Identification of Atuveciclib (BAY 1143572), the First Highly Selective, Clinical PTEFb/CDK9 Inhibitor for the Treatment of Cancer von Lücking, Ulrich, Scholz, Arne, Lienau, Philip, Siemeister, Gerhard, Kosemund, Dirk, Bohlmann, Rolf, Briem, Hans, Terebesi, Ildiko, Meyer, Kirstin, Prelle, Katja, Denner, Karsten, Bömer, Ulf, Schäfer, Martina, Eis, Knut, Valencia, Ray, Ince, Stuart, von Nussbaum, Franz, Mumberg, Dominik, Ziegelbauer, Karl, Klebl, Bert, Choidas, Axel, Nussbaumer, Peter, Baumann, Matthias, Schultz‐Fademrecht, Carsten, Rühter, Gerd, Eickhoff, Jan, Brands, Michael

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Discovery of a Novel Inhibitor of the Hedgehog Signaling Pathway through Cell‐based Compound Discovery and Target Prediction von Kremer, Lea, Schultz‐Fademrecht, Carsten, Baumann, Matthias, Habenberger, Peter, Choidas, Axel, Klebl, Bert, Kordes, Susanne, Schöler, Hans R., Sterneckert, Jared, Ziegler, Slava, Schneider, Gisbert, Waldmann, Herbert

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A PDE6δ‐KRas Inhibitor Chemotype with up to Seven H‐Bonds and Picomolar Affinity that Prevents Efficient Inhibitor Release by Arl2 von Martín‐Gago, Pablo, Fansa, Eyad K., Klein, Christian H., Murarka, Sandip, Janning, Petra, Schürmann, Marc, Metz  , Malte, Ismail, Shehab, Schultz‐Fademrecht, Carsten, Baumann, Matthias, Bastiaens, Philippe I. H., Wittinghofer, Alfred, Waldmann, Herbert

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Identification of pyrazolopyridazinones as PDEδ inhibitors von Papke, Björn, Murarka, Sandip, Vogel, Holger A, Martín-Gago, Pablo, Kovacevic, Marija, Truxius, Dina C, Fansa, Eyad K, Ismail, Shehab, Zimmermann, Gunther, Heinelt, Kaatje, Schultz-Fademrecht, Carsten, Al Saabi, Alaa, Baumann, Matthias, Nussbaumer, Peter, Wittinghofer, Alfred, Waldmann, Herbert, Bastiaens, Philippe I.H.

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The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells von Paolino, Magdalena, Choidas, Axel, Wallner, Stephanie, Pranjic, Blanka, Uribesalgo, Iris, Loeser, Stefanie, Jamieson, Amanda M., Langdon, Wallace Y., Ikeda, Fumiyo, Fededa, Juan Pablo, Cronin, Shane J., Nitsch, Roberto, Schultz-Fademrecht, Carsten, Eickhoff, Jan, Menninger, Sascha, Unger, Anke, Torka, Robert, Gruber, Thomas, Hinterleitner, Reinhard, Baier, Gottfried, Wolf, Dominik, Ullrich, Axel, Klebl, Bert M., Penninger, Josef M.

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Insight into the Inhibition of Drug-Resistant Mutants of the Receptor Tyrosine Kinase EGFR von Engel, Julian, Becker, Christian, Lategahn, Jonas, Keul, Marina, Ketzer, Julia, Mühlenberg, Thomas, Kollipara, Laxmikanth, Schultz-Fademrecht, Carsten, Zahedi, René P., Bauer, Sebastian, Rauh, Daniel

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Indazole-Based Covalent Inhibitors To Target Drug-Resistant Epidermal Growth Factor Receptor von Tomassi, Stefano, Lategahn, Jonas, Engel, Julian, Keul, Marina, Tumbrink, Hannah L, Ketzer, Julia, Mühlenberg, Thomas, Baumann, Matthias, Schultz-Fademrecht, Carsten, Bauer, Sebastian, Rauh, Daniel

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Discovery of 2-{4-[(3S)-Piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): A Novel Oral Poly(ADP-ribose)polymerase (PARP) Inhibitor Efficacious in BRCA-1 and -2 Mutant Tum... von Jones, Philip, Altamura, Sergio, Boueres, Julia, Ferrigno, Federica, Fonsi, Massimiliano, Giomini, Claudia, Lamartina, Stefania, Monteagudo, Edith, Ontoria, Jesus M, Orsale, Maria Vittoria, Palumbi, Maria Cecilia, Pesci, Silvia, Roscilli, Giuseppe, Scarpelli, Rita, Schultz-Fademrecht, Carsten, Toniatti, Carlo, Rowley, Michael

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Cellular model system to dissect the isoform-selectivity of Akt inhibitors von Quambusch, Lena, Depta, Laura, Landel, Ina, Lubeck, Melissa, Kirschner, Tonia, Nabert, Jonas, Uhlenbrock, Niklas, Weisner, Jörn, Kostka, Michael, Levy, Laura M., Schultz-Fademrecht, Carsten, Glanemann, Franziska, Althoff, Kristina, Müller, Matthias P., Siveke, Jens T., Rauh, Daniel

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Development of Pyridazinone Chemotypes Targeting the PDEδ Prenyl Binding Site von Murarka, Sandip, Martín‐Gago, Pablo, Schultz‐Fademrecht, Carsten, Al Saabi, Alaa, Baumann, Matthias, Fansa, Eyad K., Ismail, Shehab, Nussbaumer, Peter, Wittinghofer, Alfred, Waldmann, Herbert

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New insights into the intracellular distribution pattern of cationic amphiphilic drugs von Vater, Magdalena, Möckl, Leonhard, Gormanns, Vanessa, Schultz Fademrecht, Carsten, Mallmann, Anna M., Ziegart-Sadowska, Karolina, Zaba, Monika, Frevert, Marie L., Bräuchle, Christoph, Holsboer, Florian, Rein, Theo, Schmidt, Ulrike, Kirmeier, Thomas

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Discovery of a Novel Inhibitor of the Hedgehog Signaling Pathway through Cell‐based Compound Discovery and Target Prediction von Kremer, Lea, Schultz‐Fademrecht, Carsten, Baumann, Matthias, Habenberger, Peter, Choidas, Axel, Klebl, Bert, Kordes, Susanne, Schöler, Hans R., Sterneckert, Jared, Ziegler, Slava, Schneider, Gisbert, Waldmann, Herbert

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Synthesis of Enantiomerically Enriched Allenes by (−)-Sparteine-Mediated Lithiation of Alkynyl Carbamates von Schultz-Fademrecht, Carsten, Wibbeling, Birgit, Fröhlich, Roland, Hoppe, Dieter

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A PDE6δ‐KRas Inhibitor Chemotype with up to Seven H‐Bonds and Picomolar Affinity that Prevents Efficient Inhibitor Release by Arl2 von Martín‐Gago, Pablo, Fansa, Eyad K., Klein, Christian H., Murarka, Sandip, Janning, Petra, Schürmann, Marc, Metz  , Malte, Ismail, Shehab, Schultz‐Fademrecht, Carsten, Baumann, Matthias, Bastiaens, Philippe I. H., Wittinghofer, Alfred, Waldmann, Herbert

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Synthesis of Enantioenriched 5-Alkylidene-2-cyclopentenones from Chiral Allenyl Carbamates: Generation of a Chiral Lithium Allenolate and Allylic Activation for a Conrotatory 4π-El... von Schultz-Fademrecht, Carsten, Tius, Marc A., Grimme, Stefan, Wibbeling, B., Hoppe, Dieter

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Covalent Protein Labeling at Glutamic Acids von Martín-Gago, Pablo, Fansa, Eyad K., Winzker, Michael, Murarka, Sandip, Janning, Petra, Schultz-Fademrecht, Carsten, Baumann, Matthias, Wittinghofer, Alfred, Waldmann, Herbert

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Preclinical Efficacy of Covalent-Allosteric AKT Inhibitor Borussertib in Combination with Trametinib in KRAS -Mutant Pancreatic and Colorectal Cancer von Weisner, Jörn, Landel, Ina, Reintjes, Christoph, Uhlenbrock, Niklas, Trajkovic-Arsic, Marija, Dienstbier, Niklas, Hardick, Julia, Ladigan, Swetlana, Lindemann, Marius, Smith, Steven, Quambusch, Lena, Scheinpflug, Rebekka, Depta, Laura, Gontla, Rajesh, Unger, Anke, Müller, Heiko, Baumann, Matthias, Schultz-Fademrecht, Carsten, Günther, Georgia, Maghnouj, Abdelouahid, Müller, Matthias P, Pohl, Michael, Teschendorf, Christian, Wolters, Heiner, Viebahn, Richard, Tannapfel, Andrea, Uhl, Waldemar, Hengstler, Jan G, Hahn, Stephan A, Siveke, Jens T, Rauh, Daniel

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Structure Guided Design and Kinetic Analysis of Highly Potent Benzimidazole Inhibitors Targeting the PDEδ Prenyl Binding Site von Zimmermann, Gunther, Schultz-Fademrecht, Carsten, Küchler, Philipp, Murarka, Sandip, Ismail, Shehab, Triola, Gemma, Nussbaumer, Peter, Wittinghofer, Alfred, Waldmann, Herbert

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Targeting Drug Resistance in EGFR with Covalent Inhibitors: A Structure-Based Design Approach von Engel, Julian, Richters, André, Getlik, Matthäus, Tomassi, Stefano, Keul, Marina, Termathe, Martin, Lategahn, Jonas, Becker, Christian, Mayer-Wrangowski, Svenja, Grütter, Christian, Uhlenbrock, Niklas, Krüll, Jasmin, Schaumann, Niklas, Eppmann, Simone, Kibies, Patrick, Hoffgaard, Franziska, Heil, Jochen, Menninger, Sascha, Ortiz-Cuaran, Sandra, Heuckmann, Johannes M., Tinnefeld, Verena, Zahedi, René P., Sos, Martin L., Schultz-Fademrecht, Carsten, Thomas, Roman K., Kast, Stefan M., Rauh, Daniel

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Insight into Targeting Exon20 Insertion Mutations of the Epidermal Growth Factor Receptor with Wild Type-Sparing Inhibitors von Lategahn, Jonas, Tumbrink, Hannah L., Schultz-Fademrecht, Carsten, Heimsoeth, Alena, Werr, Lisa, Niggenaber, Janina, Keul, Marina, Parmaksiz, Fatma, Baumann, Matthias, Menninger, Sascha, Zent, Eldar, Landel, Ina, Weisner, Jörn, Jeyakumar, Kirujan, Heyden, Leonie, Russ, Nicole, Müller, Fabienne, Lorenz, Carina, Brägelmann, Johannes, Spille, Inga, Grabe, Tobias, Müller, Matthias P., Heuckmann, Johannes M., Klebl, Bert M., Nussbaumer, Peter, Sos, Martin L., Rauh, Daniel

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