Combined immunotherapy encompassing intratumoral poly-ICLC, dendritic-cell vaccination and radiotherapy in advanced cancer patients von Rodríguez-Ruiz, M.E., Perez-Gracia, J.L., Rodríguez, I., Alfaro, C., Oñate, C., Pérez, G., Gil-Bazo, I., Benito, A., Inogés, S., López-Diaz de Cerio, A., Ponz-Sarvise, M., Resano, L., Berraondo, P., Barbés, B., Martin-Algarra, S., Gúrpide, A., Sanmamed, M.F., de Andrea, C., Salazar, A.M., Melero, I.

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3D systems to study pancreatic ductal adenocarcinoma (PDAC). Comparison of the most referenced models using a bibliometric approach von De Carvajal Cebrian, C., Vicent, S., Ponz-Sarvise, M.

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Oxaliplatin, irinotecan and capecitabine as first-line therapy in metastatic colorectal cancer (mCRC): a dose-finding study and pharmacogenomic analysis von Zarate, R, Rodríguez, J, Bandres, E, Patiño-Garcia, A, Ponz-Sarvise, M, Viudez, A, Ramirez, N, Bitarte, N, Chopitea, A, Gacía-Foncillas, J

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194 Pancreatic ductal organoids as a new platform for drug discovery von Ponz-Sarvise, M, Corbo, V, Öhlund, D, Oni, T, Handly-Santana, A, Engle, D, Tiriac, H, Chio, C, Feigin, M, Baker, L, Ardito-Abraham, C, Park, Y, Hwang, C, Elyada, E, Yu, K, Clevers, H, Tuveson, D.A

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Association of RRM1 –37A>C polymorphism with clinical outcome in colorectal cancer patients treated with gemcitabine-based chemotherapy von Rodriguez, J, Boni, V, Hernández, A, Bitarte, N, Zarate, R, Ponz-Sarvisé, M, Chopitea, A, Bandres, E, Garcia-Foncillas, J

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Epidermal growth factor receptor inhibitors in colorectal cancer treatment: what's new? von Ponz-Sarvisé, M, Rodríguez, J, Viudez, A, Chopitea, A, Calvo, A, García-Foncillas, J, Gil-Bazo, I

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1027P First results for intravenous (IV) VSV-GP (BI 1831169) in patients (pts) with advanced solid tumors from the 1456-0001 study von Oliva Bernal, M., Greillier, L., Ponz-Sarvise, M., Moreno Garcia, V., Prenen, H., Wolf, D., Quinson, A-M., Luecke, S., Hern, V., Porosnicu, M.

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44P Chemo-immunotherapy combination of mFOLFOX6, bevacizumab and atezolizumab after first-line therapy for advanced biliary tract cancer: The COMBATBIL imCORE trial von Ponz-Sarvise, M., Gromke, T., Magdalena, A. Landa, Richly, H., Liffers, S-T., Kasper-Virchow, S., Garonce-Hediger, R., Alvarez, E. Castanon, Paredes, L. Ceniceros, Ortega, A. Chopitea, Siveke, J.T.

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1018P Leveraging innate and adaptive immunity with AFM24 and atezolizumab in metastatic gastric cancer von Saavedra Santa Gadea, O., Oberoi, A., Lopez, J.S., Cervantes, A., Ponz-Sarvise, M., Kim, H.R., El-Khoueiry, A.B., Shim, B., Kim, J.W., Boni, V., Lugowska, I., Szczylik, C., Rogowski, W., Mandziuk, S., Ramlau, R., Gaertner, U., Lutkewitz, S., Schütz, D., Emig, M., Morales-Espinosa, D.

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PD-10 Comprehensive circulating tumor (ct) DNA NGS for molecular profiling in advanced cholangiocarcinoma von Visa, L., Sauri, T., Esposito, F., Adeva Alfonso, J., Peinado, P., Ponz-Sarvise, M., Fabregat Franco, C., Carames, C., Salinas, P., Kushnir, M., Macarulla, T., Cubillo, A., Garcia-Carbonero, R., Victoria, I., Bellosillo, B., Montagut, C.

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232P Identification of ‘secondary’ germline cancer predisposition variants from somatic tumour testing: Should we evolve towards universal screening? von Gallego Martinez, A., Imizcoz, T., Sánchez-Lorenzo, L., Mora, M., Domínguez, D., Gurpide, A., Espinos Jimenez, J., Aramendia, J.M., Chopitea Ortega, A., Santisteban Eslava, M., Ponz-Sarvise, M., González, J.L., Landa Magdalena, A., Sanmamed, M.F., Alkorta-Aranburu, G., Rodriguez Rodriguez, J., Herráiz Bayod, T., Gonzalez Martin, A., Patiño-García, A.

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1636P Circulating tumor DNA (ctDNA) profile in patients (pts) with pancreatic cancer (PC): A multicenter experience and challenges for clinical application von Ghiglione, L., Muñoz i Carrillo, F.J., Esposito, F.M., Pesantez Coronel, D., Delcuratolo, M.D., Garcia-Carbonero, R., Fabregat-Franco, C., Alonso, G., Macarulla, T., Ceniceros Paredes, L., Ponz-Sarvise, M., Visa Turmo, L., López Muñoz, A.M., Pastor, B., Indacochea, A., Vicente Lazcano, M.P., Riva, F.N., Prat, A., Victoria, I., Sauri Nadal, T.

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First-in-human safety, pharmacokinetics, and preliminary efficacy of TPX-0022, a novel inhibitor of MET/SRC/CSF1R in patients with advanced solid tumors harboring genetic alteratio... von Hong, D., Bazhenova, L., Cho, B.C., Sen, S., Ponz-Sarvise, M., Heist, R., Zimmerman, Z., Le, X., Xuan, D., Junming, Z., Lee, J.

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PD-5 MONEO: Phase II study of avelumab (Av) plus FLOT in the peri-operative treatment for patients (pts) with resectable gastric or gastroesophageal junction cancer (GC) von Alsina, M., Ponz-Sarvise, M., Garcia, D. Lopez, Villacampa, G., De Andrea, C., Ochoa, C., López-Janeiro, A., Jiménez-Fonseca, P., Arrazubi, V., García, M. Díez, Sanz-García, E., Martinez de Castro, E., Sanchez, R. Guardeño, Campos, M. Calvo, Sánchez, C. Bugés, Longo, F., Navarro, V., Gros, A., Vivancos, A., Tabernero, J., Muñoz, S., Melero, I.

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Chemotherapy after immunotherapy failure in patients with advanced gastrointestinal tumors von Baraibar Argota, I., Martin Romano, P., Sanmamed, M.F., Rodríguez Ruiz, M., Melero, I., Resano, L., Chopitea Ortega, A., Ponz-Sarvisé, M., Castanon Alvarez, E.

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1544P Use of pharmacokinetic parameters of preoperative 5-FU as a prognostic factor in resected pancreatic cancer von Vilalta, A., Urrizola, A., Aldaz, A., Elarre, P. Sala, Rotellar, F., Pardo, F., Subtil, J.C., Salas Benito, D., Eguren, I., Chopitea Ortega, A., Rodriguez Rodriguez, J., Ponz-Sarvise, M.

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Intratumoral BO-112, a double-stranded RNA (dsRNA), alone and in combination with systemic anti-PD-1 in solid tumors von Marquez Rodas, I., Longo, F., Rodriguez-Ruiz, M., Calles, A., Pérez-Gracia, J.L., Gomez-Rueda, A., Lopez-Tarruella, S., Ponz-Sarvisé, M., Alvarez, R.M., Soria, A., de-Miguel, E., Gayarre, J., Aznar, M.A., Calvo, A., Lopez-Casas, P.P., Tersago, D., Quintero, M., Martin-Algarra, S., Martín, M., Melero, I.

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P-164 MONEO: A phase II study of avelumab plus FLOT in the peri-operative treatment for patients with resectable gastric or gastroesophageal junction cancer von Alsina, M., Ponz-Sarvise, M., Lopez Garcia, D., Gonzalez, M., De Andrea, C., Gros, A., Vivancos, A., Jimenez Fonseca, P., Diez, M., Arrazubi, V., Sanz-García, E., Martinez de Castro, E., Guardeño Sanchez, R., Calvo Campos, M., Bugés Sánchez, C., Muñoz, F., Tabernero, J., Villacampa, G., Muñoz, S., Melero, I.

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A Multi-Center Phase IIA Trial to Assess the Safety and Efficacy of BL-8040 (a CXCR4 Inhibitor) in Combination with Pembrolizumab and Chemotherapy in Patients with Metastatic Pancr... von Hidalgo, M., Semenisty, V., Bockorny, B., Borazanci, E., von Hoff, D.D., Feliu, J., Sarvise, M. Ponz, Abad, D. Gutierrez, Peled, A., Bohana-Kashtan, O., Gozlan, Y., Sorani, E., Chaney, M., Kadosh, S., Vainstein, A.V., Macarulla, T.

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Previous immunotherapy treatments may improve tumor responses with subsequent chemotherapy regimens von Baraibar Argota, I., Martin-Romano, P., Sanmamed, M.F., Rodriguez-Ruiz, M., Pérez-Gracia, J.L., Gil-Bazo, I., Melero, I., Resano, L., Chopitea Ortega, A., Rodriguez, J., Aramendia, J.M., Gardeazabal, I., Ceniceros, L., Sala Elarre, P., Ponz-Sarvisé, M., Castanon Alvarez, E.

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