L-735,524: An Orally Bioavailable Human Immunodeficiency Virus Type 1 Protease Inhibitor von Vacca, J. P., Dorsey, B. D., Schleif, W. A., Levin, R. B., McDaniel, S. L., Darke, P. L., Zugay, J., Quintero, J. C., Blahy, O. M., Roth, E., Sardana, V. V., Schlabach, A. J., Graham, P. I., Condra, J. H., Gotlib, L., Holloway, M. K., Lin, J., I.-W. Chen, Vastag, K., Ostovic, D., Anderson, P. S., Emini, E. A., Huff, J. R.

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In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors von Condra, Jon H, Schleif, William A, Blahy, Olga M, Gabryelski, Lori J, Graham, Donald J, Quintero, Julio, Rhodes, Audrey, Robbins, Helen L, Roth, Elizabeth, Shivaprakash, Malathi, Titus, Donna, Yang, Tao, Tepplert, Hedy, Squires, Kathleen E, Deutsch, Paul J, Emini, Emilio A

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Simultaneous vs Sequential Initiation of Therapy With Indinavir, Zidovudine, and Lamivudine for HIV-1 Infection: 100-Week Follow-up von Gulick, Roy M, Mellors, John W, Havlir, Diane, Eron, Joseph J, Gonzalez, Charles, McMahon, Deborah, Jonas, Leslie, Meibohm, Anne, Holder, Daniel, Schleif, William A, Condra, Jon H, Emini, Emilio A, Isaacs, Robin, Chodakewitz, Jeffrey A, Richman, Douglas D

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Active Human Immunodeficiency Virus Protease is Required for Viral Infectivity von Kohl, Nancy E., Emini, Emilio A., Schleif, William A., Davis, Lenora J., Heimbach, Jill C., Richard A. F. Dixon, Scolnick, Edward M., Sigal, Irving S.

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Genetic correlates of in vivo viral resistance to indinavir, a human immunodeficiency virus type 1 protease inhibitor von Condra, J H, Holder, D J, Schleif, W A, Blahy, O M, Danovich, R M, Gabryelski, L J, Graham, D J, Laird, D, Quintero, J C, Rhodes, A, Robbins, H L, Roth, E, Shivaprakash, M, Yang, T, Chodakewitz, J A, Deutsch, P J, Leavitt, R Y, Massari, F E, Mellors, J W, Squires, K E, Steigbigel, R T, Teppler, H, Emini, E A

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L-743, 726 (DMP-266): a novel, highly potent nonnucleoside inhibitor of the human immunodeficiency virus type 1 reverse transcriptase von YOUNG, S. D, BRITCHER, S. F, PETTIBONE, D. J, O'BRIEN, J. A, BALL, R. G, BALANI, S. K, LIN, J. H, I-WU CHEN, SCHLEIF, W. A, SARDANA, V. V, LONG, W. J, BYRNES, V. W, TRAN, L. O, EMINI, E. A, PAYNE, L. S, LUMMA, W. C, LYLE, T. A, HUFF, J. R, ANDERSON, P. S, OLSEN, D. B, CARROLL, S. S

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Viral resistance to human immunodeficiency virus type 1-specific pyridinone reverse transcriptase inhibitors von NUNBERG, J. H, SCHLEIF, W. A, BOOTS, E. J, O'BRIEN, J. A, QUINTERO, J. C, HOFFMAN, J. M, EMINI, E. A, GOLDMAN, M. E

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Requirement of active human immunodeficiency virus type 1 integrase enzyme for productive infection of human T-lymphoid cells von LAFEMINA, RL, SCHNEIDER, CL, ROBBINS, HL, CALLAHAN, PL, LEGROW, K, ROTH, E, SCHLEIF, WA, EMINI, EA

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Pyridinone Derivatives: Specific Human Immunodeficiency Virus Type 1 Reverse Transcriptase Inhibitors with Antiviral Activity von Goldman, Mark E., Nunberg, Jack H., O'Brien, Julie A., Quintero, Julio C., Schleif, William A., Freund, Kurt F., Gaul, S. Lee, Saari, Walfred S., Wai, John S., Hoffman, Jacob M., Anderson, Paul S., Hupe, Donald J., Emini, Emilio A., Stern, Andrew M.

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L-735,524 : the design of a potent and orally bioavailable HIV protease inhibitor von DORSEY, B. D, LEVIN, R. B, LIN, J. H, CHEN, I.-W, HOLLOWAY, M. K, FITZGERALD, P. M. D, AXEL, M. G, OSTOVIC, D, ANDERSON, P. S, HUFF, J. R, MCDANIEL, S. L, VACCA, J. P, GUARE, J. P, DARKE, P. L, ZUGAY, J. A, EMINI, E. A, SCHLEIF, W. A, QUINTERO, J. C

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An Orally Bioavailable Pyrrolinone Inhibitor of HIV-1 Protease:  Computational Analysis and X-ray Crystal Structure of the Enzyme Complex von Smith, Amos B, Hirschmann, Ralph, Pasternak, Alexander, Yao, Wenquing, Sprengeler, Paul A, Holloway, M. Katharine, Kuo, Lawrence C, Chen, Zhongguo, Darke, Paul L, Schleif, William A

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PREVENTION OF HIV-1 INFECTION IN CHIMPANZEES BY GP120 V3 DOMAIN-SPECIFIC MONOCLONAL-ANTIBODY von EMINI, EA, SCHLEIF, WA, NUNBERG, JH, CONLEY, AJ, EDA, Y, TOKIYOSHI, S, PUTNEY, SD, MATSUSHITA, S, COBB, KE, JETT, CM, EICHBERG, JW, MURTHY, KK

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Comprehensive mutant enzyme and viral variant assessment of human immunodeficiency virus type 1 reverse transcriptase resistance to nonnucleoside inhibitors von BYRNES, V. W, SARDANA, V. V, GRAHAM, D. J, GOTLIB, L, RHODES, A, TITUS, D. L, ROTH, E, BLAHY, O. M, QUINTERO, J. C, STASZEWSKI, S, EMINI, E. A, SCHLEIF, W. A, CONDRA, J. H, WATERBURY, J. A, WOLFGANG, J. A, LONG, W. J, SCHNEIDER, C. L, SCHLABACH, A. J, WOLANSKI, B. S

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The consequence of passive administration of an anti-human immunodeficiency virus type 1 neutralizing monoclonal antibody before challenge of chimpanzees with a primary virus isola... von Conley, A J, Kessler, 2nd, J A, Boots, L J, McKenna, P M, Schleif, W A, Emini, E A, Mark, 3rd, G E, Katinger, H, Cobb, E K, Lunceford, S M, Rouse, S R, Murthy, K K

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4-Aryl-2,4-dioxobutanoic Acid Inhibitors of HIV-1 Integrase and Viral Replication in Cells von Wai, John S, Egbertson, Melissa S, Payne, Linda S, Fisher, Thorsten E, Embrey, Mark W, Tran, Lekhanh O, Melamed, Jeffrey Y, Langford, H. Marie, Guare, James P, Zhuang, Linghang, Grey, Vanessa E, Vacca, Joseph P, Holloway, M. Katharine, Naylor-Olsen, Adel M, Hazuda, Daria J, Felock, Peter J, Wolfe, Abigail L, Stillmock, Kara A, Schleif, William A, Gabryelski, Lori J, Young, Steven D

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Drug Resistance and Predicted Virologic Responses to Human Immunodeficiency Virus Type 1 Protease Inhibitor Therapy von Condra, Jon H., Petropoulos, Christos J., Ziermann, Rainer, Schleif, William A., Shivaprakash, Malathi, Emini, Emilio A.

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SYNTHESIS AND ANTIVIRAL ACTIVITY OF A SERIES OF HIV-1 PROTEASE INHIBITORS WITH FUNCTIONALITY TETHERED TO THE P1 OR P1' PHENYL SUBSTITUENTS - X-RAY CRYSTAL-STRUCTURE ASSISTED DESIGN von THOMPSON, WJ, FITZGERALD, PMD, HOLLOWAY, MK, EMINI, EA, DARKE, PL, MCKEEVER, BM, SCHLEIF, WA, QUINTERO, JC, ZUGAY, JA, TUCKER, TJ, SCHWERING, JE, HOMNICK, CF, NUNBERG, J, SPRINGER, JP, HUFF

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L-687,908, a potent hydroxyethylene containing HIV protease inhibitor von Vacca, Joseph P, Guare, J. P, DeSolms, S. J, Sanders, W. M, Giuliani, E. A, Young, S. D, Darke, P. L, Sigal, I. S, Schleif, W. A

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Prevention of HIV-1 infection in chimpanzees by gpl20 V3 domain-specific monoclonal antibody von Emini, E. A, Schleif, W. A, Nunberg, J. H, Conley, A. J, Eda, Y, Tokiyoshi, S, Putney, S. D, Matsushrta, S, Cobb, K. E, Jett, C. M, Eichberg, J. W, Murthy, K. K

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Combinatorial diversification of indinavir: in vivo mixture dosing of an HIV protease inhibitor library von Rano, Thomas A, Cheng, Yuan, Huening, Tracy T, Zhang, Fengqi, Schleif, William A, Gabryelski, Lori, Olsen, David B, Kuo, Lawrence C, Lin, Jiunn H, Xu, Xin, Olah, Timothy V, McLoughlin, Debra A, King, Richard, Chapman, Kevin T, Tata, James R

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