Synaptic Vesicle Glycoprotein 2A Ligands in the Treatment of Epilepsy and Beyond von Löscher, Wolfgang, Gillard, Michel, Sands, Zara A., Kaminski, Rafal M., Klitgaard, Henrik

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Reconstruction of apo A2A receptor activation pathways reveal ligand-competent intermediates and state-dependent cholesterol hotspots von Lovera, Silvia, Cuzzolin, Alberto, Kelm, Sebastian, De Fabritiis, Gianni, Sands, Zara A.

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PlayMolecule CrypticScout: Predicting Protein Cryptic Sites Using Mixed-Solvent Molecular Simulations von Martinez-Rosell, Gerard, Lovera, Silvia, Sands, Zara A, De Fabritiis, Gianni

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Crystal structure of dopamine D1 receptor in complex with G protein and a non-catechol agonist von Sun, Bingfa, Feng, Dan, Chu, Matthew Ling-Hon, Fish, Inbar, Lovera, Silvia, Sands, Zara A., Kelm, Sebastian, Valade, Anne, Wood, Martyn, Ceska, Tom, Kobilka, Tong Sun, Lebon, Florence, Kobilka, Brian K.

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Further evidence for a differential interaction of brivaracetam and levetiracetam with the synaptic vesicle 2A protein von Wood, Martyn D., Sands, Zara A., Vandenplas, Catherine, Gillard, Michel

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Crystal structure of the adenosine A2A receptor bound to an antagonist reveals a potential allosteric pocket von Sun, Bingfa, Bachhawat, Priti, Chu, Matthew Ling-Hon, Wood, Martyn, Ceska, Tom, Sands, Zara A., Mercier, Joel, Lebon, Florence, Kobilka, Tong Sun, Kobilka, Brian K.

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Exploring the interaction of SV2A with racetams using homology modelling, molecular dynamics and site-directed mutagenesis von Lee, Joanna, Daniels, Veronique, Sands, Zara A, Lebon, Florence, Shi, Jiye, Biggin, Philip C

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An aqueous H+ permeation pathway in the voltage-gated proton channel Hv1 von Ramsey, I Scott, Mokrab, Younes, Carvacho, Ingrid, Sands, Zara A, Sansom, Mark S P, Clapham, David E

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Binding Mode and Structure-Activity Relationships around Direct Inhibitors of the Nrf2-Keap1 Complex von Jnoff, Eric, Albrecht, Claudia, Barker, John J., Barker, Oliver, Beaumont, Edward, Bromidge, Steven, Brookfield, Frederick, Brooks, Mark, Bubert, Christian, Ceska, Tom, Corden, Vincent, Dawson, Graham, Duclos, Stephanie, Fryatt, Tara, Genicot, Christophe, Jigorel, Emilie, Kwong, Jason, Maghames, Rosemary, Mushi, Innocent, Pike, Richard, Sands, Zara A., Smith, Myron A., Stimson, Christopher C., Courade, Jean-Philippe

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Front Cover: Identification of ß‐Glucocerebrosidase Activators for Glucosylceramide hydrolysis (ChemMedChem 7/2024) von Schulze, Monika‐Sarah E. D., Scholz, Diana, Jnoff, Eric, Hall, Adrian, Melin, Jonathan, Sands, Zara A., Rodriguez, Elizabeth, Andre, Veronique M.

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Accelerating GPCR Drug Discovery With Conformation-Stabilizing VHHs von Laeremans, Toon, Sands, Zara A, Claes, Pieter, De Blieck, Ann, De Cesco, Stephane, Triest, Sarah, Busch, Andreas, Felix, David, Kumar, Abhinav, Jaakola, Veli-Pekka, Menet, Christel

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Structure elucidation of a human melanocortin-4 receptor specific orthosteric nanobody agonist von Fontaine, Thomas, Busch, Andreas, Laeremans, Toon, De Cesco, Stéphane, Liang, Yi-Lynn, Jaakola, Veli-Pekka, Sands, Zara, Triest, Sarah, Masiulis, Simonas, Dekeyzer, Lies, Samyn, Noor, Loeys, Nicolas, Perneel, Lisa, Debaere, Melanie, Martini, Murielle, Vantieghem, Charlotte, Virmani, Richa, Skieterska, Kamila, Staelens, Stephanie, Barroco, Rosa, Van Roy, Maarten, Menet, Christel

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Identification of ß-Glucocerebrosidase Activators for Glucosylceramide hydrolysis von Schulze, Monika-Sarah E D, Scholz, Diana, Jnoff, Eric, Hall, Adrian, Melin, Jonathan, Sands, Zara A, Rodriguez, Elizabeth, Andre, Veronique M

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Alchembed: A Computational Method for Incorporating Multiple Proteins into Complex Lipid Geometries von Jefferys, Elizabeth, Sands, Zara A, Shi, Jiye, Sansom, Mark S. P, Fowler, Philip W

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The Aminotriazole Antagonist Cmpd‐1 Stabilises a Distinct Inactive State of the Adenosine 2A Receptor von Landin, Erik J. B., Lovera, Silvia, de Fabritiis, Gianni, Kelm, Sebastian, Mercier, Joël, McMillan, David, Sessions, Richard B., Taylor, Richard J., Sands, Zara A., Joedicke, Lisa, Crump, Matthew P.

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How Does a Voltage Sensor Interact with a Lipid Bilayer? Simulations of a Potassium Channel Domain von Sands, Zara A., Sansom, Mark S.P.

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Molecular Dynamics Simulations of Duplex Stretching Reveal the Importance of Entropy in Determining the Biomechanical Properties of DNA von Harris, Sarah A., Sands, Zara A., Laughton, Charles A.

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Crystal structure of the adenosine A 2A receptor bound to an antagonist reveals a potential allosteric pocket von Sun, Bingfa, Bachhawat, Priti, Chu, Matthew Ling-Hon, Wood, Martyn, Ceska, Tom, Sands, Zara A, Mercier, Joel, Lebon, Florence, Kobilka, Tong Sun, Kobilka, Brian K

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Design, Synthesis, and Biophysical and Biological Evaluation of a Series of Pyrrolobenzodiazepine−Poly(N-methylpyrrole) Conjugates von Wells, Geoff, Martin, Christopher R. H, Howard, Philip W, Sands, Zara A, Laughton, Charles A, Tiberghien, Arnaud, Woo, Chi Kit, Masterson, Luke A, Stephenson, Marissa J, Hartley, John A, Jenkins, Terence C, Shnyder, Steven D, Loadman, Paul M, Waring, Michael J, Thurston, David E

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Insight into the Mechanism of Inactivation and pH Sensitivity in Potassium Channels from Molecular Dynamics Simulations von Stansfeld, Phillip J, Grottesi, Alessandro, Sands, Zara A, Sansom, Mark S. P, Gedeck, Peter, Gosling, Martin, Cox, Brian, Stanfield, Peter R, Mitcheson, John S, Sutcliffe, Michael J

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