Evaluation of a Three-Dimensional Primary Human Hepatocyte Spheroid Model: Adoption and Industrialization for the Enhanced Detection of Drug-Induced Liver Injury von Schofield, Christopher A, Walker, Tracy M, Taylor, Maxine A, Patel, Metul, Vlachou, Denise F, Macina, Justyna M, Vidgeon-Hart, Martin P, Williams, Ann, McGill, Paul J, Newman, Carla F, Sakatis, Melanie Z

Volltext

A Scalable 3D High-Content Imaging Protocol for Measuring a Drug Induced DNA Damage Response Using Immunofluorescent Subnuclear γH2AX Spots in Patient Derived Ovarian Cancer Organo... von Keles, Hakan, Schofield, Christopher A., Rannikmae, Helena, Edwards, Erin Elizabeth, Mohamet, Lisa

Volltext

A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity von Sison-Young, Rowena L., Lauschke, Volker M., Johann, Esther, Alexandre, Eliane, Antherieu, Sébastien, Aerts, Hélène, Gerets, Helga H. J., Labbe, Gilles, Hoët, Delphine, Dorau, Martina, Schofield, Christopher A., Lovatt, Cerys A., Holder, Julie C., Stahl, Simone H., Richert, Lysiane, Kitteringham, Neil R., Jones, Robert P., Elmasry, Mohamed, Weaver, Richard J., Hewitt, Philip G., Ingelman-Sundberg, Magnus, Goldring, Chris E., Park, B. Kevin

Volltext

Development of phosphorus-containing metallo-β-lactamase inhibitors: Synthesis and binding studies by solution NMR and molecular docking von Palica, Katarzyna

Volltext bestellen

Molecular Approaches to Explore Drug-Target Interactions von Al-Amin, Abdullah

Volltext bestellen

A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity von Sison-Young, Rowena L., Lauschke, Volker M., Johann, Esther, Alexandre, Eliane, Antherieu, Sébastien, Aerts, Hélène, Gerets, Helga H. J., Labbe, Gilles, Hoët, Delphine, Dorau, Martina, Schofield, Christopher A., Lovatt, Cerys A., Holder, Julie C., Stahl, Simone H., Richert, Lysiane, Kitteringham, Neil R., Jones, Robert P., Elmasry, Mohamed, Weaver, Richard J., Hewitt, Philip G., Ingelman-Sundberg, Magnus, Goldring, Chris E., Park, B. Kevin

Volltext

Lateral Magma Flow in Mafic Sill-complexes von Magee, Craig, Muirhead, James D, Karvelas, Alex, Holford, Simon P, Jackson, Christopher A-L, Bastow, Ian D., Schofield, Nick, Stevenson, Carl TE, McLean, Charlotte, McCarthy, William, Shtukert, Olga

Volltext

2-Oxoglutarate-Dependent Oxygenases von Islam, Md. Saiful, Leissing, Thomas M, Chowdhury, Rasheduzzaman, Hopkinson, Richard J, Schofield, Christopher J

Volltext

Physiological and biochemical aspects of hydroxylations and demethylations catalyzed by human 2-oxoglutarate oxygenases von Loenarz, Christoph, Schofield, Christopher J.

Volltext

Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials von Yeh, Tzu-Lan, Leissing, Thomas M, Abboud, Martine I, Thinnes, Cyrille C, Atasoylu, Onur, Holt-Martyn, James P, Zhang, Dong, Tumber, Anthony, Lippl, Kerstin, Lohans, Christopher T, Leung, Ivanhoe K H, Morcrette, Helen, Clifton, Ian J, Claridge, Timothy D W, Kawamura, Akane, Flashman, Emily, Lu, Xin, Ratcliffe, Peter J, Chowdhury, Rasheduzzaman, Pugh, Christopher W, Schofield, Christopher J

Volltext

Expanding chemical biology of 2-oxoglutarate oxygenases von Loenarz, Christoph, Schofield, Christopher J

Volltext

Elimination of Rhodnius prolixus in Central America von Hashimoto, Ken, Schofield, Christopher J

Volltext

Biochemistry of the hypoxia-inducible factor hydroxylases von Fiorini, Giorgia, Schofield, Christopher J.

Volltext

Fixing the Achilles Heel of Pfizer’s Paxlovid for COVID-19 Treatment von Brewitz, Lennart, Schofield, Christopher J.

Volltext

Mechanisms of substrate recognition and N6-methyladenosine demethylation revealed by crystal structures of ALKBH5–RNA complexes von Kaur, Simranjeet, Tam, Nok Yin, McDonough, Michael A, Schofield, Christopher J, Aik, Wei Shen

Volltext

Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases von Chan, Mun Chiang, Ilott, Nicholas E., Schödel, Johannes, Sims, David, Tumber, Anthony, Lippl, Kerstin, Mole, David R., Pugh, Christopher W., Ratcliffe, Peter J., Ponting, Chris P., Schofield, Christopher J.

Volltext

A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene von Church, Chris, Lee, Sheena, Bagg, Eleanor A L, McTaggart, James S, Deacon, Robert, Gerken, Thomas, Lee, Angela, Moir, Lee, Mecinović, Jasmin, Quwailid, Mohamed M, Schofield, Christopher J, Ashcroft, Frances M, Cox, Roger D

Volltext

Synthesis of meta-substituted arene bioisosteres from [3.1.1]propellane von Frank, Nils, Nugent, Jeremy, Shire, Bethany R., Pickford, Helena D., Rabe, Patrick, Sterling, Alistair J., Zarganes-Tzitzikas, Tryfon, Grimes, Thomas, Thompson, Amber L., Smith, Russell C., Schofield, Christopher J., Brennan, Paul E., Duarte, Fernanda, Anderson, Edward A.

Volltext

Protein Hydroxylation Catalyzed by 2-Oxoglutarate-dependent Oxygenases von Markolovic, Suzana, Wilkins, Sarah E., Schofield, Christopher J.

Volltext

Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors von King, Oliver N F, Li, Xuan Shirley, Sakurai, Masaaki, Kawamura, Akane, Rose, Nathan R, Ng, Stanley S, Quinn, Amy M, Rai, Ganesha, Mott, Bryan T, Beswick, Paul, Klose, Robert J, Oppermann, Udo, Jadhav, Ajit, Heightman, Tom D, Maloney, David J, Schofield, Christopher J, Simeonov, Anton

Volltext