Pediatric and adult H3 K27M-mutant diffuse midline glioma treated with the selective DRD2 antagonist ONC201 von Chi, Andrew S., Tarapore, Rohinton S., Hall, Matthew D., Shonka, Nicole, Gardner, Sharon, Umemura, Yoshie, Sumrall, Ashley, Khatib, Ziad, Mueller, Sabine, Kline, Cassie, Zaky, Wafik, Khatua, Soumen, Weathers, Shiao-Pei, Odia, Yazmin, Niazi, Toba N., Daghistani, Doured, Cherrick, Irene, Korones, David, Karajannis, Matthias A., Kong, Xiao-Tang, Minturn, Jane, Waanders, Angela, Arillaga-Romany, Isabel, Batchelor, Tracy, Wen, Patrick Y., Merdinger, Krystal, Schalop, Lee, Stogniew, Martin, Allen, Joshua E., Oster, Wolfgang, Mehta, Minesh P.

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ONC201 and imipridones: Anti-cancer compounds with clinical efficacy von Prabhu, Varun Vijay, Morrow, Sara, Rahman Kawakibi, Abed, Zhou, Lanlan, Ralff, Marie, Ray, Jocelyn, Jhaveri, Aakash, Ferrarini, Isacco, Lee, Young, Parker, Cassandra, Zhang, Yiqun, Borsuk, Robyn, Chang, Wen-I, Honeyman, Joshua N., Tavora, Fabio, Carneiro, Benedito, Raufi, Alexander, Huntington, Kelsey, Carlsen, Lindsey, Louie, Anna, Safran, Howard, Seyhan, Attila A., Tarapore, Rohinton S., Schalop, Lee, Stogniew, Martin, Allen, Joshua E., Oster, Wolfgang, El-Deiry, Wafik S.

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Discovery and clinical introduction of first-in-class imipridone ONC201 von Allen, Joshua E, Kline, C Leah B, Prabhu, Varun V, Wagner, Jessica, Ishizawa, Jo, Madhukar, Neel, Lev, Avital, Baumeister, Marie, Zhou, Lanlan, Lulla, Amriti, Stogniew, Martin, Schalop, Lee, Benes, Cyril, Kaufman, Howard L, Pottorf, Richard S, Nallaganchu, B Rao, Olson, Gary L, Al-Mulla, Fahd, Duvic, Madeleine, Wu, Gen Sheng, Dicker, David T, Talekar, Mala K, Lim, Bora, Elemento, Olivier, Oster, Wolfgang, Bertino, Joseph, Flaherty, Keith, Wang, Michael L, Borthakur, Gautam, Andreeff, Michael, Stein, Mark, El-Deiry, Wafik S

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Integrated stress response and immune cell infiltration in an ibrutinib‐refractory mantle cell lymphoma patient following ONC201 treatment von Romaguera, Jorge E., Lee, Hun J., Tarapore, Rohinton, Prabhu, Varun, Allen, Joshua, Schalop, Lee, Zloza, Andrew, Ok, Chi Y., Sadimin, Evita T., Schenkel, Jason, Badillo, Maria, Wang, Michael

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Integrated stress response and immune cell infiltration in an ibrutinib‐refractory mantle cell lymphoma patient following ONC 201 treatment von Romaguera, Jorge E., Lee, Hun J., Tarapore, Rohinton, Prabhu, Varun, Allen, Joshua, Schalop, Lee, Zloza, Andrew, Ok, Chi Y., Sadimin, Evita T., Schenkel, Jason, Badillo, Maria, Wang, Michael

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First-in-class small molecule ONC201 in b-cell malignancies von Lee, Hun Ju, Andreeff, Michael, Benes, Cyril, Allen, Joshua E., Schalop, Lee, Oster, Wolfgang, Wang, Michael

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Integrated Stress Response and Immune Cell Infiltration in an Ibrutinib-Refractory Mantle Cell Lymphoma Patient Following ONC201 Treatment von Romaguera, Jorge Enrique, Lee, Hun Ju, Tarapore, Rohinton, Prabhu, Varun Vijay, Allen, Joshua E., Schalop, Lee, Zloza, Andrew, Ok, Chi Young, Badillo, Maria, Wang, Michael

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Integrated clinical experience with ONC201 in H3 K27M glioma von Chi, Andrew S., Gardner, Sharon L., Arrillaga, Isabel, Wen, Patrick Y., Batchelor, Tracy, Hall, Matthew David, Odia, Yazmin, Zaky, Wafik Tharwat, Khatua, Soumen, Shonka, Nicole A., Khatib, Ziad, Tarapore, Rohinton, Schalop, Lee, Allen, Joshua E., Oster, Wolfgang, Mehta, Minesh P.

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DIPG-42. CAN WE CHANGE THE LANDSCAPE OF PEDIATRIC DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG)? FIRST DEMONSTRATION OF CLINICAL AND RADIOGRAPHIC RESPONSE IN A PEDIATRIC H3-K27M MUTATED... von Hall, Matthew, Odia, Yazmin, Allen, Joshua, Tarapore, Rohinton, Khatib, Ziad, Maher, Ossama, Niazi, Toba, Daghistani, Doured, Schalop, Lee, Chi, Andrew, Oster, Wolfgang, Mehta, Minesh

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Abstract 4826: ONC212 exhibits increased cytotoxicity relative to ONC201 in a subset of human pancreatic cancer cell lines von Lev, Avital, Wagner, Jessica, Dicker, David T., Stogniew, Martin, Allen, Joshua E., Schalop, Lee, Oster, Wolfgang, Olson, Gary L., El-Deiry, Wafik S.

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Correction: Discovery and clinical introduction of first-in-class imipridone ONC201 von Allen, Joshua E., Kline, C. Leah B., Prabhu, Varun V., Wagner, Jessica, Ishizawa, Jo, Madhukar, Neel, Lev, Avital, Baumeister, Marie, Zhou, Lanlan, Lulla, Amriti, Stogniew, Martin, Schalop, Lee, Benes, Cyril, Kaufman, Howard L., Pottorf, Richard S., Nallaganchu, B. Rao, Olson, Gary L., Al-Mulla, Fahd, Duvic, Madeleine, Wu, Gen Sheng, Dicker, David T., Talekar, Mala K., Lim, Bora, Elemento, Olivier, Oster, Wolfgang, Bertino, Joseph, Flaherty, Keith, Wang, Michael L., Borthakur, Gautam, Andreeff, Michael, Stein, Mark, El-Deiry, Wafik S.

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Abstract 349: Structure-activity relationships and mechanistic analysis of analogues of the clinical-stage anti-cancer small molecule ONC201 von Wagner, Jessica, Olson, Gary, Bhaskara, Nallaganchu Rao, Pottorf, Richard S., Mathew, Garnett J., Benes, Cyril H., Tarapore, Rohinton, Stogniew, Martin, Schalop, Lee, Oster, Wolfgang, Allen, Josh E., El-Deiry, Wafik S.

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Abstract LB-209: D2-like dopamine receptor antagonism by ONC201 identified by confluence of computational, receptor binding, and clinical studies von Madhukar, Neel S., Elemento, Olivier, Benes, Cyril H., Garnett, Mathew J., Stein, Mark, Bertino, Joseph R., Kaufman, Howard L., Arrillaga-Romany, Isabel, Batchelor, Tracy T., Schalop, Lee, Oster, Wolfgang, Stogniew, Martin, Andreeff, Michael, El-Deiry, Wafik S., Allen, Joshua E.

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Structure-activity relationships (SAR) and mechanistic analysis of clinical-stage anti-cancer small molecule ONC201 analogues von Wagner, Jessica, Olson, Gary, Nallaganchu, Bhaskara Rao, Pottorf, Richard, Stogniew, Martin, Schalop, Lee, Oster, Wolfgang, Garnett, Mathew, McDermott, Ultan, Benes, Cyril, Tarapore, Rohinton, Allen, Joshua E., El-Deiry, Wafik S.

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ACTR-34. INTEGRATED CLINICAL EXPERIENCE WITH ONC201 IN PREVIOUSLY-TREATED H3 K27M-MUTANT GLIOMA PATIENTS von Chi, Andrew, Arrillaga-Romany, Isabel, Gardner, Sharon, Wen, Patrick, Batchelor, Tracy, Hall, Matthew, Odia, Yazmin, Khatua, Soumen, Zaky, Wafik, McGovern, Susan, Harrison, Rebecca, de Groot, John, Sumrall, Ashley, Shonka, Nicole, Khatib, Zaid, Karajannis, Matthias, Mueller, Sabine, Tarapore, Rohinton, Merdinger, Krystal, Schalop, Lee, Allen, Joshua, Oster, Wolfgang, P Mehta, Minesh

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Discovery and clinical introduction of first-in-class imipridone ONC201 von Allen, Joshua E, Kline, C. Leah B, Prabhu, Varun V, Wagner, Jessica, Ishizawa, Jo, Madhukar, Neel, Lev, Avital, Baumeister, Marie, Zhou, Lanlan, Lulla, Amriti, Stogniew, Martin, Schalop, Lee, Benes, Cyril, Kaufman, Howard L, Pottorf, Richard S, Nallaganchu, B. Rao, Olson, Gary L, Al-Mulla, Fahd, Duvic, Madeleine, Wu, Gen Sheng, Dicker, David T, Talekar, Mala K, Lim, Bora, Elemento, Olivier, Oster, Wolfgang, Bertino, Joseph, Flaherty, Keith, Wang, Michael L, Borthakur, Gautam, Andreeff, Michael, Stein, Mark, El-Deiry, Wafik S

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NAREIT campaign, strong results attract retail cash von Schalop, Lee

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