Transcriptional Programs Define Intratumoral Heterogeneity of Ewing Sarcoma at Single-Cell Resolution von Aynaud, Marie-Ming, Mirabeau, Olivier, Gruel, Nadege, Grossetête, Sandrine, Boeva, Valentina, Durand, Simon, Surdez, Didier, Saulnier, Olivier, Zaïdi, Sakina, Gribkova, Svetlana, Fouché, Aziz, Kairov, Ulykbek, Raynal, Virginie, Tirode, Franck, Grünewald, Thomas G.P., Bohec, Mylene, Baulande, Sylvain, Janoueix-Lerosey, Isabelle, Vert, Jean-Philippe, Barillot, Emmanuel, Delattre, Olivier, Zinovyev, Andrei

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An OTX2-PAX3 signaling axis regulates Group 3 medulloblastoma cell fate von Zagozewski, Jamie, Shahriary, Ghazaleh M., Morrison, Ludivine Coudière, Saulnier, Olivier, Stromecki, Margaret, Fresnoza, Agnes, Palidwor, Gareth, Porter, Christopher J., Forget, Antoine, Ayrault, Olivier, Hawkins, Cynthia, Chan, Jennifer A., Vladoiu, Maria C., Sundaresan, Lakshmikirupa, Arsenio, Janilyn, Taylor, Michael D., Ramaswamy, Vijay, Werbowetski-Ogilvie, Tamra E.

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scRNA-seq in medulloblastoma shows cellular heterogeneity and lineage expansion support resistance to SHH inhibitor therapy von Ocasio, Jennifer Karin, Babcock, Benjamin, Malawsky, Daniel, Weir, Seth J., Loo, Lipin, Simon, Jeremy M., Zylka, Mark J., Hwang, Duhyeong, Dismuke, Taylor, Sokolsky, Marina, Rosen, Elias P., Vibhakar, Rajeev, Zhang, Jiao, Saulnier, Olivier, Vladoiu, Maria, El-Hamamy, Ibrahim, Stein, Lincoln D., Taylor, Michael D., Smith, Kyle S., Northcott, Paul A., Colaneri, Alejandro, Wilhelmsen, Kirk, Gershon, Timothy R.

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Oncogenic chimeric transcription factors drive tumor-specific transcription, processing, and translation of silent genomic regions von Vibert, Julien, Saulnier, Olivier, Collin, Céline, Petit, Floriane, Borgman, Kyra J E, Vigneau, Jérômine, Gautier, Maud, Zaidi, Sakina, Pierron, Gaëlle, Watson, Sarah, Gruel, Nadège, Hénon, Clémence, Postel-Vinay, Sophie, Deloger, Marc, Raynal, Virginie, Baulande, Sylvain, Laud-Duval, Karine, Hill, Véronique, Grossetête, Sandrine, Dingli, Florent, Loew, Damarys, Torrejon, Jacob, Ayrault, Olivier, Orth, Martin F, Grünewald, Thomas G P, Surdez, Didier, Coulon, Antoine, Waterfall, Joshua J, Delattre, Olivier

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A therapeutically targetable positive feedback loop between lnc-HLX-2-7, HLX, and MYC that promotes group 3 medulloblastoma von Katsushima, Keisuke, Joshi, Kandarp, Yuan, Menglang, Romero, Brigette, Batish, Mona, Stapleton, Stacie, Jallo, George, Kolanthai, Elayaraja, Seal, Sudipta, Saulnier, Olivier, Taylor, Michael D., Wechsler-Reya, Robert J., Eberhart, Charles G., Perera, Ranjan J.

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The LIN28B-let-7-PBK pathway is essential for group 3 medulloblastoma tumor growth and survival von Shahab, Shubin W, Roggeveen, Christianna M, Sun, Jiarong, Kunhiraman, Haritha, McSwain, Leon F, Juraschka, Kyle, Kumar, Sachin A, Saulnier, Olivier, Taylor, Michael D, Schniederjan, Matthew, Schnepp, Robert W, MacDonald, Tobey J, Kenney, Anna Marie

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Systematic transcriptomic analysis of childhood medulloblastoma identifies N6-methyladenosine-dependent lncRNA signatures associated with molecular subtype, immune cell infiltratio... von Joshi, Kandarp, Yuan, Menglang, Katsushima, Keisuke, Saulnier, Olivier, Ray, Animesh, Amankwah, Ernest, Stapleton, Stacie, Jallo, George, Taylor, Michael D, Eberhart, Charles G, Perera, Ranjan J

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Author Correction: scRNA-seq in medulloblastoma shows cellular heterogeneity and lineage expansion support resistance to SHH inhibitor therapy von Ocasio, Jennifer Karin, Babcock, Benjamin, Malawsky, Daniel, Weir, Seth J., Loo, Lipin, Simon, Jeremy M., Zylka, Mark J., Hwang, Duhyeong, Dismuke, Taylor, Sokolsky, Marina, Rosen, Elias P., Vibhakar, Rajeev, Zhang, Jiao, Saulnier, Olivier, Vladoiu, Maria, El-Hamamy, Ibrahim, Stein, Lincoln D., Taylor, Michael D., Smith, Kyle S., Northcott, Paul A., Colaneri, Alejandro, Wilhelmsen, Kirk, Gershon, Timothy R.

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miRNA-211 maintains metabolic homeostasis in medulloblastoma through its target gene long-chain acyl-CoA synthetase 4 von Yuan, Menglang, Mahmud, Iqbal, Katsushima, Keisuke, Joshi, Kandarp, Saulnier, Olivier, Pokhrel, Rudramani, Lee, Bongyong, Liyanage, Wathsala, Kunhiraman, Haritha, Stapleton, Stacie, Gonzalez-Gomez, Ignacio, Kannan, Rangaramanujam M, Eisemann, Tanja, Kolanthai, Elayaraja, Seal, Sudipta, Garrett, Timothy J, Abbasi, Saed, Bockley, Kimberly, Hanes, Justin, Chapagain, Prem, Jallo, George, Wechsler-Reya, Robert J, Taylor, Michael D, Eberhart, Charles G, Ray, Animesh, Perera, Ranjan J

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Combined MEK and JAK/STAT3 pathway inhibition effectively decreases SHH medulloblastoma tumor progression von Zagozewski, Jamie, Borlase, Stephanie, Guppy, Brent J., Coudière-Morrison, Ludivine, Shahriary, Ghazaleh M., Gordon, Victor, Liang, Lisa, Cheng, Stephen, Porter, Christopher J., Kelley, Rhonda, Hawkins, Cynthia, Chan, Jennifer A., Liang, Yan, Gong, Jingjing, Nör, Carolina, Saulnier, Olivier, Wechsler-Reya, Robert J., Ramaswamy, Vijay, Werbowetski-Ogilvie, Tamra E.

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Combined analysis of TERT, EGFR, and IDH status defines distinct prognostic glioblastoma classes von Labussière, Marianne, Boisselier, Blandine, Mokhtari, Karima, Di Stefano, Anna-Luisa, Rahimian, Anais, Rossetto, Marta, Ciccarino, Pietro, Saulnier, Olivier, Paterra, Rosina, Marie, Yannick, Finocchiaro, Gaetano, Sanson, Marc

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CSIG-28. THE HEDGEHOG GENE EXPRESSION PROGRAM REGULATES LIPID FEEDBACK MECHANISMS UNDERLYING HEDGEHOG-ASSOCIATED MEDULLOBLASTOMA von Daggubati, Vikas, Choudhury, Abrar, Vykunta, Akshara, Saulnier, Olivier, Gardell, Zachary, Reiter, Jeremy, Taylor, Michael, Raleigh, David

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Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma von Michealraj, Kulandaimanuvel Antony, Kumar, Sachin A., Kim, Leo J.Y., Cavalli, Florence M.G., Przelicki, David, Wojcik, John B., Delaidelli, Alberto, Bajic, Andrea, Saulnier, Olivier, MacLeod, Graham, Vellanki, Ravi N., Vladoiu, Maria C., Guilhamon, Paul, Ong, Winnie, Lee, John J.Y., Jiang, Yanqing, Holgado, Borja L., Rasnitsyn, Alex, Malik, Ahmad A., Tsai, Ricky, Richman, Cory M., Juraschka, Kyle, Haapasalo, Joonas, Wang, Evan Y., De Antonellis, Pasqualino, Suzuki, Hiromichi, Farooq, Hamza, Balin, Polina, Kharas, Kaitlin, Van Ommeren, Randy, Sirbu, Olga, Rastan, Avesta, Krumholtz, Stacey L., Ly, Michelle, Ahmadi, Moloud, Deblois, Geneviève, Srikanthan, Dilakshan, Luu, Betty, Loukides, James, Wu, Xiaochong, Garzia, Livia, Ramaswamy, Vijay, Kanshin, Evgeny, Sánchez-Osuna, María, El-Hamamy, Ibrahim, Coutinho, Fiona J., Prinos, Panagiotis, Singh, Sheila, Donovan, Laura K., Daniels, Craig, Schramek, Daniel, Tyers, Mike, Weiss, Samuel, Stein, Lincoln D., Lupien, Mathieu, Wouters, Bradly G., Garcia, Benjamin A., Arrowsmith, Cheryl H., Sorensen, Poul H., Angers, Stephane, Jabado, Nada, Dirks, Peter B., Mack, Stephen C., Agnihotri, Sameer, Rich, Jeremy N., Taylor, Michael D.

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ZRANB2 and SYF2-mediated splicing programs converging on ECT2 are involved in breast cancer cell resistance to doxorubicin von Tanaka, Iris, Chakraborty, Alina, Saulnier, Olivier, Benoit-Pilven, Clara, Vacher, Sophie, Labiod, Dalila, Lam, Eric W F, Bièche, Ivan, Delattre, Olivier, Pouzoulet, Frédéric, Auboeuf, Didier, Vagner, Stéphan, Dutertre, Martin

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Failure of human rhombic lip differentiation underlies medulloblastoma formation von Hendrikse, Liam D., Haldipur, Parthiv, Saulnier, Olivier, Millman, Jake, Erickson, Anders W., Gordon, Victor, Coudière-Morrison, Ludivine, Shokouhian, Mohammad, Suárez, Raúl A., Ly, Michelle, Borlase, Stephanie, Scott, David S., Farooq, Hamza, Sirbu, Olga, Nambu, Shohei, Funakoshi, Yusuke, Diaz-Mejia, J. Javier, Golser, Joseph, Bach, Kathleen, Phuong-Bao, Tram, Skowron, Patryk, Wang, Evan Y., Kumar, Sachin A., Balin, Polina, Visvanathan, Abhirami, Lee, John J. Y., Ayoub, Ramy, Mungall, Karen L., Wang, Yu C., Kim, Seung-Ki, Bourdeaut, Franck, Doz, François, Masliah-Planchon, Julien, Grajkowska, Wieslawa A., Loukides, James, Dirks, Peter, Fèvre-Montange, Michelle, French, Pim J., Kros, Johan M., Zitterbart, Karel, Bailey, Swneke D., Eberhart, Charles G., Rao, Amulya A. N., Giannini, Caterina, Olson, James M., Phillips, Joanna J., Ra, Young S., de Torres, Carmen, Mora, Jaume, Li, Kay K. W., Poon, Wai S., Pollack, Ian F., López-Aguilar, Enrique, Gillespie, G. Yancey, Shofuda, Tomoko, Vibhakar, Rajeev, Thompson, Reid C., Rubin, Joshua B., Jung, Shin, Lach, Boleslaw, Iolascon, Achille, Ferrucci, Veronica, Zollo, Massimo, Cinalli, Giuseppe, Robinson, Shenandoah, Stearns, Duncan S., Van Meir, Erwin G., Porrati, Paola, Massimino, Maura, Carlotti, Carlos G., Faria, Claudia C., Chan, Jennifer A., Aldinger, Kimberly A., Razavi, Ferechte, McLendon, Roger E., Thompson, Eric M., Ansari, Marc, Garre, Maria L., Chico, Fernando, Eguía, Pilar, Morrissy, A. Sorana, Wu, Xiaochong, Daniels, Craig, Rich, Jeremy N., Jones, Steven J. M., Marra, Marco A., Reimand, Jüri, Sorensen, Poul H., Wechsler-Reya, Robert J., Kleinman, Claudia L., Jabado, Nada, Malkin, David, Ayrault, Olivier, Golden, Jeffrey A., Ellison, David W., Doble, Brad, Ramaswamy, Vijay, Werbowetski-Ogilvie, Tamra E., Suzuki, Hiromichi, Millen, Kathleen J.

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Abstract IA009: Oncogenic transcription factors drive highly tumor-specific LincRNA von Delattre, Olivier, Vibert, Julien, Saulnier, Olivier, Waterfall, Joshua

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Targeting Microglial Metabolic Rewiring Synergizes with Immune-Checkpoint Blockade Therapy for Glioblastoma von Ye, Zengpanpan, Ai, Xiaolin, Yang, Kailin, Yang, Zhengnan, Fei, Fan, Liao, Xiaoling, Qiu, Zhixin, Gimple, Ryan C, Yuan, Huairui, Huang, Hao, Gong, Yanqiu, Xiao, Chaoxin, Yue, Jing, Huang, Liang, Saulnier, Olivier, Wang, Wei, Zhang, Peidong, Dai, Lunzhi, Wang, Xin, Wang, Xiuxing, Ahn, Young Ha, You, Chao, Xu, Jianguo, Wan, Xiaoxiao, Taylor, Michael D, Zhao, Linjie, Rich, Jeremy N, Zhou, Shengtao

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A single-cell transcriptomic map of the developing Atoh1 lineage identifies neural fate decisions and neuronal diversity in the hindbrain von Butts, Jessica C., Wu, Sih-Rong, Durham, Mark A., Dhindsa, Ryan S., Revelli, Jean-Pierre, Ljungberg, M. Cecilia, Saulnier, Olivier, McLaren, Madison E., Taylor, Michael D., Zoghbi, Huda Y.

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ERG transcription factors have a splicing regulatory function involving RBFOX2 that is altered in the EWS-FLI1 oncogenic fusion von Saulnier, Olivier, Guedri-Idjouadiene, Katia, Aynaud, Marie-Ming, Chakraborty, Alina, Bruyr, Jonathan, Pineau, Joséphine, O’Grady, Tina, Mirabeau, Olivier, Grossetête, Sandrine, Galvan, Bartimée, Claes, Margaux, Al Oula Hassoun, Zahra, Sadacca, Benjamin, Laud, Karine, Zaïdi, Sakina, Surdez, Didier, Baulande, Sylvain, Rambout, Xavier, Tirode, Franck, Dutertre, Martin, Delattre, Olivier, Dequiedt, Franck

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Oncogenic chimeric transcription factors drive tumor-specific transcription, processing, and translation of silent genomic regions von Vibert, Julien, Saulnier, Olivier, Collin, Céline, Petit, Floriane, Borgman, Kyra J E, Vigneau, Jérômine, Gautier, Maud, Zaidi, Sakina, Pierron, Gaëlle, Watson, Sarah, Gruel, Nadège, Hénon, Clémence, Postel-Vinay, Sophie, Deloger, Marc, Raynal, Virginie, Baulande, Sylvain, Laud-Duval, Karine, Hill, Véronique, Grossetête, Sandrine, Dingli, Florent, Loew, Damarys, Torrejon, Jacob, Ayrault, Olivier, Orth, Martin F, Grünewald, Thomas G P, Surdez, Didier, Coulon, Antoine, Waterfall, Joshua J, Delattre, Olivier

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