Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB von Sarbassov, Dos D., Ali, Siraj M., Sengupta, Shomit, Sheen, Joon-Ho, Hsu, Peggy P., Bagley, Alex F., Markhard, Andrew L., Sabatini, David M.

Volltext

FoxO Transcription Factors Promote AKT Ser473 Phosphorylation and Renal Tumor Growth in Response to Pharmacologic Inhibition of the PI3K-AKT Pathway von AIFU LIN, PIAO, Hai-Long, LI ZHUANG, SARBASSOV, Dos D, LI MA, BOYI GAN

Volltext

Skp2-Mediated RagA Ubiquitination Elicits a Negative Feedback to Prevent Amino-Acid-Dependent mTORC1 Hyperactivation by Recruiting GATOR1 von Jin, Guoxiang, Lee, Szu-Wei, Zhang, Xian, Cai, Zhen, Gao, Yuan, Chou, Ping-Chieh, Rezaeian, Abdol Hossein, Han, Fei, Wang, Chi-Yun, Yao, Juo-Chin, Gong, Zhaohui, Chan, Chia-Hsin, Huang, Chih-Yang, Tsai, Fuu-Jen, Tsai, Chang-Hai, Tu, Shih-Hsin, Wu, Chih-Hsiung, Sarbassov, Dos D., Ho, Yuan-Soon, Lin, Hui-Kuan

Volltext

ATF4 induction through an atypical integrated stress response to ONC201 triggers p53-independent apoptosis in hematological malignancies von Ishizawa, Jo, Kojima, Kensuke, Chachad, Dhruv, Ruvolo, Peter, Ruvolo, Vivian, Jacamo, Rodrigo O, Borthakur, Gautam, Mu, Hong, Zeng, Zhihong, Tabe, Yoko, Allen, Joshua E, Wang, Zhiqiang, Ma, Wencai, Lee, Hans C, Orlowski, Robert, Sarbassov, Dos D, Lorenzi, Philip L, Huang, Xuelin, Neelapu, Sattva S, McDonnell, Timothy, Miranda, Roberto N, Wang, Michael, Kantarjian, Hagop, Konopleva, Marina, Davis, R Eric, Andreeff, Michael

Volltext

Formation of mammalian preribosomes proceeds from intermediate to composed state during ribosome maturation von Abetov, Danysh A., Kiyan, Vladimir S., Zhylkibayev, Assylbek A., Sarbassova, Dilara A., Alybayev, Sanzhar D., Spooner, Eric, Song, Min Sup, Bersimbaev, Rakhmetkazhy I., Sarbassov, Dos D.

Volltext

Autoregulation of the Mechanistic Target of Rapamycin (mTOR) Complex 2 Integrity Is Controlled by an ATP-dependent Mechanism von Chen, Chien-Hung, Kiyan, Vladimir, Zhylkibayev, Assylbek A., Kazyken, Dubek, Bulgakova, Olga, Page, Kent E., Bersimbaev, Rakhmet I., Spooner, Eric, Sarbassov, Dos D.

Volltext

High-throughput profiling of signaling networks identifies mechanism-based combination therapy to eliminate microenvironmental resistance in acute myeloid leukemia von Zeng, Zhihong, Liu, Wenbin, Tsao, Twee, Qiu, YiHua, Zhao, Yang, Samudio, Ismael, Sarbassov, Dos D, Kornblau, Steven M, Baggerly, Keith A, Kantarjian, Hagop M, Konopleva, Marina, Andreeff, Michael

Volltext

Rictor/mTORC2 Drives Progression and Therapeutic Resistance of HER2-Amplified Breast Cancers von Morrison Joly, Meghan, Hicks, Donna J, Jones, Bayley, Sanchez, Violeta, Estrada, Monica Valeria, Young, Christian, Williams, Michelle, Rexer, Brent N, Sarbassov, Dos D, Muller, William J, Brantley-Sieders, Dana, Cook, Rebecca S

Volltext

Isolation of the mTOR Complexes by Affinity Purification von Sarbassov, Dos D., Bulgakova, Olga, Bersimbaev, Rakhmet I., Shaiken, Tattym

Volltext

Insulin Receptor Substrate-1 and Phosphatidylinositol 3-Kinase Regulate Extracellular Signal-Regulated Kinase-Dependent and -Independent Signaling Pathways during Myogenic Differen... von Sarbassov, Dos D, Peterson, Charlotte A

Volltext

(734) Post-Mortem Genetic Testing of Sudden Cardiac Death Cases in Young Individuals: Value of Next-Generation Sequencing in Molecular Autopsy von Akilzhanova, A., Zhalbinova, M., Chamoieva, A., Samatkyzy, D., Rakhimova, S., Kozhamkulov, U., Akilzhanova, G., Kairov, U., Akilzhanov, K., Polyakova, T., Zhakupova, T., Bekbossynova, M., Sarbassov, D.

Volltext

Rictor phosphorylation on the Thr-1135 site does not require mammalian target of rapamycin complex 2 von Boulbes, Delphine, Chen, Chien-Hung, Shaikenov, Tattym, Agarwal, Nitin K, Peterson, Timothy R, Addona, Terri A, Keshishian, Hasmik, Carr, Steven A, Magnuson, Mark A, Sabatini, David M, Sarbassov, Dos D

Volltext

(380) - Sudden Cardiac Death: The Utility of Genetic Screening Using NGS in Kazakhstan von Akilzhanova, A., Zhalbinova, M., Chamoieva, A., Samatkyzy, D., Shahmarova, T., Mirmanova, Z., Rakhimova, S., Akilzhanova, G., Kozhamkulov, U., Akilzhanov, K., Kairov, U., Polyakova, T., Zhakupova, T., Bekbosynova, M., Sarbassov, D.

Volltext

The nuclear import of ribosomal proteins is regulated by mTOR von Kazyken, Dubek, Kaz, Yelimbek, Kiyan, Vladimir, Zhylkibayev, Assylbek A, Chen, Chien-Hung, Agarwal, Nitin K, Sarbassov, Dos D

Volltext

Extracellular Signal-Regulated Kinase-1 and -2 Respond Differently to Mitogenic and Differentiative Signaling Pathways in Myoblasts von Sarbassov, Dos D, Jones, Linda G, Peterson, Charlotte A

Volltext

Rictor encounters RhoGDI2: The second pilot is taking a lead von Agarwal, Nitin K., Kazyken, Dubek, Sarbassov, Dos D.

Volltext

Insulin receptor substrate-1 and phosphatidylinositol 3-kinase regulate extracellular signal-regulated kinase-dependent and -independent signaling pathways during myogenic differen... von Sarbassov, D D, Peterson, C A

Volltext

Role of Insulin-Like Growth Factors and Myogenin in the Altered Program of Proliferation and Differentiation in the NFB4 Mutant Muscle Cell Line von Sarbassov, Dos D., Stefanova, Rossina, Grigoriev, Vitalii G., Peterson, Charlotte A.

Volltext

A Chirality-Dependent Action of Vitamin C in Suppressing KRAS Mutant Tumor Growth by the Oxidative Combination: Rationale for Cancer Therapeutics von Wu, Xinggang, Park, Mikyung, Sarbassova, Dilara A., Ying, Haoqiang, Lee, Min Gyu, Bhattacharya, Rajat, Ellis, Lee, Peterson, Christine B., Hung, Mien-Chie, Lin, Hui-Kuan, Bersimbaev, Rakhmetkazhi I., Song, Min Sup, Sarbassov, Dos D.

Volltext

Peptidyl-prolyl cis/trans isomerase Pint is critical for the regulation of PKB/Akt stability and activation phosphorylation von LIAO, Y, WEI, Y, HUNG, M.-C, ZHOU, X, YANG, J.-Y, DAI, C, CHEN, Y.-J, AGARWAL, N. K, SARBASSOV, D, SHI, D, YU, D

Volltext