Potent, orally active imidazo[4,5-b]pyridine-based angiotensin II receptor antagonists von Mantlo, Nathan B, Chakravarty, Prasun K, Ondeyka, Debra L, Siegl, Peter K. S, Chang, Raymond S, Lotti, Victor J, Faust, Kristie A, Schorn, Terry W, Chen, Tsing Bau

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Renin inhibitors. Syntheses of subnanomolar, competitive, transition-state analog inhibitors containing a novel analog of statine von Boger, Joshua, Payne, Linda S, Perlow, Debra S, Lohr, Nancy S, Poe, Martin, Blaine, Edward H, Ulm, Edgar H, Schorn, Terry W, LaMont, Bruce I

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Design and Synthesis of Novel α1a Adrenoceptor-Selective Dihydropyridine Antagonists for the Treatment of Benign Prostatic Hyperplasia von Nagarathnam, Dhanapalan, Wetzel, John M, Miao, Shou Wu, Marzabadi, Mohammad R, Chiu, George, Wong, Wai C, Hong, Xingfang, Fang, James, Forray, Carlos, Branchek, Theresa A, Heydorn, William E, Chang, Raymond S. L, Broten, Theodore, Schorn, Terry W, Gluchowski, Charles

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Renin inhibitors containing C-termini derived from mercaptoheterocycles von Ashton, Wallace T, Cantone, Christine L, Meurer, Laura C, Tolman, Richard L, Greenlee, William J, Patchett, Arthur A, Lynch, Robert J, Schorn, Terry W, Strouse, John F, Siegl, Peter K. S

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In vitro and in vivo evaluation of dihydropyrimidinone C-5 amides as potent and selective alpha(1A) receptor antagonists for the treatment of benign prostatic hyperplasia von Barrow, J C, Nantermet, P G, Selnick, H G, Glass, K L, Rittle, K E, Gilbert, K F, Steele, T G, Homnick, C F, Freidinger, R M, Ransom, R W, Kling, P, Reiss, D, Broten, T P, Schorn, T W, Chang, R S, O'Malley, S S, Olah, T V, Ellis, J D, Barrish, A, Kassahun, K, Leppert, P, Nagarathnam, D, Forray, C

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Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 1. Structure-activity relationship in dihydropyrimidinones von Nagarathnam, D, Miao, S W, Lagu, B, Chiu, G, Fang, J, Murali Dhar, T G, Zhang, J, Tyagarajan, S, Marzabadi, M R, Zhang, F, Wong, W C, Sun, W, Tian, D, Wetzel, J M, Forray, C, Chang, R S, Broten, T P, Ransom, R W, Schorn, T W, Chen, T B, O'Malley, S, Kling, P, Schneck, K, Bendesky, R, Harrell, C M

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De Novo Design of a Novel Oxazolidinone Analogue as a Potent and Selective α1A Adrenergic Receptor Antagonist with High Oral Bioavailability von Lagu, Bharat, Tian, Dake, Jeon, Yoon, Li, Chao, Wetzel, John M, Nagarathnam, Dhanapalan, Shen, Quanrong, Forray, Carlos, Chang, Raymond S. L, Broten, Theodore P, Ransom, Richard W, Chan, Tsing-Bao, O'Malley, Stacey S, Schorn, Terry W, Rodrigues, A. David, Kassahun, Kelem, Pettibone, Douglas J, Freidinger, Roger, Gluchowski, Charles

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Design and Synthesis of Novel α1 a Adrenoceptor-Selective Antagonists. 1. Structure−Activity Relationship in Dihydropyrimidinones von Nagarathnam, Dhanapalan, Miao, Shou Wu, Lagu, Bharat, Chiu, George, Fang, James, Murali Dhar, T. G, Zhang, Jack, Tyagarajan, Sriram, Marzabadi, Mohammad R, Zhang, Fengqi, Wong, Wai C, Sun, Wanying, Tian, Dake, Wetzel, John M, Forray, Carlos, Chang, Raymond S. L, Broten, Theodore P, Ransom, Richard W, Schorn, Terry W, Chen, Tsing B, O'Malley, Stacey, Kling, Paul, Schneck, Kathryn, Bendesky, Robert, Harrell, Charles M, Vyas, Kamlesh P, Gluchowski, Charles

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Highly potent, orally active diester macrocyclic human renin inhibitors von Weber, Ann E, Steiner, Mark G, Krieter, Philip A, Colletti, Adria E, Tata, James R, Halgren, Thomas A, Ball, Richard G, Doyle, John J, Schorn, Terry W

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Design and Synthesis of Novel α1 a Adrenoceptor-Selective Antagonists. 2. Approaches To Eliminate Opioid Agonist Metabolites via Modification of Linker and 4-Methoxycarbonyl-4-phen... von Murali Dhar, T. G, Nagarathnam, Dhanapalan, Marzabadi, Mohammad R, Lagu, Bharat, Wong, Wai C, Chiu, George, Tyagarajan, Sriram, Miao, Shou Wu, Zhang, Fengqi, Sun, Wanying, Tian, Dake, Shen, Quanrong, Zhang, Jack, Wetzel, John M, Forray, Carlos, Chang, Raymond S. L, Broten, Theodore P, Schorn, Terry W, Chen, Tsing Bao, O'Malley, Stacy, Ransom, Richard, Schneck, Kathryn, Bendesky, Robert, Harrell, Charles M, Vyas, Kamlesh P, Zhang, Kanyin, Gilbert, John, Pettibone, Douglas J, Patane, Michael A, Bock, Mark G, Freidinger, Roger M, Gluchowski, Charles

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Novel renin inhibitors containing the amino acid statine von Boger, Joshua, Lohr, Nancy S, Ulm, Edgar H, Poe, Martin, Blaine, Edward H, Fanelli, George M, Lin, Tsau-Yen, Payne, Linda S, Schorn, Terry W, LaMont, Bruce I, Vassil, Ted C, Stabilito, Inez I, Veber, Daniel F, Rich, Daniel H, Bopari, Amrit S

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Statine-Containing Renin Inhibitor: Dissociation of Blood Pressure Lowering and Renin Inhibition in Sodium-Deficient Dogs von BLAINE, EDWARD H, SCHORN, TERRY W, BOGER, JOSHUA

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Renin inhibitors containing conformationally restricted P1-P1' dipeptide mimetics von Williams, Peter D, Perlow, Debra S, Payne, Linda S, Holloway, M. Katherine, Siegl, Peter K. S, Schorn, Terry W, Lynch, Robert J, Doyle, John J, Strouse, John F

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Inhibitors of human renin with C-termini derived from amides and esters of .alpha.-mercaptoalkanoic acids von Ashton, Wallace T, Cantone, Christine L, Tolman, Richard L, Greenlee, William J, Lynch, Robert J, Schorn, Terry W, Strouse, John F, Siegl, Peter K. S

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Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 2. Approaches to eliminate opioid agonist metabolites via modification of linker and 4-methoxycarbonyl... von Murali Dhar, T G, Nagarathnam, D, Marzabadi, M R, Lagu, B, Wong, W C, Chiu, G, Tyagarajan, S, Miao, S W, Zhang, F, Sun, W, Tian, D, Shen, Q, Zhang, J, Wetzel, J M, Forray, C, Chang, R S, Broten, T P, Schorn, T W, Chen, T B, O'Malley, S, Ransom, R, Schneck, K, Bendesky, R, Harrell, C M, Vyas, K P

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Comparison of Renin and Converting Enzyme Inhibition in Sodium-Deficient Dogs von BLAINE, EDWARD H, NELSON, BARBARA J, SEYMOUR, ANDREA A, SCHORN, TERRY W, SWEET, CHARLES S, SLATER, EVE E, NUSSBERGER, JURGE, BOGER, JOSHUA

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Angiotensin II receptor subtypes in renal cortex of rats and rhesus monkeys von Gibson, R. E, Thorpe, H. H, Cartwright, M. E, Frank, J. D, Schorn, T. W, Bunting, P. B, Siegl, P. K

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A highly potent, orally active imidazo-[4,5-b]pyridine biphenylacylsulfonamide (MK-996;L-159,282) : a new AT1-selective angiotensin II receptor antagonist von CHAKRAVARTY, P. K, NAYLOR, E. M, SCHORN, T. W, SCHAFFER, L. W, BROTEN, T. P, SIEGL, P. K. S, PATCHETT, A. A, GREENLEE, W. J, CHEN, A, CHANG, R. S. L, TSING-BAU CHEN, FAUST, K. A, LOTTI, V. J, KIVLIGHN, S. D, GABLE, R. A, ZINGARO, G. J

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Nonpeptide angiotensin II antagonists derived from 4H-1,2,4-triazoles and 3H-imidazo[1,2-b][1,2,4]triazoles von Ashton, Wallace T, Cantone, Christine L, Chang, Linda L, Hutchins, Steven M, Strelitz, Robert A, MacCoss, Malcolm, Chang, Raymond S. L, Lotti, Victor J, Faust, Kristie A

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Triazolinone Biphenylsulfonamide Derivatives as Orally Active Angiotensin II Antagonists with Potent AT1 Receptor Affinity and Enhanced AT2 Affinity von Ashton, Wallace T, Chang, Linda L, Flanagan, Kelly L, Hutchins, Steven M, Naylor, Elizabeth M, Chakravarty, Prasun K, Patchett, Arthur A, Greenlee, William J, Chen, Tsing-Bau

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