Survival benefit with checkpoint inhibitors versus chemotherapy is modified by brain metastases in patients with recurrent small cell lung cancer von Althoff, Friederike C., Schäfer, Lisa V., Acker, Fabian, Aguinarte, Lukas, Heinzen, Sophie, Rost, Maximilian, Atmaca, Akin, Rosery, Vivian, Alt, Jürgen, Waller, Cornelius F., Reinmuth, Niels, Rohde, Gernot, Saalfeld, Felix C., Becker von Rose, Aaron, Möller, Miriam, Frost, Nikolaj, Sebastian, Martin, Stratmann, Jan A.

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SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo von Hou, Yixuan J., Chiba, Shiho, Halfmann, Peter, Ehre, Camille, Kuroda, Makoto, Dinnon, Kenneth H., Leist, Sarah R., Schafer, Alexandra, Nakajima, Noriko, Takahashi, Kenta, Lee, Rhianna E., Mascenik, Teresa M., Graham, Rachel, Edwards, Caitlin E., Tse, Longping, Okuda, Kenichi, Markmann, Alena J., Bartelt, Luther, de Silva, Aravinda, Margolis, David M., Boucher, Richard C., Randell, Scott H., Suzuki, Tadaki, Gralinski, Lisa E., Kawaoka, Yoshihiro, Baric, Ralph S.

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A Mouse-Adapted SARS-CoV-2 Induces Acute Lung Injury and Mortality in Standard Laboratory Mice von Leist, Sarah R., Dinnon, Kenneth H., Schäfer, Alexandra, Tse, Longping V., Okuda, Kenichi, Hou, Yixuan J., West, Ande, Edwards, Caitlin E., Sanders, Wes, Fritch, Ethan J., Gully, Kendra L., Scobey, Trevor, Brown, Ariane J., Sheahan, Timothy P., Moorman, Nathaniel J., Boucher, Richard C., Gralinski, Lisa E., Montgomery, Stephanie A., Baric, Ralph S.

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Elicitation of Potent Neutralizing Antibody Responses by Designed Protein Nanoparticle Vaccines for SARS-CoV-2 von Walls, Alexandra C., Fiala, Brooke, Schäfer, Alexandra, Wrenn, Samuel, Pham, Minh N., Murphy, Michael, Tse, Longping V., Shehata, Laila, O’Connor, Megan A., Chen, Chengbo, Navarro, Mary Jane, Miranda, Marcos C., Pettie, Deleah, Ravichandran, Rashmi, Kraft, John C., Ogohara, Cassandra, Palser, Anne, Chalk, Sara, Lee, E-Chiang, Guerriero, Kathryn, Kepl, Elizabeth, Chow, Cameron M., Sydeman, Claire, Hodge, Edgar A., Brown, Brieann, Fuller, Jim T., Dinnon, Kenneth H., Gralinski, Lisa E., Leist, Sarah R., Gully, Kendra L., Lewis, Thomas B., Guttman, Miklos, Chu, Helen Y., Lee, Kelly K., Fuller, Deborah H., Baric, Ralph S., Kellam, Paul, Carter, Lauren, Pepper, Marion, Sheahan, Timothy P., Veesler, David, King, Neil P.

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Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause deadly disease von Zhou, Panpan, Song, Ge, Liu, Hejun, Yuan, Meng, He, Wan-ting, Beutler, Nathan, Zhu, Xueyong, Tse, Longping V., Martinez, David R., Schäfer, Alexandra, Anzanello, Fabio, Yong, Peter, Peng, Linghang, Dueker, Katharina, Musharrafieh, Rami, Callaghan, Sean, Capozzola, Tazio, Limbo, Oliver, Parren, Mara, Garcia, Elijah, Rawlings, Stephen A., Smith, Davey M., Nemazee, David, Jardine, Joseph G., Safonova, Yana, Briney, Bryan, Rogers, Thomas F., Wilson, Ian A., Baric, Ralph S., Gralinski, Lisa E., Burton, Dennis R., Andrabi, Raiees

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Rapid identification of a human antibody with high prophylactic and therapeutic efficacy in three animal models of SARS-CoV-2 infection von Li, Wei, Chen, Chuan, Drelich, Aleksandra, Martinez, David R., Gralinski, Lisa E., Sun, Zehua, Schäfer, Alexandra, Kulkarni, Swarali S., Liu, Xianglei, Leist, Sarah R., Zhelev, Doncho V., Zhang, Liyong, Kim, Ye-Jin, Peterson, Eric C., Conard, Alex, Mellors, John W., Tseng, Chien-Te K., Falzarano, Darryl, Baric, Ralph S., Dimitrov, Dimiter S.

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Targeted isolation of diverse human protective broadly neutralizing antibodies against SARS-like viruses von He, Wan-ting, Musharrafieh, Rami, Song, Ge, Dueker, Katharina, Tse, Longping V., Martinez, David R., Schäfer, Alexandra, Callaghan, Sean, Yong, Peter, Beutler, Nathan, Torres, Jonathan L., Volk, Reid M., Zhou, Panpan, Yuan, Meng, Liu, Hejun, Anzanello, Fabio, Capozzola, Tazio, Parren, Mara, Garcia, Elijah, Rawlings, Stephen A., Smith, Davey M., Wilson, Ian A., Safonova, Yana, Ward, Andrew B., Rogers, Thomas F., Baric, Ralph S., Gralinski, Lisa E., Burton, Dennis R., Andrabi, Raiees

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Atopic Diseases, Allergic Sensitization, and Exposure to Traffic-related Air Pollution in Children von Morgenstern, Verena, Zutavern, Anne, Cyrys, Josef, Brockow, Inken, Koletzko, Sibylle, Kramer, Ursula, Behrendt, Heidrun, Herbarth, Olf, von Berg, Andrea, Bauer, Carl Peter, Wichmann, H.-Erich, Heinrich, Joachim, GINI Study Group, and LISA Study Group

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The Cooperative Health Research in South Tyrol (CHRIS) study: rationale, objectives, and preliminary results von Pattaro, Cristian, Gögele, Martin, Mascalzoni, Deborah, Melotti, Roberto, Schwienbacher, Christine, De Grandi, Alessandro, Foco, Luisa, D'Elia, Yuri, Linder, Barbara, Fuchsberger, Christian, Minelli, Cosetta, Egger, Clemens, Kofink, Lisa S, Zanigni, Stefano, Schäfer, Torsten, Facheris, Maurizio F, Smárason, Sigurður V, Rossini, Alessandra, Hicks, Andrew A, Weiss, Helmuth, Pramstaller, Peter P

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Effects of antiresorptive therapies on glucose metabolism: Results from the FIT, HORIZON‐PFT, and FREEDOM trials von Schwartz, Ann V, Schafer, Anne L, Grey, Andrew, Vittinghoff, Eric, Palermo, Lisa, Lui, Li‐Yung L, Wallace, Robert B, Cummings, Steven R, Black, Dennis M, Bauer, Douglas C, Reid, Ian R

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Protonation versus Oxonium Salt Formation: Basicity and Stability Tuning of Cyanoborate Anions von Kerpen, Christoph, Sprenger, Jan A. P., Herkert, Lorena, Schäfer, Marius, Bischoff, Lisa A., Zeides, Pierre, Grüne, Matthias, Bertermann, Rüdiger, Brede, Franziska A., Müller‐Buschbaum, Klaus, Ignat'ev, Nikolai V., Finze, Maik

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SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract von Hou, Yixuan J., Okuda, Kenichi, Edwards, Caitlin E., Martinez, David R., Asakura, Takanori, Dinnon, Kenneth H., Kato, Takafumi, Lee, Rhianna E., Yount, Boyd L., Mascenik, Teresa M., Chen, Gang, Olivier, Kenneth N., Ghio, Andrew, Tse, Longping V., Leist, Sarah R., Gralinski, Lisa E., Schäfer, Alexandra, Dang, Hong, Gilmore, Rodney, Nakano, Satoko, Sun, Ling, Fulcher, M. Leslie, Livraghi-Butrico, Alessandra, Nicely, Nathan I., Cameron, Mark, Cameron, Cheryl, Kelvin, David J., de Silva, Aravinda, Margolis, David M., Markmann, Alena, Bartelt, Luther, Zumwalt, Ross, Martinez, Fernando J., Salvatore, Steven P., Borczuk, Alain, Tata, Purushothama R., Sontake, Vishwaraj, Kimple, Adam, Jaspers, Ilona, O’Neal, Wanda K., Randell, Scott H., Boucher, Richard C., Baric, Ralph S.

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Comparative evaluation of the impact on endothelial cells induced by different nanoparticle structures and functionalization von Landgraf, Lisa, Müller, Ines, Ernst, Peter, Schäfer, Miriam, Rosman, Christina, Schick, Isabel, Köhler, Oskar, Oehring, Hartmut, Breus, Vladimir V, Basché, Thomas, Sönnichsen, Carsten, Tremel, Wolfgang, Hilger, Ingrid

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Targeted isolation of panels of diverse human protective broadly neutralizing antibodies against SARS-like viruses von He, Wan-ting, Musharrafieh, Rami, Song, Ge, Dueker, Katharina, Tse, Longping V., Martinez, David R., Schäfer, Alexandra, Callaghan, Sean, Yong, Peter, Beutler, Nathan, Torres, Jonathan L., Volk, Reid M., Zhou, Panpan, Yuan, Meng, Liu, Hejun, Anzanello, Fabio, Capozzola, Tazio, Parren, Mara, Garcia, Elijah, Rawlings, Stephen A., Smith, Davey M., Wilson, Ian A., Safonova, Yana, Ward, Andrew B., Rogers, Thomas F., Baric, Ralph S., Gralinski, Lisa E., Burton, Dennis R., Andrabi, Raiees

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Common alleles at 6q25.1 and 1p11.2 are associated with breast cancer risk for BRCA1 and BRCA2 mutation carriers von Antoniou, Antonis C, Soucy, Penny, McGuffog, Lesley, Healey, Sue, Lee, Andrew, Peterlongo, Paolo, Manoukian, Siranoush, Peissel, Bernard, Zaffaroni, Daniela, Barile, Monica, Pasini, Barbara, Dolcetti, Riccardo, Giannini, Giuseppe, Varesco, Liliana, Radice, Paolo, Greene, Mark H., Glendon, Gord, Birk Jensen, Uffe, Crüger, Dorthe G., Caligo, Maria A., Laitman, Yael, Milgrom, Roni, Kaufman, Bella, Friedman, Eitan, Lindblom, Annika, Ehrencrona, Hans, Nathanson, Katherine L., Domchek, Susan M., Rebbeck, Timothy, Jakubowska, Ania, Gronwald, Jacek, Byrski, Tomasz, Cybulski, Cezary, Osorio, Ana, Ramón y Cajal, Teresa, Fostira, Florentia, Hogervorst, Frans B., Hooning, Maartje J., Meijers-Heijboer, Hanne E.J., Gómez Garcia, Encarna B., Peock, Susan, Platte, Radka, Lalloo, Fiona, Eeles, Ros, Davidson, Rosemarie, Eccles, Diana, Ong, Kai-ren, Cook, Jackie, Douglas, Fiona, Paterson, Joan, John Kennedy, M., Miedzybrodzka, Zosia, Godwin, Andrew, Stoppa-Lyonnet, Dominique, Buecher, Bruno, Tirapo, Carole, Barjhoux, Laure, Faivre, Laurence, Nogues, Catherine, Rouleau, Etienne, Pujol, Pascal, Coupier, Isabelle, Frénay, Marc, Daly, Mary B., John, Esther M., Singer, Christian F., Catharina Dressler, Anne, Offit, Kenneth, Rodriguez, Gustavo, Small, Laurie, Boggess, John, Blank, Stephanie, Basil, Jack, Ewart Toland, Amanda, Montagna, Marco, Tognazzo, Silvia, Blanco, Ignacio, Pharoah, Paul D.P., Karlan, Beth Y., Walsh, Christine S., Olah, Edith, Teo, Soo-Hwang, Beattie, Mary S., van Rensburg, Elizabeth J., Sluiter, Michelle D., Diez, Orland, Engel, Christoph, Meindl, Alfons, Ruehl, Ina, Varon-Mateeva, Raymonda, Niederacher, Dieter, Arnold, Norbert, Gadzicki, Dorothea, Caldes, Trinidad, de la Hoya, Miguel, Chen, Xiaoqing, Spurdle, Amanda B., Fredericksen, Zachary, Couch, Fergus, Simard, Jacques

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Cover Picture: Protonation versus Oxonium Salt Formation: Basicity and Stability Tuning of Cyanoborate Anions (Angew. Chem. Int. Ed. 10/2017) von Kerpen, Christoph, Sprenger, Jan A. P., Herkert, Lorena, Schäfer, Marius, Bischoff, Lisa A., Zeides, Pierre, Grüne, Matthias, Bertermann, Rüdiger, Brede, Franziska A., Müller‐Buschbaum, Klaus, Ignat'ev, Nikolai V., Finze, Maik

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Preferences in Clinical Care of Individuals With Differences of Sex Development von Avanceña, Anton L V, Rose, Angela M, Gardner, Melissa D, Rutter, Meilan M, Schafer-Kalkhoff, Tara, Suorsa-Johnson, Kristina I, van Leeuwen, Kathleen D, Weidler, Erica M, Gebremariam, Acham, Sandberg, David E, Prosser, Lisa A

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Four-Week Mentalizing Imagery Therapy for Family Dementia Caregivers: A Randomized Controlled Trial with Neural Circuit Changes von Jain, Felipe A., Chernyak, Sergey V., Nickerson, Lisa D., Morgan, Stefana, Schafer, Rhiana, Mischoulon, David, Bernard-Negron, Richard, Nyer, Maren, Cusin, Cristina, Ramirez Gomez, Liliana, Yeung, Albert

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Change in Undercarboxylated Osteocalcin Is Associated with Changes in Body Weight, Fat Mass, and Adiponectin: Parathyroid Hormone (1-84) or Alendronate Therapy in Postmenopausal Wo... von Schafer, Anne L, Sellmeyer, Deborah E, Schwartz, Ann V, Rosen, Clifford J, Vittinghoff, Eric, Palermo, Lisa, Bilezikian, John P, Shoback, Dolores M, Black, Dennis M

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Diversity of Human Copy Number Variation and Multicopy Genes von Sudmant, Peter H., Kitzman, Jacob O., Antonacci, Francesca, Alkan, Can, Malig, Maika, Tsalenko, Anya, Sampas, Nick, Bruhn, Laurakay, Shendure, Jay, Eichler, Evan E.

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