The Current Status and Prospects of Antibody Engineering for Therapeutic Use: Focus on Glycoengineering Technology von Niwa, Rinpei, Satoh, Mitsuo

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Allergic diseases: From bench to clinic - Contribution of the discovery of interleukin-5 von Yanagibashi, Tsutomu, Satoh, Mitsuo, Nagai, Yoshinori, Koike, Masamichi, Takatsu, Kiyoshi

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Production of therapeutic antibodies with controlled fucosylation von Yamane-Ohnuki, Naoko, Satoh, Mitsuo

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Engineered therapeutic antibodies with improved effector functions von Kubota, Tsuguo, Niwa, Rinpei, Satoh, Mitsuo, Akinaga, Shiro, Shitara, Kenya, Hanai, Nobuo

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Improving effector functions of antibodies for cancer treatment: Enhancing ADCC and CDC von Natsume, Akito, Niwa, Rinpei, Satoh, Mitsuo

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Importance of the Side Chain at Position 296 of Antibody Fc in Interactions with FcγRIIIa and Other Fcγ Receptors von Isoda, Yuya, Yagi, Hirokazu, Satoh, Tadashi, Shibata-Koyama, Mami, Masuda, Kazuhiro, Satoh, Mitsuo, Kato, Koichi, Iida, Shigeru

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Structural Comparison of Fucosylated and Nonfucosylated Fc Fragments of Human Immunoglobulin G1 von Matsumiya, Shigeki, Yamaguchi, Yoshiki, Saito, Jun-ichi, Nagano, Mayumi, Sasakawa, Hiroaki, Otaki, Shizuo, Satoh, Mitsuo, Shitara, Kenya, Kato, Koichi

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Non-fucosylated therapeutic antibodies as next-generation therapeutic antibodies von Satoh, Mitsuo, Iida, Shigeru, Shitara, Kenya

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The Absence of Fucose but Not the Presence of Galactose or Bisecting N-Acetylglucosamine of Human IgG1 Complex-type Oligosaccharides Shows the Critical Role of Enhancing Antibody-d... von Shinkawa, Toyohide, Nakamura, Kazuyasu, Yamane, Naoko, Shoji-Hosaka, Emi, Kanda, Yutaka, Sakurada, Mikiko, Uchida, Kazuhisa, Anazawa, Hideharu, Satoh, Mitsuo, Yamasaki, Motoo, Hanai, Nobuo, Shitara, Kenya

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Nonfucosylated Therapeutic IgG1 Antibody Can Evade the Inhibitory Effect of Serum Immunoglobulin G on Antibody-Dependent Cellular Cytotoxicity through its High Binding to FcγRIIIa von IIDA, Shigeru, MISAKA, Hirofumi, INOUE, Miho, SHIBATA, Mami, NAKANO, Ryosuke, YAMANE-OHNUKI, Naoko, WAKITANI, Masako, YANO, Keiichi, SHITARA, Kenya, SATOH, Mitsuo

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A Peptidomics Strategy for Discovering Endogenous Bioactive Peptides von Sasaki, Kazuki, Takahashi, Noriyuki, Satoh, Mitsuo, Yamasaki, Motoo, Minamino, Naoto

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Engineered anti‐CD20 antibodies with enhanced complement‐activating capacity mediate potent anti‐lymphoma activity von Natsume, Akito, Shimizu‐Yokoyama, Yukiko, Satoh, Mitsuo, Shitara, Kenya, Niwa, Rinpei

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Two mechanisms of the enhanced antibody-dependent cellular cytotoxicity (ADCC) efficacy of non-fucosylated therapeutic antibodies in human blood von Iida, Shigeru, Kuni-Kamochi, Reiko, Mori, Katsuhiro, Misaka, Hirofumi, Inoue, Miho, Okazaki, Akira, Shitara, Kenya, Satoh, Mitsuo

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Double knockdown of α1,6-fucosyltransferase (FUT8) and GDP-mannose 4,6-dehydratase (GMD) in antibody-producing cells: a new strategy for generating fully non-fucosylated therapeuti... von Imai-Nishiya, Harue, Mori, Katsuhiro, Inoue, Miho, Wakitani, Masako, Iida, Shigeru, Shitara, Kenya, Satoh, Mitsuo

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A Nonfucosylated Anti-HER2 Antibody Augments Antibody-Dependent Cellular Cytotoxicity in Breast Cancer Patients von SUZUKI, Eiji, NIWA, Rinpei, TOI, Masakazu, SAJI, Shigehira, MUTA, Mariko, HIROSE, Makiko, IIDA, Shigeru, SHIOTSU, Yukimasa, SATOH, Mitsuo, SHITARA, Kenya, KONDO, Masahide

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Establishment of a GDP-mannose 4,6-dehydratase ( GMD) knockout host cell line: A new strategy for generating completely non-fucosylated recombinant therapeutics von Kanda, Yutaka, Imai-Nishiya, Harue, Kuni-Kamochi, Reiko, Mori, Katsuhiro, Inoue, Miho, Kitajima-Miyama, Kazuko, Okazaki, Akira, Iida, Shigeru, Shitara, Kenya, Satoh, Mitsuo

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Engineering Chinese hamster ovary cells to maximize effector function of produced antibodies using FUT8 siRNA von Mori, Katsuhiro, Kuni-Kamochi, Reiko, Yamane-Ohnuki, Naoko, Wakitani, Masako, Yamano, Kazuya, Imai, Harue, Kanda, Yutaka, Niwa, Rinpei, Iida, Shigeru, Uchida, Kazuhisa, Shitara, Kenya, Satoh, Mitsuo

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Non-fucosylated therapeutic antibodies : the next generation of therapeutic antibodies von MORI, Katsuhiro, IIDA, Shigeru, NIWA, Rinpei, SHITARA, Kenya, SATOH, Mitsuo, YAMANE-OHNUKI, Naoko, KANDA, Yutaka, KUNI-KAMOCHI, Reiko, NAKANO, Ryosuke, IMAI-NISHIYA, Harue, OKAZAKI, Akira, SHINKAWA, Toyohide, NATSUME, Akihito

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Fucose Removal from Complex-Type Oligosaccharide Enhances the Antibody-Dependent Cellular Cytotoxicity of Single-Gene-Encoded Bispecific Antibody Comprising of Two Single-Chain Ant... von Natsume, Akito, Wakitani, Masako, Yamane-Ohnuki, Naoko, Shoji-Hosaka, Emi, Niwa, Rinpei, Uchida, Kazuhisa, Satoh, Mitsuo, Shitara, Kenya

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Structural basis for improved efficacy of therapeutic antibodies on defucosylation of their Fc glycans von Mizushima, Tsunehiro, Yagi, Hirokazu, Takemoto, Emi, Shibata‐Koyama, Mami, Isoda, Yuya, Iida, Shigeru, Masuda, Kazuhiro, Satoh, Mitsuo, Kato, Koichi

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