Cases, Statutes and Recent Developments von Lucchi, Neal, Porzeinski, Robert A., Counts, Lajuana, Schleicher, Steven J., McNamara, Kathleen, Rauzi, Dave, Backhus, Terri, Armstrong, Alison, Morgan, Edwina, Biersmith, Carolyn, Gladstone, Lois A., Karl, Stephanie, Francis, Allison, Klosterman, Joan, Jones, Steve, Pardoe, Pamela A., Box, Mike, Burns, Anita

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Global prevalence and disease burden of vitamin D deficiency: a roadmap for action in low‐ and middle‐income countries von Roth, Daniel E., Abrams, Steven A., Aloia, John, Bergeron, Gilles, Bourassa, Megan W., Brown, Kenneth H., Calvo, Mona S., Cashman, Kevin D., Combs, Gerald, De‐Regil, Luz María, Jefferds, Maria Elena, Jones, Kerry S., Kapner, Hallie, Martineau, Adrian R., Neufeld, Lynnette M., Schleicher, Rosemary L., Thacher, Tom D., Whiting, Susan J.

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The mutational constraint spectrum quantified from variation in 141,456 humans von Karczewski, Konrad J., Francioli, Laurent C., Tiao, Grace, Cummings, Beryl B., Alföldi, Jessica, Wang, Qingbo, Collins, Ryan L., Laricchia, Kristen M., Ganna, Andrea, Birnbaum, Daniel P., Gauthier, Laura D., Brand, Harrison, Solomonson, Matthew, Watts, Nicholas A., Rhodes, Daniel, Singer-Berk, Moriel, England, Eleina M., Seaby, Eleanor G., Kosmicki, Jack A., Walters, Raymond K., Tashman, Katherine, Farjoun, Yossi, Banks, Eric, Poterba, Timothy, Wang, Arcturus, Seed, Cotton, Whiffin, Nicola, Chong, Jessica X., Samocha, Kaitlin E., Pierce-Hoffman, Emma, Zappala, Zachary, O’Donnell-Luria, Anne H., Minikel, Eric Vallabh, Weisburd, Ben, Lek, Monkol, Ware, James S., Vittal, Christopher, Armean, Irina M., Bergelson, Louis, Cibulskis, Kristian, Connolly, Kristen M., Covarrubias, Miguel, Donnelly, Stacey, Ferriera, Steven, Gabriel, Stacey, Gentry, Jeff, Gupta, Namrata, Jeandet, Thibault, Kaplan, Diane, Llanwarne, Christopher, Munshi, Ruchi, Novod, Sam, Petrillo, Nikelle, Roazen, David, Ruano-Rubio, Valentin, Saltzman, Andrea, Schleicher, Molly, Soto, Jose, Tibbetts, Kathleen, Tolonen, Charlotte, Wade, Gordon, Talkowski, Michael E., Neale, Benjamin M., Daly, Mark J., MacArthur, Daniel G.

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Exploring acute-to-chronic neuropathic pain in rats after contusion spinal cord injury von Gaudet, Andrew D., Ayala, Monica T., Schleicher, Wolfgang E., Smith, Elana J., Bateman, Emily M., Maier, Steven F., Watkins, Linda R.

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Transcript expression-aware annotation improves rare variant interpretation von Cummings, Beryl B., Karczewski, Konrad J., Kosmicki, Jack A., Seaby, Eleanor G., Watts, Nicholas A., Singer-Berk, Moriel, Mudge, Jonathan M., Karjalainen, Juha, Satterstrom, F. Kyle, O’Donnell-Luria, Anne H., Poterba, Timothy, Seed, Cotton, Solomonson, Matthew, Alföldi, Jessica, Daly, Mark J., MacArthur, Daniel G.

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The Composition of Comets von Cochran, Anita L., Levasseur-Regourd, Anny-Chantal, Cordiner, Martin, Hadamcik, Edith, Lasue, Jérémie, Gicquel, Adeline, Schleicher, David G., Charnley, Steven B., Mumma, Michael J., Paganini, Lucas, Bockelée-Morvan, Dominique, Biver, Nicolas, Kuan, Yi-Jehng

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LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells von Brand, Almut, Singer, Katrin, Koehl, Gudrun E., Kolitzus, Marlene, Schoenhammer, Gabriele, Thiel, Annette, Matos, Carina, Bruss, Christina, Klobuch, Sebastian, Peter, Katrin, Kastenberger, Michael, Bogdan, Christian, Schleicher, Ulrike, Mackensen, Andreas, Ullrich, Evelyn, Fichtner-Feigl, Stefan, Kesselring, Rebecca, Mack, Matthias, Ritter, Uwe, Schmid, Maximilian, Blank, Christian, Dettmer, Katja, Oefner, Peter J., Hoffmann, Petra, Walenta, Stefan, Geissler, Edward K., Pouyssegur, Jacques, Villunger, Andreas, Steven, André, Seliger, Barbara, Schreml, Stephan, Haferkamp, Sebastian, Kohl, Elisabeth, Karrer, Sigrid, Berneburg, Mark, Herr, Wolfgang, Mueller-Klieser, Wolfgang, Renner, Kathrin, Kreutz, Marina

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A genomic mutational constraint map using variation in 76,156 human genomes von Chen, Siwei, Francioli, Laurent C., Goodrich, Julia K., Collins, Ryan L., Kanai, Masahiro, Wang, Qingbo, Alföldi, Jessica, Watts, Nicholas A., Vittal, Christopher, Gauthier, Laura D., Poterba, Timothy, Wilson, Michael W., Tarasova, Yekaterina, Phu, William, Grant, Riley, Yohannes, Mary T., Koenig, Zan, Farjoun, Yossi, Banks, Eric, Donnelly, Stacey, Gabriel, Stacey, Gupta, Namrata, Ferriera, Steven, Tolonen, Charlotte, Novod, Sam, Bergelson, Louis, Roazen, David, Ruano-Rubio, Valentin, Covarrubias, Miguel, Llanwarne, Christopher, Petrillo, Nikelle, Wade, Gordon, Jeandet, Thibault, Munshi, Ruchi, Tibbetts, Kathleen, O’Donnell-Luria, Anne, Solomonson, Matthew, Seed, Cotton, Martin, Alicia R., Talkowski, Michael E., Rehm, Heidi L., Daly, Mark J., Tiao, Grace, Neale, Benjamin M., MacArthur, Daniel G., Karczewski, Konrad J.

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A structural variation reference for medical and population genetics von Collins, Ryan L., Brand, Harrison, Karczewski, Konrad J., Zhao, Xuefang, Alföldi, Jessica, Francioli, Laurent C., Khera, Amit V., Lowther, Chelsea, Gauthier, Laura D., Wang, Harold, Watts, Nicholas A., Solomonson, Matthew, O’Donnell-Luria, Anne, Baumann, Alexander, Munshi, Ruchi, Walker, Mark, Whelan, Christopher W., Huang, Yongqing, Brookings, Ted, Sharpe, Ted, Stone, Matthew R., Valkanas, Elise, Fu, Jack, Tiao, Grace, Laricchia, Kristen M., Ruano-Rubio, Valentin, Stevens, Christine, Gupta, Namrata, Cusick, Caroline, Margolin, Lauren, Taylor, Kent D., Lin, Henry J., Rich, Stephen S., Post, Wendy S., Chen, Yii-Der Ida, Rotter, Jerome I., Nusbaum, Chad, Philippakis, Anthony, Lander, Eric, Gabriel, Stacey, Neale, Benjamin M., Kathiresan, Sekar, Daly, Mark J., Banks, Eric, MacArthur, Daniel G., Talkowski, Michael E.

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Landscape of multi-nucleotide variants in 125,748 human exomes and 15,708 genomes von Wang, Qingbo, Pierce-Hoffman, Emma, Cummings, Beryl B., Alföldi, Jessica, Francioli, Laurent C., Gauthier, Laura D., Hill, Andrew J., O’Donnell-Luria, Anne H., Karczewski, Konrad J., MacArthur, Daniel G.

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The effect of LRRK2 loss-of-function variants in humans von Whiffin, Nicola, Armean, Irina M., Kleinman, Aaron, Marshall, Jamie L., Minikel, Eric V., Goodrich, Julia K., Quaife, Nicholas M., Cole, Joanne B., Wang, Qingbo, Karczewski, Konrad J., Cummings, Beryl B., Francioli, Laurent, Laricchia, Kristen, Guan, Anna, Alipanahi, Babak, Morrison, Peter, Baptista, Marco A. S., Merchant, Kalpana M., Ware, James S., Havulinna, Aki S., Iliadou, Bozenna, Lee, Jung-Jin, Nadkarni, Girish N., Whiteman, Cole, Daly, Mark, Esko, Tõnu, Hultman, Christina, Loos, Ruth J. F., Milani, Lili, Palotie, Aarno, Pato, Carlos, Pato, Michele, Saleheen, Danish, Sullivan, Patrick F., Alföldi, Jessica, Cannon, Paul, MacArthur, Daniel G.

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Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations von Boer, Cindy G., Hatzikotoulas, Konstantinos, Southam, Lorraine, Zhang, Yanfei, Coutinho de Almeida, Rodrigo, Wu, Tian T., Zheng, Jie, Hartley, April, Teder-Laving, Maris, Terao, Chikashi, Zengini, Eleni, Alexiadis, George, Bjornsdottir, Gyda, Gilly, Arthur, Ingvarsson, Thorvaldur, Luetge, Almut, Lund, Sigrun H., Mangino, Massimo, Takuwa, Hiroshi, Thomas, Laurent F., Loughlin, John, Arden, Nigel, Doherty, Michael, Ollier, William E.R., Spector, Tim D., Wallis, Gillian A., Martinsen, Amy E., Fors, Egil Andreas, Hagen, Knut, Nilsen, Kristian Bernhard, Lie, Marie Udnesseter, Børte, Sigrid, Brumpton, Ben, Fritsche, Lars G., Zhou, Wei, Heuch, Ingrid, Storheim, Kjersti, Tyrpenou, Evangelos, Koukakis, Athanasios, Efstathios, Chronopoulos, Nikolaou, Vasileios S., Malizos, Konstantinos, Anastasopoulou, Lydia, Abecasis, Goncalo, Baras, Aris, Cantor, Michael, Coppola, Giovanni, Lotta, Luca A., Shuldiner, Alan, Karalis, Katia, Siminovitch, Katherine, Beechert, Christina, Forsythe, Caitlin, Fuller, Erin D., Gu, Zhenhua, Lattari, Michael, Padilla, Maria Sotiropoulos, Widom, Louis, Wolf, Sarah E., Pradhan, Manasi, Manoochehri, Kia, Bai, Xiaodong, Balasubramanian, Suganthi, Boutkov, Boris, Eom, Gisu, Habegger, Lukas, Hawes, Alicia, Maxwell, Evan K., Orelus, Max, Panea, Razvan, Polanco, Tommy, Salerno, William, Staples, Jeffrey C., Li, Dadong, Sharma, Deepika, Banerjee, Ilanjana, Locke, Adam, Haas, Mary, Akbari, Parsa, Ferreira, Manuel A.R., Jones, Marcus B., Mitnaul, Lyndon J., Babis, George C., Cheung, Jason Pui Yin, Kang, Jae Hee, Lietman, Steven A., Samartzis, Dino, Stefansson, Kari, Uitterlinden, André G., Davey Smith, George, Valdes, Ana M., Tsezou, Aspasia, Cheah, Kathryn S.E., Hveem, Kristian, Wilkinson, J. Mark, Meulenbelt, Ingrid, Lee, Ming Ta Michael, van Meurs, Joyce B.J., Styrkársdóttir, Unnur, Zeggini, Eleftheria

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Development of a Standard Reference Material for Metabolomics Research von Phinney, Karen W, Ballihaut, Guillaume, Bedner, Mary, Benford, Brandi S, Camara, Johanna E, Christopher, Steven J, Davis, W. Clay, Dodder, Nathan G, Eppe, Gauthier, Lang, Brian E, Long, Stephen E, Lowenthal, Mark S, McGaw, Elizabeth A, Murphy, Karen E, Nelson, Bryant C, Prendergast, Jocelyn L, Reiner, Jessica L, Rimmer, Catherine A, Sander, Lane C, Schantz, Michele M, Sharpless, Katherine E, Sniegoski, Lorna T, Tai, Susan S.-C, Thomas, Jeanice B, Vetter, Thomas W, Welch, Michael J, Wise, Stephen A, Wood, Laura J, Guthrie, William F, Hagwood, Charles R, Leigh, Stefan D, Yen, James H, Zhang, Nien-Fan, Chaudhary-Webb, Madhu, Chen, Huiping, Fazili, Zia, LaVoie, Donna J, McCoy, Leslie F, Momin, Shahzad S, Paladugula, Neelima, Pendergrast, Elizabeth C, Pfeiffer, Christine M, Powers, Carissa D, Rabinowitz, Daniel, Rybak, Michael E, Schleicher, Rosemary L, Toombs, Bridgette M. H, Xu, Mary, Zhang, Mindy, Castle, Arthur L

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Characterising the loss-of-function impact of 5’ untranslated region variants in 15,708 individuals von Whiffin, Nicola, Karczewski, Konrad J., Zhang, Xiaolei, Chothani, Sonia, Smith, Miriam J., Evans, D. Gareth, Roberts, Angharad M., Quaife, Nicholas M., Schafer, Sebastian, Rackham, Owen, Alföldi, Jessica, O’Donnell-Luria, Anne H., Francioli, Laurent C., Cook, Stuart A., Barton, Paul J. R., MacArthur, Daniel G., Ware, James S.

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Evaluating drug targets through human loss-of-function genetic variation von Minikel, Eric Vallabh, Karczewski, Konrad J., Martin, Hilary C., Cummings, Beryl B., Whiffin, Nicola, Rhodes, Daniel, Alföldi, Jessica, Trembath, Richard C., van Heel, David A., Daly, Mark J., Schreiber, Stuart L., MacArthur, Daniel G.

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The Impact of Recent Tobacco Regulations and COVID-19 Restrictions and Implications for Future E-Cigarette Retail: Perspectives from Vape and Vape-and-Smoke Shop Merchants von Duan, Zongshuan, Romm, Katelyn F, Henriksen, Lisa, Schleicher, Nina C, Johnson, Trent O, Wagener, Theodore L, Sussman, Steven Y, Schillo, Barbara A, Huang, Jidong, Berg, Carla J

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Spinal Cord Injury in Rats Dysregulates Diurnal Rhythms of Fecal Output and Liver Metabolic Indicators von Gaudet, Andrew D, Fonken, Laura K, Ayala, Monica T, Dangelo, Heather M, Smith, Elana J, Bateman, Emily M, Schleicher, Wolfgang E, Maier, Steven F, Watkins, Linda R

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Addendum: The mutational constraint spectrum quantified from variation in 141,456 humans von Gudmundsson, Sanna, Karczewski, Konrad J., Francioli, Laurent C., Tiao, Grace, Cummings, Beryl B., Alföldi, Jessica, Wang, Qingbo, Collins, Ryan L., Laricchia, Kristen M., Ganna, Andrea, Birnbaum, Daniel P., Gauthier, Laura D., Brand, Harrison, Solomonson, Matthew, Watts, Nicholas A., Rhodes, Daniel, Singer-Berk, Moriel, England, Eleina M., Seaby, Eleanor G., Kosmicki, Jack A., Walters, Raymond K., Tashman, Katherine, Farjoun, Yossi, Banks, Eric, Poterba, Timothy, Wang, Arcturus, Seed, Cotton, Whiffin, Nicola, Chong, Jessica X., Samocha, Kaitlin E., Pierce-Hoffman, Emma, Zappala, Zachary, O’Donnell-Luria, Anne H., Minikel, Eric Vallabh, Weisburd, Ben, Lek, Monkol, Ware, James S., Vittal, Christopher, Armean, Irina M., Bergelson, Louis, Cibulskis, Kristian, Connolly, Kristen M., Covarrubias, Miguel, Donnelly, Stacey, Ferriera, Steven, Gabriel, Stacey, Gentry, Jeff, Gupta, Namrata, Jeandet, Thibault, Kaplan, Diane, Llanwarne, Christopher, Munshi, Ruchi, Novod, Sam, Petrillo, Nikelle, Roazen, David, Ruano-Rubio, Valentin, Saltzman, Andrea, Schleicher, Molly, Soto, Jose, Tibbetts, Kathleen, Tolonen, Charlotte, Wade, Gordon, Talkowski, Michael E., Neale, Benjamin M., Daly, Mark J., MacArthur, Daniel G.

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Spinal Cord Injury in Rats Disrupts the Circadian System von Gaudet, Andrew D, Fonken, Laura K, Ayala, Monica T, Bateman, Emily M, Schleicher, Wolfgang E, Smith, Elana J, D'Angelo, Heather M, Maier, Steven F, Watkins, Linda R

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Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3 von Böttcher, Jark, Dilworth, David, Reiser, Ulrich, Neumüller, Ralph A., Schleicher, Michael, Petronczki, Mark, Zeeb, Markus, Mischerikow, Nikolai, Allali-Hassani, Abdellah, Szewczyk, Magdalena M., Li, Fengling, Kennedy, Steven, Vedadi, Masoud, Barsyte-Lovejoy, Dalia, Brown, Peter J., Huber, Kilian V. M., Rogers, Catherine M., Wells, Carrow I., Fedorov, Oleg, Rumpel, Klaus, Zoephel, Andreas, Mayer, Moriz, Wunberg, Tobias, Böse, Dietrich, Zahn, Stephan, Arnhof, Heribert, Berger, Helmut, Reiser, Christoph, Hörmann, Alexandra, Krammer, Teresa, Corcokovic, Maja, Sharps, Bernadette, Winkler, Sandra, Häring, Daniela, Cockcroft, Xiao-Ling, Fuchs, Julian E., Müllauer, Barbara, Weiss-Puxbaum, Alexander, Gerstberger, Thomas, Boehmelt, Guido, Vakoc, Christopher R., Arrowsmith, Cheryl H., Pearson, Mark, McConnell, Darryl B.

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