A potent and selective PARP14 inhibitor decreases protumor macrophage gene expression and elicits inflammatory responses in tumor explants von Schenkel, Laurie B., Molina, Jennifer R., Swinger, Kerren K., Abo, Ryan, Blackwell, Danielle J., Lu, Alvin Z., Cheung, Anne E., Church, W. David, Kunii, Kaiko, Kuplast-Barr, Kristy G., Majer, Christina R., Minissale, Elena, Mo, Jan-Rung, Niepel, Mario, Reik, Christopher, Ren, Yue, Vasbinder, Melissa M., Wigle, Tim J., Richon, Victoria M., Keilhack, Heike, Kuntz, Kevin W.

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Optimization of a Novel Quinazolinone-Based Series of Transient Receptor Potential A1 (TRPA1) Antagonists Demonstrating Potent in Vivo Activity von Schenkel, Laurie B, Olivieri, Philip R, Boezio, Alessandro A, Deak, Holly L, Emkey, Renee, Graceffa, Russell F, Gunaydin, Hakan, Guzman-Perez, Angel, Lee, Josie H, Teffera, Yohannes, Wang, Weiya, Youngblood, Beth D, Yu, Violeta L, Zhang, Maosheng, Gavva, Narender R, Lehto, Sonya G, Geuns-Meyer, Stephanie

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Application of a Parallel Synthetic Strategy in the Discovery of Biaryl Acyl Sulfonamides as Efficient and Selective NaV1.7 Inhibitors von DiMauro, Erin F, Altmann, Stephen, Berry, Loren M, Bregman, Howard, Chakka, Nagasree, Chu-Moyer, Margaret, Bojic, Elma Feric, Foti, Robert S, Fremeau, Robert, Gao, Hua, Gunaydin, Hakan, Guzman-Perez, Angel, Hall, Brian E, Huang, Hongbing, Jarosh, Michael, Kornecook, Thomas, Lee, Josie, Ligutti, Joseph, Liu, Dong, Moyer, Bryan D, Ortuno, Daniel, Rose, Paul E, Schenkel, Laurie B, Taborn, Kristin, Wang, Jean, Wang, Yan, Yu, Violeta, Weiss, Matthew M

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In Vitro and Cellular Probes to Study PARP Enzyme Target Engagement von Wigle, Tim J., Blackwell, Danielle J., Schenkel, Laurie B., Ren, Yue, Church, W. David, Desai, Hetvi J., Swinger, Kerren K., Santospago, Andrew G., Majer, Christina R., Lu, Alvin Z., Niepel, Mario, Perl, Nicholas R., Vasbinder, Melissa M., Keilhack, Heike, Kuntz, Kevin W.

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Targeted Degradation of PARP14 Using a Heterobifunctional Small Molecule von Wigle, Tim J., Ren, Yue, Molina, Jennifer R., Blackwell, Danielle J., Schenkel, Laurie B., Swinger, Kerren K., Kuplast‐Barr, Kristy, Majer, Christina R., Church, W. David, Lu, Alvin Z., Mo, Jason, Abo, Ryan, Cheung, Anne, Dorsey, Bryan W., Niepel, Mario, Perl, Nicholas R., Vasbinder, Melissa M., Keilhack, Heike, Kuntz, Kevin W.

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Preclinical Evaluation of AMG 900, a Novel Potent and Highly Selective Pan-Aurora Kinase Inhibitor with Activity in Taxane-Resistant Tumor Cell Lines von PAYTON, Marc, BUSH, Tammy L, NHO NGUYEN, Hanh, OLIVIERI, Philip R, ROMERO, Karina, SCHENKEL, Laurie B, BAK, Annette, STANTON, Mary, DUSSAULT, Isabelle, PATEL, Vinod F, GEUNS-MEYER, Stephanie, RADINSKY, Robert, CHUNG, Grace, KENDALL, Richard L, ZIEGLER, Beth, EDEN, Patrick, MCELROY, Patricia, ROSS, Sandra, CEE, Victor J, DEAK, Holly L, HODOUS, Brian L

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New Air-Stable Catalysts for General and Efficient Suzuki−Miyaura Cross-Coupling Reactions of Heteroaryl Chlorides von Guram, Anil S, King, Anthony O, Allen, John G, Wang, Xianghong, Schenkel, Laurie B, Chan, Johann, Bunel, Emilio E, Faul, Margaret M, Larsen, Robert D, Martinelli, Michael J, Reider, Paul J

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Discovery of N‑(4-(3-(2-Aminopyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine (AMG 900), A Highly Selective, Orally Bioavailable Inhibitor of Auro... von Geuns-Meyer, Stephanie, Cee, Victor J, Deak, Holly L, Du, Bingfan, Hodous, Brian L, Nguyen, Hanh Nho, Olivieri, Philip R, Schenkel, Laurie B, Vaida, Karina R, Andrews, Paul, Bak, Annette, Be, Xuhai, Beltran, Pedro J, Bush, Tammy L, Chaves, Mary K, Chung, Grace, Dai, Yang, Eden, Patrick, Hanestad, Kelly, Huang, Liyue, Lin, Min-Hwa Jasmine, Tang, Jin, Ziegler, Beth, Radinsky, Robert, Kendall, Richard, Patel, Vinod F, Payton, Marc

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Discovery of a biarylamide series of potent, state-dependent NaV1.7 inhibitors von Schenkel, Laurie B., DiMauro, Erin F., Nguyen, Hanh N., Chakka, Nagasree, Du, Bingfan, Foti, Robert S., Guzman-Perez, Angel, Jarosh, Michael, La, Daniel S., Ligutti, Joseph, Milgram, Benjamin C., Moyer, Bryan D., Peterson, Emily A., Roberts, John, Yu, Violeta L., Weiss, Matthew M.

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Synthesis of 4-Substituted Chlorophthalazines, Dihydrobenzoazepinediones, 2-Pyrazolylbenzoic Acid, and 2-Pyrazolylbenzohydrazide via 3-Substituted 3-Hydroxyisoindolin-1-ones von Nguyen, Hanh Nho, Cee, Victor J, Deak, Holly L, Du, Bingfan, Faber, Kathleen Panter, Gunaydin, Hakan, Hodous, Brian L, Hollis, Steven L, Krolikowski, Paul H, Olivieri, Philip R, Patel, Vinod F, Romero, Karina, Schenkel, Laurie B, Geuns-Meyer, Stephanie D

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Forced Self-Modification Assays as a Strategy to Screen MonoPARP Enzymes von Wigle, Tim J., Church, W. David, Majer, Christina R., Swinger, Kerren K., Aybar, Demet, Schenkel, Laurie B., Vasbinder, Melissa M., Brendes, Arne, Beck, Claudia, Prahm, Martin, Wegener, Dennis, Chang, Paul, Kuntz, Kevin W.

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Development of novel azabenzofuran TRPA1 antagonists as in vivo tools von Copeland, Katrina W, Boezio, Alessandro A, Cheung, Eugene, Lee, Josie, Olivieri, Philip, Schenkel, Laurie B, Wan, Qian, Wang, Weiya, Wells, Mary C, Youngblood, Beth, Gavva, Narender R, Lehto, Sonya G, Geuns-Meyer, Stephanie

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Discovery of Potent and Highly Selective Thienopyridine Janus Kinase 2 Inhibitors von Schenkel, Laurie B, Huang, Xin, Cheng, Alan, Deak, Holly L, Doherty, Elizabeth, Emkey, Renee, Gu, Yan, Gunaydin, Hakan, Kim, Joseph L, Lee, Josie, Loberg, Robert, Olivieri, Philip, Pistillo, Jeanne, Tang, Jin, Wan, Qian, Wang, Hui-Ling, Wang, Shen-Wu, Wells, Mary C, Wu, Bin, Yu, Violeta, Liu, Liqin, Geuns-Meyer, Stephanie

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Differential selectivity of JAK2 inhibitors in enzymatic and cellular settings von Yu, Violeta, Pistillo, Jeanne, Archibeque, Ivonne, Han Lee, Josie, Sun, Bee-Chun, Schenkel, Laurie B, Geuns-Meyer, Stephanie, Liu, Liqin, Emkey, Renee

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Application of P,N-Sulfinyl Imine Ligands to Iridium-Catalyzed Asymmetric Hydrogenation of Olefins von Schenkel, Laurie B, Ellman, Jonathan A

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Selective Pharmaceutical Inhibition of PARP14 Mitigates Allergen-Induced IgE and Mucus Overproduction in a Mouse Model of Pulmonary Allergic Response von Eddie, Alex M, Chen, Kevin W, Schenkel, Laurie B, Swinger, Kerren K, Molina, Jennifer R, Kunii, Kaiko, Raybuck, Ariel L, Keilhack, Heike, Gibson-Corley, Katherine N, Niepel, Mario, Peebles, R Stokes, Boothby, Mark R, Cho, Sung Hoon

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Selective antagonism of TRPA1 produces limited efficacy in models of inflammatory- and neuropathic-induced mechanical hypersensitivity in rats von Lehto, Sonya G, Weyer, Andy D, Youngblood, Beth D, Zhang, Maosheng, Yin, Ruoyuan, Wang, Weiya, Teffera, Yohannes, Cooke, Melanie, Stucky, Cheryl L, Schenkel, Laurie, Geuns-Meyer, Stephanie, Moyer, Bryan D, Wild, Kenneth D, Gavva, Narender R

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Novel Sulfinyl Imine Ligands for Asymmetric Catalysis von Schenkel, Laurie B, Ellman, Jonathan A

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Discovery of a Potent, Selective, and Orally Bioavailable Pyridinyl-Pyrimidine Phthalazine Aurora Kinase Inhibitor von Cee, Victor J, Schenkel, Laurie B, Hodous, Brian L, Deak, Holly L, Nguyen, Hanh N, Olivieri, Philip R, Romero, Karina, Bak, Annette, Be, Xuhai, Bellon, Steve, Bush, Tammy L, Cheng, Alan C, Chung, Grace, Coats, Steve, Eden, Patrick M, Hanestad, Kelly, Gallant, Paul L, Gu, Yan, Huang, Xin, Kendall, Richard L, Lin, Min-Hwa Jasmine, Morrison, Michael J, Patel, Vinod F, Radinsky, Robert, Rose, Paul E, Ross, Sandra, Sun, Ji-Rong, Tang, Jin, Zhao, Huilin, Payton, Marc, Geuns-Meyer, Stephanie D

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Discovery of triazine-benzimidazoles as selective inhibitors of mTOR von Peterson, Emily A., Andrews, Paul S., Be, Xuhai, Boezio, Alessandro A., Bush, Tammy L., Cheng, Alan C., Coats, James R., Colletti, Adria E., Copeland, Katrina W., DuPont, Michelle, Graceffa, Russell, Grubinska, Barbara, Harmange, Jean-Christophe, Kim, Joseph L., Mullady, Erin L., Olivieri, Philip, Schenkel, Laurie B., Stanton, Mary K., Teffera, Yohannes, Whittington, Douglas A., Cai, Ti, La, Daniel S.

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