Targeted Covalent Inactivation of Protein Kinases by Resorcylic Acid Lactone Polyketides von Schirmer, Andreas, Kennedy, Jonathan, Murli, Sumati, Reid, Ralph, Santi, Daniel V.

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Combinatorial polyketide biosynthesis by de novo design and rearrangement of modular polyketide synthase genes von Santi, Daniel V, Menzella, Hugo G, Reid, Ralph, Carney, John R, Chandran, Sunil S, Reisinger, Sarah J, Patel, Kedar G, Hopwood, David A

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Total Synthesis of Long DNA Sequences: Synthesis of a Contiguous 32-kb Polyketide Synthase Gene Cluster von Kodumal, Sarah J., Patel, Kedar G., Reid, Ralph, Menzella, Hugo G., Welch, Mark, Santi, Daniel V., Stroud, Robert M.

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A Model of Structure and Catalysis for Ketoreductase Domains in Modular Polyketide Synthases von Reid, Ralph, Piagentini, Misty, Rodriguez, Eduardo, Ashley, Gary, Viswanathan, Nina, Carney, John, Santi, Daniel V, Hutchinson, C. Richard, McDaniel, Robert

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GeMS: an advanced software package for designing synthetic genes von Jayaraj, Sebastian, Reid, Ralph, Santi, Daniel V.

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The Catalytic Mechanism and Structure of Thymidylate Synthase von Carreras, C W, Santi, D V

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Synthesis and biological activities of novel 17-aminogeldanamycin derivatives von Tian, Zong-Qiang, Liu, Yaoquan, Zhang, Dan, Wang, Zhan, Dong, Steven D., Carreras, Christopher W., Zhou, Yiqing, Rastelli, Giulio, Santi, Daniel V., Myles, David C.

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Lessons and Conclusions from Dissecting the Mechanism of a Bisubstrate Enzyme:  Thymidylate Synthase Mutagenesis, Function, and Structure von Finer-Moore, Janet S, Santi, Daniel V, Stroud, Robert M

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Antifolate-Resistant Mutants of Plasmodium falciparum Dihydrofolate Reductase von Sirawaraporn, Worachart, Sathitkul, Tanajit, Sirawaraporn, Rachada, Yuthavong, Yongyuth, Santi, Daniel V.

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A Multiplasmid Approach to Preparing Large Libraries of Polyketides von Xue, Qun, Ashley, Gary, Hutchinson, C. Richard, Santi, Daniel V.

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Exposition of a family of RNA m(5)C methyltransferases from searching genomic and proteomic sequences von Reid, R, Greene, P J, Santi, D V

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Production of a polyketide natural product in nonpolyketide-producing prokaryotic and eukaryotic hosts von Kealey, J.T, Liu, L, Santi, D.V, Betlach, M.C, Barr, P.J

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Metabolic Engineering of a Methylmalonyl-CoA Mutase−Epimerase Pathway for Complex Polyketide Biosynthesis in Escherichia coli von Dayem, Linda C, Carney, John R, Santi, Daniel V, Pfeifer, Blaine A, Khosla, Chaitan, Kealey, James T

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The Mechanism of Pseudouridine Synthase I as Deduced from Its Interaction with 5-fluorouracil-tRNA von Gu, Xiangrong, Liu, Yaoquan, Santi, Daniel V.

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A Conserved Aspartate of tRNA Pseudouridine Synthase Is Essential for Activity and a Probable Nucleophilic Catalyst von Huang, Lixuan, Pookanjanatavip, Manee, Gu, Xiangrong, Santi, Daniel V

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Redesign, synthesis and functional expression of the 6-deoxyerythronolide B polyketide synthase gene cluster von Menzella, Hugo G, Reisinger, Sarah J, Welch, Mark, Kealey, James T, Kennedy, Jonathan, Reid, Ralph, Tran, Chau Q, Santi, Daniel V

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The structural basis for tRNA recognition and pseudouridine formation by pseudouridine synthase I von Stroud, Robert M, Foster, Paul G, Huang, Lixuan, Santi, Daniel V

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Structure-Based Discovery of Inhibitors of Thymidylate Synthase von Shoichet, Brian K., Stroud, Robert M., Santi, Daniel V., Kuntz, Irwin D., Perry, Kathy M.

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Peptoids: A Modular Approach to Drug Discovery von Simon, Reyna J., Kania, Robert S., Zuckermann, Ronald N., Huebner, Verena D., Jewell, David A., Banville, Steven, Ng, Simon, Wang, Liang, Rosenberg, Steven, Marlowe, Charles K., Spellmeyer, David C., Tan, Ruoying, Frankel, Alan D., Santi, Daniel V., Cohen, Fred E., Bartlett, Paul A.

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Identification of New RNA Modifying Enzymes by Iterative Genome Search Using Known Modifying Enzymes as Probes von Gustafsson, Claes, Reid, Ralph, Greene, Patricia J., Santi, Daniel V.

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