BRCA1, a ‘complex’ protein involved in the maintenance of genomic stability von Savage, Kienan I., Harkin, D. Paul

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Identification of a BRCA1-mRNA Splicing Complex Required for Efficient DNA Repair and Maintenance of Genomic Stability von Savage, Kienan I., Gorski, Julia J., Barros, Eliana M., Irwin, Gareth W., Manti, Lorenzo, Powell, Alexander J., Pellagatti, Andrea, Lukashchuk, Natalia, McCance, Dennis J., McCluggage, W. Glenn, Schettino, Giuseppe, Salto-Tellez, Manuel, Boultwood, Jacqueline, Richard, Derek J., McDade, Simon S., Harkin, D. Paul

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Use of the γ-H2AX assay to investigate DNA repair dynamics following multiple radiation exposures von Mariotti, Luca G, Pirovano, Giacomo, Savage, Kienan I, Ghita, Mihaela, Ottolenghi, Andrea, Prise, Kevin M, Schettino, Giuseppe

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The RNA processing factors THRAP3 and BCLAF1 promote the DNA damage response through selective mRNA splicing and nuclear export von Vohhodina, Jekaterina, Barros, Eliana M, Savage, Abigail L, Liberante, Fabio G, Manti, Lorenzo, Bankhead, Peter, Cosgrove, Nicola, Madden, Angelina F, Harkin, D Paul, Savage, Kienan I

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Homologous recombination deficiency in breast cancer: Implications for risk, cancer development, and therapy von Ali, Rayhaan M. M., McIntosh, Stuart A., Savage, Kienan I.

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The Nuclear Oncogene SET Controls DNA Repair by KAP1 and HP1 Retention to Chromatin von Kalousi, Alkmini, Hoffbeck, Anne-Sophie, Selemenakis, Platonas N., Pinder, Jordan, Savage, Kienan I., Khanna, Kum Kum, Brino, Laurent, Dellaire, Graham, Gorgoulis, Vassilis G., Soutoglou, Evi

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BRCA1 Deficiency Exacerbates Estrogen-Induced DNA Damage and Genomic Instability von SAVAGE, Kienan I, MATCHETT, Kyle B, POWELL, Alexander, MANTI, Lorenzo, MCDADE, Simon S, BEN HO PARK, PRISE, Kevin M, MCINTOSH, Stuart A, SALTO-TELLEZ, Manuel, RICHARD, Derek J, ELLIOTT, Christopher T, HARKIN, D. Paul, BARROS, Eliana M, COOPER, Kevin M, IRWIN, Gareth W, GORSKI, Julia J, ORR, Katy S, VOHHODINA, Jekaterina, KAVANAGH, Joy N, MADDEN, Angelina F

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Chronic loss of STAG2 leads to altered chromatin structure contributing to de-regulated transcription in AML von Smith, James S., Lappin, Katrina M., Craig, Stephanie G., Liberante, Fabio G., Crean, Clare M., McDade, Simon S., Thompson, Alexander, Mills, Ken I., Savage, Kienan I.

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BRD7, a Subunit of SWI/SNF Complexes, Binds Directly to BRCA1 and Regulates BRCA1-Dependent Transcription von HARTE, Mary T, O'BRIEN, Garrett J, RYAN, Niamh M, GORSKI, Julia J, SAVAGE, Kienan I, CRAWFORD, Nyree T, MULLAN, Paul B, HARKIN, D. Paul

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‘From R-lupus to cancer’: Reviewing the role of R-loops in innate immune responses von Bradley, Leanne, Savage, Kienan I.

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Activation of STING-Dependent Innate Immune Signaling By S-Phase-Specific DNA Damage in Breast Cancer von Parkes, Eileen E, Walker, Steven M, Taggart, Laura E, McCabe, Nuala, Knight, Laura A, Wilkinson, Richard, McCloskey, Karen D, Buckley, Niamh E, Savage, Kienan I, Salto-Tellez, Manuel, McQuaid, Stephen, Harte, Mary T, Mullan, Paul B, Harkin, D Paul, Kennedy, Richard D

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Multifocal breast cancers are more prevalent in BRCA2 versus BRCA1 mutation carriers von McCrorie, Alan D, Ashfield, Susannah, Begley, Aislinn, Mcilmunn, Colin, Morrison, Patrick J, Boyd, Clinton, Eccles, Bryony, Greville‐Heygate, Stephanie, Copson, Ellen R, Cutress, Ramsey I, Eccles, Diana M, Savage, Kienan I, McIntosh, Stuart A

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The DNA damage induced immune response: Implications for cancer therapy von Barros, Eliana M., McIntosh, Stuart A., Savage, Kienan I.

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COMMD4 functions with the histone H2A-H2B dimer for the timely repair of DNA double-strand breaks von Suraweera, Amila, Gandhi, Neha S., Beard, Sam, Burgess, Joshua T., Croft, Laura V., Bolderson, Emma, Naqi, Ali, Ashton, Nicholas W., Adams, Mark N., Savage, Kienan I., Zhang, Shu-Dong, O’Byrne, Kenneth J., Richard, Derek J.

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PARP inhibition induces BAX/BAK-independent synthetic lethality of BRCA1-deficient non-small cell lung cancer von Paul, Ian, Savage, Kienan I, Blayney, Jaine K, Lamers, Elisabeth, Gately, Kathy, Kerr, Keith, Sheaff, Michael, Arthur, Kenneth, Richard, Derek J, Hamilton, Peter W, James, Jacqueline A, O'Byrne, Kenneth J, Harkin, D Paul, Quinn, Jennifer E, Fennell, Dean A

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Cancer-Associated SF3B1 Mutations Confer a BRCA-Like Cellular Phenotype and Synthetic Lethality to PARP Inhibitors von Lappin, Katrina M, Barros, Eliana M, Jhujh, Satpal S, Irwin, Gareth W, McMillan, Hayley, Liberante, Fabio G, Latimer, Cheryl, La Bonte, Melissa J, Mills, Ken I, Harkin, D Paul, Stewart, Grant S, Savage, Kienan I

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Mechanistic Rationale to Target PTEN-Deficient Tumor Cells with Inhibitors of the DNA Damage Response Kinase ATM von McCabe, Nuala, Hanna, Conor, Walker, Steven M, Gonda, David, Li, Jie, Wikstrom, Katarina, Savage, Kienan I, Butterworth, Karl T, Chen, Clark, Harkin, D Paul, Prise, Kevin M, Kennedy, Richard D

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Altered splicing and cytoplasmic levels of tRNA synthetases in SF3B1-mutant myelodysplastic syndromes as a therapeutic vulnerability von Liberante, Fabio Giuseppe, Lappin, Katrina, Barros, Eliana M., Vohhodina, Jekaterina, Grebien, Florian, Savage, Kienan I., Mills, Kenneth Ian

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Activation of a cGAS-STING-mediated immune response predicts response to neoadjuvant chemotherapy in early breast cancer von Parkes, Eileen E., Savage, Kienan I., Lioe, Tong, Boyd, Clinton, Halliday, Sophia, Walker, Steven M., Lowry, Keith, Knight, Laura, Buckley, Niamh E., Grogan, Andrena, Logan, Gemma E., Clayton, Alison, Hurwitz, Jane, Kirk, Stephen J., Xu, Jiamei, Sidi, Fatima Abdullahi, Humphries, Matthew P., Bingham, Victoria, James, Jaqueline A., James, Colin R., Paul Harkin, D., Kennedy, Richard D., McIntosh, Stuart A.

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ACE: A Workbench Using Evolutionary Genetic Algorithms for Analyzing Association in TCGA von Gilmore, Alan R, Alderdice, Matthew, Savage, Kienan I, O'Reilly, Paul G, Roddy, Aideen C, Dunne, Philip D, Lawler, Mark, McDade, Simon S, Waugh, David J, McArt, Darragh G

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