmitri, Grawert, Melissa A., Aramendia, Pedro F., Leroux, Alejandro E., Potter, Barry, Camacho, Carlos J., Biondi, Ricardo M.

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Evolutionary Relationship between Initial Enzymes of Tetrapyrrole Biosynthesis von Schulze, Jörg O., Schubert, Wolf-Dieter, Moser, Jürgen, Jahn, Dieter, Heinz, Dirk W.

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Allosteric Regulation of Protein Kinase PKCζ by the N-Terminal C1 Domain and Small Compounds to the PIF-Pocket von Lopez-Garcia, Laura A., Schulze, Jörg O., Fröhner, Wolfgang, Zhang, Hua, Süß, Evelyn, Weber, Nadja, Navratil, Jeanette, Amon, Sabine, Hindie, Valerie, Zeuzem, Stefan, Jørgensen, Thomas J.D., Alzari, Pedro M., Neimanis, Sonja, Engel, Matthias, Biondi, Ricardo M.

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Molecular Mechanism of Regulation of the Atypical Protein Kinase C by N-terminal Domains and an Allosteric Small Compound von Zhang, Hua, Neimanis, Sonja, Lopez-Garcia, Laura A., Arencibia, José M., Amon, Sabine, Stroba, Adriana, Zeuzem, Stefan, Proschak, Ewgen, Stark, Holger, Bauer, Angelika F., Busschots, Katrien, Jørgensen, Thomas J.D., Engel, Matthias, Schulze, Jörg O., Biondi, Ricardo M.

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