Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine von Ross, Leila S., Dhingra, Satish K., Mok, Sachel, Yeo, Tomas, Wicht, Kathryn J., Kümpornsin, Krittikorn, Takala-Harrison, Shannon, Witkowski, Benoit, Fairhurst, Rick M., Ariey, Frederic, Menard, Didier, Fidock, David A.

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Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies von Veiga, M. Isabel, Dhingra, Satish K., Henrich, Philipp P., Straimer, Judith, Gnädig, Nina, Uhlemann, Anne-Catrin, Martin, Rowena E., Lehane, Adele M., Fidock, David A.

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Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness von Stokes, Barbara H., Dhingra, Satish K., Rubiano, Kelly, Mok, Sachel, Straimer, Judith, Gnadig, Nina F., Deni, Ioanna, Schindler, Kyra A., Bath, Jade R., Ward, Kurt E., Striepen, Josefine, Yeo, Tomas, Ross, Leila S., Legrand, Eric, Ariey, Frederic, Cunningham, Clark H., Souleymane, Issa M., Gansane, Adama, Nzoumbou-Boko, Romaric, Ndayikunda, Claudette, Kabanywanyi, Abdunoor M., Uwimana, Aline, Smith, Samuel J., Kolley, Olimatou, Ndounga, Mathieu, Warsame, Marian, Leang, Rithea, Nosten, Francois, Anderson, Timothy J. C., Rosenthal, Philip J., Menard, Didier, Fidock, David A.

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Adaptive evolution of malaria parasites in French Guiana: Reversal of chloroquine resistance by acquisition of a mutation in pfcrt von Pelleau, Stéphane, Moss, Eli L., Dhingra, Satish K., Volney, Béatrice, Casteras, Jessica, Gabryszewski, Stanislaw J., Volkman, Sarah K., Wirth, Dyann F., Legrand, Eric, Fidock, David A., Neafsey, Daniel E., Musset, Lise

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Evidence for the early emergence of piperaquine-resistant Plasmodium falciparum malaria and modeling strategies to mitigate resistance von Small-Saunders, Jennifer L, Hagenah, Laura M, Wicht, Kathryn J, Dhingra, Satish K, Deni, Ioanna, Kim, Jonathan, Vendome, Jeremie, Gil-Iturbe, Eva, Roepe, Paul D, Mehta, Monica, Mancia, Filippo, Quick, Matthias, Eppstein, Margaret J, Fidock, David A

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Global Spread of Mutant PfCRT and Its Pleiotropic Impact on Plasmodium falciparum Multidrug Resistance and Fitness von Dhingra, Satish K, Gabryszewski, Stanislaw J, Small-Saunders, Jennifer L, Yeo, Tomas, Henrich, Philipp P, Mok, Sachel, Fidock, David A

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Evolution of Fitness Cost-Neutral Mutant PfCRT Conferring P. falciparum 4-Aminoquinoline Drug Resistance Is Accompanied by Altered Parasite Metabolism and Digestive Vacuole Physiol... von Gabryszewski, Stanislaw J, Dhingra, Satish K, Combrinck, Jill M, Lewis, Ian A, Callaghan, Paul S, Hassett, Matthew R, Siriwardana, Amila, Henrich, Philipp P, Lee, Andrew H, Gnädig, Nina F, Musset, Lise, Llinás, Manuel, Egan, Timothy J, Roepe, Paul D, Fidock, David A

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Additional PfCRT mutations driven by selective pressure for improved fitness can result in the loss of piperaquine resistance and altered Plasmodium falciparum physiology von Hagenah, Laura M, Dhingra, Satish K, Small-Saunders, Jennifer L, Qahash, Tarrick, Willems, Andreas, Schindler, Kyra A, Rangel, Gabriel W, Gil-Iturbe, Eva, Kim, Jonathan, Akhundova, Emiliya, Yeo, Tomas, Okombo, John, Mancia, Filippo, Quick, Matthias, Roepe, Paul D, Llinás, Manuel, Fidock, David A

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Balancing drug resistance and growth rates via compensatory mutations in the Plasmodium falciparum chloroquine resistance transporter von Petersen, Ines, Gabryszewski, Stanislaw J., Johnston, Geoffrey L., Dhingra, Satish K., Ecker, Andrea, Lewis, Rebecca E., Almeida, Mariana Justino, Straimer, Judith, Henrich, Philipp P., Palatulan, Eugene, Johnson, David J., Coburn‐Flynn, Olivia, Sanchez, Cecilia, Lehane, Adele M., Lanzer, Michael, Fidock, David A.

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Plasmodium falciparum resistance to piperaquine driven by PfCRT von Dhingra, Satish K, Small-Saunders, Jennifer L, Ménard, Didier, Fidock, David A

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Structure and drug resistance of the Plasmodium falciparum transporter PfCRT von Kim, Jonathan, Tan, Yong Zi, Wicht, Kathryn J., Erramilli, Satchal K., Dhingra, Satish K., Okombo, John, Vendome, Jeremie, Hagenah, Laura M., Giacometti, Sabrina I., Warren, Audrey L., Nosol, Kamil, Roepe, Paul D., Potter, Clinton S., Carragher, Bridget, Kossiakoff, Anthony A., Quick, Matthias, Fidock, David A., Mancia, Filippo

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Safety, pharmacokinetics, and antimalarial activity of the novel plasmodium eukaryotic translation elongation factor 2 inhibitor M5717: a first-in-human, randomised, placebo-contro... von McCarthy, James S, Yalkinoglu, Özkan, Odedra, Anand, Webster, Rebecca, Oeuvray, Claude, Tappert, Aliona, Bezuidenhout, Deon, Giddins, Marla J, Dhingra, Satish K, Fidock, David A, Marquart, Louise, Webb, Lachlan, Yin, Xiaoyan, Khandelwal, Akash, Bagchus, Wilhelmina M

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Preclinical Antimalarial Combination Study of M5717, a Plasmodium falciparum Elongation Factor 2 Inhibitor, and Pyronaridine, a Hemozoin Formation Inhibitor von Rottmann, Matthias, Jonat, Brian, Gumpp, Christin, Dhingra, Satish K., Giddins, Marla J., Yin, Xiaoyan, Badolo, Lassina, Greco, Beatrice, Fidock, David A., Oeuvray, Claude, Spangenberg, Thomas

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A Variant PfCRT Isoform Can Contribute to Plasmodium falciparum Resistance to the First-Line Partner Drug Piperaquine von Dhingra, Satish K, Redhi, Devasha, Combrinck, Jill M, Yeo, Tomas, Okombo, John, Henrich, Philipp P, Cowell, Annie N, Gupta, Purva, Stegman, Matthew L, Hoke, Jonathan M, Cooper, Roland A, Winzeler, Elizabeth, Mok, Sachel, Egan, Timothy J, Fidock, David A

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Integrative Genetic Manipulation of Plasmodium cynomolgi Reveals Multidrug Resistance-1 Y976F Associated With Increased In Vitro Susceptibility to Mefloquine von Ward, Kurt E, Christensen, Peter, Racklyeft, Annie, Dhingra, Satish K, Chua, Adeline C Y, Remmert, Caroline, Suwanarusk, Rossarin, Matheson, Jessica, Blackman, Michael J, Kaneko, Osamu, Kyle, Dennis E, Lee, Marcus C S, Moon, Robert W, Snounou, Georges, Rénia, Laurent, Fidock, David A, Russell, Bruce, Bifani, Pablo

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Causal chemoprophylactic activity of cabamiquine against Plasmodium falciparum in a controlled human malaria infection: a randomised, double-blind, placebo-controlled study in the... von van der Plas, Johan L, Kuiper, Vincent P, Bagchus, Wilhelmina M, Bödding, Matthias, Yalkinoglu, Özkan, Tappert, Aliona, Seitzinger, Andrea, Spangenberg, Thomas, Bezuidenhout, Deon, Wilkins, Justin, Oeuvray, Claude, Dhingra, Satish K, Thathy, Vandana, Fidock, David A, Smidt, Lisanne C A, Roozen, Geert V T, Koopman, Jan Pieter R, Lamers, Olivia A C, Sijtsma, Jeroen, van Schuijlenburg, Roos, Wessels, Els, Meij, Pauline, Kamerling, Ingrid M C, Roestenberg, Meta, Khandelwal, Akash

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Evidence for Regulation of Hemoglobin Metabolism and Intracellular Ionic Flux by the Plasmodium falciparum Chloroquine Resistance Transporter von Lee, Andrew H., Dhingra, Satish K., Lewis, Ian A., Singh, Maneesh K., Siriwardana, Amila, Dalal, Seema, Rubiano, Kelly, Klein, Matthias S., Baska, Katelynn S., Krishna, Sanjeev, Klemba, Michael, Roepe, Paul D., Llinás, Manuel, Garcia, Celia R. S., Fidock, David A.

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Identification and Mechanistic Understanding of Dihydroorotate Dehydrogenase Point Mutations in Plasmodium falciparum that Confer in Vitro Resistance to the Clinical Candidate DSM2... von White, John, Dhingra, Satish K, Deng, Xiaoyi, El Mazouni, Farah, Lee, Marcus C. S, Afanador, Gustavo A, Lawong, Aloysus, Tomchick, Diana R, Ng, Caroline L, Bath, Jade, Rathod, Pradipsinh K, Fidock, David A, Phillips, Margaret A

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Mapping the genomic landscape of multidrug resistance in Plasmodium falciparum and its impact on parasite fitness von Mok, Sachel, Yeo, Tomas, Hong, Davin, Shears, Melanie J, Ross, Leila S, Ward, Kurt E, Dhingra, Satish K, Kanai, Mariko, Bridgford, Jessica L, Tripathi, Abhai K, Mlambo, Godfree, Burkhard, Anna Y, Ansbro, Megan R, Fairhurst, Kate J, Gil-Iturbe, Eva, Park, Heekuk, Rozenberg, Felix D, Kim, Jonathan, Mancia, Filippo, Fairhurst, Rick M, Quick, Matthias, Uhlemann, Anne-Catrin, Sinnis, Photini, Fidock, David A

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Integrative Genetic Manipulation of Plasmodium cynomolgi Reveals Multidrug Resistance-1 Y976F Associated With Increased In Vitro Susceptibility to Mefloquine von Ward, Kurt E, Christensen, Peter, Racklyeft, Annie, Dhingra, Satish K, Chua, Adeline CY, Remmert, Caroline, Suwanarusk, Rossarin, Matheson, Jessica, Blackman, Michael J, Kaneko, Osamu, Kyle, Dennis E, Lee, Marcus CS, Moon, Robert W, Snounou, Georges, Rénia, Laurent, Fidock, David A, Russell, Bruce, Bifani, Pablo

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