Monoclonal antibody-based therapies in cancer: Advances and challenges von SAPRA, Puja, SHOR, Boris

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Combining antibody–drug conjugates and immune-mediated cancer therapy: What to expect? von Gerber, Hans-Peter, Sapra, Puja, Loganzo, Frank, May, Chad

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The Next Generation of Antibody Drug Conjugates von Mack, Fiona, Ritchie, Michael, Sapra, Puja

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A general approach to site-specific antibody drug conjugates von Tian, Feng, Lu, Yingchun, Manibusan, Anthony, Sellers, Aaron, Tran, Hon, Sun, Ying, Phuong, Trung, Barnett, Richard, Hehli, Brad, Song, Frank, DeGuzman, Michael J., Ensari, Semsi, Pinkstaff, Jason K., Sullivan, Lorraine M., Biroc, Sandra L., Ho Cho, Schultz, Peter G., DiJoseph, John, Dougher, Maureen, Ma, Dangshe, Dushin, Russell, Leal, Mauricio, Tchistiakova, Lioudmila, Feyfant, Eric, Gerber, Hans-Peter, Sapra, Puja

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Advances in bispecific biotherapeutics for the treatment of cancer von May, Chad, Sapra, Puja, Gerber, Hans-Peter

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Antibody-drug conjugates: an emerging modality for the treatment of cancer von Leal, Mauricio, Sapra, Puja, Hurvitz, Sara A., Senter, Peter, Wahl, Alan, Schutten, Melissa, Shah, Dhaval K., Haddish-Berhane, Nahor, Kabbarah, Omar

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Novel Prodrugs of SN38 Using Multiarm Poly(ethylene glycol) Linkers von Zhao, Hong, Rubio, Belen, Sapra, Puja, Wu, Dechun, Reddy, Prasanna, Sai, Prakash, Martinez, Anthony, Gao, Ying, Lozanguiez, Yoany, Longley, Clifford, Greenberger, Lee M, Horak, Ivan D

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Multivalent peptidic linker enables identification of preferred sites of conjugation for a potent thialanstatin antibody drug conjugate von Puthenveetil, Sujiet, He, Haiyin, Loganzo, Frank, Musto, Sylvia, Teske, Jesse, Green, Michael, Tan, Xingzhi, Hosselet, Christine, Lucas, Judy, Tumey, L Nathan, Sapra, Puja, Subramanyam, Chakrapani, O'Donnell, Christopher J, Graziani, Edmund I

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Novel Delivery of SN38 Markedly Inhibits Tumor Growth in Xenografts, Including a Camptothecin-11–Refractory Model von SAPRA, Puja, HONG ZHAO, MEHLIG, Mary, MALABY, Jennifer, KRAFT, Patricia, LONGLEY, Clifford, GREENBERGER, Lee M, HORAK, Ivan D

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Gemtuzumab Ozogamicin (GO) Inclusion to Induction Chemotherapy Eliminates Leukemic Initiating Cells and Significantly Improves Survival in Mouse Models of Acute Myeloid Leukemia von Zhang, Cathy C, Yan, Zhengming, Pascual, Bernadette, Jackson-Fisher, Amy, Huang, Donghui Stephen, Zong, Qing, Elliott, Mark, Fan, Conglin, Huser, Nanni, Lee, Joseph, Sung, Matthew, Sapra, Puja

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Biodistribution and Targeting of Anti-5T4 Antibody-Drug Conjugate Using Fluorescence Molecular Tomography von Giddabasappa, Anand, Gupta, Vijay R, Norberg, Rand, Gupta, Parul, Spilker, Mary E, Wentland, Joann, Rago, Brian, Eswaraka, Jeetendra, Leal, Mauricio, Sapra, Puja

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Tumor Regression and Curability of Preclinical Neuroblastoma Models by PEGylated SN38 (EZN-2208), a Novel Topoisomerase I Inhibitor von PASTORINO, Fabio, LOI, Monica, SAPRA, Puja, BECHERINI, Pamela, CILLI, Michele, EMIONITE, Laura, RIBATTI, Domenico, GREENBERGER, Lee M, HORAK, Ivan D, PONZONI, Mirco

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Preclinical Development of an anti-5T4 Antibody–Drug Conjugate: Pharmacokinetics in Mice, Rats, and NHP and Tumor/Tissue Distribution in Mice von Leal, Mauricio, Wentland, JoAnn, Han, Xiaogang, Zhang, Yanhua, Rago, Brian, Duriga, Nicole, Spriggs, Franklin, Kadar, Eugene, Song, Wei, McNally, James, Shakey, Quazi, Lorello, Leslie, Lucas, Judy, Sapra, Puja

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Targeting and pharmacology of an anti-IL13Rα2 antibody and antibody-drug conjugate in a melanoma xenograft model von Gupta, Parul, Jiang, Ziyue Karen, Yang, Bing, Manzuk, Lisa, Rosfjord, Edward, Yao, Johnny, Lemon, Luanna, Noorbehesht, Kavon, David, John, Puthenveetil, Sujiet, Casavant, Jeffrey M, Muszynska, Elwira, Li, Fengping, Leal, Mauricio, Sapra, Puja, Giddabasappa, Anand

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Improved Outcome When B-Cell Lymphoma Is Treated with Combinations of Immunoliposomal Anticancer Drugs Targeted to Both the CD19 and CD20 Epitopes von SAPRA, Puja, ALLEN, Theresa M

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On translation of antibody drug conjugates efficacy from mouse experimental tumors to the clinic: a PK/PD approach von Haddish-Berhane, Nahor, Shah, Dhaval K., Ma, Dangshe, Leal, Mauricio, Gerber, Hans-Peter, Sapra, Puja, Barton, Hugh A., Betts, Alison M.

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Discovery and optimization of a novel anti-GUCY2c x CD3 bispecific antibody for the treatment of solid tumors von Root, Adam R., Guntas, Gurkan, Katragadda, Madan, Apgar, James R., Narula, Jatin, Chang, Chew Shun, Hanscom, Sara, McKenna, Matthew, Wade, Jason, Meade, Caryl, Ma, Weijun, Guo, Yongjing, Liu, Yan, Duan, Weili, Hendershot, Claire, King, Amy C., Zhang, Yan, Sousa, Eric, Tam, Amy, Benard, Susan, Yang, Han, Kelleher, Kerry, Jin, Fang, Piche-Nicholas, Nicole, Keating, Sinead E., Narciandi, Fernando, Lawrence-Henderson, Rosemary, Arai, Maya, Stochaj, Wayne R., Svenson, Kristine, Mosyak, Lidia, Lam, Khetemcnee, Francis, Christopher, Marquette, Kimberly, Wroblewska, Liliana, Zhu, H. Lily, Sheehan, Alfredo Darmanin, LaVallie, Edward R., D'Antona, Aaron M., Betts, Alison, King, Lindsay, Rosfjord, Edward, Cunningham, Orla, Lin, Laura, Sapra, Puja, Tchistiakova, Lioudmila, Mathur, Divya, Bloom, Laird

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Targeting the 5T4 oncofetal glycoprotein with an antibody drug conjugate (A1mcMMAF) improves survival in patient-derived xenograft models of acute lymphoblastic leukemia von McGinn, Owen J, Krishnan, Shekhar, Bourquin, Jean-Pierre, Sapra, Puja, Dempsey, Clare, Saha, Vaskar, Stern, Peter L

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Mediation of antitumor activity by AZD4820 oncolytic vaccinia virus encoding IL-12 von Kurokawa, Cheyne, Agrawal, Sonia, Mitra, Abhisek, Galvani, Elena, Burke, Shannon, Varshine, Ankita, Rothstein, Raymond, Schifferli, Kevin, Monks, Noel R, Foloppe, Johann, Silvestre, Nathalie, Quemeneur, Eric, Demeusoit, Christelle, Kleinpeter, Patricia, Sapra, Puja, Barrett, Carl, Hammond, Scott A, Kelly, Elizabeth J, Laliberte, Jason, Durham, Nicholas M, Oberst, Michael, Broggi, Maria A S

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Reduced expression of the androgen receptor by third generation of antisense shows antitumor activity in models of prostate cancer von Zhang, Yixian, Castaneda, Stephen, Dumble, Melissa, Wang, Maoliang, Mileski, Mary, Qu, Zhengxing, Kim, Steven, Shi, Victoria, Kraft, Patricia, Gao, Ying, Pak, Jenny, Sapra, Puja, Bandaru, Raj, Zhao, Hong, Vessella, Robert L, Horak, Ivan D, Greenberger, Lee M

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