Thousands of chemical starting points for antimalarial lead identification von Vanderwall, Dana E, Hasan, Samiul, Cardon, Lon R, Kumar, Vinod, de Cozar, Cristina, Green, Darren V. S, Peishoff, Catherine E, Brown, James R, Gamo, Francisco-Javier, Garcia-Bustos, Jose F, Sanz, Laura M, Alvarez, Emilio, Lavandera, Jose-Luis, Vidal, Jaume

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A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue von Sonoiki, Ebere, Ng, Caroline L., Lee, Marcus C. S., Guo, Denghui, Zhang, Yong-Kang, Zhou, Yasheen, Alley, M. R. K., Ahyong, Vida, Sanz, Laura M., Lafuente-Monasterio, Maria Jose, Dong, Chen, Schupp, Patrick G., Gut, Jiri, Legac, Jenny, Cooper, Roland A., Gamo, Francisco-Javier, DeRisi, Joseph, Freund, Yvonne R., Fidock, David A., Rosenthal, Philip J.

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P. falciparum in vitro killing rates allow to discriminate between different antimalarial mode-of-action von Sanz, Laura M, Crespo, Benigno, De-Cózar, Cristina, Ding, Xavier C, Llergo, Jose L, Burrows, Jeremy N, García-Bustos, Jose F, Gamo, Francisco-Javier

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Discovery and Structure–Activity Relationships of Quinazolinone-2-carboxamide Derivatives as Novel Orally Efficacious Antimalarials von Laleu, Benoît, Akao, Yuichiro, Ochida, Atsuko, Duffy, Sandra, Lucantoni, Leonardo, Shackleford, David M, Chen, Gong, Katneni, Kasiram, Chiu, Francis C. K, White, Karen L, Chen, Xue, Sturm, Angelika, Dechering, Koen J, Crespo, Benigno, Sanz, Laura M, Wang, Binglin, Wittlin, Sergio, Charman, Susan A, Avery, Vicky M, Cho, Nobuo, Kamaura, Masahiro

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Benzoxaborole Antimalarial Agents. Part 5. Lead Optimization of Novel Amide Pyrazinyloxy Benzoxaboroles and Identification of a Preclinical Candidate von Zhang, Yong-Kang, Plattner, Jacob J, Easom, Eric E, Jacobs, Robert T, Guo, Denghui, Freund, Yvonne R, Berry, Pamela, Ciaravino, Vic, Erve, John C. L, Rosenthal, Philip J, Campo, Brice, Gamo, Francisco-Javier, Sanz, Laura M, Cao, Jianxin

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Analyzing the Impact of COVID-19 Trauma on Developing Post-Traumatic Stress Disorder among Emergency Medical Workers in Spain von Martinez-Caballero, Carmen M., Cardaba-Garcia, Rosa M., Varas-Manovel, Rocio, Garcia-Sanz, Laura M., Martinez-Piedra, Jorge, Fernandez-Carbajo, Juan J., Perez-Perez, Lucia, Madrigal-Fernandez, Miguel A., Barba-Perez, M. Angeles, Olea, Elena, Durantez-Fernandez, Carlos, Herrero-Frutos, M. Teresa

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Development of a Novel High-Density [3H]Hypoxanthine Scintillation Proximity Assay To Assess Plasmodium falciparum Growth von de Cózar, Cristina, Caballero, Iván, Colmenarejo, Gonzalo, Sanz, Laura M, Álvarez-Ruiz, Emilio, Gamo, Francisco-Javier, Cid, Concepción

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Synthesis, Profiling, and in Vivo Evaluation of Cyclopeptides Containing N‑Methyl Amino Acids as Antiplasmodial Agents von Fagundez, Catherine, Sellanes, Diver, Peña, Stella, Scarone, Laura, Aguiar, Anna C. C, de Souza, Juliana O, Guido, Rafael V. C, Stewart, Lindsay, Yardley, Vanessa, Ottilie, Sabine, Winzeler, Elizabeth A, Gamo, Francisco-J, Sanz, Laura M, Serra, Gloria L

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Cyclopropyl Carboxamides, a Chemically Novel Class of Antimalarial Agents Identified in a Phenotypic Screen von Sanz, Laura M, Jiménez-Díaz, M. Belen, Crespo, Benigno, De-Cozar, Cristina, Almela, M. Jesus, Angulo-Barturen, Iñigo, Castañeda, Pablo, Ibañez, Javier, Fernández, Esther Pilar, Ferrer, Santiago, Herreros, Esperanza, Lozano, Sonia, Martínez, María Santos, Rueda, Lourdes, Burrows, Jeremy N, García-Bustos, Jose F, Gamo, Francisco-Javier

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A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission von Baker, David A., Stewart, Lindsay B., Large, Jonathan M., Bowyer, Paul W., Ansell, Keith H., Jiménez-Díaz, María B., El Bakkouri, Majida, Birchall, Kristian, Dechering, Koen J., Bouloc, Nathalie S., Coombs, Peter J., Whalley, David, Harding, Denise J., Smiljanic-Hurley, Ela, Wheldon, Mary C., Walker, Eloise M., Dessens, Johannes T., Lafuente, María José, Sanz, Laura M., Gamo, Francisco-Javier, Ferrer, Santiago B., Hui, Raymond, Bousema, Teun, Angulo-Barturén, Iñigo, Merritt, Andy T., Croft, Simon L., Gutteridge, Winston E., Kettleborough, Catherine A., Osborne, Simon A.

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Histone methyltransferase inhibitors are orally bioavailable, fast-acting molecules with activity against different species causing malaria in humans von Malmquist, Nicholas A, Sundriyal, Sandeep, Caron, Joachim, Chen, Patty, Witkowski, Benoit, Menard, Didier, Suwanarusk, Rossarin, Renia, Laurent, Nosten, Francois, Jiménez-Díaz, María Belén, Angulo-Barturen, Iñigo, Santos Martínez, María, Ferrer, Santiago, Sanz, Laura M, Gamo, Francisco-Javier, Wittlin, Sergio, Duffy, Sandra, Avery, Vicky M, Ruecker, Andrea, Delves, Michael J, Sinden, Robert E, Fuchter, Matthew J, Scherf, Artur

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Evaluation of 4-Amino 2-Anilinoquinazolines against Plasmodium and Other Apicomplexan Parasites In Vitro and in a P. falciparum Humanized NOD- scid IL2Rγ null Mouse Model of Malari... von Gilson, Paul R, Nguyen, William, Poole, William A, Teixeira, Jose E, Thompson, Jennifer K, Guo, Kaiyuan, Stewart, Rebecca J, Ashton, Trent D, White, Karen L, Sanz, Laura M, Gamo, Francisco-Javier, Charman, Susan A, Wittlin, Sergio, Duffy, James, Tonkin, Christopher J, Tham, Wai-Hong, Crabb, Brendan S, Cooke, Brian M, Huston, Christopher D, Cowman, Alan F, Sleebs, Brad E

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Optimisation of 2-(N-phenyl carboxamide) triazolopyrimidine antimalarials with moderate to slow acting erythrocytic stage activity von Bailey, Brodie L., Nguyen, William, Ngo, Anna, Goodman, Christopher D., Gancheva, Maria R., Favuzza, Paola, Sanz, Laura M., Gamo, Francisco-Javier, Lowes, Kym N., McFadden, Geoffrey I., Wilson, Danny W., Laleu, Benoît, Brand, Stephen, Jackson, Paul F., Cowman, Alan F., Sleebs, Brad E.

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Benzoxaborole Antimalarial Agents. Part 4. Discovery of Potent 6‑(2-(Alkoxycarbonyl)pyrazinyl-5-oxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles von Zhang, Yong-Kang, Plattner, Jacob J, Easom, Eric E, Jacobs, Robert T, Guo, Denghui, Sanders, Virginia, Freund, Yvonne R, Campo, Brice, Rosenthal, Philip J, Bu, Wei, Gamo, Francisco-Javier, Sanz, Laura M, Ge, Min, Li, Liang, Ding, Jie, Yang, Yin

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A Developability-Focused Optimization Approach Allows Identification of in Vivo Fast-Acting Antimalarials: N‑[3-[(Benzimidazol-2-yl)amino]propyl]amides von Keurulainen, Leena, Vahermo, Mikko, Puente-Felipe, Margarita, Sandoval-Izquierdo, Elena, Crespo-Fernández, Benigno, Guijarro-López, Laura, Huertas-Valentín, Leticia, de las Heras-Dueña, Laura, Leino, Teppo O, Siiskonen, Antti, Ballell-Pages, Lluís, Sanz, Laura M, Castañeda-Casado, Pablo, Jiménez-Díaz, M. Belén, Martínez-Martínez, María S, Viera, Sara, Kiuru, Paula, Calderón, Félix, Yli-Kauhaluoma, Jari

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Carbamoyl Triazoles, Known Serine Protease Inhibitors, Are a Potent New Class of Antimalarials von McConville, Matthew, Fernández, Jorge, Angulo-Barturen, Íñigo, Bahamontes-Rosa, Noemi, Ballell-Pages, Lluis, Castañeda, Pablo, de Cózar, Cristina, Crespo, Benigno, Guijarro, Laura, Jiménez-Díaz, María Belén, Martínez-Martínez, Maria S, de Mercado, Jaime, Santos-Villarejo, Ángel, Sanz, Laura M, Frigerio, Micol, Washbourn, Gina, Ward, Stephen A, Nixon, Gemma L, Biagini, Giancarlo A, Berry, Neil G, Blackman, Michael J, Calderón, Félix, O’Neill, Paul M

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Repositioning and Characterization of 1‑(Pyridin-4-yl)pyrrolidin-2-one Derivatives as Plasmodium Cytoplasmic Prolyl-tRNA Synthetase Inhibitors von Okaniwa, Masanori, Shibata, Akira, Ochida, Atsuko, Akao, Yuichiro, White, Karen L, Shackleford, David M, Duffy, Sandra, Lucantoni, Leonardo, Dey, Sumanta, Striepen, Josefine, Yeo, Tomas, Mok, Sachel, Aguiar, Anna Caroline C, Sturm, Angelika, Crespo, Benigno, Sanz, Laura M, Churchyard, Alisje, Baum, Jake, Pereira, Dhelio B, Guido, Rafael V. C, Dechering, Koen J, Wittlin, Sergio, Uhlemann, Anne-Catrin, Fidock, David A, Niles, Jacquin C, Avery, Vicky M, Charman, Susan A, Laleu, Benoît

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Benzoxaborole antimalarial agents. Part 2: Discovery of fluoro-substituted 7-(2-carboxyethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles von Zhang, Yong-Kang, Plattner, Jacob J., Freund, Yvonne R., Easom, Eric E., Zhou, Yasheen, Ye, Long, Zhou, Huchen, Waterson, David, Gamo, Francisco-Javier, Sanz, Laura M., Ge, Min, Li, Zhiya, Li, Lingchao, Wang, Hailong, Cui, Han

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Substituted Aminoacetamides as Novel Leads for Malaria Treatment von Norcross, Neil R., Wilson, Caroline, Baragaña, Beatriz, Hallyburton, Irene, Osuna‐Cabello, Maria, Norval, Suzanne, Riley, Jennifer, Fletcher, Daniel, Sinden, Robert, Delves, Michael, Ruecker, Andrea, Duffy, Sandra, Meister, Stephan, Antonova‐Koch, Yevgeniya, Crespo, Benigno, de Cózar, Cristina, Sanz, Laura M., Gamo, Francisco Javier, Avery, Vicky M., Frearson, Julie A., Gray, David W., Fairlamb, Alan H., Winzeler, Elizabeth A., Waterson, David, Campbell, Simon F., Willis, Paul A., Read, Kevin D., Gilbert, Ian H.

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Inhibitors of Plasmodial Serine Hydroxymethyltransferase (SHMT): Cocrystal Structures of Pyrazolopyrans with Potent Blood- and Liver-Stage Activities von Witschel, Matthias C, Rottmann, Matthias, Schwab, Anatol, Leartsakulpanich, Ubolsree, Chitnumsub, Penchit, Seet, Michael, Tonazzi, Sandro, Schwertz, Geoffrey, Stelzer, Frank, Mietzner, Thomas, McNamara, Case, Thater, Frank, Freymond, Céline, Jaruwat, Aritsara, Pinthong, Chatchadaporn, Riangrungroj, Pinpunya, Oufir, Mouhssin, Hamburger, Matthias, Mäser, Pascal, Sanz-Alonso, Laura M, Charman, Susan, Wittlin, Sergio, Yuthavong, Yongyuth, Chaiyen, Pimchai, Diederich, François

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