In vitro and in vivo antitumor effects of the dual insulin-like growth factor-I/insulin receptor inhibitor, BMS-554417 von Haluska, Paul, Carboni, Joan M, Loegering, David A, Lee, Francis Y, Wittman, Mark, Saulnier, Mark G, Frennesson, David B, Kalli, Kimberly R, Conover, Cheryl A, Attar, Ricardo M, Kaufmann, Scott H, Gottardis, Marco, Erlichman, Charles

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5‑Bromo-2-chloro-4-fluoro-3-iodopyridine as a Halogen-rich Intermediate for the Synthesis of Pentasubstituted Pyridines von Wu, Yong-Jin, Porter, Gerard J, Frennesson, David B, Saulnier, Mark G

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Discovery and Preclinical Profiling of GSK3839919, a Potent HIV‑1 Allosteric Integrase Inhibitor von Parcella, Kyle, Wang, Tao, Eastman, Kyle, Zhang, Zhongxing, Yin, Zhiwei, Patel, Manoj, Tu, Yong, Zheng, Barbara Zhizhen, Walker, Michael A., Saulnier, Mark G., Frennesson, David, Bowsher, Michael, Gillis, Eric, Peese, Kevin, Belema, Makonen, Cianci, Christopher, Dicker, Ira B., McAuliffe, Brian, Ding, Bo, Falk, Paul, Simmermacher, Jean, Parker, Dawn D., Sivaprakasam, Prasanna, Kish, Kevin, Lewis, Hal, Hanumegowda, Umesh, Jenkins, Susan, Kadow, John F., Krystal, Mark, Meanwell, Nicholas A., Naidu, B. Narasimhulu

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Discovery of a 1H-Benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) Inhibitor of Insulin-like Growth Factor I Receptor Kinase with in Vivo Antitumor Activity von Wittman, Mark, Carboni, Joan, Attar, Ricardo, Balasubramanian, Balu, Balimane, Praveen, Brassil, Patrick, Beaulieu, Francis, Chang, Chiehying, Clarke, Wendy, Dell, Janet, Eummer, Jeffrey, Frennesson, David, Gottardis, Marco, Greer, Ann, Hansel, Steven, Hurlburt, Warren, Jacobson, Bruce, Krishnananthan, Subramaniam, Lee, Francis Y, Li, Aixin, Lin, Tai-An, Liu, Peiying, Ouellet, Carl, Sang, Xiaopeng, Saulnier, Mark G, Stoffan, Karen, Sun, Yax, Velaparthi, Upender, Wong, Henry, Yang, Zheng, Zimmermann, Kurt, Zoeckler, Mary, Vyas, Dolatrai

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Insulin-like growth factor-1 receptor (IGF-1R) kinase inhibitors: SAR of a series of 3-[6-(4-substituted-piperazin-1-yl)-4-methyl-1H-benzimidazol-2-yl]-1H-pyridine-2-one von VELAPARTHI, Upender, SAULNIER, Mark G, CLARKE, Wendy, ZHENG YANG, MENARD, Krista, LEE, Francis Y, TRAINOR, George, VYAS, Dolatrai, WITTMAN, Mark D, PEIYING LIU, FRENNESSON, David B, ZIMMERMANN, Kurt, CARBONI, Joan M, GOTTARDIS, Marco, AIXIN LI, GREER, Ann

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Nucleophilic Capture of the Imino-Quinone Methide Type Intermediates Generated from 2-Aminothiazol-5-yl Carbinols von Saulnier, Mark G, Dodier, Marco, Frennesson, David B, Langley, David R, Vyas, Dolatrai M

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SAR of PXR transactivation in benzimidazole-based IGF-1R kinase inhibitors von Zimmermann, Kurt, Wittman, Mark D., Saulnier, Mark G., Velaparthi, Upender, Sang, Xiaopeng, Frennesson, David B., Struzynski, Charles, Seitz, Steven P., He, Liqi, Carboni, Joan M., Li, Aixin, Greer, Ann F., Gottardis, Marco, Attar, Ricardo M., Yang, Zheng, Balimane, Praveen, Discenza, Lorell N., Lee, Francis Y., Sinz, Michael, Kim, Sean, Vyas, Dolatrai

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Balancing oral exposure with Cyp3A4 inhibition in benzimidazole-based IGF-IR inhibitors von Zimmermann, Kurt, Wittman, Mark D., Saulnier, Mark G., Velaparthi, Upender, Langley, David R., Sang, Xiaopeng, Frennesson, David, Carboni, Joan, Li, Aixin, Greer, Ann, Gottardis, Marco, Attar, Ricardo M., Yang, Zheng, Balimane, Praveen, Discenza, Lorell N., Vyas, Dolatrai

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2-(1 H-Imidazol-4-yl)ethanamine and 2-(1 H-pyrazol-1-yl)ethanamine side chain variants of the IGF-1R inhibitor BMS-536924 von Saulnier, Mark G., Frennesson, David B., Wittman, Mark D., Zimmermann, Kurt, Velaparthi, Upender, Langley, David R., Struzynski, Charles, Sang, Xiaopeng, Carboni, Joan, Li, Aixin, Greer, Ann, Yang, Zheng, Balimane, Praveen, Gottardis, Marco, Attar, Ricardo, Vyas, Dolatrai

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Discovery of a Fluoroindolo[2,3-a]carbazole Clinical Candidate with Broad Spectrum Antitumor Activity in Preclinical Tumor Models Superior to the Marketed Oncology Drug, CPT-11 von Saulnier, Mark G, Balasubramanian, Balu N, Long, Byron H, Frennesson, David B, Ruediger, Edward, Zimmermann, Kurt, Eummer, Jeffrey T, St. Laurent, Denis R, Stoffan, Karen M, Naidu, B. Narasimhulu, Mahler, Mikael, Beaulieu, Francis, Bachand, Carol, Lee, Frank Y, Fairchild, Craig R, Stadnick, Linda K, Rose, William C, Solomon, Carola, Wong, Henry, Martel, Alain, Wright, John J, Kramer, Robert, Langley, David R, Vyas, Dolatrai M

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An unusual oxidative cyclization. A synthesis and absolute stereochemical assignment of (-)-rocaglamide von Trost, Barry M, Greenspan, Paul D, Yang, Bingwei V, Saulnier, Mark G

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Design and Synthesis of a Fluoroindolocarbazole Series as Selective Topoisomerase I Active Agents. Discovery of Water-Soluble 3,9-Difluoro-12,13-dihydro-13-[6-amino-β- d-glucopyran... von Balasubramanian, Balu N, St. Laurent, Denis R, Saulnier, Mark G, Long, Byron H, Bachand, Carol, Beaulieu, Francis, Clarke, Wendy, Deshpande, Milind, Eummer, Jeffrey, Fairchild, Craig R, Frennesson, David B, Kramer, Robert, Lee, Frank Y, Mahler, Mikael, Martel, Alain, Naidu, B. Narasimhulu, Rose, William C, Russell, John, Ruediger, Edward, Solomon, Carola, Stoffan, Karen M, Wong, Henry, Zimmermann, Kurt, Vyas, Dolatrai M

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Generation and reactions of 3-lithio-1-(phenylsulfonyl)indole von Saulnier, Mark G, Gribble, Gordon W

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Synthesis and Diels-Alder reactions of 1,3-dimethyl-4-(phenylsulfonyl)-4H-furo[3,4-b]indole. A new annulation strategy for the construction of ellipticine and isoellipticine von Gribble, Gordon W, Saulnier, Mark G, Sibi, Mukund P, Obaza-Nutaitis, Judy A

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Synthesis of new pyrrolo[3,4-b]indol-3-ones as latent substrates for pyrrolo[3,4-b]indoles von Saulnier, Mark G., Schreiber, Steven M., Cavanaugh, Kerri L., Perni, Robert B., Joyner, H. Howard, Gribble, and Gordon W.

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Design and Synthesis of a Fluoroindolocarbazole Series as Selective Topoisomerase I Active Agents. Discovery of Water-Soluble 3,9-Difluoro-12,13-dihydro-13-[6-amino-β-d-glucopyrano... von Balasubramanian, Balu N, St. Laurent, Denis R, Saulnier, Mark G, Long, Byron H, Bachand, Carol, Beaulieu, Francis, Clarke, Wendy, Deshpande, Milind, Eummer, Jeffrey, Fairchild, Craig R, Frennesson, David B, Kramer, Robert, Lee, Frank Y, Mahler, Mikael, Martel, Alain, Naidu, B. Narasimhulu, Rose, William C, Russell, John, Ruediger, Edward, Solomon, Carola, Stoffan, Karen M, Wong, Henry, Wright, John J, Zimmermann, Kurt, Vyas, Dolatrai M

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Syntheses and Diels-Alder cycloaddition reactions of 4H-furo[3,4-b]indoles. A regiospecific Diels-Alder synthesis of ellipticine von Gribble, Gordon W., Keavy, Daniel J., Davis, Deborah A., Saulnier, Mark G., Pelcman, Benjamin, Barden, Timothy C., Sibi, Mukund P., Olson, Erik R., BelBruno, Joseph J.

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Intramolecular Diels-Alder Reactions of 4H-Furo[3,4-b]indoles. New Syntheses of Benzo[a]carbazoles and Benzo[c]carbazoles von Gribble, Gordon W., Silva, Richard A., Saulnier, Mark G.

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Synthesis of etoposide phosphate, BMY-40481: A water-soluble clinically active prodrug of etoposide von Saulnier, Mark G., Langley, David R., Kadow, John F., Senter, Peter D., Knipe, Jay O, Tun, Min Min, Vyas, Dolatrai M., Doyle, Terrence W.

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Chemoselective synthesis of allyltrimethylsilanes by cross-coupling of vinyl triflates with tris((trimethylsilyl)methyl)aluminum catalyzed by palladium(0) von Saulnier, Mark G, Kadow, John F, Tun, Min Min, Langley, David R, Vyas, Dolatrai M

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