High‐Parameter Mass Cytometry Evaluation of Relapsed/Refractory Multiple Myeloma Patients Treated with Daratumumab Demonstrates Immune Modulation as a Novel Mechanism of Action von Adams, Homer C., Stevenaert, Frederik, Krejcik, Jakub, Van der Borght, Koen, Smets, Tina, Bald, Jaime, Abraham, Yann, Ceulemans, Hugo, Chiu, Christopher, Vanhoof, Greet, Usmani, Saad Z., Plesner, Torben, Lonial, Sagar, Nijhof, Inger, Lokhorst, Henk M., Mutis, Tuna, Donk, Niels W.C.J., Sasser, Amy Kate, Casneuf, Tineke

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Abstract 1101: Telomerase inhibitor imetelstat in combination with the BCL-2 inhibitor venetoclax enhances apoptosis in vitro and increases survival in vivo in acute myeloid leukem... von Rusbuldt, Joshua J., Luistro, Leopoldo, Chin, Diana, Smith, Melissa, Wong, Amy, Romero, Margarita, Rizo, Aleksandra, Bussolari, Jacqueline, Huang, Fei, Sasser, Amy (Kate)

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CD38 expression and complement inhibitors affect response and resistance to daratumumab therapy in myeloma von Nijhof, Inger S., Casneuf, Tineke, van Velzen, Jeroen, van Kessel, Berris, Axel, Amy E., Syed, Khaja, Groen, Richard W.J., van Duin, Mark, Sonneveld, Pieter, Minnema, Monique C., Zweegman, Sonja, Chiu, Christopher, Bloem, Andries C., Mutis, Tuna, Lokhorst, Henk M., Sasser, A.Kate, van de Donk, Niels W.C.J.

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Clinical efficacy of daratumumab monotherapy in patients with heavily pretreated relapsed or refractory multiple myeloma von Usmani, Saad Z., Weiss, Brendan M., Plesner, Torben, Bahlis, Nizar J., Belch, Andrew, Lonial, Sagar, Lokhorst, Henk M., Voorhees, Peter M., Richardson, Paul G., Chari, Ajai, Sasser, A.Kate, Axel, Amy, Feng, Huaibao, Uhlar, Clarissa M., Wang, Jianping, Khan, Imran, Ahmadi, Tahamtan, Nahi, Hareth

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Effects of daratumumab on natural killer cells and impact on clinical outcomes in relapsed or refractory multiple myeloma von Casneuf, Tineke, Xu, Xu Steven, Adams, Homer C., Axel, Amy E., Chiu, Christopher, Khan, Imran, Ahmadi, Tahamtan, Yan, Xiaoyu, Lonial, Sagar, Plesner, Torben, Lokhorst, Henk M., van de Donk, Niels W.C.J., Clemens, Pamela L., Sasser, A. Kate

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Monitoring multiple myeloma patients treated with daratumumab: teasing out monoclonal antibody interference von McCudden, Christopher, Axel, Amy E, Slaets, Dominique, Dejoie, Thomas, Clemens, Pamela L, Frans, Sandy, Bald, Jaime, Plesner, Torben, Jacobs, Joannes F M, van de Donk, Niels W C J, Moreau, Philippe, Schecter, Jordan M, Ahmadi, Tahamtan, Sasser, A Kate

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Interleukin‐6 is a potent growth factor for ER‐α‐positive human breast cancer von Sasser, A. Kate, Sullivan, Nicholas J., Studebaker, Adam W., Hendey, Lindsay F., Axel, Amy E., Hall, Brett M.

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Interference of daratumumab in monitoring multiple myeloma patients using serum immunofixation electrophoresis can be abrogated using the daratumumab IFE reflex assay (DIRA) von van de Donk, Niels W C J, Otten, Henny G, El Haddad, Omar, Axel, Amy, Sasser, A Kate, Croockewit, Sandra, Jacobs, Joannes F M

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Human bone marrow stromal cells enhance breast cancer cell growth rates in a cell line-dependent manner when evaluated in 3D tumor environments von Sasser, A. Kate, Mundy, Bethany L, Smith, Kristen M, Studebaker, Adam W, Axel, Amy E, Haidet, Amanda M, Fernandez, Soledad A, Hall, Brett M

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Interleukin-6 is a potential therapeutic target in interleukin-6 dependent, estrogen receptor-α-positive breast cancer von Casneuf, Tineke, Axel, Amy E, King, Peter, Alvarez, John D, Werbeck, Jillian L, Verhulst, Tinne, Verstraeten, Karin, Hall, Brett M, Sasser, A Kate

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Response to: Interference of daratumumab on the serum protein electrophoresis von McCudden, Christopher, Axel, Amy E., Slaets, Dominique, Dejoie, Thomas, Clemens, Pamela, Frans, Sandy, Bald, Jaime, Plesner, Torben, Jacobs, Joannes F.M., van de Donk, Niels W.C.J., Moreau, Philippe, Schecter, Jordan M., Ahmadi, Tahamtan, Sasser, A. Kate

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Preclinical Evaluation of CSL362/JNJ-56022473 in Combination with Decitabine or Azacitidine in in Vitro Assays von Syed, Khaja, Pietsch, Christine, Axel, Amy, Forslund, Ann, Sasser, Kate, Salvati, Mark

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Preclinical Evaluation of CSL362/JNJ-56022473 Single Agent in in Vitro Assays von Syed, Khaja, Pietsch, Christine, Axel, Amy, Forslund, Ann, Sasser, Kate, Salvati, Mark

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Effects of Ibrutinib on Rituximab and GA-101 Induced Antibody-Dependent Cell Cytotoxicity (ADCC) in Lymphoma Cells in Vitro von Davis, Cuc, Stepanchick, Emily, Syed, Khaja, Axel, Amy, Hall, Brett, Sasser, Kate, Balasubramanian, Sriram

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Daratumumab in Combination with Lenalidomide Plus Dexamethasone Induces Clonality Increase and T-Cell Expansion: Results from a Phase 3 Randomized Study (POLLUX) von Chiu, Christopher, Casneuf, Tineke, Axel, Amy, Lysaght, Andrew, Bald, Jaime, Khokhar, Nushmia Z, Plesner, Torben, Usmani, Saad Z, Goldschmidt, Hartmut, Ahmadi, Tahamtan, Chan, Kenneth, Sasser, A. Kate

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Overcoming the Interference of Daratumumab with Immunofixation Electrophoresis (IFE) Using an Industry-Developed Dira Test : Hydrashift 2/4 Daratumumab von Caillon, Helene, Irimia, Alix, Simon, Jason S., Axel, Amy, Sasser, Kate, Scullion, Matthew James, Ligneel, Thierry, Nouadje, Georges, Moreau, Philippe, Dejoie, Thomas

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Ex Vivo Activity Profile of the CD123xCD3 Duobody® Antibody JNJ-63709178 Against Primary Acute Myeloid Leukemia Bone Marrow Samples von Forslund, Ann, Syed, Khaja, Axel, Amy, McDaid, Ronan, Li, Yingzhe, Ballesteros, Juan, Gaudet, Francois, Attar, Ricardo M., Salvati, Mark, Huang, Fei, Sasser, Kate

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Abstract 2563: Development of clinical assay to mitigate daratumumab, an IgG1κ monoclonal antibody, interference with serum immunofixation (IFE) and clinical assessment of M-protei... von Axel, Amy E., McCudden, Christopher R., Xie, Hong, Hall, Brett M., Sasser, A. Kate

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Assessing clinical response in multiple myeloma (MM) patients treated with monoclonal antibodies (mAbs): Validation of a daratumumab IFE reflex assay (DIRA) to distinguish malignan... von McCudden, Christopher, Axel, Amy, Slaets, Dominique, Frans, Sandy, Bald, Jaime, Schecter, Jordan Mark, Ahmadi, Tahamtan, Plesner, Torben, Sasser, Kate

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Clinical Efficacy of Daratumumab Monotherapy in Patients with Heavily Pretreated Relapsed or Refractory Multiple Myeloma von Usmani, Saad, Weiss, Brendan, Bahlis, Nizar J, Belch, Andrew, Lonial, Sagar, Lokhorst, Henk, Voorhees, Peter M., Richardson, Paul G., Sasser, A Kate, Axel, Amy, Feng, Huaibao, Uhlar, Clarissa, Wang, Jianping, Khan, Imran, Ahmadi, Tahamtan, Nahi, Hareth

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