Transplantation of engineered organoids enables rapid generation of metastatic mouse models of colorectal cancer von O'Rourke, Kevin P, Loizou, Evangelia, Livshits, Geulah, Schatoff, Emma M, Baslan, Timour, Manchado, Eusebio, Simon, Janelle, Romesser, Paul B, Leach, Benjamin, Han, Teng, Pauli, Chantal, Beltran, Himisha, Rubin, Mark A, Dow, Lukas E, Lowe, Scott W

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R-Spondin chromosome rearrangements drive Wnt-dependent tumour initiation and maintenance in the intestine von Han, Teng, Schatoff, Emma M., Murphy, Charles, Zafra, Maria Paz, Wilkinson, John E., Elemento, Olivier, Dow, Lukas E.

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An In Vivo Kras Allelic Series Reveals Distinct Phenotypes of Common Oncogenic Variants von Zafra, Maria Paz, Parsons, Marie J, Kim, Jangkyung, Alonso-Curbelo, Direna, Goswami, Sukanya, Schatoff, Emma M, Han, Teng, Katti, Alyna, Fernandez, Maria Teresa Calvo, Wilkinson, John E, Piskounova, Elena, Dow, Lukas E

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Distinct Colorectal Cancer-Associated APC Mutations Dictate Response to Tankyrase Inhibition von Schatoff, Emma M, Goswami, Sukanya, Zafra, Maria Paz, Foronda, Miguel, Shusterman, Michael, Leach, Benjamin I, Katti, Alyna, Diaz, Bianca J, Dow, Lukas E

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Exploiting the Therapeutic Interaction of WNT Pathway Activation and Asparaginase for Colorectal Cancer Therapy von Hinze, Laura, Labrosse, Roxane, Degar, James, Han, Teng, Schatoff, Emma M, Schreek, Sabine, Karim, Salmaan, McGuckin, Connor, Sacher, Joshua R, Wagner, Florence, Stanulla, Martin, Yuan, Chen, Sicinska, Ewa, Giannakis, Marios, Ng, Kimmie, Dow, Lukas E, Gutierrez, Alejandro

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Tankyrase inhibition sensitizes cells to CDK4 blockade von Foronda, Miguel, Tarumoto, Yusuke, Schatoff, Emma M, Leach, Benjamin I, Diaz, Bianca J, Zimmerman, Jill, Goswami, Sukanya, Shusterman, Michael, Vakoc, Christopher R, Dow, Lukas E

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WNT Signaling and Colorectal Cancer von Schatoff, Emma M., Leach, Benjamin I., Dow, Lukas E.

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Detection of Marker-Free Precision Genome Editing and Genetic Variation through the Capture of Genomic Signatures von Billon, Pierre, Nambiar, Tarun S., Hayward, Samuel B., Zafra, Maria P., Schatoff, Emma M., Oshima, Koichi, Dunbar, Andrew, Breinig, Marco, Park, Young C., Ryu, Han S., Tschaharganeh, Darjus F., Levine, Ross L., Baer, Richard, Ferrando, Adolfo, Dow, Lukas E., Ciccia, Alberto

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Optimized base editors enable efficient editing in cells, organoids and mice von Zafra, Maria Paz, Schatoff, Emma M, Katti, Alyna, Foronda, Miguel, Breinig, Marco, Schweitzer, Anabel Y, Simon, Amber, Han, Teng, Goswami, Sukanya, Montgomery, Emma, Thibado, Jordana, Kastenhuber, Edward R, Sánchez-Rivera, Francisco J, Shi, Junwei, Vakoc, Christopher R, Lowe, Scott W, Tschaharganeh, Darjus F, Dow, Lukas E

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Dietary fructose improves intestinal cell survival and nutrient absorption von Taylor, Samuel R., Ramsamooj, Shakti, Liang, Roger J., Katti, Alyna, Pozovskiy, Rita, Vasan, Neil, Hwang, Seo-Kyoung, Nahiyaan, Navid, Francoeur, Nancy J., Schatoff, Emma M., Johnson, Jared L., Shah, Manish A., Dannenberg, Andrew J., Sebra, Robert P., Dow, Lukas E., Cantley, Lewis C., Rhee, Kyu Y., Goncalves, Marcus D.

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Base editing the mammalian genome von Schatoff, Emma M., Zafra, Maria Paz, Dow, Lukas E.

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D-dimer cut-off points and risk of venous thromboembolism in adult hospitalized patients with COVID-19 von Choi, Justin J., Wehmeyer, Graham T., Li, Han A., Alshak, Mark N., Nahid, Musarrat, Rajan, Mangala, Liu, Bethina, Schatoff, Emma M., Elahjji, Rahmi, Abdelghany, Youmna, D'Angelo, Debra, Crossman, Daniel, Evans, Arthur T., Steel, Peter, Pinheiro, Laura C., Goyal, Parag, Safford, Monika M., Mints, Gregory, DeSancho, Maria T.

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In situ CRISPR‐Cas9 base editing for the development of genetically engineered mouse models of breast cancer von Annunziato, Stefano, Lutz, Catrin, Henneman, Linda, Bhin, Jinhyuk, Wong, Kim, Siteur, Bjørn, van Gerwen, Bas, de Korte‐Grimmerink, Renske, Zafra, Maria Paz, Schatoff, Emma M, Drenth, Anne Paulien, van der Burg, Eline, Eijkman, Timo, Mukherjee, Siddhartha, Boroviak, Katharina, Wessels, Lodewyk FA, van de Ven, Marieke, Huijbers, Ivo J, Adams, David J, Dow, Lukas E, Jonkers, Jos

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Adenine base editing in an adult mouse model of tyrosinaemia von Song, Chun-Qing, Jiang, Tingting, Richter, Michelle, Rhym, Luke H., Koblan, Luke W., Zafra, Maria Paz, Schatoff, Emma M., Doman, Jordan L., Cao, Yueying, Dow, Lukas E., Zhu, Lihua Julie, Anderson, Daniel G, Liu, David R., Yin, Hao, Xue, Wen

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Endogenous spacing enables co-processing of microRNAs and efficient combinatorial RNAi von Amen, Alexandra M., Loughran, Ryan M., Huang, Chun-Hao, Lew, Rachel J., Ravi, Archna, Guan, Yuanzhe, Schatoff, Emma M., Dow, Lukas E., Emerling, Brooke M., Fellmann, Christof

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Abstract PR06: An in vivo KRAS allelic series reveals distinct phenotypes of common oncogenic variants von Zafra, Maria Paz, Alonso-Curbelo, Direna, Goswami, Sukanya, Schatoff, Emma M, Han, Teng, Wilkinson, John E., Dow, Lukas E.

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Abstract LB-089: Targeting WNT signaling in vivo via Tankyrase inhibition von Schatoff, Emma M., Leach, Benjamin I., Foronda, Miguel, Zafra, Maria Paz, Goswami, Sukanya, Dow, Lukas E.

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Abstract LB-040: New conditional Kras-alleles generated by CRISPR-based genome editing to model tumor initiation von Zafra, Maria Paz, Schatoff, Emma M., Han, Teng, Dow, Lukas E.

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Abstract B32: Targeting WNT signaling in vivo via Tankyrase inhibition von Schatoff, Emma M., Leach, Benjamin I., Foronda, Miguel, Zafra, Maria Paz, Dow, Lukas

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Abstract A18: Generation of new conditional Kras-alleles by CRISPR-based genome editing von Zafra, Maria Paz, Schatoff, Emma M., Han, Teng, Dow, Lukas E.

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