670 Delayed Enzymatic Debridement of Burn Wounds using the Proteolytic Gel SN514 von Jockheck-Clark, Angela R, Stone, Randolph, Holik, Michelle, Schaffer, Lucy, Natesan, Shanmugasundaram, Roche, Eric, Christy, Robert J

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Examining and Measuring the Therapeutic Alliance in a Neuropsychological Assessment Setting: A Preliminary Study von Schaffer, Jamie B., Walsh, Lucy, Eubanks, Catherine F.

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Hypoxia-induced carbonic anhydrase mediated dorsal horn neuron activation and induction of neuropathic pain von Da Vitoria Lobo, Marlene E., Weir, Nick, Hardowar, Lydia, Al Ojaimi, Yara, Madden, Ryan, Gibson, Alex, Bestall, Samuel M., Hirashima, Masanori, Schaffer, Chris B., Donaldson, Lucy F., Bates, David O., Hulse, Richard Philip

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OpenSAFELY: A platform for analysing electronic health records designed for reproducible research von Nab, Linda, Schaffer, Andrea L., Hulme, William, DeVito, Nicholas J., Dillingham, Iain, Wiedemann, Milan, Andrews, Colm D., Curtis, Helen, Fisher, Louis, Green, Amelia, Massey, Jon, Walters, Caroline E., Higgins, Rose, Cunningham, Christine, Morley, Jessica, Mehrkar, Amir, Hart, Liam, Davy, Simon, Evans, David, Hickman, George, Inglesby, Peter, Morton, Caroline E., Smith, Rebecca M., Ward, Tom, O'Dwyer, Thomas, Maude, Steven, Bridges, Lucy, Butler‐Cole, Ben F. C., Stables, Catherine L., Stokes, Pete, Bates, Chris, Cockburn, Jonny, Hester, Frank, Parry, John, Bhaskaran, Krishnan, Schultze, Anna, Rentsch, Christopher T., Mathur, Rohini, Tomlinson, Laurie A., Williamson, Elizabeth J., Smeeth, Liam, Walker, Alex, Bacon, Sebastian, MacKenna, Brian, Goldacre, Ben

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The impact of COVID‐19 on medication reviews in English primary care. An OpenSAFELY‐TPP analysis of 20 million adult electronic health records von Wood, Christopher, Speed, Victoria, Fisher, Louis, Curtis, Helen J., Schaffer, Andrea L., Walker, Alex J., Croker, Richard, Brown, Andrew D., Cunningham, Christine, Hulme, William J., Andrews, Colm D., Butler‐Cole, Ben F. C., Evans, David, Inglesby, Peter, Dillingham, Iain, Bacon, Sebastian C. J., Davy, Simon, Ward, Tom, Hickman, George, Bridges, Lucy, O'Dwyer, Thomas, Maude, Steven, Smith, Rebecca M., Mehrkar, Amir, Bates, Chris, Cockburn, Jonathan, Parry, John, Hester, Frank, Harper, Sam, Goldacre, Ben, MacKenna, Brian

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Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations von Schubert, Desirée, Bode, Claudia, Kenefeck, Rupert, Hou, Tie Zheng, Wing, James B, Kennedy, Alan, Bulashevska, Alla, Petersen, Britt-Sabina, Schäffer, Alejandro A, Grüning, Björn A, Unger, Susanne, Frede, Natalie, Baumann, Ulrich, Witte, Torsten, Schmidt, Reinhold E, Dueckers, Gregor, Niehues, Tim, Seneviratne, Suranjith, Kanariou, Maria, Speckmann, Carsten, Ehl, Stephan, Rensing-Ehl, Anne, Warnatz, Klaus, Rakhmanov, Mirzokhid, Thimme, Robert, Hasselblatt, Peter, Emmerich, Florian, Cathomen, Toni, Backofen, Rolf, Fisch, Paul, Seidl, Maximilian, May, Annette, Schmitt-Graeff, Annette, Ikemizu, Shinji, Salzer, Ulrich, Franke, Andre, Sakaguchi, Shimon, Walker, Lucy S K, Sansom, David M, Grimbacher, Bodo

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Two-Year-Old Cognitive Outcomes in Children of Pregnant Women With Epilepsy in the Maternal Outcomes and Neurodevelopmental Effects of Antiepileptic Drugs Study von Meador, Kimford J, Cohen, Morris J, Loring, David W, May, Ryan C, Brown, Carrie, Robalino, Chelsea P, Matthews, Abigail G, Kalayjian, Laura A, Gerard, Elizabeth E, Gedzelman, Evan R, Penovich, Patricia E, Cavitt, Jennifer, Hwang, Sean, Sam, Maria, Pack, Alison M, French, Jacqueline, Tsai, Jeffrey J, Pennell, Page B

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Hypoxia-induced carbonic anhydrase mediated dorsal horn neuron activation and induction of neuropathic pain von Da Vitoria Lobo, Marlene E., Weir, Nick, Hardowar, Lydia, Al Ojaimi, Yara, Madden, Ryan, Gibson, Alex, Bestall, Samuel M., Hirashima, Masanori, Schaffer, Chris B., Donaldson, Lucy F., Bates, David O., Hulse, Richard Philip

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Changes in opioid prescribing during the COVID-19 pandemic in England: an interrupted time-series analysis in the OpenSAFELY-TTP cohort von Schaffer, Andrea L, Andrews, Colm D, Brown, Andrew D, Croker, Richard, Hulme, William J, Nab, Linda, Quinlan, Jane, Speed, Victoria, Wood, Christopher, Wiedemann, Milan, Massey, Jon, Inglesby, Peter, Bacon, Seb C J, Mehrkar, Amir, Bates, Chris, Goldacre, Ben, Walker, Alex J, MacKenna, Brian

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Predictors of Mortality, Withdrawal of Life-Sustaining Measures, and Discharge Disposition in Octogenarians with Subdural Hematomas von Kashkoush, Ahmed, Petitt, Jordan C., Ladhani, Husayn, Ho, Vanessa P., Kelly, Michael L., Ghneim, Mira, Albrecht, Jennifer S., Brasel, Karen, Livaris, Anna, Watras, Jill B., Michetti, Christopher P., Haan, James M., Lightwine, Kelly, Winfield, Robert D., Adams, Sasha D., Podbielski, Jeanette M., Armen, Scott B., Zacko, J. Christopher, Nasrallah, Fady S., Schaffer, Kathryn B., Dunn, Julie, Widdel, Lars, Schroeppel, Thomas J., Stillman, Zachery, Cooper, Zara, Stein, Deborah, Adams, Charles, Lueckel, Stephanie, Murry, Jason, Patel, Nikita, Hsu, Cindy, Bhatti, Umer F., Lissauer, Matthew E., LaFonte, Marc, Najafi, Kaveh, Lewandowski, Karen, Mukherjee, Kaushik, Imperio-Lagabon, Kristelle J., Martin, Niels D., Hirsch, Kathleen, Berry, Cherisse, Freitas, Derek, Cullinane, Daniel, Ramawi, Roshini, Truitt, Michael, Pearcy, Chris, Hashimi, Habiba, Kaups, Krista, Claridge, Jeffrey, Hartwell, Jennifer L., Ballou, Jessica, Croce, Martin, Markle, Stephanie, Osserwaarde, Sally, Posluszny, Joseph, Stocker, Benjamin, Hranjec, Tjasa, Solomon, Rachele, Martinek, Lucy, Gupta, Alok, Grabo, Daniel J., Khan, Uzer, Tatum, Danielle, Jacome, Tomas, Gates, Jonathan, Jawani, Alisha, Berndtson, Allison E., Curry, Terry G., Bala, Miklosh, Dultz, Linda A., Houshmand, Natasha N., Pieri, Paola, Zielinski, Martin D., Hughes, Joy D., Hartwell, Jennifer, Malhotra, Ajai K., Lee, Tim, Petrone, Patrizio, Joseph, D'andrea, Marshall, Gary T., Carrick, Matthew M., Pathak, Abhijit, Van Zandt, Andrea, Glass, Nina, Livingston, David, Gregg, Shea, Webb, Travis, Drumheller, Byron, Kozar, Rosemary, Barraco, Robert, Joseph, Bellal

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Implementing Germ Defence digital behaviour change intervention via all primary care practices in England to reduce respiratory infections during the COVID-19 pandemic: an efficien... von Ainsworth, Ben, Horwood, Jeremy, Walter, Scott R, Miller, Sascha, Chalder, Melanie, De Vocht, Frank, Denison-Day, James, Elwenspoek, Martha M C, Curtis, Helen J, Bates, Chris, Mehrkar, Amir, Bacon, Seb, Goldacre, Ben, Craggs, Pippa, Amlôt, Richard, Francis, Nick, Little, Paul, Macleod, John, Moore, Michael, Morton, Kate, Rice, Cathy, Sterne, Jonathan, Stuart, Beth, Towler, Lauren, Willcox, Merlin L, Yardley, Lucy

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Gender differences in the relationship between symptoms of depression and high-sensitivity CRP von Vetter, M L, Wadden, T A, Vinnard, C, Moore, R H, Khan, Z, Volger, S, Sarwer, D B, Faulconbridge, L F

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Impact of long COVID on health-related quality-of-life: an OpenSAFELY population cohort study using patient-reported outcome measures (OpenPROMPT) von Carlile, Oliver, Briggs, Andrew, Henderson, Alasdair D., Butler-Cole, Ben F.C., Tazare, John, Tomlinson, Laurie A., Marks, Michael, Jit, Mark, Lin, Liang-Yu, Bates, Chris, Parry, John, Bacon, Sebastian C.J., Dillingham, Iain, Dennison, William A., Costello, Ruth E., Walker, Alex J., Hulme, William, Goldacre, Ben, Mehrkar, Amir, MacKenna, Brian, Walker, Alex, Green, Amelia, Mehrkar, Amir, Schaffer, Andrea, Brown, Andrew, Goldacre, Ben, Butler-Cole, Ben, MacKenna, Brian, Morton, Caroline, Walters, Caroline, Stables, Catherine, Cunningham, Christine, Wood, Christopher, Andrews, Colm, Hickman, George, Curtis, Helen, Drysdale, Henry, Dillingham, Iain, Morley, Jessica, Massey, Jon, Nab, Linda, Hopcroft, Lisa, Fisher, Louis, Wiedemann, Milan, DeVito, Nicholas, Macdonald, Orla, Inglesby, Peter, Smith, Rebecca, Croker, Richard, Park, Robin, Higgins, Rose, Bacon, Sebastian, Davy, Simon, Maude, Steven, O'Dwyer, Thomas, Ward, Tom, Speed, Victoria, Hulme, William, Hart, Liam, Stokes, Pete, Costello, Ruth, Cowling, Thomas, Douglas, Ian, Eggo, Rosalind, Evans, Stephen, Forbes, Harriet, Grieve, Richard, Herrett, Emily, Langan, Sinead, Mahalingasivam, Viyaasan, Mansfield, Kathryn, Mathur, Rohini, McDonald, Helen, Parker, Edward, Rentsch, Christopher, Schultze, Anna, Tazare, John, Tomlinson, Laurie, Walker, Jemma, Williamson, Elizabeth, Wing, Kevin, Wong, Angel, Zheng, Bang, Bates, Christopher, Cockburn, Jonathan, Parry, John, Hester, Frank, Harper, Sam, O'Hanlon, Shaun, Eavis, Alex, Jarvis, Richard, Avramov, Dima, Griffiths, Paul, Fowles, Aaron, Harrison, David, Khunti, Kamlesh, Sterne, Jonathan, Quint, Jennifer, Herrett, Emily, Eggo, Rosalind M.

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Clinical and health inequality risk factors for non-COVID-related sepsis during the global COVID-19 pandemic: a national case-control and cohort study von Zhong, Xiaomin, Ashiru-Oredope, Diane, Pate, Alexander, Martin, Glen P., Sharma, Anita, Dark, Paul, Felton, Tim, Lake, Claire, MacKenna, Brian, Mehrkar, Amir, Bacon, Sebastian C.J., Massey, Jon, Inglesby, Peter, Goldacre, Ben, Walker, Alex J., MacKenna, Brian, Inglesby, Peter, Goldacre, Ben, Curtis, Helen J., Morley, Jessica, Mehrkar, Amir, Bacon, Sebastian C.J., Hickman, George, Croker, Richard, Evans, David, Ward, Tom, DeVito, Nicholas J., Fisher, Louis, Green, Amelia C.A., Massey, Jon, Smith, Rebecca M., Hulme, William J., Davy, Simon, Andrews, Colm D., Hopcroft, Lisa E.M., Dillingham, Iain, Higgins, Rose, Cunningham, Christine, Wiedemann, Milan, Nab, Linda, Maude, Steven, Macdonald, Orla, Butler-Cole, Ben F.C., O'Dwyer, Thomas, Stables, Catherine L., Wood, Christopher, Brown, Andrew D., Speed, Victoria, Bridges, Lucy, Schaffer, Andrea L., Walters, Caroline E., Bates, Christopher, Cockburn, Jonathan, Parry, John, Hester, Frank, Harper, Sam, Hand, Kieran, Bladon, Sian, Cunningham, Neil, Gilham, Ellie, Brown, Colin S., Mirfenderesky, Mariyam, Palin, Victoria, van Staa, Tjeerd Pieter

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Changes in opioid prescribing during the COVID-19 pandemic in England: an interrupted time-series analysis in the OpenSAFELY-TPP cohort von Schaffer, Andrea L, Andrews, Colm D, Brown, Andrew D, Croker, Richard, Hulme, William J, Nab, Linda, Quinlan, Jane, Speed, Victoria, Wood, Christopher, Wiedemann, Milan, Massey, Jon, Inglesby, Peter, Bacon, Seb C J, Mehrkar, Amir, Bates, Chris, Goldacre, Ben, Walker, Alex J, MacKenna, Brian, Bridges, Lucy, Butler-Cole, Benjamin FC, Davy, Simon, Dillingham, Iain, Evans, David, Fisher, Louis, Green, Amelia, Hart, Liam, Hickman, George, Maude, Steven, O'Dwyer, Thomas, Smith, Rebecca M, Stokes, Pete, Ward, Tom, Cockburn, Johnathan, Harper, Sam, Hester, Frank, Parry, John

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Clinical coding of long COVID in primary care 2020–2023 in a cohort of 19 million adults: an OpenSAFELY analysis von Henderson, Alasdair D., Butler-Cole, Ben FC, Tazare, John, Tomlinson, Laurie A., Marks, Michael, Briggs, Andrew, Lin, Liang-Yu, Carlile, Oliver, Bates, Chris, Parry, John, Bacon, Sebastian CJ, Dillingham, Iain, Dennison, William A., Costello, Ruth E., Wei, Yinghui, Goldacre, Ben, Mehrkar, Amir, MacKenna, Brian, Green, Amelia, Mehrkar, Amir, Schaffer, Andrea, Brown, Andrew, Goldacre, Ben, Butler-Cole, Ben, MacKenna, Brian, Morton, Caroline, Walters, Caroline, Stables, Catherine, Cunningham, Christine, Wood, Christopher, Andrews, Colm, Evans, David, Hickman, George, Curtis, Helen, Drysdale, Henry, Dillingham, Iain, Morley, Jessica, Massey, Jon, Nab, Linda, Hopcroft, Lisa, Fisher, Louis, Bridges, Lucy, Wiedemann, Milan, DeVito, Nicholas, Macdonald, Orla, Inglesby, Peter, Smith, Rebecca, Park, Robin, Higgins, Rose, Bacon, Sebastian, Davy, Simon, Maude, Steven, Ward, Tom, Speed, Victoria, Hulme, William, Hart, Liam, Stokes, Pete, Bhaskaran, Krishnan, Costello, Ruth, Cowling, Thomas, Douglas, Ian, Eggo, Rosalind, Evans, Stephen, Forbes, Harriet, Grieve, Richard, Grint, Daniel, Langan, Sinead, Mahalingasivam, Viyaasan, Mansfield, Kathryn, Mathur, Rohini, McDonald, Helen, Parker, Edward, Rentsch, Christopher, Schultze, Anna, Smeeth, Liam, Tazare, John, Tomlinson, Laurie, Walker, Jemma, Williamson, Elizabeth, Wing, Kevin, Wong, Angel, Zheng, Bang, Bates, Christopher, Parry, John, Hester, Frank, Harper, Sam, O'Hanlon, Shaun, Eavis, Alex, Jarvis, Richard, Avramov, Dima, Griffiths, Paul, Fowles, Aaron, Parkes, Nasreen, Perera, Rafael, Harrison, David, Khunti, Kamlesh, Sterne, Jonathan, Quint, Jennifer, Herrett, Emily, Eggo, Rosalind M.

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Clinical coding of long COVID in primary care 2020–2023 in a cohort of 19 million adults: an OpenSAFELY analysisResearch in context von Alasdair D. Henderson, Ben FC. Butler-Cole, John Tazare, Laurie A. Tomlinson, Michael Marks, Mark Jit, Andrew Briggs, Liang-Yu Lin, Oliver Carlile, Chris Bates, John Parry, Sebastian CJ. Bacon, Iain Dillingham, William A. Dennison, Ruth E. Costello, Yinghui Wei, Alex J. Walker, William Hulme, Ben Goldacre, Amir Mehrkar, Brian MacKenna, Emily Herrett, Rosalind M. Eggo, Alex Walker, Amelia Green, Amir Mehrkar, Andrea Schaffer, Andrew Brown, Ben Goldacre, Ben Butler-Cole, Brian MacKenna, Caroline Morton, Caroline Walters, Catherine Stables, Christine Cunningham, Christopher Wood, Colm Andrews, David Evans, George Hickman, Helen Curtis, Henry Drysdale, Iain Dillingham, Jessica Morley, Jon Massey, Linda Nab, Lisa Hopcroft, Louis Fisher, Lucy Bridges, Milan Wiedemann, Nicholas DeVito, Orla Macdonald, Peter Inglesby, Rebecca Smith, Richard Croker, Robin Park, Rose Higgins, Sebastian Bacon, Simon Davy, Steven Maude, Thomas O'Dwyer, Tom Ward, Victoria Speed, William Hulme, Liam Hart, Pete Stokes, Krishnan Bhaskaran, Ruth Costello, Thomas Cowling, Ian Douglas, Rosalind Eggo, Stephen Evans, Harriet Forbes, Richard Grieve, Daniel Grint, Emily Herrett, Sinead Langan, Viyaasan Mahalingasivam, Kathryn Mansfield, Rohini Mathur, Helen McDonald, Edward Parker, Christopher Rentsch, Anna Schultze, Liam Smeeth, John Tazare, Laurie Tomlinson, Jemma Walker, Elizabeth Williamson, Kevin Wing, Angel Wong, Bang Zheng, Christopher Bates, Jonathan Cockburn, John Parry, Frank Hester, Sam Harper, Shaun O'Hanlon, Alex Eavis, Richard Jarvis, Dima Avramov

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Impact of long COVID on health-related quality-of-life: an OpenSAFELY population cohort study using patient-reported outcome measures (OpenPROMPT)Research in context von Oliver Carlile, Andrew Briggs, Alasdair D. Henderson, Ben F.C. Butler-Cole, John Tazare, Laurie A. Tomlinson, Michael Marks, Mark Jit, Liang-Yu Lin, Chris Bates, John Parry, Sebastian C.J. Bacon, Iain Dillingham, William A. Dennison, Ruth E. Costello, Alex J. Walker, William Hulme, Ben Goldacre, Amir Mehrkar, Brian MacKenna, Emily Herrett, Rosalind M. Eggo, Alex Walker, Amelia Green, Amir Mehrkar, Andrea Schaffer, Andrew Brown, Ben Goldacre, Ben Butler-Cole, Brian MacKenna, Caroline Morton, Caroline Walters, Catherine Stables, Christine Cunningham, Christopher Wood, Colm Andrews, David Evans, George Hickman, Helen Curtis, Henry Drysdale, Iain Dillingham, Jessica Morley, Jon Massey, Linda Nab, Lisa Hopcroft, Louis Fisher, Lucy Bridges, Milan Wiedemann, Nicholas DeVito, Orla Macdonald, Peter Inglesby, Rebecca Smith, Richard Croker, Robin Park, Rose Higgins, Sebastian Bacon, Simon Davy, Steven Maude, Thomas O'Dwyer, Tom Ward, Victoria Speed, William Hulme, Liam Hart, Pete Stokes, Krishnan Bhaskaran, Ruth Costello, Thomas Cowling, Ian Douglas, Rosalind Eggo, Stephen Evans, Harriet Forbes, Richard Grieve, Daniel Grint, Emily Herrett, Sinead Langan, Viyaasan Mahalingasivam, Kathryn Mansfield, Rohini Mathur, Helen McDonald, Edward Parker, Christopher Rentsch, Anna Schultze, Liam Smeeth, John Tazare, Laurie Tomlinson, Jemma Walker, Elizabeth Williamson, Kevin Wing, Angel Wong, Bang Zheng, Christopher Bates, Jonathan Cockburn, John Parry, Frank Hester, Sam Harper, Shaun O'Hanlon, Alex Eavis, Richard Jarvis, Dima Avramov, Paul Griffiths

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An audit of cancer of unknown primary notifications: A cautionary tale for population health research using cancer registry data von Vajdic, Claire M, Er, Chuang Ching, Schaffer, Andrea, Dobbins, Timothy, Wyld, Lucy, Meagher, Nicola S, Barrett, Jane, Ward, Robyn L, Pearson, Sallie-Anne

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Factors associated with receipt of intracranial pressure monitoring in older adults with traumatic brain injury von Ghneim, Mira, Albrecht, Jennifer, Brasel, Karen, Knight, Ariel, Liveris, Anna, Watras, Jill, Michetti, Christopher P, Haan, James, Lightwine, Kelly, Winfield, Robert D, Adams, Sasha D, Podbielski, Jeanette, Armen, Scott, Zacko, J Christopher, Nasrallah, Fady S, Schaffer, Kathryn B, Dunn, Julie A, Smoot, Brittany, Schroeppel, Thomas J, Stillman, Zachery, Cooper, Zara, Stein, Deborah M, Adams, Charles, Lueckel, Stephanie, Murry, Jason, Hsu, Cindy, Bhatti, Umer F., Lissauer, Matthew E, LaFonte, Marc, Najafi, Kaveh, Lewandowski, Karen, Mukherjee, Kaushik, Imperio-Lagabon, Kristelle J., Martin, Niels D., Hirsch, Kathleen, Berry, Cherisse, Freitas, Derek, Cullinane, Daniel, Ramawani, Roshini, Truitt, Michael, Pearcy, Chris, Hashimi, Habiba, Kaups, Krista, Claridge, Jeffry, Ladhani, Husayn, Hartwell, Jennifer L., Ballou, Jessica, Croce, Martin, Markle, Stephanie, Osserwaarde, Sally, Posluszny, Joseph, Stocker, Benjamin, Hranjec, Tjasa, Solomon, Rachele, Martinek, Lucy, Gupta, Alok, Grabo, Daniel J., Khan, Uzer, Tatum, Danielle, Jacome, Tomas, Gates, Jonathan, Jawani, Alisha, Berndtson, Allison E., Curry, Terry G., Bala, Miklosh, Dultz, Linda A., Houshmand, Natasha N., Pieri, Paola, Zielinski, Martin D, Hughes, Joy D., Hartwell, Jennifer, Malhotra, Ajai K., Lee, Tim, Petrone, Patrizio, Joseph, D'andrea, Marshall, Gary T., Carrick, Matthew M., Pathak, Abhijit, Zandt, Andrea Van, Glass, Nina, Livingston, David, Gregg, Shea, Webb, Travis, Drumheller, Byron, Kozar, Rosemary, Barraco, Robert, Joseph, Bellal

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