Ubiquitin receptors play redundant roles in the proteasomal degradation of the p53 repressor MDM2 von Sparks, Alison, Kelly, Christopher J., Saville, Mark K.

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p53 isoforms can regulate p53 transcriptional activity von Bourdon, Jean-Christophe, Fernandes, Kenneth, Murray-Zmijewski, Fiona, Liu, Geng, Diot, Alexandra, Xirodimas, Dimitris P, Saville, Mark K, Lane, David P

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Suppression of the Deubiquitinating Enzyme USP5 Causes the Accumulation of Unanchored Polyubiquitin and the Activation of p53 von Dayal, Saurabh, Sparks, Alison, Jacob, Jimmy, Allende-Vega, Nerea, Lane, David P., Saville, Mark K.

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Mdm2-Mediated NEDD8 Conjugation of p53 Inhibits Its Transcriptional Activity von Xirodimas, Dimitris P, Saville, Mark K, Bourdon, Jean-Christophe, Hay, Ronald T, Lane, David P

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Suppression of mutant Kirsten-RAS (KRASG12D)-driven pancreatic carcinogenesis by dual-specificity MAP kinase phosphatases 5 and 6 von Kidger, Andrew M., Saville, Mark K., Rushworth, Linda K., Davidson, Jane, Stellzig, Julia, Ono, Motoharu, Kuebelsbeck, Ludwig A., Janssen, Klaus-Peter, Holzmann, Bernhard, Morton, Jennifer P., Sansom, Owen J., Caunt, Christopher J., Keyse, Stephen M.

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The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2 von Stevenson, Lauren F, Sparks, Alison, Allende-Vega, Nerea, Xirodimas, Dimitris P, Lane, David P, Saville, Mark K

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Preclinical comparison of proteasome and ubiquitin E1 enzyme inhibitors in cutaneous squamous cell carcinoma: the identification of mechanisms of differential sensitivity von McHugh, Angela, Fernandes, Kenneth, South, Andrew P, Mellerio, Jemima E, Salas-Alanís, Julio C, Proby, Charlotte M, Leigh, Irene M, Saville, Mark K

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Targeting the ubiquitin–proteasome system to activate wild-type p53 for cancer therapy von Allende-Vega, Nerea, Saville, Mark K

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The Identification of Potential Therapeutic Targets for Cutaneous Squamous Cell Carcinoma von McHugh, Angela, Fernandes, Kenneth, Chinner, Nerime, Ibrahim, Adel F.M., Garg, Amit K., Boag, Garry, Hepburn, Lydia A., Proby, Charlotte M., Leigh, Irene M., Saville, Mark K.

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Lysine-63-linked ubiquitination is required for endolysosomal degradation of class I molecules von Duncan, Lidia M, Piper, Siân, Dodd, Roger B, Saville, Mark K, Sanderson, Chris M, Luzio, J Paul, Lehner, Paul J

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Targeting the spliceosome for cutaneous squamous cell carcinoma therapy: a role for c-MYC and wild-type p53 in determining the degree of tumour selectivity von Hepburn, Lydia A, McHugh, Angela, Fernandes, Kenneth, Boag, Garry, Proby, Charlotte M, Leigh, Irene M, Saville, Mark K

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Elevated Levels of Oncogenic Protein Kinase Pim-1 Induce the p53 Pathway in Cultured Cells and Correlate with Increased Mdm2 in Mantle Cell Lymphoma von Hogan, Carol, Hutchison, Caroline, Marcar, Lynnette, Milne, Diane, Saville, Mark, Goodlad, John, Kernohan, Neil, Meek, David

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Regulation of p53 by the Ubiquitin-conjugating Enzymes UbcH5B/C in Vivo von Saville, Mark K, Sparks, Alison, Xirodimas, Dimitris P, Wardrop, Julie, Stevenson, Lauren F, Bourdon, Jean-Christophe, Woods, Yvonne L, Lane, David P

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Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms von Stad, Robert, Little, Natalie A, Xirodimas, Dimitris P, Frenk, Ruth, van der Eb, Alex J, Lane, David P, Saville, Mark K, Jochemsen, Aart G

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Different effects of p14ARF on the levels of ubiquitinated p53 and Mdm2 in vivo von XIRODIMAS, Dimitris, SAVILLE, Mark K, EDLING, Charlotte, LANE, David P, LAIN, Sonia

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p14 Arf Promotes Small Ubiquitin-like Modifier Conjugation of Werners Helicase von Woods, Yvonne L., Xirodimas, Dimitris P., Prescott, Alan R., Sparks, Alison, Lane, David P., Saville, Mark K.

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Helium-oxygen reduces the production of carbon dioxide during weaning from mechanical ventilation von Flynn, Gordon, Mandersloot, Gerlinde, Healy, Marie, Saville, Mark, McAuley, Daniel F

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The cell-cycle regulated transcription factor B-Myb is phosphorylated by cyclin A/Cdk2 at sites that enhance its transactivation properties von SAVILLE, M. K, WATSON, R. J

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Inhibition of cyclin A/Cdk2 phosphorylation impairs B-Myb transactivation function without affecting interactions with DNA or the CBP coactivator von BESSA, Maria, SAVILLE, Mark K, WATSON, Roger J

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B-Myb overcomes a p107-mediated cell proliferation block by interacting with an N-terminal domain of p107 von JOAQUIN, Manel, BESSA, Maria, SAVILLE, Mark K, WATSON, Roger J

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