Base Excision Repair: Mechanisms and Impact in Biology, Disease, and Medicine von Gohil, Dhara, Sarker, Altaf H, Roy, Rabindra

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Tobacco-specific nitrosamine 1-(N-methyl-N-nitrosamino)-1-(3-pyridinyl)-4-butanal (NNA) causes DNA damage and impaired replication/transcription in human lung cells von Sarker, Altaf H, Hang, Bo

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Classical non-homologous end-joining pathway utilizes nascent RNA for error-free double-strand break repair of transcribed genes von Chakraborty, Anirban, Tapryal, Nisha, Venkova, Tatiana, Horikoshi, Nobuo, Pandita, Raj K., Sarker, Altaf H., Sarkar, Partha S., Pandita, Tej K., Hazra, Tapas K.

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Human Flap Endonuclease Structures, DNA Double-Base Flipping, and a Unified Understanding of the FEN1 Superfamily von Tsutakawa, Susan E., Classen, Scott, Chapados, Brian R., Arvai, Andrew S., Finger, L. David, Guenther, Grant, Tomlinson, Christopher G., Thompson, Peter, Sarker, Altaf H., Shen, Binghui, Cooper, Priscilla K., Grasby, Jane A., Tainer, John A.

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Phosphate steering by Flap Endonuclease 1 promotes 5′-flap specificity and incision to prevent genome instability von Tsutakawa, Susan E., Thompson, Mark J., Arvai, Andrew S., Neil, Alexander J., Shaw, Steven J., Algasaier, Sana I., Kim, Jane C., Finger, L. David, Jardine, Emma, Gotham, Victoria J.B., Sarker, Altaf H., Her, Mai Z., Rashid, Fahad, Hamdan, Samir M., Mirkin, Sergei M., Grasby, Jane A., Tainer, John A.

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Neil2-null Mice Accumulate Oxidized DNA Bases in the Transcriptionally Active Sequences of the Genome and Are Susceptible to Innate Inflammation von Chakraborty, Anirban, Wakamiya, Maki, Venkova-Canova, Tatiana, Pandita, Raj K., Aguilera-Aguirre, Leopoldo, Sarker, Altaf H., Singh, Dharmendra Kumar, Hosoki, Koa, Wood, Thomas G., Sharma, Gulshan, Cardenas, Victor, Sarkar, Partha S., Sur, Sanjiv, Pandita, Tej K., Boldogh, Istvan, Hazra, Tapas K.

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The DNA glycosylase NEIL2 is protective during SARS-CoV-2 infection von Tapryal, Nisha, Chakraborty, Anirban, Saha, Kaushik, Islam, Azharul, Pan, Lang, Hosoki, Koa, Sayed, Ibrahim M., Duran, Jason M., Alcantara, Joshua, Castillo, Vanessa, Tindle, Courtney, Sarker, Altaf H., Wakamiya, Maki, Cardenas, Victor J., Sharma, Gulshan, Crotty Alexander, Laura E., Sur, Sanjiv, Sahoo, Debashis, Ghosh, Gourisankar, Das, Soumita, Ghosh, Pradipta, Boldogh, Istvan, Hazra, Tapas K.

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NEIL2 protects against oxidative DNA damage induced by sidestream smoke in human cells von Sarker, Altaf H, Chatterjee, Arpita, Williams, Monique, Lin, Sabrina, Havel, Christopher, Jacob, 3rd, Peyton, Boldogh, Istvan, Hazra, Tapas K, Talbot, Prudence, Hang, Bo

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Cell-autonomous progeroid changes in conditional mouse models for repair endonuclease XPG deficiency von Barnhoorn, Sander, Uittenboogaard, Lieneke M, Jaarsma, Dick, Vermeij, Wilbert P, Tresini, Maria, Weymaere, Michael, Menoni, Hervé, Brandt, Renata M C, de Waard, Monique C, Botter, Sander M, Sarker, Altaf H, Jaspers, Nicolaas G J, van der Horst, Gijsbertus T J, Cooper, Priscilla K, Hoeijmakers, Jan H J, van der Pluijm, Ingrid

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Recognition of RNA Polymerase II and Transcription Bubbles by XPG, CSB, and TFIIH: Insights for Transcription-Coupled Repair and Cockayne Syndrome von Sarker, Altaf H., Tsutakawa, Susan E., Kostek, Seth, Ng, Cliff, Shin, David S., Peris, Marian, Campeau, Eric, Tainer, John A., Nogales, Eva, Cooper, Priscilla K.

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Functional analysis of a conserved site mutation in the DNA end processing enzyme PNKP leading to ataxia with oculomotor apraxia type 4 in humans von Islam, Azharul, Chakraborty, Anirban, Gambardella, Stefano, Campopiano, Rosa, Sarker, Altaf H., Boldogh, Istvan, Hazra, Tapas

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Slot Blot Assay for Detection of R Loops von Sarker, Altaf H., Cooper, Priscilla K.

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Human DNA polymerase η promotes RNA-templated error-free repair of DNA double-strand breaks von Chakraborty, Anirban, Tapryal, Nisha, Islam, Azharul, Sarker, Altaf H., Manohar, Kodavati, Mitra, Joy, Hegde, Muralidhar L., Hazra, Tapas

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Site-specific acetylation of polynucleotide kinase 3′-phosphatase regulates its distinct role in DNA repair pathways von Islam, Azharul, Chakraborty, Anirban, Sarker, Altaf H, Aryal, Uma K, Pan, Lang, Sharma, Gulshan, Boldogh, Istvan, Hazra, Tapas

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Breaking the Rules: Protein Sculpting in NEIL2 Regulation von Tsutakawa, Susan E., Sarker, Altaf H.

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DNA glycosylase NEIL2 functions in multiple cellular processes von Sarker, Altaf H., Cooper, Priscilla K., Hazra, Tapas K.

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Transient and stabilized complexes of Nsp7, Nsp8, and Nsp12 in SARS-CoV-2 replication von Wilamowski, Mateusz, Hammel, Michal, Leite, Wellington, Zhang, Qiu, Kim, Youngchang, Weiss, Kevin L., Jedrzejczak, Robert, Rosenberg, Daniel J., Fan, Yichong, Wower, Jacek, Bierma, Jan C., Sarker, Altaf H., Tsutakawa, Susan E., Pingali, Sai Venkatesh, O’Neill, Hugh M., Joachimiak, Andrzej, Hura, Greg L.

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Deficiency in classical nonhomologous end-joining–mediated repair of transcribed genes is linked to SCA3 pathogenesis von Chakraborty, Anirban, Tapryal, Nisha, Venkova, Tatiana, Mitra, Joy, Vasquez, Velmarini, Sarke, Altaf H., Duarte-Silva, Sara, Huai, Weihan, Ashizawa, Tetsuo, Ghosh, Gourisankar, Macield, Patricia, Sarkar, Partha S., Hegde, Muralidhar L., Cheni, Xu, Hazra, Tapas K.

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Human XPG nuclease structure, assembly, and activities with insights for neurodegeneration and cancer from pathogenic mutations von Tsutakawa, Susan E., Sarker, Altaf H., Ng, Clifford, Arvai, Andrew S., Shin, David S., Shih, Brian, Jiang, Shuai, Thwin, Aye C., Tsai, Miaw-Sheue, Willcox, Alexandra, Her, Mai Zong, Trego, Kelly S., Raetz, Alan G., Rosenberg, Daniel, Bacolla, Albino, Hammel, Michal, Griffith, Jack D., Cooper, Priscilla K., Tainer, John A.

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ASCC1 structures and bioinformatics reveal a novel helix-clasp-helix RNA-binding motif linked to a two-histidine phosphodiesterase von Chinnam, Naga babu, Thapar, Roopa, Arvai, Andrew S., Sarker, Altaf H., Soll, Jennifer M., Paul, Tanmoy, Syed, Aleem, Rosenberg, Daniel J., Hammel, Michal, Bacolla, Albino, Katsonis, Panagiotis, Asthana, Abhishek, Tsai, Miaw-Sheue, Ivanov, Ivaylo, Lichtarge, Olivier, Silverman, Robert H., Mosammaparast, Nima, Tsutakawa, Susan E., Tainer, John A.

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