The Chosen Few: Parallel Library Reaction Methodologies for Drug Discovery von Dombrowski, Amanda W, Aguirre, Ana L, Shrestha, Anurupa, Sarris, Kathy A, Wang, Ying

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ChemBeads-Enabled Photoredox High-Throughput Experimentation Platform to Improve C(sp2)–C(sp3) Decarboxylative Couplings von Gesmundo, Nathan J., Tu, Noah P., Sarris, Kathy A., Wang, Ying

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Design and Development of Glucocorticoid Receptor Modulators as Immunology Antibody–Drug Conjugate Payloads von Hobson, Adrian D, McPherson, Michael J, Waegell, Wendy, Goess, Christian A, Stoffel, Robert H, Li, Xiang, Zhou, Jian, Wang, Zhongyuan, Yu, Yajie, Hernandez, Axel, Bryant, Shaughn H, Mathieu, Suzanne L, Bischoff, Agnieszka K, Fitzgibbons, Julia, Pawlikowska, Martyna, Puthenveetil, Sujiet, Santora, Ling C, Wang, Lu, Wang, Lu, Marvin, Christopher C, Hayes, Martin E, Shrestha, Anurupa, Sarris, Kathy A, Li, Biqin

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Discovery of A‑971432, An Orally Bioavailable Selective Sphingosine-1-Phosphate Receptor 5 (S1P5) Agonist for the Potential Treatment of Neurodegenerative Disorders von Hobson, Adrian D, Harris, Christopher M, van der Kam, Elizabeth L, Turner, Sean C, Abibi, Ayome, Aguirre, Ana L, Bousquet, Peter, Kebede, Tegest, Konopacki, Donald B, Gintant, Gary, Kim, Youngjae, Larson, Kelly, Maull, John W, Moore, Nigel S, Shi, Dan, Shrestha, Anurupa, Tang, Xiubo, Zhang, Peng, Sarris, Kathy K

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Correction to “Design and Development of Glucocorticoid Receptor Modulators as Immunology Antibody–Drug Conjugate Payloads” von Hobson, Adrian D., McPherson, Michael J., Waegell, Wendy, Goess, Christian A., Stoffel, Robert H., Li, Xiang, Zhou, Jian, Wang, Zhongyuan, Yu, Yajie, Hernandez, Axel, Bryant, Shaughn H., Mathieu, Suzanne L., Bischoff, Agnieszka K., Fitzgibbons, Julia, Pawlikowska, Martyna, Puthenveetil, Sujiet, Santora, Ling C., Wang, Lu, Wang, Lu, Marvin, Christopher C., Hayes, Martin E., Shrestha, Anurupa, Sarris, Kathy A., Li, Biqin

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SAR of amino pyrrolidines as potent and novel protein-protein interaction inhibitors of the PRC2 complex through EED binding von Curtin, Michael L., Pliushchev, Marina A., Li, Huan-Qiu, Torrent, Maricel, Dietrich, Justin D., Jakob, Clarissa G., Zhu, Haizhong, Zhao, Hongyu, Wang, Ying, Ji, Zhiqin, Clark, Richard F., Sarris, Kathy A., Selvaraju, Sujatha, Shaw, Bailin, Algire, Mikkel A., He, Yupeng, Richardson, Paul L., Sweis, Ramzi F., Sun, Chaohong, Chiang, Gary G., Michaelides, Michael R.

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Identification of Selective Dual ROCK1 and ROCK2 Inhibitors Using Structure-Based Drug Design von Hobson, Adrian D, Judge, Russell A, Aguirre, Ana L, Brown, Brian S, Cui, Yifang, Ding, Ping, Dominguez, Eric, DiGiammarino, Enrico, Egan, David A, Freiberg, Gail M, Gopalakrishnan, Sujatha M, Harris, Christopher M, Honore, Marie P, Kage, Karen L, Kapecki, Nicolas J, Ling, Christopher, Ma, Junli, Mack, Helmut, Mamo, Mulugeta, Maurus, Stefan, McRae, Bradford, Moore, Nigel S, Mueller, Bernhard K, Mueller, Reinhold, Namovic, Marian T, Patel, Kaushal, Pratt, Steve D, Putman, C. Brent, Queeney, Kara L, Sarris, Kathy K, Schaffter, Lisa M, Stoll, Vincent, Vasudevan, Anil, Wang, Lei, Wang, Lu, Wirthl, William, Yach, Kimberly

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SAR and characterization of non-substrate isoindoline urea inhibitors of nicotinamide phosphoribosyltransferase (NAMPT) von Curtin, Michael L., Heyman, H. Robin, Clark, Richard F., Sorensen, Bryan K., Doherty, George A., Hansen, T. Matthew, Frey, Robin R., Sarris, Kathy A., Aguirre, Ana L., Shrestha, Anurupa, Tu, Noah, Woller, Kevin, Pliushchev, Marina A., Sweis, Ramzi F., Cheng, Min, Wilsbacher, Julie L., Kovar, Peter J., Guo, Jun, Cheng, Dong, Longenecker, Kenton L., Raich, Diana, Korepanova, Alla V., Soni, Nirupama B., Algire, Mikkel A., Richardson, Paul L., Marin, Violeta L., Badagnani, Ilaria, Vasudevan, Anil, Buchanan, F. Greg, Maag, David, Chiang, Gary G., Tse, Chris, Michaelides, Michael R.

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Discovery of 4-(5-(4-Chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744) as a Novel Positive Allosteric Modulator of the α7 Nicotinic Acetylcholine Rece... von Faghih, Ramin, Gopalakrishnan, Sujatha M, Gronlien, Jens Halvard, Malysz, John, Briggs, Clark A, Wetterstrand, Caroline, Ween, Hilde, Curtis, Michael P, Sarris, Kathy A, Gfesser, Gregory A, El-Kouhen, Rachid, Robb, Holly M, Radek, Richard J, Marsh, Kennan C, Bunnelle, William H, Gopalakrishnan, Murali

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Discovery of a novel small molecule binding site of human survivin von Wendt, Michael D., Sun, Chaohong, Kunzer, Aaron, Sauer, Daryl, Sarris, Kathy, Hoff, Ethan, Yu, Liping, Nettesheim, David G., Chen, Jun, Jin, Sha, Comess, Kenneth M., Fan, Yihong, Anderson, Steven N., Isaac, Binumol, Olejniczak, Edward T., Hajduk, Philip J., Rosenberg, Saul H., Elmore, Steven W.

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Discovery and Pharmacological Evaluation of Growth Hormone Secretagogue Receptor Antagonists von Xin, Zhili, Serby, Michael D, Zhao, Hongyu, Kosogof, Christi, Szczepankiewicz, Bruce G, Liu, Mei, Hutchins, Charles W, Sarris, Kathy A, Hoff, Ethan D, Falls, H. Douglas, Lin, Chun W, Ogiela, Christopher A, Collins, Christine A, Brune, Michael E, Bush, Eugene N, Droz, Brian A, Fey, Thomas A, Knourek-Segel, Victoria E, Shapiro, Robin, Jacobson, Peer B, Beno, David W. A, Turner, Teresa M, Sham, Hing L, Liu, Gang

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A simple and efficient one step synthesis of benzoxazoles and benzimidazoles from carboxylic acids von Wang, Ying, Sarris, Kathy, Sauer, Daryl R., Djuric, Stevan W.

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Isoindolinone ureas: a novel class of KDR kinase inhibitors von Curtin, Michael L, Frey, Robin R, Heyman, H.Robin, Sarris, Kathy A, Steinman, Douglas H, Holmes, James H, Bousquet, Peter F, Cunha, George A, Moskey, Maria D, Ahmed, Asma A, Pease, Lori J, Glaser, Keith B, Stewart, Kent D, Davidsen, Steven K, Michaelides, Michael R

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Development of Orally Efficacious Allosteric Inhibitors of TNFα via Fragment-Based Drug Design von Dietrich, Justin D, Longenecker, Kenton L, Wilson, Noel S, Goess, Christian, Panchal, Sanjay C, Swann, Steven L, Petros, Andrew M, Hobson, Adrian D, Ihle, David, Song, Danying, Richardson, Paul, Comess, Kenneth M, Cox, Philip B, Dombrowski, Amanda, Sarris, Kathy, Donnelly-Roberts, Diana L, Duignan, David B, Gomtsyan, Arthur, Jung, Paul, Krueger, A Chris, Mathieu, Suzanne, McClure, Andrea, Stoll, Vincent S, Wetter, Jill, Mankovich, John A, Hajduk, Philip J, Vasudevan, Anil, Stoffel, Robert H, Sun, Chaohong

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Tandem Click-Suzuki reactions in a novel flow reactor incorporating immobilized and exchangeable reagents von Tu, Noah P., Sarris, Kathy, Djuric, Stevan W.

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An Automated Microwave-Assisted Synthesis Purification System for Rapid Generation of Compound Libraries von Tu, Noah P., Searle, Philip A., Sarris, Kathy

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A simple and efficient automatable one step synthesis of triazolopyridines from carboxylic acids von Wang, Ying, Sarris, Kathy, Sauer, Daryl R., Djuric, Stevan W.

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An expeditious and convenient synthesis of acylsulfonamides utilizing polymer-supported reagents von Wang, Ying, Sarris, Kathy, Sauer, Daryl R., Djuric, Stevan W.

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Tandem Click-Suzuki reactions in a novel flow reactor incorporating immobilized and exchangeable reagentsElectronic supplementary information (ESI) available: Detailed experimental... von Tu, Noah P, Sarris, Kathy, Djuric, Stevan W

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Biochemical and biophysical characterization of unique switch pocket inhibitors of p38α von Swann, Steven L., Merta, Philip J., Kifle, Lemma, Groebe, Duncan, Sarris, Kathy, Hajduk, Philip J., Sun, Chaohong

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