Unique Metabolic Adaptations Dictate Distal Organ-Specific Metastatic Colonization von Schild, Tanya, Low, Vivien, Blenis, John, Gomes, Ana P.

Volltext

Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression von Li, Zhongchi, Low, Vivien, Luga, Valbona, Sun, Janet, Earlie, Ethan, Parang, Bobak, Shobana Ganesh, Kripa, Cho, Sungyun, Endress, Jennifer, Schild, Tanya, Hu, Mengying, Lyden, David, Jin, Wenbing, Guo, Chunjun, Dephoure, Noah, Cantley, Lewis C., Laughney, Ashley M., Blenis, John

Volltext

NADK is activated by oncogenic signaling to sustain pancreatic ductal adenocarcinoma von Schild, Tanya, McReynolds, Melanie R., Shea, Christie, Low, Vivien, Schaffer, Bethany E., Asara, John M., Piskounova, Elena, Dephoure, Noah, Rabinowitz, Joshua D., Gomes, Ana P., Blenis, John

Volltext

NADK-mediated de novo NADP(H) synthesis is a metabolic adaptation essential for breast cancer metastasis von Ilter, Didem, Drapela, Stanislav, Schild, Tanya, Ward, Nathan P., Adhikari, Emma, Low, Vivien, Asara, John, Oskarsson, Thordur, Lau, Eric K., DeNicola, Gina M., McReynolds, Melanie R., Gomes, Ana P.

Volltext

Revealing de novo pyrimidine synthesis as a key vulnerability in brain tumors von Schild, Tanya, Keshari, Kayvan R.

Volltext

Age-induced accumulation of methylmalonic acid promotes tumour progression von Gomes, Ana P., Ilter, Didem, Low, Vivien, Endress, Jennifer E., Fernández-García, Juan, Rosenzweig, Adam, Schild, Tanya, Broekaert, Dorien, Ahmed, Adnan, Planque, Melanie, Elia, Ilaria, Han, Julie, Kinzig, Charles, Mullarky, Edouard, Mutvei, Anders P., Asara, John, de Cabo, Rafael, Cantley, Lewis C., Dephoure, Noah, Fendt, Sarah-Maria, Blenis, John

Volltext

Adding Polyamine Metabolism to the mTORC1 Toolkit in Cell Growth and Cancer von Gomes, Ana P., Schild, Tanya, Blenis, John

Volltext

Dynamic Incorporation of Histone H3 Variants into Chromatin Is Essential for Acquisition of Aggressive Traits and Metastatic Colonization von Gomes, Ana P., Ilter, Didem, Low, Vivien, Rosenzweig, Adam, Shen, Zih-Jie, Schild, Tanya, Rivas, Martin A., Er, Ekrem E., McNally, Dylan R., Mutvei, Anders P., Han, Julie, Ou, Yi-Hung, Cavaliere, Paola, Mullarky, Edouard, Nagiec, Michal, Shin, Sejeong, Yoon, Sang-Oh, Dephoure, Noah, Massagué, Joan, Melnick, Ari M., Cantley, Lewis C., Tyler, Jessica K., Blenis, John

Volltext

Fructose Treatment Targets Myeloid Leukemogenesis in IDH2 Mutants By Exhausting Alpha-Ketoglutarate Pools von Savino, Angela Maria, Turner, Briana, Jeong, Sangmoo, Schild, Tanya, Yang, Xuejing, Luo, Hanzhi, Chirayil, Rachel, Cullen, Quinlan, Chan, Mandy, Han, Grace, Chang, Kathryn, Raman, Sudha Janaki, Cross, Justin R, Keshari, Kayvan, Kharas, Michael G

Volltext

Altered propionate metabolism contributes to tumour progression and aggressiveness von Gomes, Ana P., Ilter, Didem, Low, Vivien, Drapela, Stanislav, Schild, Tanya, Mullarky, Edouard, Han, Julie, Elia, Ilaria, Broekaert, Dorien, Rosenzweig, Adam, Nagiec, Michal, Nunes, Joana B., Schaffer, Bethany E., Mutvei, Anders P., Asara, John M., Cantley, Lewis C., Fendt, Sarah-Maria, Blenis, John

Volltext

Abstract 2890: Investigating dynamic IDO-Kyn-Ahr pathway induced tumor immunosuppression using imaging modality to optimize therapeutic Intervention von Bah, Mamadou Alpha, Serganova, Inna, Budhu, Sadna, Schild, Tanya, Khan, Jonathan F., Keshari, Kayvan R., Wolchok, Jedd D., Merghoub, Taha

Volltext

Interferon α/β Enhances the Cytotoxic Response of MEK Inhibition in Melanoma von Litvin, Oren, Schwartz, Sarit, Wan, Zhenmao, Schild, Tanya, Rocco, Mark, Oh, Nul Loren, Chen, Bo-Juen, Goddard, Noel, Pratilas, Christine, Pe’er, Dana

Volltext

Age-induced accumulation of methylmalonic acid promotes tumour progression von Gomes, Ana P, Ilter, Didem, Low, Vivien, Endress, Jennifer E, Fernandez-Garcia, Juan, Rosenzweig, Adam, Schild, Tanya, Broekaert, Dorien, Ahmed, Adnan, Planque, Melanie, Elia, Ilaria, Han, Julie, Kinzig, Charles, Mullarky, Edouard, Mutvei, Anders P, Asara, John, de Cabo, Rafael, Cantley, Lewis C, Dephoure, Noah, Fendt, Sarah-Maria, Blenis, John

Volltext

Age-induced methylmalonic acid accumulation promotes tumor progression von Gomes, Ana P., Ilter, Didem, Low, Vivien, Endress, Jennifer E., Fernández-García, Juan, Rosenzweig, Adam, Schild, Tanya, Broekaert, Dorien, Ahmed, Adnan, Planque, Melanie, Elia, Ilaria, Han, Julie, Kinzig, Charles, Mullarky, Edouard, Mutvei, Anders P., Asara, John, de Cabo, Rafael, Cantley, Lewis C., Dephoure, Noah, Fendt, Sarah-Maria, Blenis, John

Volltext

Inhibition of Treg suppression by GITR stimulation causes tumor regression selectively in the context of a pro-inflammatory tumor microenvironment (TUM9P.1005) von Zappasodi, Roberta, Budhu, Sadna, Decicco, Emily, Schild, Tanya, Draleau, Kyle, Schaer, David, Yang, Xia, Merghoub, Taha, Wolchok, Jedd

Volltext

Abstract 5236: Novel network analysis framework identifies context-specific drug combinations in melanoma von Litvin, Oren, Schwartz, Sarit, Rocco, Mark, Schild, Tanya, Rosen, Neal, Pe'er, Dana

Volltext

Altered propionate metabolism contributes to tumour progression and aggressiveness von Gomes, Ana P, Ilter, Didem, Low, Vivien, Drapela, Stanislav, Schild, Tanya, Mullarky, Edouard, Han, Julie, Elia, Ilaria, Broekaert, Dorien, Rosenzweig, Adam, Nagiec, Michal, Nunes, Joana B, Schaffer, Bethany E, Mutvei, Anders P, Asara, John M, Cantley, Lewis C, Fendt, Sarah-Maria, Blenis, John

Volltext

Abstract IA30: Towards rationale therapy: Dealing with intertumor and intratumor heterogeneity von Amir, El-ad David, Litvin, Oren, Levine, Jacob, Bendall, Sean C., Davis, Kara L., Simonds, Erin F., Schild, Tanya, Rocco, Mark, Rosen, Neal, Nolan, Garry P., Pe'er, Dana

Volltext

NADK is activated by oncogenic signaling to sustain pancreatic ductal adenocarcinoma. Schild et al von Schild, Tanya

Volltext bestellen

NADK is activated by oncogenic signaling to sustain pancreatic ductal adenocarcinoma. Schild et al von Schild, Tanya

Volltext bestellen