Structural and functional insights into the Pseudomonas aeruginosa glycosyltransferase WaaG and the implications for lipopolysaccharide biosynthesis von Scaletti, Emma R., Pettersson, Pontus, Patrick, Joan, Shilling, Patrick J., Westergren, Robert Gustafsson, Daley, Daniel O., Mäler, Lena, Widmalm, Göran, Stenmark, Pål

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Kinetic and structural characterization of NUDT15 and NUDT18 as catalysts of isoprene pyrophosphate hydrolysis von Scaletti, Emma R., Unterlass, Judith E., Almlöf, Ingrid, Koolmeister, Tobias, Vallin, Karl S., Kapsitidou, Despina, Tsuber, Viktoriia, Helleday, Thomas, Stenmark, Pål, Jemth, Ann‐Sofie

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The First Structure of Human MTHFD2L and Its Implications for the Development of Isoform‐Selective Inhibitors von Scaletti, Emma R., Gustafsson Westergren, Robert, Andersson, Yasmin, Wiita, Elisee, Henriksson, Martin, Homan, Evert J., Jemth, Ann‐Sofie, Helleday, Thomas, Stenmark, Pål

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Discovery of Potent and Selective Methylenephosphonic Acid CD73 Inhibitors von Sharif, Ehesan U., Kalisiak, Jaroslaw, Lawson, Kenneth, Miles, Dillon H., Newcomb, Eric, Lindsey, Erick A., Rosen, Brandon R., Debien, Laurent P. P., Chen, Ada, Zhao, Xiaoning, Young, Stephen W., Walker, Nigel P., Straeter, Norbert, Scaletti, Emma R., Jin, Lixia, Xu, Guifen, Leleti, Manmohan R., Powers, Jay P.

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Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function von Michel, Maurice, Benítez-Buelga, Carlos, Calvo, Patricia A., Hanna, Bishoy M. F., Mortusewicz, Oliver, Masuyer, Geoffrey, Davies, Jonathan, Wallner, Olov, Sanjiv, Kumar, Albers, Julian J., Castañeda-Zegarra, Sergio, Jemth, Ann-Sofie, Visnes, Torkild, Sastre-Perona, Ana, Danda, Akhilesh N., Homan, Evert J., Marimuthu, Karthick, Zhenjun, Zhao, Chi, Celestine N., Sarno, Antonio, Wiita, Elisée, von Nicolai, Catharina, Komor, Anna J., Rajagopal, Varshni, Müller, Sarah, Hank, Emily C., Varga, Marek, Scaletti, Emma R., Pandey, Monica, Karsten, Stella, Haslene-Hox, Hanne, Loevenich, Simon, Marttila, Petra, Rasti, Azita, Mamonov, Kirill, Ortis, Florian, Schömberg, Fritz, Loseva, Olga, Stewart, Josephine, D’Arcy-Evans, Nicholas, Koolmeister, Tobias, Henriksson, Martin, Michel, Dana, de Ory, Ana, Acero, Lucia, Calvete, Oriol, Scobie, Martin, Hertweck, Christian, Vilotijevic, Ivan, Kalderén, Christina, Osorio, Ana, Perona, Rosario, Stolz, Alexandra, Stenmark, Pål, Berglund, Ulrika Warpman, de Vega, Miguel, Helleday, Thomas

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Structural features and kinetic characterization of alanine racemase from Staphylococcus aureus (Mu50) von Scaletti, Emma R., Luckner, Sylvia R., Krause, Kurt L.

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Front Cover: The First Structure of Human MTHFD2L and Its Implications for the Development of Isoform‐Selective Inhibitors (ChemMedChem 18/2022) von Scaletti, Emma R., Gustafsson Westergren, Robert, Andersson, Yasmin, Wiita, Elisee, Henriksson, Martin, Homan, Evert J., Jemth, Ann‐Sofie, Helleday, Thomas, Stenmark, Pål

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Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress von Bonagas, Nadilly, Gustafsson, Nina M S, Henriksson, Martin, Marttila, Petra, Gustafsson, Robert, Wiita, Elisée, Borhade, Sanjay, Green, Alanna C, Vallin, Karl S A, Sarno, Antonio, Svensson, Richard, Göktürk, Camilla, Pham, Therese, Jemth, Ann-Sofie, Loseva, Olga, Cookson, Victoria, Kiweler, Nicole, Sandberg, Lars, Rasti, Azita, Unterlass, Judith E, Haraldsson, Martin, Andersson, Yasmin, Scaletti, Emma R, Bengtsson, Christoffer, Paulin, Cynthia B J, Sanjiv, Kumar, Abdurakhmanov, Eldar, Pudelko, Linda, Kunz, Ben, Desroses, Matthieu, Iliev, Petar, Färnegårdh, Katarina, Krämer, Andreas, Garg, Neeraj, Michel, Maurice, Häggblad, Sara, Jarvius, Malin, Kalderén, Christina, Jensen, Amanda Bögedahl, Almlöf, Ingrid, Karsten, Stella, Zhang, Si Min, Häggblad, Maria, Eriksson, Anders, Liu, Jianping, Glinghammar, Björn, Nekhotiaeva, Natalia, Klingegård, Fredrik, Koolmeister, Tobias, Martens, Ulf, Llona-Minguez, Sabin, Moulson, Ruth, Nordström, Helena, Parrow, Vendela, Dahllund, Leif, Sjöberg, Birger, Vargas, Irene L, Vo, Duy Duc, Wannberg, Johan, Knapp, Stefan, Krokan, Hans E, Arvidsson, Per I, Scobie, Martin, Meiser, Johannes, Stenmark, Pål, Berglund, Ulrika Warpman, Homan, Evert J, Helleday, Thomas

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Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress von Bonagas, Nadilly, Gustafsson, Nina M. S, Henriksson, Martin, Marttila, Petra, Gustafsson, Robert, Wiita, Elisee, Borhade, Sanjay, Green, Alanna C, Vallin, Karl S. A, Sarno, Antonio, Svensson, Richard, Gokturk, Camilla, Pham, Therese, Jemth, Ann-Sofie, Loseva, Olga, Cookson, Victoria, Kiweler, Nicole, Sandberg, Lars, Rasti, Azita, Unterlass, Judith E, Haraldsson, Martin, Andersson, Yasmin, Scaletti, Emma R, Bengtsson, Christoffer, Paulin, Cynthia B. J, Sanjiv, Kumar, Abdurakhmanov, Eldar, Pudelko, Linda, Kunz, Ben, Desroses, Matthieu, Iliev, Petar, Farnegardh, Katarina, Kramer, Andreas, Garg, Neeraj, Michel, Maurice, Haggblad, Sara, Jarvius, Malin, Kalderen, Christina, Jensen, Amanda Bogedahl, Almlof, Ingrid, Karsten, Stella, Zhang, Si Min, Haggblad, Maria, Eriksson, Anders, Liu, Jianping, Glinghammar, Bjorn, Nekhotiaeva, Natalia, Klingegard, Fredrik, Koolmeister, Tobias, Martens, Ulf, Llona-Minguez, Sabin, Moulson, Ruth, Nordström, Helena, Parrow, Vendela, Dahllund, Leif, Sjoberg, Birger, Vargas, Irene L, Vo, Duy Duc, Wannberg, Johan, Knapp, Stefan, Krokan, Hans E, Arvidsson, Per, I, Scobie, Martin, Meiser, Johannes, Stenmark, Pal, Berglund, Ulrika Warpman, Homan, Evert J, Helleday, Thomas

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Nudix hydrolase 18 catalyzes the hydrolysis of active triphosphate metabolites of the antivirals remdesivir, ribavirin, and molnupiravir von Jemth, Ann-Sofie, Scaletti, Emma Rose, Homan, Evert, Stenmark, Pål, Helleday, Thomas, Michel, Maurice

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Optimization of N‐Piperidinyl‐Benzimidazolone Derivatives as Potent and Selective Inhibitors of 8‐Oxo‐Guanine DNA Glycosylase 1 von Wallner, Olov, Cázares‐Körner, Armando, Scaletti, Emma Rose, Masuyer, Geoffrey, Bekkhus, Tove, Visnes, Torkild, Mamonov, Kirill, Ortis, Florian, Lundbäck, Thomas, Volkova, Maria, Koolmeister, Tobias, Wiita, Elisée, Loseva, Olga, Pandey, Monica, Homan, Evert, Benítez‐Buelga, Carlos, Davies, Jonathan, Scobie, Martin, Warpman Berglund, Ulrika, Kalderén, Christina, Stenmark, Pål, Helleday, Thomas, Michel, Maurice

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MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool von Scaletti, Emma Rose, Vallin, Karl S., Bräutigam, Lars, Sarno, Antonio, Warpman Berglund, Ulrika, Helleday, Thomas, Stenmark, Pål, Jemth, Ann-Sofie

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Massively parallel variant characterization identifies NUDT15 alleles associated with thiopurine toxicity von Suiter, Chase C., Moriyama, Takaya, Matreyek, Kenneth A., Yang, Wentao, Scaletti, Emma Rose, Nishii, Rina, Yang, Wenjian, Hoshitsuki, Keito, Singh, Minu, Trehan, Amita, Parish, Chris, Smith, Colton, Li, Lie, Bhojwani, Deepa, Yuen, Liz Y. P., Li, Chi-kong, Li, Chak-ho, Yang, Yung-li, Walker, Gareth J., Goodhand, James R., Kennedy, Nicholas A., Klussmann, Federico Antillon, Bhatia, Smita, Relling, Mary V., Kato, Motohiro, Hori, Hiroki, Bhatia, Prateek, Ahmad, Tariq, Yeoh, Allen E. J., Stenmark, Pål, Fowler, Douglas M., Yang, Jun J.

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Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity von Rehling, Daniel, Zhang, Si Min, Jemth, Ann-Sofie, Koolmeister, Tobias, Throup, Adam, Wallner, Olov, Scaletti, Emma, Moriyama, Takaya, Nishii, Rina, Davies, Jonathan, Desroses, Matthieu, Rudd, Sean G., Scobie, Martin, Homan, Evert, Berglund, Ulrika Warpman, Yang, Jun J., Helleday, Thomas, Stenmark, Pål

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Discovery of AB680: A Potent and Selective Inhibitor of CD73 von Lawson, Kenneth V, Kalisiak, Jaroslaw, Lindsey, Erick A, Newcomb, Eric T, Leleti, Manmohan Reddy, Debien, Laurent, Rosen, Brandon R, Miles, Dillon H, Sharif, Ehesan U, Jeffrey, Jenna L, Tan, Joanne B. L, Chen, Ada, Zhao, Sharon, Xu, Guifen, Fu, Lijuan, Jin, Lixia, Park, Tim W, Berry, Wade, Moschütz, Susanne, Scaletti, Emma, Sträter, Norbert, Walker, Nigel P, Young, Stephen W, Walters, Matthew J, Schindler, Uli, Powers, Jay P

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