Discovery and SAR of 1,3,4-thiadiazole derivatives as potent Abl tyrosine kinase inhibitors and cytodifferentiating agents von Radi, Marco, Crespan, Emmanuele, Botta, Giorgia, Falchi, Federico, Maga, Giovanni, Manetti, Fabrizio, Corradi, Valentina, Mancini, Manuela, Santucci, Maria Alessandra, Schenone, Silvia, Botta, Maurizio

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Identification of the first non-peptidic small molecule inhibitor of the c-Abl/14-3-3 protein–protein interactions able to drive sensitive and Imatinib-resistant leukemia cells to... von Corradi, Valentina, Mancini, Manuela, Manetti, Fabrizio, Petta, Sara, Santucci, Maria Alessandra, Botta, Maurizio

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A New Nonpeptidic Inhibitor of 14-3-3 Induces Apoptotic Cell Death in Chronic Myeloid Leukemia Sensitive or Resistant to Imatinib von Mancini, Manuela, Corradi, Valentina, Petta, Sara, Barbieri, Enza, Manetti, Fabrizio, Botta, Maurizio, Santucci, Maria Alessandra

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FOXM1 Transcription Factor: A New Component of Chronic Myeloid Leukemia Stem Cell Proliferation Advantage von Mancini, Manuela, Castagnetti, Fausto, Soverini, Simona, Leo, Elisa, De Benedittis, Caterina, Gugliotta, Gabriele, Rosti, Gianantonio, Bavaro, Luana, De Santis, Sara, Monaldi, Cecilia, Martelli, Margherita, Santucci, Maria Alessandra, Cavo, Michele, Martinelli, Giovanni

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Computational techniques are valuable tools for the discovery of protein–protein interaction inhibitors: The 14-3-3σ case von Corradi, Valentina, Mancini, Manuela, Santucci, Maria Alessandra, Carlomagno, Teresa, Sanfelice, Domenico, Mori, Mattia, Vignaroli, Giulia, Falchi, Federico, Manetti, Fabrizio, Radi, Marco, Botta, Maurizio

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BCR-ABL1-associated reduction of beta catenin antagonist Chibby1 in chronic myeloid leukemia von Leo, Elisa, Mancini, Manuela, Aluigi, Michela, Luatti, Simona, Castagnetti, Fausto, Testoni, Nicoletta, Soverini, Simona, Santucci, Maria Alessandra, Martinelli, Giovanni

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14-3-3 Binding and Sumoylation Concur to the Down-Modulation of β-catenin Antagonist chibby 1 in Chronic Myeloid Leukemia von Mancini, Manuela, Leo, Elisa, Takemaru, Ken-Ichi, Campi, Virginia, Castagnetti, Fausto, Soverini, Simona, De Benedittis, Caterina, Rosti, Gianantonio, Cavo, Michele, Santucci, Maria Alessandra, Martinelli, Giovanni

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Histone H3 covalent modifications driving response of BCR-ABL1+ cells sensitive and resistant to imatinib to Aurora kinase inhibitor MK-0457 von Mancini, Manuela, Aluigi, Michela, Leo, Elisa, Marcozzi, Chiara, Castagnetti, Fausto, Barbieri, Enza, Santucci, Maria Alessandra

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C6‐Unsubstituted Pyrazolo[3,4‐d]pyrimidines Are Dual Src/Abl Inhibitors Effective against Imatinib Mesylate Resistant Chronic Myeloid Leukemia Cell Lines von Santucci, Maria Alessandra, Corradi, Valentina, Mancini, Manuela, Manetti, Fabrizio, Radi, Marco, Schenone, Silvia, Botta, Maurizio

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New SRC/ABL inhibitors for chronic myeloid leukemia therapy show selectivity for T315I ABL mutant CD34+ cells von Santucci, Maria Alessandra, Mancini, Manuela, Corradi, Valentina, lacobucci, Ilaria, Martinelli, Giovanni, Botta, Maurizio, Schenone, Silvia

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Genomic imbalances associated with secondary acute leukemias in Hodgkin lymphoma von BRUSA, Gianluca, ZUFFA, Elisa, GABRIELE, Annalisa, MANCINI, Manuela, CORRADO, Patrizia, BARBIERI, Enza, ALESSANDRA SANTUCCI, Maria, HATTINGER, Claudia Maria, SERRA, Massimo, REMONDINI, Daniel, CASTELLANI, Gastone, RIGHI, Simona, CAMPIDELLI, Cristina, PILERI, Stefano, LUIGI ZINZANI, Pier

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DNA Methyltransferase 1 Drives Transcriptional Down-Modulation of β Catenin Antagonist Chibby1 Associated With the BCR-ABL1 Gene of Chronic Myeloid Leukemia von Leo, Elisa, Mancini, Manuela, Castagnetti, Fausto, Gugliotta, Gabriele, Santucci, Maria Alessandra, Martinelli, Giovanni

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Chibby 1: a new component of β-catenin-signaling in chronic myeloid leukemia von Mancini, Manuela, Soverini, Simona, Gugliotta, Gabriele, Santucci, Maria Alessandra, Rosti, Gianantonio, Cavo, Michele, Martinelli, Giovanni, Castagnetti, Fausto

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A calpain-cleaved fragment of β-catenin promotes BCRABL1+ cell survival evoked by autophagy induction in response to imatinib von Mancini, Manuela, Leo, Elisa, Campi, Virginia, Castagnetti, Fausto, Zazzeroni, Luca, Gugliotta, Gabriele, Santucci, Maria Alessandra, Martinelli, Giovanni

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Ponatinib treatment in chronic myeloid leukemia cell lines targets aurora kinase A/FOXM1 axis von Mancini, Manuela, De Santis, Sara, Monaldi, Cecilia, Bavaro, Luana, Martelli, Margherita, Gugliotta, Gabriele, Castagnetti, Fausto, Rosti, Gianantonio, Santucci, Maria Alessandra, Martinelli, Giovanni, Cavo, Michele, Soverini, Simona

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DNA Methyltransferase 1 Drives Transcriptional Down-Modulation of [beta] Catenin Antagonist Chibby1 Associated With the BCR-ABL1 Gene of Chronic Myeloid Leukemia von Leo, Elisa, Mancini, Manuela, Castagnetti, Fausto, Gugliotta, Gabriele, Santucci, Maria Alessandra, Martinelli, Giovanni

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Zinc-finger transcription factor slug contributes to the survival advantage of chronic myeloid leukemia cells von Mancini, Manuela, Petta, Sara, Iacobucci, Ilaria, Salvestrini, Valentina, Barbieri, Enza, Santucci, Maria Alessandra

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Aurora Kinase a: A New Component of Imatinib Resistance in Chronic Myeloid Leukemia von Mancini, Manuela, Soverini, Simona, Leo, Elisa, Castagnetti, Fausto, De Benedittis, Caterina, Gugliotta, Gabriele, Rosti, Gianantonio, Santucci, Maria Alessandra, Cavo, Michele, Martinelli, Giovanni

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Cytoplasmatic compartmentalization by Bcr-Abl promotes TET2 loss-of-function in chronic myeloid leukemia von Mancini, Manuela, Veljkovic, Nevena, Leo, Elisa, Aluigi, Michela, Borsi, Enrica, Galloni, Chiara, Iacobucci, Ilaria, Barbieri, Enza, Santucci, Maria Alessandra

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Chibby drives β catenin cytoplasmic accumulation leading to activation of the unfolded protein response in BCR-ABL1+ cells von Mancini, Manuela, Leo, Elisa, Takemaru, Ken-Ichi, Campi, Virginia, Borsi, Enrica, Castagnetti, Fausto, Gugliotta, Gabriele, Santucci, Maria Alessandra, Martinelli, Giovanni

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