Potent and Highly Selective Benzimidazole Inhibitors of PI3-Kinase Delta von Murray, Jeremy M, Sweeney, Zachary K, Chan, Bryan K, Balazs, Mercedesz, Bradley, Erin, Castanedo, Georgette, Chabot, Christine, Chantry, David, Flagella, Michael, Goldstein, David M, Kondru, Rama, Lesnick, John, Li, Jun, Lucas, Matthew C, Nonomiya, Jim, Pang, Jodie, Price, Stephen, Salphati, Laurent, Safina, Brian, Savy, Pascal P. A, Seward, Eileen M, Ultsch, Mark, Sutherlin, Daniel P

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Discovery of Novel PI3-Kinase δ Specific Inhibitors for the Treatment of Rheumatoid Arthritis: Taming CYP3A4 Time-Dependent Inhibition von Safina, Brian S, Baker, Stewart, Baumgardner, Matt, Blaney, Paul M, Chan, Bryan K, Chen, Yung-Hsiang, Cartwright, Matthew W, Castanedo, Georgette, Chabot, Christine, Cheguillaume, Arnaud J, Goldsmith, Paul, Goldstein, David M, Goyal, Bindu, Hancox, Timothy, Handa, Raj K, Iyer, Pravin S, Kaur, Jasmit, Kondru, Rama, Kenny, Jane R, Krintel, Sussie L, Li, Jun, Lesnick, John, Lucas, Matthew C, Lewis, Cristina, Mukadam, Sophie, Murray, Jeremy, Nadin, Alan J, Nonomiya, Jim, Padilla, Fernando, Palmer, Wylie S, Pang, Jodie, Pegg, Neil, Price, Steve, Reif, Karin, Salphati, Laurent, Savy, Pascal A, Seward, Eileen M, Shuttleworth, Stephen, Sohal, Sukhjit, Sweeney, Zachary K, Tay, Suzanne, Tivitmahaisoon, Parcharee, Waszkowycz, Bohdan, Wei, Binqing, Yue, Qin, Zhang, Chenghong, Sutherlin, Daniel P

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Accurate structure prediction of biomolecular interactions with AlphaFold 3 von Abramson, Josh, Adler, Jonas, Dunger, Jack, Evans, Richard, Green, Tim, Pritzel, Alexander, Ronneberger, Olaf, Willmore, Lindsay, Ballard, Andrew J., Bambrick, Joshua, Bodenstein, Sebastian W., Evans, David A., Hung, Chia-Chun, O’Neill, Michael, Reiman, David, Tunyasuvunakool, Kathryn, Wu, Zachary, Žemgulytė, Akvilė, Arvaniti, Eirini, Beattie, Charles, Bertolli, Ottavia, Bridgland, Alex, Cherepanov, Alexey, Congreve, Miles, Cowen-Rivers, Alexander I., Cowie, Andrew, Figurnov, Michael, Fuchs, Fabian B., Gladman, Hannah, Jain, Rishub, Khan, Yousuf A., Low, Caroline M. R., Perlin, Kuba, Potapenko, Anna, Savy, Pascal, Singh, Sukhdeep, Stecula, Adrian, Thillaisundaram, Ashok, Tong, Catherine, Yakneen, Sergei, Zhong, Ellen D., Zielinski, Michal, Žídek, Augustin, Bapst, Victor, Kohli, Pushmeet, Jaderberg, Max, Hassabis, Demis, Jumper, John M.

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Addendum: Accurate structure prediction of biomolecular interactions with AlphaFold 3 von Abramson, Josh, Adler, Jonas, Dunger, Jack, Evans, Richard, Green, Tim, Pritzel, Alexander, Ronneberger, Olaf, Willmore, Lindsay, Ballard, Andrew J., Bambrick, Joshua, Bodenstein, Sebastian W., Evans, David A., Hung, Chia-Chun, O’Neill, Michael, Reiman, David, Tunyasuvunakool, Kathryn, Wu, Zachary, Žemgulytė, Akvilė, Arvaniti, Eirini, Beattie, Charles, Bertolli, Ottavia, Bridgland, Alex, Cherepanov, Alexey, Congreve, Miles, Cowen-Rivers, Alexander I., Cowie, Andrew, Figurnov, Michael, Fuchs, Fabian B., Gladman, Hannah, Jain, Rishub, Khan, Yousuf A., Low, Caroline M. R., Perlin, Kuba, Potapenko, Anna, Savy, Pascal, Singh, Sukhdeep, Stecula, Adrian, Thillaisundaram, Ashok, Tong, Catherine, Yakneen, Sergei, Zhong, Ellen D., Zielinski, Michal, Žídek, Augustin, Bapst, Victor, Kohli, Pushmeet, Jaderberg, Max, Hassabis, Demis, Jumper, John M.

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Structure based design of novel 6,5 heterobicyclic mitogen-activated protein kinase kinase (MEK) inhibitors leading to the discovery of imidazo[1,5-a] pyrazine G-479 von Robarge, Kirk D., Lee, Wendy, Eigenbrot, Charles, Ultsch, Mark, Wiesmann, Christian, Heald, Robert, Price, Steve, Hewitt, Joanne, Jackson, Philip, Savy, Pascal, Burton, Brenda, Choo, Edna F., Pang, Jodie, Boggs, Jason, Yang, April, Yang, Xioaye, Baumgardner, Matthew

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Discovery of Novel Allosteric Mitogen-Activated Protein Kinase Kinase (MEK) 1,2 Inhibitors Possessing Bidentate Ser212 Interactions von Heald, Robert A, Jackson, Philip, Savy, Pascal, Jones, Mark, Gancia, Emanuela, Burton, Brenda, Newman, Richard, Boggs, Jason, Chan, Emily, Chan, Jocelyn, Choo, Edna, Merchant, Mark, Rudewicz, Patrick, Ultsch, Mark, Wiesmann, Christian, Yue, Qin, Belvin, Marcia, Price, Steve

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Identification of N-sulfonyl-tetrahydroquinolines as RORc inverse agonists von Fauber, Benjamin P., Gobbi, Alberto, Savy, Pascal, Burton, Brenda, Deng, Yuzhong, Everett, Christine, La, Hank, Johnson, Adam R., Lockey, Peter, Norman, Maxine, Wong, Harvey

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Bcl-2/Bcl-xL inhibition increases the efficacy of MEK inhibition alone and in combination with PI3 kinase inhibition in lung and pancreatic tumor models von Tan, Nguyen, Wong, Maureen, Nannini, Michelle A, Hong, Rebecca, Lee, Leslie B, Price, Stephen, Williams, Karen, Savy, Pierre Pascal, Yue, Peng, Sampath, Deepak, Settleman, Jeffrey, Fairbrother, Wayne J, Belmont, Lisa D

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Identification and hit-to-lead exploration of a novel series of histamine H4 receptor inverse agonists von Cramp, Sue, Dyke, Hazel J., Higgs, Christopher, Clark, David E., Gill, Matthew, Savy, Pascal, Jennings, Neil, Price, Steve, Lockey, Peter M., Norman, Dennis, Porres, Soraya, Wilson, Francis, Jones, Alison, Ramsden, Nigel, Mangano, Raffaella, Leggate, Dan, Andersson, Marie, Hale, Richard

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Aromatic Sulfide Inhibitors of Histone Deacetylase Based on Arylsulfinyl-2,4-hexadienoic Acid Hydroxyamides von Marson, Charles M, Savy, Pascal, Rioja, Alphonso S, Mahadevan, Thevaki, Mikol, Catherine, Veerupillai, Arthi, Nsubuga, Eva, Chahwan, Angela, Joel, Simon P

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UREA COMPOUNDS AS ACTIVATORS OF POTASSIUM CHANNELS KV7.2/7.3 USEFUL IN THE TREATMENT OF CNS AND PNS DISORDERS von KNIGHT, Jamie David, OMBRATO, Rosella, PALLIN, Thomas David, PRATI, Federica, SAVY, Pascal, GAROFALO, Barbara

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AMIDE COMPOUNDS AS ACTIVATORS OF THE POTASSIUM CHANNELS KV7.2/KV7.3 USEFUL IN THE TREATMENT OF CNS AND PNS DISORDERS von KNIGHT, Jamie David, OMBRATO, Rosella, PALLIN, Thomas David, PRATI, Federica, SAVY, Pascal, GAROFALO, Barbara

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Composti attivatori dei canali potassio KV7.2/KV7.3 von PALLIN, THOMAS DAVID, SAVY, PASCAL, GAROFALO, BARBARA, PRATI, FEDERICA, KNIGHT, JAMIE DAVID, OMBRATO, ROSELLA

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Composti attivatori dei canali potassio Kv7.2/Kv7.3 von PALLIN, THOMAS DAVID, SAVY, PASCAL, GAROFALO, BARBARA, PRATI, FEDERICA, KNIGHT, JAMIE DAVID, OMBRATO, ROSELLA

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Bicyclic anti-VZV nucleosides: Thieno analogues retain full antiviral activity von Brancale, Andrea, McGuigan, Christopher, Algain, Berthe, Savy, Pascal, Benhida, Rachid, Fourrey, Jean-Louis, Andrei, Graciela, Snoeck, Robert, De Clercq, Erik, Balzarini, Jan

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DNA triplex structures are stabilized by the incorporation of 3′- endo blocked pyrimidine nucleosides in the hoogsteen strand von Savy, Pascal, Benhida, Rachid, Fourrey, Jean-Louis, Maurisse, Rosalie, Sun, Jian-Sheng

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Binding properties of oligonucleotides containing a modified 2'-deoxyuridine with a thymine ended linker to pair with 2'-deoxyadenosine von SAVY, Pascal, BENHIDA, Rachid, FOURREY, Jean-Louis, MAURISSE, Rosalie, SUN, Jian-Sheng

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NEW 2-SUBSTITUTED INDAZOLES, METHODS FOR PRODUCING SAME, PHARMACEUTICAL PREPARATIONS THAT CONTAIN SAME, AND USE OF SAME TO PRODUCE DRUGS von SCHMIDT, Nicole, NUBBEMEYER, Reinhard, GÜNTHER, Judith, BOTHE, Ulrich, LANGE, Martin, STEUBER, Holger, BÖMER, Ulf, SIEBENEICHER, Holger, RAY, Nicholas, Charles, SAVY, Pascal

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Synthesis of A Novel Sialyl Lewis X Analogue Containing A Pyrrolidine in Place of N-Acetyl Glucosamine von Dechaux, Elsa, Savy, Pascal, Bouyain, Samule, Monneret, Claude, Florent, Jean-Claude

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2-substituted indazoles, methods for producing same, pharmaceutical preparations that contain same, and use of same to produce drugs von Siebeneicher, Holger, Bömer, Ulf, Lange, Martin, Ray, Nicholas Charles, Schmidt, Nicole, Nubbemeyer, Reinhard, Bothe, Ulrich, Steuber, Holger, Savy, Pascal, Günther, Judith

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