Marine derived hamacanthins as lead for the development of novel PDGFRβ protein kinase inhibitors von Pinchuk, Boris, Johannes, Eugen, Gul, Sheraz, Schlosser, Joachim, Schaechtele, Christoph, Totzke, Frank, Peifer, Christian

Volltext

Abstract 5683: Value of new spontaneous and carcinogen-induced mouse-derived isograft (MDI) tumor models for drug development of novel immune therapeutic approaches von Beshay, Janette, Jantscheff, Peter, Obodozie, Cynthia, Schaechtele, Christoph, Weber, Holger

Volltext

Discovery of novel substituted benzo-anellated 4-benzylamino pyrrolopyrimidines as dual EGFR and VEGFR2 inhibitors von Fischer, Tim, Krüger, Thomas, Najjar, Abdulkarim, Totzke, Frank, Schächtele, Christoph, Sippl, Wolfgang, Ritter, Christoph, Hilgeroth, Andreas

Volltext

Novel 2-chloro-4-anilino-quinazoline derivatives as EGFR and VEGFR-2 dual inhibitors von Barbosa, Maria Letícia de Castro, Lima, Lídia Moreira, Tesch, Roberta, Sant'Anna, Carlos Mauricio R., Totzke, Frank, Kubbutat, Michael H.G., Schächtele, Christoph, Laufer, Stefan A., Barreiro, Eliezer J.

Volltext

Abstract 1156: New spontaneous and carcinogen-induced mouse-derived isograft (MDI) tumor models for immune therapeutic approaches von Jantscheff, Peter, Beshay, Janette, Lemarchand, Thomas, Obodozie, Cynthia, Schaechtele, Christoph, Weber, Holger

Volltext

Abstract 2388: IC50 profiling against 320 protein kinases: Improving the accuracy of kinase inhibitor selectivity testing von Mueller, Daniel, Totzke, Frank, Weber, Thomas, Pathe, Marcel, Schaechtele, Christoph, Kubbutat, Michael H.

Volltext

Optimization of Potent DFG-in Inhibitors of Platelet Derived Growth Factor Receptorβ (PDGF-Rβ) Guided by Water Thermodynamics von Horbert, Rebecca, Pinchuk, Boris, Johannes, Eugen, Schlosser, Joachim, Schmidt, Dorian, Cappel, Daniel, Totzke, Frank, Schächtele, Christoph, Peifer, Christian

Volltext

Cytotoxic Metabolites from the Fungal Endophyte Alternaria sp. and Their Subsequent Detection in Its Host Plant Polygonum senegalense von Aly, Amal H, Edrada-Ebel, RuAngelie, Indriani, Ine Dewi, Wray, Victor, Müller, Werner E. G, Totzke, Frank, Zirrgiebel, Ute, Schächtele, Christoph, Kubbutat, Michael H. G, Lin, W. H, Proksch, Peter, Ebel, Rainer

Volltext

Mouse-Derived Isograft (MDI) In Vivo Tumor Models I. Spontaneous sMDI Models: Characterization and Cancer Therapeutic Approaches von Jantscheff, Peter, Beshay, Janette, Lemarchand, Thomas, Obodozie, Cynthia, Schächtele, Christoph, Weber, Holger

Volltext

Novel Protein Kinase Inhibitors Related to Tau Pathology Modulate Tau Protein-Self Interaction Using a Luciferase Complementation Assay von Holzer, Max, Schade, Nico, Opitz, Ansgar, Hilbrich, Isabel, Stieler, Jens, Vogel, Tim, Neukel, Valentina, Oberstadt, Moritz, Totzke, Frank, Schächtele, Christoph, Sippl, Wolfgang, Hilgeroth, Andreas

Volltext

Discovery of 4-anilino α-carbolines as novel Brk inhibitors von Mahmoud, Kazem Ahmed, Krug, Martin, Wersig, Tom, Slynko, Inna, Schächtele, Christoph, Totzke, Frank, Sippl, Wolfgang, Hilgeroth, Andreas

Volltext

Tri- and Tetrasubstituted Pyrazole Derivates: Regioisomerism Switches Activity from p38MAP Kinase to Important Cancer Kinases von Thaher, Bassam Abu, Arnsmann, Martina, Totzke, Frank, Ehlert, Jan E, Kubbutat, Michael H. G, Schächtele, Christoph, Zimmermann, Markus O, Koch, Pierre, Boeckler, Frank M, Laufer, Stefan A

Volltext

Scaffold hopping identifies 6,8-disubstituted purines as novel anaplastic lymphoma kinase inhibitors von Schlütke, Laura, Immer, Markus, Preu, Lutz, Totzke, Frank, Schächtele, Christoph, Kubbutat, Michael H.G., Kunick, Conrad

Volltext

Mouse-Derived Isograft (MDI) In Vivo Tumor Models II. Carcinogen-Induced cMDI Models: Characterization and Cancer Therapeutic Approaches von Beshay, Janette, Jantscheff, Peter, Lemarchand, Thomas, Obodozie, Cynthia, Schächtele, Christoph, Weber, Holger

Volltext

Abstract 5010: A versatile tool to study immune checkpoint therapeutics: Syngenic tumor mouse models in vivo von Schaefer-Obodozie, Cynthia, Jantscheff, Peter, Moor, Sandra, Hoffmann, Steffen, Saso, Tihomir, Schaechtele, Christoph, Weber, Holger

Volltext

Bioactive Metabolites from the Endophytic Fungus Stemphylium globuliferum Isolated from Mentha pulegium von Debbab, Abdessamad, Aly, Amal H, Edrada-Ebel, RuAngelie, Wray, Victor, Müller, Werner E. G, Totzke, Frank, Zirrgiebel, Ute, Schächtele, Christoph, Kubbutat, Michael H. G, Lin, Wen Han, Mosaddak, Mahjouba, Hakiki, Abdelhak, Proksch, Peter, Ebel, Rainer

Volltext

Discovery of novel dual inhibitors of receptor tyrosine kinases EGFR and PDGFR-β related to anticancer drug resistance von Fischer, Tim, Najjar, Abdulkarim, Totzke, Frank, Schächtele, Christoph, Sippl, Wolfgang, Ritter, Christoph, Hilgeroth, Andreas

Volltext

Abstract A16: Boosting of in vivo hollow fiber assay by using luciferase-labeled tumor cell lines von Schaefer-Obodozie, Cynthia, Leisegang, Ulrike, Ruf, Susanne, Giesen, Bianca, Schaechtele, Christoph, Weber, Holger

Volltext

Novel SAR for quinazoline inhibitors of EHMT1 and EHMT2 von Leenders, Ruben, Zijlmans, Remco, van Bree, Bart, van de Sande, Marc, Trivarelli, Federica, Damen, Eddy, Wegert, Anita, Müller, Daniel, Ehlert, Jan Erik, Feger, Daniel, Heidemann-Dinger, Carolin, Kubbutat, Michael, Schächtele, Christoph, Lenstra, Danny C., Mecinović, Jasmin, Müller, Gerhard

Volltext

Abstract 1222: Establishment of a reliable metastasizing syngeneic breast cancer mouse model using orthotopically implanted 4T1 cells after several rounds of isolating and reimplan... von Lingnau, Andreas, Hoffmann, Steffen, Moor, Sandra, Schaefer-Obodozie, Cynthia, Schaechtele, Christoph

Volltext