Discovery of Reversible DNA Methyltransferase and Lysine Methyltransferase G9a Inhibitors with Antitumoral in Vivo Efficacy von Rabal, Obdulia, San José-Enériz, Edurne, Agirre, Xabier, Sánchez-Arias, Juan Antonio, Vilas-Zornoza, Amaia, Ugarte, Ana, de Miguel, Irene, Miranda, Estíbaliz, Garate, Leire, Fraga, Mario, Santamarina, Pablo, Fernandez Perez, Raul, Ordoñez, Raquel, Sáez, Elena, Roa, Sergio, García-Barchino, María José, Martínez-Climent, José Angel, Liu, Yingying, Wu, Wei, Xu, Musheng, Prosper, Felipe, Oyarzabal, Julen

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Detailed Exploration around 4‑Aminoquinolines Chemical Space to Navigate the Lysine Methyltransferase G9a and DNA Methyltransferase Biological Spaces von Rabal, Obdulia, Sánchez-Arias, Juan Antonio, San José-Enériz, Edurne, Agirre, Xabier, de Miguel, Irene, Garate, Leire, Miranda, Estibaliz, Sáez, Elena, Roa, Sergio, Martínez-Climent, José Angel, Liu, Yingying, Wu, Wei, Xu, Musheng, Prosper, Felipe, Oyarzabal, Julen

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BOSO: A novel feature selection algorithm for linear regression with high-dimensional data von Valcárcel, Luis V, San José-Enériz, Edurne, Cendoya, Xabier, Rubio, Ángel, Agirre, Xabier, Prósper, Felipe, Planes, Francisco J

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Down-Regulation of hsa-miR-10a in Chronic Myeloid Leukemia CD34+ Cells Increases USF2-Mediated Cell Growth von Agirre, Xabier, Jiménez-Velasco, Antonio, San José-Enériz, Edurne, Garate, Leire, Bandrés, Eva, Cordeu, Lucia, Aparicio, Oscar, Saez, Borja, Navarro, Germán, Vilas-Zornoza, Amaia, Pérez-Roger, Ignacio, García-Foncillas, Jesús, Torres, Antonio, Heiniger, Anabel, Calasanz, María José, Fortes, Puri, Román-Gómez, José, Prósper, Felipe

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Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with In Vivo Efficacy in Multiple Myel... von Rabal, Obdulia, San José-Enériz, Edurne, Agirre, Xabier, Sánchez-Arias, Juan Antonio, de Miguel, Irene, Ordoñez, Raquel, Garate, Leire, Miranda, Estíbaliz, Sáez, Elena, Vilas-Zornoza, Amaia, Pineda-Lucena, Antonio, Estella, Ander, Zhang, Feifei, Wu, Wei, Xu, Musheng, Prosper, Felipe, Oyarzabal, Julen

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Epigenomic profiling of myelofibrosis reveals widespread DNA methylation changes in enhancer elements and ZFP36L1 as a potential tumor suppressor gene that is epigenetically regula... von Martínez-Calle, Nicolás, Pascual, Marien, Ordoñez, Raquel, Enériz, Edurne San José, Kulis, Marta, Miranda, Estíbaliz, Guruceaga, Elisabeth, Segura, Víctor, Larráyoz, María José, Bellosillo, Beatriz, Calasanz, María José, Besses, Carles, Rifón, José, Martín-Subero, José I, Agirre, Xabier, Prosper, Felipe

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Inhibiting Histone and DNA Methylation Improves Cancer Vaccination in an Experimental Model of Melanoma von De Beck, Lien, Awad, Robin Maximilian, Basso, Veronica, Casares, Noelia, De Ridder, Kirsten, De Vlaeminck, Yannick, Gnata, Alessandra, Goyvaerts, Cleo, Lecocq, Quentin, San José-Enériz, Edurne, Verhulst, Stefaan, Maes, Ken, Vanderkerken, Karin, Agirre, Xabier, Prosper, Felipe, Lasarte, Juan José, Mondino, Anna, Breckpot, Karine

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Epigenetic regulation of Wnt-signaling pathway in acute lymphoblastic leukemia von Román-Gómez, José, Cordeu, Lucia, Agirre, Xabier, Jiménez-Velasco, Antonio, San José-Eneriz, Edurne, Garate, Leire, Calasanz, María José, Heiniger, Anabel, Torres, Antonio, Prosper, Felipe

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An automated network-based tool to search for metabolic vulnerabilities in cancer von Valcárcel, Luis V., San José-Enériz, Edurne, Ordoñez, Raquel, Apaolaza, Iñigo, Olaverri-Mendizabal, Danel, Barrena, Naroa, Valcárcel, Ana, Garate, Leire, San Miguel, Jesús, Pineda-Lucena, Antonio, Agirre, Xabier, Prósper, Felipe, Planes, Francisco J.

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Deregulation of FGFR1 and CDK6 oncogenic pathways in acute lymphoblastic leukaemia harbouring epigenetic modifications of the MIR9 family von Rodriguez‐Otero, Paula, Román‐Gómez, José, Vilas‐Zornoza, Amaia, José‐Eneriz, Edurne San, Martín‐Palanco, Vanesa, Rifón, José, Torres, Antonio, Calasanz, María José, Agirre, Xabier, Prosper, Felipe

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An in-silico approach to predict and exploit synthetic lethality in cancer metabolism von Apaolaza, Iñigo, San José-Eneriz, Edurne, Tobalina, Luis, Miranda, Estíbaliz, Garate, Leire, Agirre, Xabier, Prósper, Felipe, Planes, Francisco J.

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Deregulation of linc-PINT in acute lymphoblastic leukemia is implicated in abnormal proliferation of leukemic cells von Garitano-Trojaola, Andoni, José-Enériz, Edurne San, Ezponda, Teresa, Unfried, Juan Pablo, Carrasco-León, Arantxa, Razquin, Nerea, Barriocanal, Marina, Vilas-Zornoza, Amaia, Sangro, Bruno, Segura, Victor, Prósper, Felipe, Fortes, Puri, Agirre, Xabier

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BET inhibitors down-regulate the expression of the essential lncRNA SMILO in multiple myeloma through regulation of the transcription factor FLI1 von Gómez-Echarte, Nahia, José-Enériz, Edurne San, Carrasco-León, Arantxa, Barrena, Naroa, Miranda, Estibaliz, Garate, Leire, García-Torre, Beatriz, Alonso-Moreno, Sandra, Gimenez-Camino, Naroa, Urizar-Compains, Estibaliz, Olaverri-Mendizabal, Danel, Aguirre-Ruiz, Paula, Ariceta, Beñat, Tamariz-Amador, Luis-Esteban, Rodriguez-Otero, Paula, Planes, Francisco J, Belver, Laura, Martín-Subero, José Ignacio, Prosper, Felipe, Agirre, Xabier

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HDAC Inhibitors in Acute Myeloid Leukemia von San José-Enériz, Edurne, Gimenez-Camino, Naroa, Agirre, Xabier, Prosper, Felipe

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MicroRNA expression profiling in Imatinib-resistant Chronic Myeloid Leukemia patients without clinically significant ABL1-mutations von San José-Enériz, Edurne, Román-Gómez, José, Jiménez-Velasco, Antonio, Garate, Leire, Martin, Vanesa, Cordeu, Lucia, Vilas-Zornoza, Amaia, Rodríguez-Otero, Paula, Calasanz, María José, Prósper, Felipe, Agirre, Xabier

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In-silico gene essentiality analysis of polyamine biosynthesis reveals APRT as a potential target in cancer von Pey, Jon, San José-Eneriz, Edurne, Ochoa, María Carmen, Apaolaza, Iñigo, de Atauri, Pedro, Rubio, Angel, Cendoya, Xabier, Miranda, Estíbaliz, Garate, Leire, Cascante, Marta, Carracedo, Arkaitz, Agirre, Xabier, Prosper, Felipe, Planes, Francisco J.

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Epigenetic down-regulation of BIM expression is associated with reduced optimal responses to imatinib treatment in chronic myeloid leukaemia von San José-Eneriz, Edurne, Agirre, Xabier, Jiménez-Velasco, Antonio, Cordeu, Lucia, Martín, Vanesa, Arqueros, Victor, Gárate, Leire, Fresquet, Vicente, Cervantes, Francisco, Martínez-Climent, José A, Heiniger, Anabel, Torres, Antonio, Prósper, Felipe, Roman-Gomez, Jose

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A network-based approach to integrate nutrient microenvironment in the prediction of synthetic lethality in cancer metabolism von Apaolaza, Iñigo, San José-Enériz, Edurne, Valcarcel, Luis V, Agirre, Xabier, Prosper, Felipe, Planes, Francisco J

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Epigenetic Silencing of the Tumor Suppressor MicroRNA Hsa-miR-124a Regulates CDK6 Expression and Confers a Poor Prognosis in Acute Lymphoblastic Leukemia von AGIRRE, Xabier, VILAS-ZORNOZA, Amaia, RIFON, José, BANDRES, Eva, CALASANZ, Maria José, MARTIN, Vanesa, HEINIGER, Anabel, TORRES, Antonio, SIEBERT, Reiner, ROMAN-GOMEZ, José, PROSPER, Felipe, JIMENEZ-VELASCO, Antonio, IGNACIO MARTIN-SUBERO, José, CORDEU, Lucia, GARATE, Leire, SAN JOSE-ENERIZ, Edurne, ABIZANDA, Gloria, RODRIGUEZ-OTERO, Paula, FORTES, Puri

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Frequent and simultaneous epigenetic inactivation of TP53 pathway genes in acute lymphoblastic leukemia von Vilas-Zornoza, Amaia, Agirre, Xabier, Martín-Palanco, Vanesa, Martín-Subero, José Ignacio, San José-Eneriz, Edurne, Garate, Leire, Álvarez, Sara, Miranda, Estíbaliz, Rodríguez-Otero, Paula, Rifón, José, Torres, Antonio, Calasanz, María José, Cruz Cigudosa, Juan, Román-Gómez, José, Prósper, Felipe

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