Antigen-specific human antibodies from mice comprising four distinct genetic modifications von Lonberg, Nils, Taylor, Lisa D, Harding, Fiona A, Trounstine, Mary, Higgins, Kay M, Schramm, Stephen R, Kuo, Chiung-Chi, Mashayekh, Roshanak, Wymore, Kathryn, McCabe, James G, Munoz-O'Regan, Donna, O'Donnell, Susan L, Lapachet, Elizabeth S. G, Bengoechea, Tasha, Fishwild, Dianne M, Carmack, Condie E, Kay, Robert M, Huszar, Dennis

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High-avidity human IgGκ monoclonal antibodies from a novel strain of minilocus transgenic mice von Fishwild, Dianne M, O'Donnell, Susan L, Bengoechea, Tasha, Hudson, Debra V, Harding, Fiona, Bernhard, Susan L, Jones, Debbie, Kay, Robert M, Higgins, Kay M, Schramm, Stephen R, Lonberg, Nils

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A transgenic mouse that expresses a diversity of human sequence heavy and light chain immunoglobulins von Taylor, Lisa D., Carmack, Condie E., Schramm, Stephen R., Mashayekh, Roshanak, Higgins, Kay M., Kuo, Chiung-Chi, Woodhouse, Clive, Kay, Robert M., Lonberg, Nils

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Human immunoglobulin transgenes undergo rearrangement, somatic mutation and class switching in mice that lack endogenous IgM von Taylor, Lisa D., Carmack, Condie E., Huszar, Dennis, Higgins, Kay M., Mashayekh, Roshanak, Sequar, Getachew, Schramm, Stephen R., Kuo, Chlung-Chi, O'Donnell, Susan L., Kay, Robert M., Woodhouse, Cllve S., Lonberg, Nils

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Rational design of an animal model for alzheimer's disease: introduction of multiple human genomic transgenes to reproduce AD pathology in a rodent von Loring, Jeanne F., Paszty, Chris, Rose, Avidan, McIntosh, Tracy K., Murai, Hisayuki, Pierce, Jean E.S., Schramm, Stephen R., Wymore, Kathryn, Lee, Virginia M.-Y., Trojanowski, John Q., Peterson, Kenneth R.

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Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth von Huang, Jinghe, Kang, Byong H., Ishida, Elise, Zhou, Tongqing, Griesman, Trevor, Sheng, Zizhang, Wu, Fan, Doria-Rose, Nicole A., Zhang, Baoshan, McKee, Krisha, O’Dell, Sijy, Chuang, Gwo-Yu, Druz, Aliaksandr, Georgiev, Ivelin S., Schramm, Chaim A., Zheng, Anqi, Joyce, M. Gordon, Asokan, Mangaiarkarasi, Ransier, Amy, Darko, Sam, Migueles, Stephen A., Bailer, Robert T., Louder, Mark K., Alam, S. Munir, Parks, Robert, Kelsoe, Garnett, Von Holle, Tarra, Haynes, Barton F., Douek, Daniel C., Hirsch, Vanessa, Seaman, Michael S., Shapiro, Lawrence, Mascola, John R., Kwong, Peter D., Connors, Mark

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Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies von Doria-Rose, Nicole A., Schramm, Chaim A., Gorman, Jason, Moore, Penny L., Bhiman, Jinal N., DeKosky, Brandon J., Ernandes, Michael J., Georgiev, Ivelin S., Kim, Helen J., Pancera, Marie, Staupe, Ryan P., Altae-Tran, Han R., Bailer, Robert T., Crooks, Ema T., Cupo, Albert, Druz, Aliaksandr, Garrett, Nigel J., Hoi, Kam H., Kong, Rui, Louder, Mark K., Longo, Nancy S., McKee, Krisha, Nonyane, Molati, O’Dell, Sijy, Roark, Ryan S., Rudicell, Rebecca S., Schmidt, Stephen D., Sheward, Daniel J., Soto, Cinque, Wibmer, Constantinos Kurt, Yang, Yongping, Zhang, Zhenhai, Mullikin, James C., Binley, James M., Sanders, Rogier W., Wilson, Ian A., Moore, John P., Ward, Andrew B., Georgiou, George, Williamson, Carolyn, Abdool Karim, Salim S., Morris, Lynn, Kwong, Peter D., Shapiro, Lawrence, Mascola, John R.

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New Member of the V1V2-Directed CAP256-VRC26 Lineage That Shows Increased Breadth and Exceptional Potency von Doria-Rose, Nicole A, Bhiman, Jinal N, Roark, Ryan S, Schramm, Chaim A, Gorman, Jason, Chuang, Gwo-Yu, Pancera, Marie, Cale, Evan M, Ernandes, Michael J, Louder, Mark K, Asokan, Mangaiarkarasi, Bailer, Robert T, Druz, Aliaksandr, Fraschilla, Isabella R, Garrett, Nigel J, Jarosinski, Marissa, Lynch, Rebecca M, McKee, Krisha, O'Dell, Sijy, Pegu, Amarendra, Schmidt, Stephen D, Staupe, Ryan P, Sutton, Matthew S, Wang, Keyun, Wibmer, Constantinos Kurt, Haynes, Barton F, Abdool-Karim, Salim, Shapiro, Lawrence, Kwong, Peter D, Moore, Penny L, Morris, Lynn, Mascola, John R

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Protection against SARS-CoV-2 Beta variant in mRNA-1273 vaccine-boosted nonhuman primates von Corbett, Kizzmekia S., Gagne, Matthew, Wagner, Danielle A., O' Connell, Sarah, Narpala, Sandeep R., Flebbe, Dillon R., Andrew, Shayne F., Davis, Rachel L., Flynn, Barbara, Johnston, Timothy S., Stringham, Christopher D., Lai, Lilin, Valentin, Daniel, Van Ry, Alex, Flinchbaugh, Zackery, Werner, Anne P., Moliva, Juan, Sriparna, Manjari, O'Dell, Sijy, Schmidt, Stephen D., Tucker, Courtney, Choi, Angela, Koch, Matthew, Bock, Kevin W., Minai, Mahnaz, Nagata, Bianca M., Alvarado, Gabriela S., Henry, Amy R., Laboune, Farida, Schramm, Chaim A., Zhang, Yi, Yang, Eun Sung, Wang, Lingshu, Choe, Misook, Boyoglu-Barnum, Seyhan, Wei, Shi, Lamb, Evan, Nurmukhambetova, Saule T., Provost, Samantha J., Donaldson, Mitzi M., Marquez, Josue, Todd, John-Paul M., Cook, Anthony, Dodson, Alan, Pekosz, Andrew, Boritz, Eli, Ploquin, Aurelie, Doria-Rose, Nicole, Pessaint, Laurent, Andersen, Hanne, Foulds, Kathryn E., Misasi, John, Wu, Kai, Carfi, Andrea, Nason, Martha C., Mascola, John, Moore, Ian N., Edwards, Darin K., Lewis, Mark G., Suthar, Mehul S., Roederer, Mario, McDermott, Adrian, Douek, Daniel C., Sullivan, Nancy J., Graham, Barney S., Seder, Robert A.

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Ultrapotent antibodies against diverse and highly transmissible SARS-CoV-2 variants von Wang, Lingshu, Zhou, Tongqing, Zhang, Yi, Yang, Eun Sung, Schramm, Chaim A., Shi, Wei, Pegu, Amarendra, Oloniniyi, Olamide K., Henry, Amy R., Darko, Samuel, Narpala, Sandeep R., Hatcher, Christian, Martinez, David R., Tsybovsky, Yaroslav, Phung, Emily, Abiona, Olubukola M., Antia, Avan, Cale, Evan M., Chang, Lauren A., Choe, Misook, Corbett, Kizzmekia S., Davis, Rachel L., DiPiazza, Anthony T., Gordon, Ingelise J., Helmold-Hait, Sabrina, Hermanus, Tandile, Kgagudi, Prudence, Laboune, Farida, Leung, Kwanyee, Liu, Tracy, Mason, Rosemarie D., Nazzari, Alexandra F., Novik, Laura, O'Connell, Sarah, O'Dell, Sijy, Olia, Adam S., Schmidt, Stephen D., Stephens, Tyler, Stringham, Christopher D., Talana, Chloe Adrienna, Teng, I-Ting, Wagner, Danielle A., Widge, Alicia T., Zhang, Baoshan, Roederer, Mario, Ledgerwood, Julie E., Ruckwardt, Tracy J., Gaudinski, Martin R., Moore, Penny L., Doria-Rose, Nicole A., Baric, Ralph S., Graham, Barney S., McDermott, Adrian B., Douek, Daniel C., Kwong, Peter D., Mascola, John R., Sullivan, Nancy J., Misasi, John

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Primary exposure to SARS-CoV-2 variants elicits convergent epitope specificities, immunoglobulin V gene usage and public B cell clones von Lima, Noemia S., Musayev, Maryam, Johnston, Timothy S., Wagner, Danielle A., Henry, Amy R., Wang, Lingshu, Yang, Eun Sung, Zhang, Yi, Birungi, Kevina, Black, Walker P., O’Dell, Sijy, Schmidt, Stephen D., Moon, Damee, Lorang, Cynthia G., Zhao, Bingchun, Chen, Man, Boswell, Kristin L., Roberts-Torres, Jesmine, Davis, Rachel L., Peyton, Lowrey, Narpala, Sandeep R., O’Connell, Sarah, Serebryannyy, Leonid, Wang, Jennifer, Schrager, Alexander, Talana, Chloe Adrienna, Shimberg, Geoffrey, Leung, Kwanyee, Shi, Wei, Khashab, Rawan, Biber, Asaf, Zilberman, Tal, Rhein, Joshua, Vetter, Sara, Ahmed, Afeefa, Novik, Laura, Widge, Alicia, Gordon, Ingelise, Guech, Mercy, Teng, I-Ting, Phung, Emily, Ruckwardt, Tracy J., Pegu, Amarendra, Misasi, John, Doria-Rose, Nicole A., Gaudinski, Martin, Koup, Richard A., Kwong, Peter D., McDermott, Adrian B., Amit, Sharon, Schacker, Timothy W., Levy, Itzchak, Mascola, John R., Sullivan, Nancy J., Schramm, Chaim A., Douek, Daniel C.

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A Placebo-Controlled Trial of Obeticholic Acid in Primary Biliary Cholangitis von Nevens, Frederik, Andreone, Pietro, Mazzella, Giuseppe, Strasser, Simone I, Bowlus, Christopher, Invernizzi, Pietro, Drenth, Joost P.H, Pockros, Paul J, Regula, Jaroslaw, Beuers, Ulrich, Trauner, Michael, Jones, David E, Floreani, Annarosa, Hohenester, Simon, Luketic, Velimir, Shiffman, Mitchell, van Erpecum, Karel J, Vargas, Victor, Vincent, Catherine, Hirschfield, Gideon M, Shah, Hemant, Hansen, Bettina, Lindor, Keith D, Marschall, Hanns-Ulrich, Kowdley, Kris V, Hooshmand-Rad, Roya, Marmon, Tonya, Sheeron, Shawn, Pencek, Richard, MacConell, Leigh, Pruzanski, Mark, Shapiro, David

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Whole-genome landscapes of major melanoma subtypes von Hayward, Nicholas K., Wilmott, James S., Waddell, Nicola, Johansson, Peter A., Field, Matthew A., Nones, Katia, Patch, Ann-Marie, Kakavand, Hojabr, Alexandrov, Ludmil B., Burke, Hazel, Jakrot, Valerie, Kazakoff, Stephen, Holmes, Oliver, Leonard, Conrad, Sabarinathan, Radhakrishnan, Mularoni, Loris, Wood, Scott, Xu, Qinying, Waddell, Nick, Tembe, Varsha, Pupo, Gulietta M., De Paoli-Iseppi, Ricardo, Vilain, Ricardo E., Shang, Ping, Lau, Loretta M. S., Dagg, Rebecca A., Schramm, Sarah-Jane, Pritchard, Antonia, Dutton-Regester, Ken, Newell, Felicity, Fitzgerald, Anna, Shang, Catherine A., Grimmond, Sean M., Pickett, Hilda A., Yang, Jean Y., Stretch, Jonathan R., Behren, Andreas, Kefford, Richard F., Hersey, Peter, Long, Georgina V., Cebon, Jonathan, Shackleton, Mark, Spillane, Andrew J., Saw, Robyn P. M., López-Bigas, Núria, Pearson, John V., Thompson, John F., Scolyer, Richard A., Mann, Graham J.

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Potent and broad HIV-1 neutralization in fusion peptide-primed SHIV-infected macaques von Wang, Hua, Cheng, Cheng, Dal Santo, James L, Shen, Chen-Hsiang, Bylund, Tatsiana, Henry, Amy R, Howe, Colin A, Hwang, Juyun, Morano, Nicholas C, Morris, Daniel J, Pletnev, Sergei, Roark, Ryan S, Zhou, Tongqing, Hansen, Bryan T, Hoyt, Forrest H, Johnston, Timothy S, Wang, Shuyi, Zhang, Baoshan, Ambrozak, David R, Becker, Jordan E, Bender, Michael F, Changela, Anita, Chaudhary, Ridhi, Corcoran, Martin, Corrigan, Angela R, Foulds, Kathryn E, Guo, Yicheng, Lee, Myungjin, Li, Yingying, Lin, Bob C, Liu, Tracy, Louder, Mark K, Mandolesi, Marco, Mason, Rosemarie D, McKee, Krisha, Nair, Vinod, O'Dell, Sijy, Olia, Adam S, Ou, Li, Pegu, Amarendra, Raju, Nagarajan, Rawi, Reda, Roberts-Torres, Jesmine, Sarfo, Edward K, Sastry, Mallika, Schaub, Andrew J, Schmidt, Stephen D, Schramm, Chaim A, Schwartz, Cindi L, Smith, Sarah C, Stephens, Tyler, Stuckey, Jonathan, Teng, I-Ting, Todd, John-Paul, Tsybovsky, Yaroslav, Van Wazer, David J, Wang, Shuishu, Doria-Rose, Nicole A, Fischer, Elizabeth R, Georgiev, Ivelin S, Karlsson Hedestam, Gunilla B, Sheng, Zizhang, Woodward, Ruth A, Douek, Daniel C, Koup, Richard A, Pierson, Theodore C, Shapiro, Lawrence, Shaw, George M, Mascola, John R, Kwong, Peter D

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Patient Age, Sex, and Inflammatory Bowel Disease Phenotype Associate With Course of Primary Sclerosing Cholangitis von Weismüller, Tobias J, Trivedi, Palak J, Bergquist, Annika, Imam, Mohamad, Lenzen, Henrike, Ponsioen, Cyriel Y, Holm, Kristian, Gotthardt, Daniel, Färkkilä, Martti A, Marschall, Hanns-Ulrich, Thorburn, Douglas, Weersma, Rinse K, Fevery, Johan, Mueller, Tobias, Chaouillères, Olivier, Schulze, Kornelius, Lazaridis, Konstantinos N, Almer, Sven, Pereira, Stephen P, Levy, Cynthia, Mason, Andrew, Naess, Sigrid, Bowlus, Christopher L, Floreani, Annarosa, Halilbasic, Emina, Yimam, Kidist K, Milkiewicz, Piotr, Beuers, Ulrich, Huynh, Dep K, Pares, Albert, Manser, Christine N, Dalekos, George N, Eksteen, Bertus, Invernizzi, Pietro, Berg, Christoph P, Kirchner, Gabi I, Sarrazin, Christoph, Zimmer, Vincent, Fabris, Luca, Braun, Felix, Marzioni, Marco, Juran, Brian D, Said, Karouk, Rupp, Christian, Jokelainen, Kalle, Benito de Valle, Maria, Saffioti, Francesca, Cheung, Angela, Trauner, Michael, Schramm, Christoph, Chapman, Roger W, Karlsen, Tom H, Schrumpf, Erik, Strassburg, Christian P, Manns, Michael P, Lindor, Keith D, Hirschfield, Gideon M, Hansen, Bettina E, Boberg, Kirsten M

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Effect of lorcaserin on prevention and remission of type 2 diabetes in overweight and obese patients (CAMELLIA-TIMI 61): a randomised, placebo-controlled trial von Bohula, Erin A, Dwyer, Jamie P, Keech, Anthony, Brown, Conville, Nicolau, Jose Carlos, Ray, Kauski, Lee, A, Lehman, R, Proietto, J, Blombery, P, d'Emden, M, Fortin, C, Kouz, S, Teitelbaum, I, Berlingieri, J, Twum-Barima, D, Perez, L, Saavedra Guajardo, V, Bayram Llamas, E, Llamas Esperon, G, Scott, D, Elliott, J, Łanda, K, Stasiewski, A, Zytkiewicz-Jaruga, D, Witek, R, Wujkowski, M, Skórski, M, Laskowska-Derlaga, E, Claxton, E, Boccalandro, F, Guarnieri, T, Singal, R, Condit, J, Einhorn, D, Schlager, D, Schramm, E, Soufer, J, Chilka, S, Wallace-Wilding, K, Aronoff, S, Karim, A, Raisinghani, A, Portnay, E, Cornett, G, Benjamin, S, Diener, J, Barker, B, Baldari, D, Zhang, L, Shayani, S, Andrawis, N, Gabra, N, Ghitis, A, Sabatino, K, Browder, D, Karlsberg, R, Wiseman, A, Gonzalez-Campoy, JM, Chokshi, S, Felten, W, Kuvin, J, Talano, J, Desai, V, Chane, M, Baron, S, Concha, M, Peterson, P, Jones, D, Longshaw, K, Jennings, W, Viswanath, D, Weinstein, D, Estevez, R, Levin, P, McNeill, R, Kalen, V, Tami, L, Cohen, K, Saba, F, Brown, J, Gorman, T, Pueblitz, G, Rink, L, Krichmar, P, Cohen, A, Tan, A, Kotek, L, Duffy, B, Lewis, D, Alberton, A, Stich, M, Davis, M, Rosario, R, Brinson, C, Abadier, R, Morris, F, Perez, A, Rodriguez, H, Izquierdo, W

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DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases von Ligthart, Symen, Marzi, Carola, Aslibekyan, Stella, Mendelson, Michael M, Conneely, Karen N, Tanaka, Toshiko, Colicino, Elena, Waite, Lindsay L, Joehanes, Roby, Guan, Weihua, Brody, Jennifer A, Elks, Cathy, Marioni, Riccardo, Jhun, Min A, Agha, Golareh, Bressler, Jan, Ward-Caviness, Cavin K, Chen, Brian H, Huan, Tianxiao, Bakulski, Kelly, Salfati, Elias L, Fiorito, Giovanni, Wahl, Simone, Schramm, Katharina, Sha, Jin, Hernandez, Dena G, Just, Allan C, Smith, Jennifer A, Sotoodehnia, Nona, Pilling, Luke C, Pankow, James S, Tsao, Phil S, Liu, Chunyu, Zhao, Wei, Guarrera, Simonetta, Michopoulos, Vasiliki J, Smith, Alicia K, Peters, Marjolein J, Melzer, David, Vokonas, Pantel, Fornage, Myriam, Prokisch, Holger, Bis, Joshua C, Chu, Audrey Y, Herder, Christian, Grallert, Harald, Yao, Chen, Shah, Sonia, McRae, Allan F, Lin, Honghuang, Horvath, Steve, Fallin, Daniele, Hofman, Albert, Wareham, Nicholas J, Wiggins, Kerri L, Feinberg, Andrew P, Starr, John M, Visscher, Peter M, Murabito, Joanne M, Kardia, Sharon L R, Absher, Devin M, Binder, Elisabeth B, Singleton, Andrew B, Bandinelli, Stefania, Peters, Annette, Waldenberger, Melanie, Matullo, Giuseppe, Schwartz, Joel D, Demerath, Ellen W, Uitterlinden, André G, van Meurs, Joyce B J, Franco, Oscar H, Chen, Yii-Der Ida, Levy, Daniel, Turner, Stephen T, Deary, Ian J, Ressler, Kerry J, Dupuis, Josée, Ferrucci, Luigi, Ong, Ken K, Assimes, Themistocles L, Boerwinkle, Eric, Koenig, Wolfgang, Arnett, Donna K, Baccarelli, Andrea A, Benjamin, Emelia J, Dehghan, Abbas

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Sequential intensification of metformin treatment in type 2 diabetes with liraglutide followed by randomized addition of basal insulin prompted by A1C targets von DeVries, J Hans, Bain, Stephen C, Rodbard, Helena W, Seufert, Jochen, D'Alessio, David, Thomsen, Anne B, Zychma, Marcin, Rosenstock, Julio

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Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth von Roark, Ryan S., Li, Hui, Williams, Wilton B., Chug, Hema, Mason, Rosemarie D., Gorman, Jason, Wang, Shuyi, Lee, Fang-Hua, Rando, Juliette, Bonsignori, Mattia, Hwang, Kwan-Ki, Saunders, Kevin O., Wiehe, Kevin, Moody, M. Anthony, Hraber, Peter T., Wagh, Kshitij, Giorgi, Elena E., Russell, Ronnie M., Bibollet-Ruche, Frederic, Liu, Weimin, Connell, Jesse, Smith, Andrew G., DeVoto, Julia, Murphy, Alexander, Smith, Jessica, Ding, Wenge, Zhao, Chengyan, Chohan, Neha, Okumura, Maho, Rosario, Christina, Ding, Yu, Lindemuth, Emily, Bauer, Anya M., Bar, Katharine J., Ambrozak, David, Chao, Cara W., Chuang, Gwo-Yu, Geng, Hui, Lin, Bob C., Louder, Mark K., Nguyen, Richard, Zhang, Baoshan, Lewis, Mark G., Raymond, Donald D., Doria-Rose, Nicole A., Schramm, Chaim A., Douek, Daniel C., Roederer, Mario, Kepler, Thomas B., Kelsoe, Garnett, Mascola, John R., Kwong, Peter D., Korber, Bette T., Harrison, Stephen C., Haynes, Barton F., Hahn, Beatrice H., Shaw, George M.

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Primary liver transplantation for autoimmune hepatitis: A comparative analysis of the European Liver Transplant Registry von Schramm, Christoph, Bubenheim, Michael, Adam, René, Karam, Vincent, Buckels, John, O'Grady, John G., Jamieson, Neville, Pollard, Stephen, Neuhaus, Peter, Manns, Michael M., Porte, Robert, Castaing, Denis, Paul, Andreas, Traynor, Oscar, Garden, James, Friman, Styrbjörn, Ericzon, Bo‐Goran, Fischer, Lutz, Vitko, Stefan, Krawczyk, Marek, Metselaar, Herold J., Foss, Aksel, Kilic, Murat, Rolles, Keith, Burra, Patrizia, Rogiers, Xavier, Lohse, Ansgar W.

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