Seizure suppression and neuroprotection by targeting the purinergic P2X7 receptor during status epilepticus in mice von Engel, Tobias, Gomez‐Villafuertes, Rosa, Tanaka, Katsuhiro, Mesuret, Guillaume, Sanz‐Rodriguez, Amaya, Garcia‐Huerta, Paula, Miras‐Portugal, M. Teresa, Henshall, David C., Diaz‐Hernandez, Miguel

Volltext

Impact of JQ1 treatment on seizures, hippocampal gene expression, and gliosis in a mouse model of temporal lobe epilepsy von Harnett, Aileen, Mathoux, Justine, Wilson, Marc‐Michel, Heiland, Mona, Mamad, Omar, Srinivas, Sujithra, Sanfeliu, Albert, Sanz‐Rodriguez, Amaya, How, Kelvin Lau E., Delanty, Norman, Cryan, Jane, Brett, Francesca M., Farrell, Michael A., O'Brien, Donncha F., Henshall, David C., Brennan, Gary P.

Volltext

Increased neocortical expression of the P2X7 receptor after status epilepticus and anticonvulsant effect of P2X7 receptor antagonist A‐438079 von Jimenez‐Pacheco, Alba, Mesuret, Guillaume, Sanz‐Rodriguez, Amaya, Tanaka, Katsuhiro, Mooney, Claire, Conroy, Ronan, Miras‐Portugal, Maria Teresa, Diaz‐Hernandez, Miguel, Henshall, David C., Engel, Tobias

Volltext

MicroRNA inhibition using antimiRs in acute human brain tissue sections von Morris, Gareth, Langa, Elena, Fearon, Conor, Conboy, Karen, Lau E‐How, Kelvin, Sanz‐Rodriguez, Amaya, O'Brien, Donncha F., Sweeney, Kieron, Lacey, Austin, Delanty, Norman, Beausang, Alan, Brett, Francesca M., Cryan, Jane B., Cunningham, Mark O., Henshall, David C.

Volltext

Protective neuronal induction of ATF5 in endoplasmic reticulum stress induced by status epilepticus von TORRES-PERAZA, Jesus F, ENGEL, Tobias, MARTIN-IBANEZ, Raquel, SANZ-RODRIGUEZ, Amaya, ROSARIO FERNANDEZ-FERNANDEZ, M, ESGLEAS, Miriam, CANALS, Josep M, HENSHALL, David C, LUCAS, José J

Volltext

Transient P2X7 Receptor Antagonism Produces Lasting Reductions in Spontaneous Seizures and Gliosis in Experimental Temporal Lobe Epilepsy von Jimenez-Pacheco, Alba, Diaz-Hernandez, Miguel, Arribas-Blázquez, Marina, Sanz-Rodriguez, Amaya, Olivos-Oré, Luis A, Artalejo, Antonio R, Alves, Mariana, Letavic, Michael, Miras-Portugal, M Teresa, Conroy, Ronan M, Delanty, Norman, Farrell, Michael A, O'Brien, Donncha F, Bhattacharya, Anindya, Engel, Tobias, Henshall, David C

Volltext

Genome-wide microRNA profiling of plasma from three different animal models identifies biomarkers of temporal lobe epilepsy von Brennan, Gary P., Bauer, Sebastian, Engel, Tobias, Jimenez-Mateos, Eva M., Del Gallo, Federico, Hill, Thomas D.M., Connolly, Niamh M.C., Costard, Lara S., Neubert, Valentin, Salvetti, Beatrice, Sanz-Rodriguez, Amaya, Heiland, Mona, Mamad, Omar, Brindley, Elizabeth, Norwood, Braxton, Batool, Aasia, Raoof, Rana, El-Naggar, Hany, Reschke, Cristina R., Delanty, Norman, Prehn, Jochen H.M., Fabene, Paolo, Mooney, Catherine, Rosenow, Felix, Henshall, David C.

Volltext

Cross-Talk between IGF-I and Estradiol in the Brain: Focus on Neuroprotection von Garcia-Segura, Luis M., Sanz, Amaya, Mendez, Pablo

Volltext

High Throughput qPCR Expression Profiling of Circulating MicroRNAs Reveals Minimal Sex- and Sample Timing-Related Variation in Plasma of Healthy Volunteers von Mooney, Catherine, Raoof, Rana, El-Naggar, Hany, Sanz-Rodriguez, Amaya, Jimenez-Mateos, Eva M, Henshall, David C

Volltext

Brain cell-specific origin of circulating microRNA biomarkers in experimental temporal lobe epilepsy von Brindley, Elizabeth, Heiland, Mona, Mooney, Catherine, Diviney, Mairead, Mamad, Omar, Hill, Thomas D M, Yan, Yan, Venø, Morten T, Reschke, Cristina R, Batool, Aasia, Langa, Elena, Sanz-Rodriguez, Amaya, Heller, Janosch P, Morris, Gareth, Conboy, Karen, Kjems, Jørgen, Brennan, Gary P, Henshall, David C

Volltext

Anti-seizure effects of JNJ-54175446 in the intra-amygdala kainic acid model of drug-resistant temporal lobe epilepsy in mice von Mamad, Omar, Heiland, Mona, Lindner, Andreas U, Hill, Thomas D M, Ronroy, Ronan M, Rentrup, Kilian, Sanz-Rodriguez, Amaya, Langa, Elena, Heller, Janosch P, Moreno, Oscar, Llop, Jordi, Bhattacharya, Anindya, Palmer, James A, Ceusters, Marc, Engel, Tobias, Henshall, David C

Volltext

Altered Biogenesis and MicroRNA Content of Hippocampal Exosomes Following Experimental Status Epilepticus von Batool, Aasia, Hill, Thomas D M, Nguyen, Ngoc T, Langa, Elena, Diviney, Mairéad, Mooney, Catherine, Brennan, Gary P, Connolly, Niamh M C, Sanz-Rodriguez, Amaya, Cavanagh, Brenton L, Henshall, David C

Volltext

Potent Anti-seizure Effects of Locked Nucleic Acid Antagomirs Targeting miR-134 in Multiple Mouse and Rat Models of Epilepsy von Reschke, Cristina R., Silva, Luiz F. Almeida, Norwood, Braxton A., Senthilkumar, Ketharini, Morris, Gareth, Sanz-Rodriguez, Amaya, Conroy, Ronán M., Costard, Lara, Neubert, Valentin, Bauer, Sebastian, Farrell, Michael A., O’Brien, Donncha F., Delanty, Norman, Schorge, Stephanie, Pasterkamp, R. Jeroen, Rosenow, Felix, Henshall, David C.

Volltext

Genetic deletion of microRNA-22 blunts the inflammatory transcriptional response to status epilepticus and exacerbates epilepsy in mice von Almeida Silva, Luiz F, Reschke, Cristina R, Nguyen, Ngoc T, Langa, Elena, Sanz-Rodriguez, Amaya, Gerbatin, Rogerio R, Temp, Fernanda R, de Freitas, Mayara L, Conroy, Ronan M, Brennan, Gary P, Engel, Tobias, Henshall, David C

Volltext

P2X7 Receptor Inhibition Interrupts the Progression of Seizures in Immature Rats and Reduces Hippocampal Damage von Mesuret, Guillaume, Engel, Tobias, Hessel, Ellen V., Sanz‐Rodriguez, Amaya, Jimenez‐Pacheco, Alba, Miras‐Portugal, M. Teresa, Diaz‐Hernandez, Miguel, Henshall, David C.

Volltext

Mitochondrial localization of the Forkhead box class O transcription factor FOXO3a in brain von Caballero‐Caballero, Aurelien, Engel, Tobias, Martinez‐Villarreal, Jaime, Sanz‐Rodriguez, Amaya, Chang, Patrick, Dunleavy, Mark, Mooney, Claire M., Jimenez‐Mateos, Eva M., Schindler, Clara K., Henshall, David C.

Volltext

Role of estrogen receptor α in membrane-initiated signaling in neural cells: Interaction with IGF-1 receptor von Marin, Raquel, Díaz, Mario, Alonso, Rafael, Sanz, Amaya, Arévalo, María Angeles, Garcia-Segura, Luis M.

Volltext

miRNA Expression Profile after Status Epilepticus and Hippocampal Neuroprotection by Targeting miR-132 von Jimenez-Mateos, Eva M, Bray, Isabella, Sanz-Rodriguez, Amaya, Engel, Tobias, McKiernan, Ross C, Mouri, Genshin, Tanaka, Katsuhiro, Sano, Takanori, Saugstad, Julie A, Simon, Roger P, Stallings, Raymond L, Henshall, David C

Volltext

Context-Specific Switch from Anti- to Pro-epileptogenic Function of the P2Y1 Receptor in Experimental Epilepsy von Alves, Mariana, Garcia, Laura De Diego, Conte, Giorgia, Jimenez-Mateos, Eva M, D'Orsi, Beatrice, Sanz-Rodriguez, Amaya, Prehn, Jochen HM, Henshall, David C, Engel, Tobias

Volltext

A systems approach delivers a functional microRNA catalog and expanded targets for seizure suppression in temporal lobe epilepsy von Venø, Morten T., Reschke, Cristina R., Morris, Gareth, Connolly, Niamh M. C., Su, Junyi, Yan, Yan, Engel, Tobias, Jimenez-Mateos, Eva M., Harder, Lea M., Pultz, Dennis, Haunsberger, Stefan J., Pal, Ajay, Heller, Janosch P., Campbell, Aoife, Langa, Elena, Brennan, Gary P., Conboy, Karen, Richardson, Amy, Norwood, Braxton A., Costard, Lara S., Neubert, Valentin, Del Gallo, Federico, Salvettik, Beatrice, Vangoor, Vamshidhar R., Sanz-Rodriguez, Amaya, Muilu, Juha, Fabene, Paolo F., Pasterkamp, R. Jeroen, Prehn, Jochen H. M., Schorge, Stephanie, Andersen, Jens S., Rosenow, Felix, Bauer, Sebastian, Kjems, Jørgen, Henshallb, David C.

Volltext