Design, synthesis and preliminary evaluation of a series of histone deacetylase inhibitors carrying a benzodiazepine ring von Guandalini, L., Balliu, M., Cellai, C., Martino, M.V., Nebbioso, A., Mercurio, C., Carafa, V., Bartolucci, G., Dei, S., Manetti, D., Teodori, E., Scapecchi, S., Altucci, L., Paoletti, F., Romanelli, M.N.

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The medicinal chemistry of multidrug resistance (MDR) reversing drugs von Teodori, E., Dei, S., Scapecchi, S., Gualtieri, F.

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Design, synthesis and preliminary biological evaluation of new hydroxamate histone deacetylase inhibitors as potential antileukemic agents von Guandalini, L., Cellai, C., Laurenzana, A., Scapecchi, S., Paoletti, F., Romanelli, M.N.

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Influence of ring size on the cognition-enhancing activity of DM235 and MN19, two potent nootropic drugs von Guandalini, L., Martini, E., Di Cesare Mannelli, L., Dei, S., Manetti, D., Scapecchi, S., Teodori, E., Ghelardini, C., Romanelli, M.N.

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Design, Synthesis, and Preliminary Pharmacological Evaluation of 4-Aminopiperidine Derivatives as N-Type Calcium Channel Blockers Active on Pain and Neuropathic Pain von Teodori, Elisabetta, Baldi, Elisabetta, Dei, Silvia, Gualtieri, Fulvio, Romanelli, Maria Novella, Scapecchi, Serena, Bellucci, Cristina, Ghelardini, Carla, Matucci, Rosanna

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Structure-affinity relationships of a unique nicotinic ligand: N(1)-dimethyl-N(4)-phenylpiperazinium iodide (DMPP) von Romanelli, M N, Manetti, D, Scapecchi, S, Borea, P A, Dei, S, Bartolini, A, Ghelardini, C, Gualtieri, F, Guandalini, L, Varani, K

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Structure−Activity Relationships Studies in a Series of N,N-Bis(alkanol)amine Aryl Esters as P-Glycoprotein (Pgp) Dependent Multidrug Resistance (MDR) Inhibitors von Martelli, Cecilia, Coronnello, Marcella, Dei, Silvia, Manetti, Dina, Orlandi, Francesca, Scapecchi, Serena, Novella Romanelli, Maria, Salerno, Milena, Mini, Enrico, Teodori, Elisabetta

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Structure–activity relationships in 2,2-diphenyl-2-ethylthioacetic acid esters: unexpected agonistic activity in a series of muscarinic antagonists von Scapecchi, S., Marucci, G., Matucci, R., Angeli, P., Bellucci, C., Buccioni, M., Dei, S., Gualtieri, F., Manetti, D., Romanelli, M.N., Teodori, E.

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Inhibition of P-glycoprotein-mediated Multidrug Resistance (MDR) by N,N-bis(cyclohexanol)amine aryl esters: Further restriction of molecular flexibility maintains high potency and... von Martelli, Cecilia, Dei, Silvia, Lambert, Catherine, Manetti, Dina, Orlandi, Francesca, Romanelli, Maria Novella, Scapecchi, Serena, Salerno, Milena, Teodori, Elisabetta

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N,N-bis(Cyclohexanol)amine Aryl Esters: A New Class of Highly Potent Transporter-Dependent Multidrug Resistance Inhibitors von Martelli, Cecilia, Alderighi, Daniela, Coronnello, Marcella, Dei, Silvia, Frosini, Maria, Le Bozec, Bénédicte, Manetti, Dina, Neri, Annalisa, Romanelli, Maria Novella, Salerno, Milena, Scapecchi, Serena, Mini, Enrico, Sgaragli, Giampietro, Teodori, Elisabetta

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Exploratory Chemistry toward the Identification of a New Class of Multidrug Resistance Reverters Inspired by Pervilleine and Verapamil Models von Teodori, Elisabetta, Dei, Silvia, Garnier-Suillerot, Arlette, Gualtieri, Fulvio, Manetti, Dina, Martelli, Cecilia, Romanelli, Maria Novella, Scapecchi, Serena, Sudwan, Paiwan, Salerno, Milena

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Regio- and Enantioselective Ring-Opening of Epoxides with HMDST: A Straightforward Access to 1,2-Mercaptoalcohols von Degl’Innocenti, Alessandro, Capperucci, Antonella, Cerreti, Arianna, Pollicino, Salvatore, Scapecchi, Serena, Malesci, Irene, Castagnoli, Giulio

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Isomeric N,N-Bis(cyclohexanol)amine Aryl Esters:  The Discovery of a New Class of Highly Potent P-Glycoprotein (Pgp)-dependent Multidrug Resistance (MDR) Inhibitors von Teodori, Elisabetta, Martelli, Cecilia, Salerno, Milena, Darghal, Nacira, Dei, Silvia, Garnier-Suillerot, Arlette, Gualtieri, Fulvio, Manetti, Dina, Scapecchi, Serena, Romanelli, Maria Novella

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R--(+)-hyoscyamine: a peripheral cholinergic amplifier von Ghelardini, C, Galeotti, N, Gualtieri, F, Scapecchi, S, Bartolini, A

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Differential analgesic activity of the enantiomers of atropine derivatives does not correlate with their muscarinic subtype selectivity von Dei, S, Bartolini, A, Bellucci, C, Ghelardini, C, Gualtieri, F, Manetti, D, Romanelli, M.N., Scapecchi, S, Teodori, E

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Highly Chiral Muscarinic Ligands:  The Discovery of (2 S ,2‘ R ,3‘ S ,5‘ R )-1-Methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine 3-sulfoxide Methyl Iodide, a Potent, Functionally... von Scapecchi, Serena, Matucci, Rosanna, Bellucci, Cristina, Buccioni, Michela, Dei, Silvia, Guandalini, Luca, Martelli, Cecilia, Manetti, Dina, Martini, Elisabetta, Marucci, Gabriella, Nesi, Marta, Romanelli, Maria Novella, Teodori, Elisabetta, Gualtieri, Fulvio

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Dialkylaminoalkyl esters of 2,2-diphenyl-2-alkylthioacetic acids: A new class of potent and functionally selective muscarinic antagonists von Scapecchi, S., Angeli, P., Dei, S., Gualtieri, P., Marucci, G., Moriconi, R., Paparelli, F., Romanelli, M.N., Teodori, E.

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Synthesis and pharmacological evaluation of verapamil analogs with restricted molecular flexibility von Teodori, E, Dei, S, Romanelli, MN, Scapecchi, S, Gualtieri, F, Budriesi, R, Chiarini, A, Lemoine, H, Mannhold, R

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Design, synthesis and preliminary biological evaluation of zatebradine analogues as potential blockers of the hyperpolarization-activated current von Novella Romanelli, Maria, Cerbai, Elisabetta, Dei, Silvia, Guandalini, Luca, Martelli, Cecilia, Martini, Elisabetta, Scapecchi, Serena, Teodori, Elisabetta, Mugelli, Alessandro

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Unexpected reactions of 2-nitro-fluorene-9-carboxylic acid von Romanelli, MN, Teodori, E, Scapecchi, S, Dei, S

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