Target identification and mechanism of action in chemical biology and drug discovery von Schenone, Monica, Dančík, Vlado, Wagner, Bridget K, Clemons, Paul A

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The NORAD lncRNA assembles a topoisomerase complex critical for genome stability von Munschauer, Mathias, Nguyen, Celina T., Sirokman, Klara, Hartigan, Christina R., Hogstrom, Larson, Engreitz, Jesse M., Ulirsch, Jacob C., Fulco, Charles P., Subramanian, Vidya, Chen, Jenny, Schenone, Monica, Guttman, Mitchell, Carr, Steven A., Lander, Eric S.

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Lenalidomide Causes Selective Degradation of IKZF1 and IKZF3 in Multiple Myeloma Cells von Krönke, Jan, Udeshi, Namrata D., Narla, Anupama, Grauman, Peter, Hurst, Slater N., McConkey, Marie, Svinkina, Tanya, Heckl, Dirk, Comer, Eamon, Li, Xiaoyu, Ciarlo, Christie, Hartman, Emily, Munshi, Nikhil, Schenone, Monica, Schreiber, Stuart L., Carr, Steven A., Ebert, Benjamin L

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The lncRNA lincNMR regulates nucleotide metabolism via a YBX1 - RRM2 axis in cancer von Gandhi, Minakshi, Groß, Matthias, Holler, Jessica M., Coggins, Si’Ana A., Patil, Nitin, Leupold, Joerg H., Munschauer, Mathias, Schenone, Monica, Hartigan, Christina R., Allgayer, Heike, Kim, Baek, Diederichs, Sven

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Selective killing of cancer cells by a small molecule targeting the stress response to ROS von Raj, Lakshmi, Ide, Takao, Gurkar, Aditi U., Foley, Michael, Schenone, Monica, Li, Xiaoyu, Tolliday, Nicola J., Golub, Todd R., Carr, Steven A., Shamji, Alykhan F., Stern, Andrew M., Mandinova, Anna, Schreiber, Stuart L., Lee, Sam W.

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Control of human hemoglobin switching by LIN28B-mediated regulation of BCL11A translation von Basak, Anindita, Munschauer, Mathias, Lareau, Caleb A., Montbleau, Kara E., Ulirsch, Jacob C., Hartigan, Christina R., Schenone, Monica, Lian, John, Wang, Yaomei, Huang, Yumin, Wu, Xianfang, Gehrke, Lee, Rice, Charles M., An, Xiuli, Christou, Helen A., Mohandas, Narla, Carr, Steven A., Chen, Jane-Jane, Orkin, Stuart H., Lander, Eric S., Sankaran, Vijay G.

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Binding of TMPRSS2-ERG to BAF Chromatin Remodeling Complexes Mediates Prostate Oncogenesis von Sandoval, Gabriel J., Pulice, John L., Pakula, Hubert, Schenone, Monica, Takeda, David Y., Pop, Marius, Boulay, Gaylor, Williamson, Kaylyn E., McBride, Matthew J., Pan, Joshua, St. Pierre, Roodolph, Hartman, Emily, Garraway, Levi A., Carr, Steven A., Rivera, Miguel N., Li, Zhe, Ronco, Lucienne, Hahn, William C., Kadoch, Cigall

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Constitutively active autophagy in macrophages dampens inflammation through metabolic and post-transcriptional regulation of cytokine production von Xu, Jinjin, Kong, Lingjia, Oliver, Blayne A., Li, Bihua, Creasey, Elizabeth A., Guzman, Gaelen, Schenone, Monica, Carey, Kimberly L., Carr, Steven A., Graham, Daniel B., Deguine, Jacques, Xavier, Ramnik J.

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BRG1 Loss Predisposes Lung Cancers to Replicative Stress and ATR Dependency von Gupta, Manav, Concepcion, Carla P, Fahey, Caroline G, Keshishian, Hasmik, Bhutkar, Arjun, Brainson, Christine F, Sanchez-Rivera, Francisco J, Pessina, Patrizia, Kim, Jonathan Y, Simoneau, Antoine, Paschini, Margherita, Beytagh, Mary C, Stanclift, Caroline R, Schenone, Monica, Mani, D R, Li, Chendi, Oh, Audris, Li, Fei, Hu, Hai, Karatza, Angeliki, Bronson, Roderick T, Shaw, Alice T, Hata, Aaron N, Wong, Kwok-Kin, Zou, Lee, Carr, Steven A, Jacks, Tyler, Kim, Carla F

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Identifying the Proteins to Which Small-Molecule Probes and Drugs Bind in Cells von Ong, Shao-En, Schenone, Monica, Margolin, Adam A., Li, Xiaoyu, Do, Kathy, Doud, Mary K., Mani, D. R., Kuai, Letian, Wang, Xiang, Wood, John L., Tolliday, Nicola J., Koehler, Angela N., Marcaurelle, Lisa A., Golub, Todd R., Gould, Robert J., Schreiber, Stuart L., Carr, Steven A.

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Cohesin mutations alter DNA damage repair and chromatin structure and create therapeutic vulnerabilities in MDS/AML von Tothova, Zuzana, Valton, Anne-Laure, Gorelov, Rebecca A, Vallurupalli, Mounica, Krill-Burger, John M, Holmes, Amie, Landers, Catherine C, Haydu, J Erika, Malolepsza, Edyta, Hartigan, Christina, Donahue, Melanie, Popova, Katerina D, Koochaki, Sebastian, Venev, Sergey V, Rivera, Jeanne, Chen, Edwin, Lage, Kasper, Schenone, Monica, D'Andrea, Alan D, Carr, Steven A, Morgan, Elizabeth A, Dekker, Job, Ebert, Benjamin L

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Castration Resistance in Prostate Cancer Is Mediated by the Kinase NEK6 von Choudhury, Atish D, Schinzel, Anna C, Cotter, Maura B, Lis, Rosina T, Labella, Katherine, Lock, Ying Jie, Izzo, Francesca, Guney, Isil, Bowden, Michaela, Li, Yvonne Y, Patel, Jinal, Hartman, Emily, Carr, Steven A, Schenone, Monica, Jaffe, Jacob D, Kantoff, Philip W, Hammerman, Peter S, Hahn, William C

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TMEM258 Is a Component of the Oligosaccharyltransferase Complex Controlling ER Stress and Intestinal Inflammation von Graham, Daniel B., Lefkovith, Ariel, Deelen, Patrick, de Klein, Niek, Varma, Mukund, Boroughs, Angela, Desch, A. Nicole, Ng, Aylwin C.Y., Guzman, Gaelen, Schenone, Monica, Petersen, Christine P., Bhan, Atul K., Rivas, Manuel A., Daly, Mark J., Carr, Steven A., Wijmenga, Cisca, Xavier, Ramnik J.

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Phenotypic drug discovery: recent successes, lessons learned and new directions von Vincent, Fabien, Nueda, Arsenio, Lee, Jonathan, Schenone, Monica, Prunotto, Marco, Mercola, Mark

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Chromatin regulator SMARCAL1 modulates cellular lipid metabolism von Nagai, Taylor Hanta, Hartigan, Chrissy, Mizoguchi, Taiji, Yu, Haojie, Deik, Amy, Bullock, Kevin, Wang, Yanyan, Cromley, Debra, Schenone, Monica, Cowan, Chad A., Rader, Daniel J., Clish, Clary B., Carr, Steven A., Xu, Yu-Xin

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Integrated Genomics of Crohn’s Disease Risk Variant Identifies a Role for CLEC12A in Antibacterial Autophagy von Begun, Jakob, Lassen, Kara G., Jijon, Humberto B., Baxt, Leigh A., Goel, Gautam, Heath, Robert J., Ng, Aylwin, Tam, Jenny M., Kuo, Szu-Yu, Villablanca, Eduardo J., Fagbami, Lola, Oosting, Marije, Kumar, Vinod, Schenone, Monica, Carr, Steven A., Joosten, Leo A.B., Vyas, Jatin M., Daly, Mark J., Netea, Mihai G., Brown, Gordon D., Wijmenga, Cisca, Xavier, Ramnik J.

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Protein interaction networks in the vasculature prioritize genes and pathways underlying coronary artery disease von Zhu, Qiuyu Martin, Hsu, Yu-Han H., Lassen, Frederik H., MacDonald, Bryan T., Stead, Stephanie, Malolepsza, Edyta, Kim, April, Li, Taibo, Mizoguchi, Taiji, Schenone, Monica, Guzman, Gaelen, Tanenbaum, Benjamin, Fornelos, Nadine, Carr, Steven A., Gupta, Rajat M., Ellinor, Patrick T., Lage, Kasper

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Identification of a Novel Regulator of Clostridioides difficile Cortex Formation von Touchette, Megan H, Benito de la Puebla, Hector, Alves Feliciano, Carolina, Tanenbaum, Benjamin, Schenone, Monica, Carr, Steven A, Shen, Aimee

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Empirical Bayes analysis of quantitative proteomics experiments von Margolin, Adam A, Ong, Shao-En, Schenone, Monica, Gould, Robert, Schreiber, Stuart L, Carr, Steven A, Golub, Todd R

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Correction: Corrigendum: Selective killing of cancer cells by a small molecule targeting the stress response to ROS von Raj, Lakshmi, Ide, Takao, Gurkar, Aditi U., Foley, Michael, Schenone, Monica, Li, Xiaoyu, Tolliday, Nicola J., Golub, Todd R., Carr, Steven A., Shamji, Alykhan F., Stern, Andrew M., Mandinova, Anna, Schreiber, Stuart L., Lee, Sam W.

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